Scientific Highlights from Research Division
Biology and Chemistry (BIO)
Single-particle cryo-electron microscopy of a functional Aβ42 pore equivalent, created by fusing Aβ42 to the oligomerizing, soluble domain of the α-hemolysin toxin, offers new insights into structure and function of proteins forming amyloid aggregates in Alzheimer’s disease.
Using a combination of computer simulations and laboratory experiments, PSI researchers have identified new binding sites for active agents on the vital protein tubulin.
Imaging and sequencing techniques combined with machine learning offer researchers countless opportunities to look inside cells with greater precision than ever before. G.V. Shivashankar, lab head at PSI, describes how such information can be used to find answers to pressing questions.
Dr. Petr Skopintsev received PSI Thesis Medal 2021 for his work on the sodium pump KR2.
The European Research Council (ERC) is funding an interdisciplinary collaborative project with 10 million euros for the structural and biophysical analysis of selected photoreceptors and their development into "OptoGPCRs", light-controlled molecular switches with a wide range of applications in biology and medicine.
Researchers at the Paul Scherrer Institute PSI have succeeded for the first time in recording a light-driven sodium pump from bacterial cells in action. The findings promise progress in developing new methods in neurobiology. The researchers used the new X-ray free-electron laser SwissFEL for their investigations.
At the neutron source SINQ, PSI researchers are producing special radionuclides that aid in the development of new and more effectively targeted cancer therapies. In this they collaborate closely with the clinics in the surrounding area.
Researchers at the Paul Scherrer Institute PSI have elucidated an important part of a siganalling pathway that transmits information through the cell membrane into the interior of a cell. This exists in all mammals and plays an important role, among other things, in the regulation of the heartbeat. The new findings could lead to new therapies.
Gebhard Schertler is head of the research division Biology and Chemistry at the Paul Scherrer Institute PSI and professor for Structural Biology at ETH Zurich. In this interview he talks about biological research at PSI and the future of drug development.