Data science (DS) and artificial intelligence (AI) methods opens up an immense range of new opportunities and challenges in the context of continuously enhancing the complex methodologies used as basis for nuclear safety assessments. To this aim, following discussions in the ETSON Technical Board on Reactor Safety, the PSI laboratory for reactor physics and thermal-hydraulics organized on October 20-21, 2022, an international workshop to review and discuss DS/AI within ETSON, the network of European research and expert organizations providing scientific support to national nuclear authorities. With close to 40 participants, the workshop, organized as a hybrid meeting, allowed to put in evidence that similarly as at PSI, a wide and growing range of developments with integration of DS/AI methods are currently taking place in order to complement and/or inform nuclear safety analysis methodologies.