Laboratory for Macromolecules and BioimagingLSB

Microcalcifications are a common sign in mammography. For example, in 90% of ductal carcinoma in situ microcalcifications are the first and unique sign indicating the presence of the lesion. Nevertheless, up to around 50% of the resulting biopsies reveal a benign lesion, a 'false positive'. Researchers were able to show now that breast microcalcifications detected in tumors have specific chemical and crystalline features different from those observed in benign samples. Moreover, microcalcifications detected in tumors but located outside the lesion show malignant features too. This indicates that cancer influences the surrounding tissue even if it exhibits apparently healthy morphological features. These results indicate that the biochemical differences between benign and malignant microcalcifications can be potentially identified by light-based tools, able to investigate microcalcifications inside the breast without performing biopsies.