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Laboratory for Macromolecules and BioimagingLSB
Highlights
3D imaging for planar samples with zooming
Researchers of the Paul Scherrer Institut have previously generated 3-D images of a commercially available computer chip. This was achieved using a high-resolution tomography method. Now they extended their imaging approach to a so-called laminography geometry to remove the requirement of preparing isolated samples, also enabling imaging at various magnification. For ptychographic X-ray laminography (PyXL) a new instrument was developed and built, and new data reconstruction algorithms were implemented to align the projections and reconstruct a 3D dataset. The new capabilities were demonstrated by imaging a 16 nm FinFET integrated circuit at 18.9 nm 3D resolution at the Swiss Light Source. The results are reported in the latest edition of the journal Nature Electronics. The imaging technique is not limited to integrated circuits, but can be used for high-resolution 3D imaging of flat extended samples. Thus the researchers start now to exploit other areas of science ranging from biology to magnetism.
Metastasierung von Tumoren verhindern
Forschende des Paul Scherrer Instituts PSI sind gemeinsam mit Kollegen des Pharmaunternehmens F. Hoffmann-La Roche AG der Entwicklung eines Wirkstoffes gegen die Metastasierung von bestimmten Krebsarten einen wichtigen Schritt nähergekommen. Mithilfe der Synchrotron Lichtquelle Schweiz SLS entschlüsselten sie die Struktur eines Rezeptors, der entscheidend an der Wanderung von Krebszellen beteiligt ist.
World record in time-resolved tomography
Researchers from the Helmholtz Zentrum Berlin (HZB) and the TOMCAT beamline have achieved a new world record in time-resolved tomography by measuring over 200 tomographies per second during heating of an evolving aluminium metal foam.
Feststoffbatterien bei der Verformung beobachten
Forschende des PSI haben mechanische Vorgänge in Feststoffbatterien so genau wie noch nie beobachtet. Mittels Röntgentomografie an der Synchrotron Lichtquelle Schweiz SLS entdeckten sie, wie sich Risse im Inneren der Batterien ausbreiten. Die Erkenntnisse können dabei helfen, Akkus für Elektroautos oder Smartphones sicherer und leistungsfähiger zu machen.
Glycation of collagen in decellularized pericardium tissue: pilot study
Aging populations and diabetics suffer from the effects of the glycation of collagen, the non-enzymatic formation of glucose bridges. While the secondary effects have been studied intensely, comparatively little is known on the direct effect of glycation on the structure of collagen. It has been demonstrated in this study, that the direct impact of glycation can be determined with sub-atomic precision, and that a model system based on abundantly available connective tissue of farm animals can be used for such studies. This opens new avenues for inspecting the effects of diabetes mellitus on connective tissues and the influence of therapies on the resulting secondary disorders.
HERCULES school 2019 at SLS
In the week of April 1-5 PSI welcomes 20 PhD students and postdocs taking part in the European HERCULES 2019 school on Neutron and Synchrotron Radiation. They will attend lectures and perform two days of practical courses at several beam lines of the Swiss Light Source.
Inside Batteries
Lithium ion batteries (LIB) are essential in modern everyday life, with increasing interest in enhancing their performance and lifetime. Secondary particles of Li-rich cathode material were examined with correlated ptychographic X-ray tomography and diffraction microscopy at different stages of cycling to probe the aging mechanism.
Insights into a well-known disease in ageing populations: Abdominal and popliteal aneurysm
Abdominal aortic aneurysm, an enlargement of the abdominal aorta, may lead to rupture and thus acute health issues and death. Scanning X-ray imaging enabled new insights in the nano-structure of calcifications associated with abdonimal and popliteal aneurysm and allowed mapping the distribution of nano- and micro-calcifications as well as of collagen, elastin and myofilament as building blocks of connective tissue across samples from human donors.
Virtuelle Linse verbessert Röntgenmikroskopie
Eine von PSI-Forschenden neu entwickelte Methode macht Röntgenbilder von Materialien noch besser. Die Forschenden bewegten dafür eine optische Linse und nahmen dabei Einzelbilder auf. Mit Hilfe von Computeralgorithmen errechneten sie daraus ein Gesamtbild.