The Dikic group at the Goethe University in Frankfurt am Main, Germany has published the first results following the opening of the "PRIORITY COVID-19 Call” at SLS.
Microcalcifications are a common sign in mammography. For example, in 90% of ductal carcinoma in situ microcalcifications are the first and unique sign indicating the presence of the lesion. Nevertheless, up to around 50% of the resulting biopsies reveal a benign lesion, a 'false positive'. Researchers were able to show now that breast microcalcifications detected in tumors have specific chemical and crystalline features different from those observed in benign samples. Moreover, microcalcifications detected in tumors but located outside the lesion show malignant features too. This indicates that cancer influences the surrounding tissue even if it exhibits apparently healthy morphological features. These results indicate that the biochemical differences between benign and malignant microcalcifications can be potentially identified by light-based tools, able to investigate microcalcifications inside the breast without performing biopsies.
Tomogramme aus dem Inneren von Fossilien, Hirnzellen oder Computerchips liefern neue Erkenntnisse über feinste Strukturen. Die 3-D-Bilder gelingen mithilfe der Röntgenstrahlen der Synchrotron Lichtquelle Schweiz SLS dank eigens entwickelter Detektoren und raffinierter Computeralgorithmen.
Mit einer neu entwickelten Untersuchungsmethode konnten Forschende die magnetische Struktur im Inneren eines Materials mit Nanometer-Auflösung abbilden. Ihnen gelang ein kurzer «Film» aus sieben Bildern, der erstmalig in 3-D zeigt, wie sich winzige Wirbel der Magnetisierung tief im Inneren eines Materials verändern.
Innovation Award on Synchrotron Radiation 2019 for the development of XFEL detectors using the adaptive gain principle
The Innovation Award on Synchrotron Radiation 2019 was given to the researchers Prof. Heinz Graafsma from Desy and Dr. Aldo Mozzanica and Dr. Bernd Schmitt both from the Paul Scherrer Institute. The three physicists were honored for their contributions to the development of detectors for XFEL applications based on the dynamic gain switching principle enabling simultaneously single photon resolution and a large dynamic range. The laudation was held by Prof. Edgar Weckert from Desy. The Synchrotron Radiation Innovation Award is sponsored by SPECS GmbH and BESTEC GmbH.
Detailed characterization of cellular structure and development of exceptionally preserved ancient tiny fossils from South China by synchrotron based X-ray tomographic microscopy at TOMCAT led an international team of researchers from the University of Bristol and Nanjing Institute of Geology and Palaeontology to the discovery that animal-like embryos evolved long before the first animals appear in the fossil record.
Forschende des Paul Scherrer Instituts PSI haben eine neues Verfahren entwickelt, mit dem sich faserverstärkte Verbundwerkstoffe präzise durchleuchten lassen. Das könnte helfen, bessere Materialien mit neuartigen Eigenschaften zu entwickeln.
Researchers of the Paul Scherrer Institut have previously generated 3-D images of a commercially available computer chip. This was achieved using a high-resolution tomography method. Now they extended their imaging approach to a so-called laminography geometry to remove the requirement of preparing isolated samples, also enabling imaging at various magnification. For ptychographic X-ray laminography (PyXL) a new instrument was developed and built, and new data reconstruction algorithms were implemented to align the projections and reconstruct a 3D dataset. The new capabilities were demonstrated by imaging a 16 nm FinFET integrated circuit at 18.9 nm 3D resolution at the Swiss Light Source. The results are reported in the latest edition of the journal Nature Electronics. The imaging technique is not limited to integrated circuits, but can be used for high-resolution 3D imaging of flat extended samples. Thus the researchers start now to exploit other areas of science ranging from biology to magnetism.