The Laboratory of Multiscale Bioimaging (LMB) investigates the molecular structure and dynamics of complex molecular machines and cascades in the context of the living cell.
Lab News & Scientific Highlights
How the cheese-pasta principle could help counter Alzheimer's
PSI researchers have discovered cellular mechanisms that could help to mitigate diseases such as Alzheimer's and Parkinson's.
Manipulating microscopic object with sound
Manipulating microscopic objects with sound: hybrid acoustic tweezers with strong acoustic field were developed and successfully applied for transient mechanical deformation and capturing of biological cells.
New insights into a rare disease
Researchers at PSI have uncovered how genetic defects damage human cilia in different ways – a step towards improving the diagnosis of primary ciliary dyskinesia, a disease that has until now been poorly understood.
Publications
-
Chen Y, Sun X, Tang Y, Tan Y, Guo C, Pan T, et al.
Pathogenic mutation ΔK280 promotes hydrophobic interactions involving microtubule-binding domain and enhances liquid-liquid phase separation of tau
Small. 2025; 21(6): 2406429 (12 pp.). https://doi.org/10.1002/smll.202406429
DORA PSI -
Aidukas T, Phillips NW, Diaz A, Poghosyan E, Müller E, Levi AFJ, et al.
High-performance 4-nm-resolution X-ray tomography using burst ptychography
Nature. 2024; 632(8023): 81-88. https://doi.org/10.1038/s41586-024-07615-6
DORA PSI -
Asmara TC, Green RJ, Suter A, Wei Y, Zhang W, Knez D, et al.
Emergence of interfacial magnetism in strongly‐correlated nickelate‐titanate superlattices
Advanced Materials. 2024; 36(38): 2310668 (14 pp.). https://doi.org/10.1002/adma.202310668
DORA PSI -
Braunger JM, Cammarata LV, Sornapudi TR, Uhler C, Shivashankar GV
Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging
Aging cell. 2024; 23(3): e14056 (18 pp.). https://doi.org/10.1111/acel.14056
DORA PSI -
Cellini A, Shankar MK, Nimmrich A, Hunt LA, Monrroy L, Mutisya J, et al.
Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
Nature Chemistry. 2024; 16: 624-632. https://doi.org/10.1038/s41557-023-01413-9
DORA PSI