Laboratory of Multiscale Bioimaging (LMB)

Cells

The Laboratory of Multiscale Bioimaging (LMB) investigates the molecular structure and dynamics of complex molecular machines and cascades in the context of the living cell.

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Research and Technology Innovation
Manipulating microscopic object with sound by hybrid acoustic tweezers for moving and deforming tiny objects with a reusable surface-acoustic-wave (SAW) chip and a disposable microfluidic cartridge

Manipulating microscopic object with sound

Biology

Manipulating microscopic objects with sound: hybrid acoustic tweezers with strong acoustic field were developed and successfully applied for transient mechanical deformation and capturing of biological cells.

Vue d’artiste de cils vibratiles: ces prolongements cellulaires extrêmement fins couvrent la surface de certains tissus de manière très dense. Ce faisant, ils assument des fonctions vitales de transport et de nettoyage dans l’organisme. Leur perturbation peut entraîner l’apparition de maladies graves.
•Innovation santé
•9 min

De nouvelles perspectives sur une maladie rare

Médecine Diagnostics

Des scientifiques du PSI décryptent la manière dont certains défauts génétiques endommagent les cils vibratiles humains de différentes façons. C’est une étape vers l’amélioration du diagnostic d’une maladie encore mal comprise à ce jour: la dyskinésie ciliaire primitive.

Electron ptychography: scanning through the sample
•Future Technologies

Demystifying electron ptychography with the PtychoScopy tool

The open-source PtychoScopy tool guides users towards higher quality and faster electron ptychographic reconstructions. 

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  • Chen Y, Sun X, Tang Y, Tan Y, Guo C, Pan T, et al.
    Pathogenic mutation ΔK280 promotes hydrophobic interactions involving microtubule-binding domain and enhances liquid-liquid phase separation of tau
    Small. 2025; 21(6): 2406429 (12 pp.). https://doi.org/10.1002/smll.202406429
    DORA PSI
  • Aidukas T, Phillips NW, Diaz A, Poghosyan E, Müller E, Levi AFJ, et al.
    High-performance 4-nm-resolution X-ray tomography using burst ptychography
    Nature. 2024; 632(8023): 81-88. https://doi.org/10.1038/s41586-024-07615-6
    DORA PSI
  • Asmara TC, Green RJ, Suter A, Wei Y, Zhang W, Knez D, et al.
    Emergence of interfacial magnetism in strongly‐correlated nickelate‐titanate superlattices
    Advanced Materials. 2024; 36(38): 2310668 (14 pp.). https://doi.org/10.1002/adma.202310668
    DORA PSI
  • Braunger JM, Cammarata LV, Sornapudi TR, Uhler C, Shivashankar GV
    Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging
    Aging cell. 2024; 23(3): e14056 (18 pp.). https://doi.org/10.1111/acel.14056
    DORA PSI
  • Cellini A, Shankar MK, Nimmrich A, Hunt LA, Monrroy L, Mutisya J, et al.
    Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
    Nature Chemistry. 2024; 16: 624-632. https://doi.org/10.1038/s41557-023-01413-9
    DORA PSI
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