We investigate the structural and functional dynamics of amyloid nanoclusters and condensates in neurodegenerative diseases, pursuing two translational goals: (1) engineering molecular glues to trigger targeted degradation of pathogenic clusters and condensates, and (2) developing a point-of-care diagnostic device for rapid detection of toxic nanoclusters, oligomers, and pathogenic fibrils. Our approach combines cutting-edge nanopore sensing and engineering with advanced X-ray–based structural analysis.
Please check more details on my homepage (https://www.psi.ch/en/lmb/people/jinghui-luo)
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