Laboratory of Nanoscale Biology (LNB)
The Laboratory of Nanoscale Biology (LNB) investigates the molecular structure and dynamics of complex molecular machines and cascades within the context of the living cell. Technological developments at the PSI provide novel approaches for studying fundamental, molecular processes of life within their physiological context. Electron diffraction and cryo-electron microscopy of bio-molecular complexes form the technological basis of the LNB, together with electron tomography and X-ray diffractive imaging of larger, nanoscopic structures. We develop these technologies in studies of fundamental, molecular aspects of neuro-degeneration and cell motility, and investigate other fundamental processes of life in collaboration. Intellectual property on novel technologies developed at the LNB may lead to commercial spin-outs. As per January 1st, 2021, the Mechano-Genomics Group of Prof. G.V. Shivashankar has been integrated into the Lab. of Nanoscale Biology.
LNB News and Scientific Highlights
Biased signalling for better drugs
A dream drug would provide a targeted therapeutic effect without side effects. Biased signalling could make this a reality. Publishing in PNAS, PSI researchers present a platform for biased signalling-based drug discovery.
Fingerprint of Copper in Peptides Linked to Alzheimer's Disease
In an interdisciplinary project, researchers from the Laboratory of Nanoscale Biology in BIO and the Laboratory for Condensed Matter in PSD have revealed the reaction between the nitrogen atoms of the amyloid-beta peptide and copper/zinc ions by using soft X-ray absorption spectroscopy.
Protein distancing
PSI researchers have developed a new method to attach proteins to the surface of virus-like particles.
LNB research topics and support activities
Nanodiffraction
Novel technologies for visualising the atomic structures within the cell.
Cellular Structure Imaging
Cryo-EM and electron/X-ray tomography of cellular structure
Structural Biology of Neuronal Systems
Molecular neurobiology of fundamental responses to protein misfolding
Mechano-Genomics
Investigating mesoscale functional links between cell mechanics, genome organization and gene expression during cellular ageing, rejuvenation and tissue homeostasis.