Laboratory of Nanoscale Biology (LNB)
In presence of TNFa, translocation of p65 from the cytolsol to the nucleus is observed.
(Fluorescence microscopy of immuno-stained cells)
The Laboratory of Nanoscale Biology (LNB) investigates the molecular structure and dynamics of complex molecular machines and cascades in the context of the living cell. Current strengths of LNB include technology innovation and the uncovering of structure-function relationships in specific biological contexts. Using our distinct expertise, we engage in the development and improvement of novel methods for electron microscopy and diffraction. In addition, we have unique capabilities in protein bioengineering, (bio-)microfabrication and correlative imaging methods. LNB’s scientific strengths are to link structural information to functional contexts at length scales ranging from proteins to single cells to tissue. Typical examples include it situ studies on eukaryotic cilia proteins in their natural context, studies of protein aggregation or chromatin structure in the context of cell function as well as computation of connectome maps of the brain based on bio-imaging data to reveal new insights into brain function.
>>> LNB Mission and Organization
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LNB News and Scientific Highlights
Millions in funding for brain and quantum research
The European Research Council approves PSI projects for the development of a quantum computer and brain research worth about 5 million euros.
Biased signalling for better drugs
A dream drug would provide a targeted therapeutic effect without side effects. Biased signalling could make this a reality. Publishing in PNAS, PSI researchers present a platform for biased signalling-based drug discovery.
Fingerprint of Copper in Peptides Linked to Alzheimer's Disease
In an interdisciplinary project, researchers from the Laboratory of Nanoscale Biology in BIO and the Laboratory for Condensed Matter in PSD have revealed the reaction between the nitrogen atoms of the amyloid-beta peptide and copper/zinc ions by using soft X-ray absorption spectroscopy.