Laboratory of Nanoscale Biology (LNB)
In presence of TNFa, translocation of p65 from the cytolsol to the nucleus is observed.
(Fluorescence microscopy of immuno-stained cells)
The Laboratory of Nanoscale Biology (LNB) investigates the molecular structure and dynamics of complex molecular machines and cascades in the context of the living cell. Current strengths of LNB include technology innovation and the uncovering of structure-function relationships in specific biological contexts. Using our distinct expertise, we engage in the development and improvement of novel methods for electron microscopy and diffraction. In addition, we have unique capabilities in protein bioengineering, (bio-)microfabrication and correlative imaging methods. LNB’s scientific strengths are to link structural information to functional contexts at length scales ranging from proteins to single cells to tissue. Typical examples include it situ studies on eukaryotic cilia proteins in their natural context, studies of protein aggregation or chromatin structure in the context of cell function as well as computation of connectome maps of the brain based on bio-imaging data to reveal new insights into brain function.
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LNB News and Scientific Highlights
Controlling topological states in bilayer graphene
Parameters of topological channels created in twisted bilayer graphene can be controlled by lithium atoms intercalation.
Hairy cells: How cilia’s motor works
Understanding this motion may help to tackle health problems that affect cilia, which range from fertility issues to lung disease and COVID-19.
Imaging biomarkers for Alzheimer’s disease
Artificial intelligence pinpoints cells indicative of Alzheimer’s disease based on DNA packing in mouse brain images, shows study in Nature Communications