The Laboratory of Multiscale Bioimaging (LMB) investigates the molecular structure and dynamics of complex molecular machines and cascades in the context of the living cell.
Lab News & Scientific Highlights
Gold nanoparticle dynamics on graphene probed by convergent beam electron diffraction.
Dynamics of single Au nanoparticles on graphene were probed simultaneously in real- and diffraction space by time-series convergent beam electron diffraction.
Using AI to identify genetic perturbations from cell images
New AI identifies genetic perturbations in chromatin – a potential approach in diagnostics and drug development.
Dynamical transitions in dense packings
Biophysical modeling points to changes in collective dynamics under confinement as a key aspect of cell state transitions.
Publications
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Chen Y, Sun X, Tang Y, Tan Y, Guo C, Pan T, et al.
Pathogenic mutation ΔK280 promotes hydrophobic interactions involving microtubule-binding domain and enhances liquid-liquid phase separation of tau
Small. 2025; 21(6): 2406429 (12 pp.). https://doi.org/10.1002/smll.202406429
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Aidukas T, Phillips NW, Diaz A, Poghosyan E, Müller E, Levi AFJ, et al.
High-performance 4-nm-resolution X-ray tomography using burst ptychography
Nature. 2024; 632(8023): 81-88. https://doi.org/10.1038/s41586-024-07615-6
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Asmara TC, Green RJ, Suter A, Wei Y, Zhang W, Knez D, et al.
Emergence of interfacial magnetism in strongly‐correlated nickelate‐titanate superlattices
Advanced Materials. 2024; 36(38): 2310668 (14 pp.). https://doi.org/10.1002/adma.202310668
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Braunger JM, Cammarata LV, Sornapudi TR, Uhler C, Shivashankar GV
Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging
Aging cell. 2024; 23(3): e14056 (18 pp.). https://doi.org/10.1111/acel.14056
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Cellini A, Shankar MK, Nimmrich A, Hunt LA, Monrroy L, Mutisya J, et al.
Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
Nature Chemistry. 2024; 16: 624-632. https://doi.org/10.1038/s41557-023-01413-9
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