The position is available in the framework of the SNF Sinergia project “Linking timeresolved structures and signal transduction within multi-domain photosensors”. Our team employs the exciting new possibilities in time-resolved structural biology at the Swiss Light Source (SLS) and the Swiss X-ray free-electron laser (SwissFEL) to investigate the allosteric signaling between domains in various photoactive protein complexes. Time-resolved IR spectroscopy in collaboration with the University of Zurich will be used to specify selected time points, at which the population of intermediates is maximized and their 3D structures can be determined. Quantum chemical and molecular dynamics simulations in collaboration with the Hebrew University of Jerusalem allow to cross-validate the experimental IR spectra. Final cell biology experiments will close the loop from the initial stimulation to signaling output. For supplementary reading we suggest Skopintsev, et al. Femtosecond-to-millisecond structural changes in a light-driven sodium pump. Nature, (2020)., and/or Bozovic, et al. Using Azobenzene Photocontrol to Set Proteins in Motion, Nature Rev. Chem. (2022).
Eligible candidates should have a PhD degree and a proven track record in structural biology, biophysics, or related fields. Adequate communication skills in English are mandatory. Experience in protein expression, purification, crystallization and timeresolved pump-probe experiments is of advantage.
Our institution is based on an interdisciplinary, innovative and dynamic collaboration. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on-site infrastructure.
Your employment contract is limited to 2 years with a possible extension up to 4 years. Application to postdoctoral Fellowships is highly encouraged.
For further information, please contact Jörg Standfuss, phone +41 56 310 25 86.
Please submit your application online by 30 April 2023 (including list of publications and addresses of referees) for the position as a Postdoctoral Fellow (index no. 2316-00).
Paul Scherrer Institut, Human Resources Management, Silja Giacomini-Diebold, 5232 Villigen PSI, Switzerland