18. August 2011

Getting inside the mind (and up the nose) of our ancient ancestors

Media Releases Biology Research Using Synchrotron Light User Experiments

Reorganisation of the brain and sense organs could be the key to the evolutionary success of vertebrates, one of the great puzzles in evolutionary biology, according to a paper by an international team of researchers, published today in Nature.

The study claims to have solved this scientific riddle by studying the brain of a 400 million year old fossilized jawless fish – an evolutionary intermediate between the living jawless and jawed vertebrates (animals with backbones, such as humans).

Palaeontologists and physicists from the University of Bristol (UK), the Institute of Vertebrate Palaeontology and Palaeoanthropology (IVPP, China), Museum national d'Histoire naturelle (Paris, France) and the Paul Scherrer Institut (Switzerland) collaborated to study the structure of the head of a primitive fossil jawless fish called a galeaspid.

Instead of breaking the fossil up, they studied it using high energy X-rays at the Swiss Light Source in Switzerland, revealing the shape of the animal's brain and sense organs.

Lead author, Gai Zhi-kun of the University of Bristol and the IVPP, China, said We were able to see the paths of all the veins, nerves and arteries that plumbed the brain of these amazing fossils. They had brains much like living sharks – but no jaws.

The origin of a mouthful of jaws and teeth is one of the biggest steps in our evolutionary history but fossils have not provided any insights – until now.

Zhi-kun continued: We've been able to show that the brain of vertebrates was reorganised before the evolutionary origin of jaws.

Co-author, Professor Philip Donoghue of the University of Bristol's School of Earth Sciences said: In the embryology of living vertebrates, jaws develop from stem cells that migrate forwards from the hindbrain, and down between the developing nostrils. This does not and cannot happen in living jawless vertebrates because they have a single nasal organ that simply gets in the way. Professor Min Zhu of IVPP continued: This is the first real evidence for the steps that led to the evolutionary origin of jawed vertebrates, and the fossil provides us with rock solid proof.

Professor Philippe Janvier of the Museum national d'Histoire naturelle, Paris, said: This research has been held back for decades, waiting for a technology that will allow us to see inside the fossil without damaging it. We could not have done this work without this crazy collaboration between palaeontologists and physicists.

Professor Marco Stampanoni of the Paul Scherrer Insitut, the location of the Swiss Light Source said: We used a particle accelerator called synchrotron as X-ray source for performing non destructive 3D microscopy of the sample. It allowed us to make a perfect computer model of the fossil that we could cut up in any way that we wanted, but without damaging the fossil in any way. We would never have got permission to study the fossil otherwise!

This work was funded by the Royal Society, the Natural Environment Research Council, the Chinese Academy of Sciences, the Chinese Foundation of Natural Sciences, EU Framework Programme 7, and the Paul Scherrer Institut.

Scientists involved:
Zhi-kun Gai is a PhD student at the School of Earth Sciences, University of Bristol, UK and a Researcher at the Institute of Vertebrate Palaeontology and Palaeonanthropology, Beijing, P. R. China.

Professor Philip Donoghue is Professor of Palaeobiology in the School of Earth Sciences, University of Bristol, UK

Professor Min Zhu is Professor at the Institute of Vertebrate Palaeontology and Palaeonanthropology, Beijing, P. R. China.

Professor Philippe Janvier is a CNRS Principal Researcher at the Museum national d'Histoire naturelle Paris, France.

Professor Marco Stampanoni is Head of the X-ray Tomography Group at the Paul Scherrer Institut, Villigen, Switzerland and Assistant Professor for X-ray Microscopy at the Institute of Biomedical Engineering of the University and ETH Zürich.

Text: Public Relations Office, Communications Division, University of Bristol
About PSI
The Paul Scherrer Institute develops, builds and operates large-scale, complex research facilities and makes them available to the national and international research community. The organisation's own research activities focus on solid state physics and materials sciences, elementary particle physics, biology and medicine, energy and the environment. It is Switzerland's largest research institution, with a workforce of 1400 and an annual budget of approximately CHF 300 million.
Prof. Dr. Marco Stampanoni, Institute for Biomedical Engineering at ETH Zurich and the Laboratory for Macromolecules and Bioimaging at the Paul Scherrer Institute, 5232 Villigen PSI, Switzerland
Tel: +41 56 310 4724; E-mail: marco.stampanoni@psi.ch [German, English, Italian, French]

Professor Philip Donoghue, School of Earth Sciences, Wills Memorial Building, Queen's Road, Clifton, Bristol, BS8 1RJ, UK
Tel: +44 117 954 5440; E-mail: Phil.Donoghue@bristol.ac.uk
Original publication:
Fossil jawless fish from China foreshadows early jawed vertebrate anatomy,
Gai, Z-k., Donoghue, P. C. J., Zhu, M., Janvier, P. and Stampanoni, M.; Nature 18 August 2011; DOI: 10.1038/nature10276

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