Metal-based nanoparticles are a promising tool in medicine – as a contrast agent, transporter of active substances, or to thermally kill tumor cells. Up to now, it has been hardly possible to study their distribution inside an organism. Researchers at the University of Basel in collaboration with the TOMCAT team have used phase contrast X-ray tomographic microscopy to take high-resolution captures of the nanoparticle aggregation inside zebrafish embryos.
The study was published in the journal Small and featured on the cover of its current issue.
The team of Prof. Thomas Hermans at the University of Strasbourg in France managed to create wall-less aqueous liquid channels called anti-tubes. Thanks to X-ray phase contrast tomography at the TOMCAT beamline those anti-tubes could be observed in 3D. The exciting results were published in Nature on May 6, 2020.
The TOMCAT beamline at the Swiss Light Source specializes in rapid high-resolution 3-dimensional tomographic microscopy measurements with a strong focus on biomedical imaging. The team has recently developed a technique to acquire micrometer-scale resolution datasets on the entire lung structure of a juvenile rat in its fresh natural state within the animal’s body and without the need for any fixation, staining or other alteration that would affect the observed structure (E. Borisova et al., 2020, Histochem Cell Biol).
The grating fabrication team of the X-ray tomography group has scored another record in etching technology of silicon by realizing a MacEtch process in gas phase. Ultra-high aspect ratios (up to 10 000 : 1) in the nanoscale regime (down to 10 nm) were achieved by platinum assisted chemical etching of silicon in the gas phase. The results were published in Nanoscale Horizons on February 17, 2020.
Detailed characterization of cellular structure and development of exceptionally preserved ancient tiny fossils from South China by synchrotron based X-ray tomographic microscopy at TOMCAT led an international team of researchers from the University of Bristol and Nanjing Institute of Geology and Palaeontology to the discovery that animal-like embryos evolved long before the first animals appear in the fossil record.
Researchers at the Paul Scherrer Institute PSI have developed a new process with which fibre-reinforced composite materials can be precisely X-rayed. This could help to develop better materials with novel properties.
Researchers from the Helmholtz Zentrum Berlin (HZB) and the TOMCAT beamline have achieved a new world record in time-resolved tomography by measuring over 200 tomographies per second during heating of an evolving aluminium metal foam.
A method developed by PSI researchers makes X-ray images of materials even better. The researchers took a number of individual images while moving an optical lens. From these, with the help of computer algorithms, they generated one overall image.
Synchrotron-based X-ray tomographic microscopy of melanophores (skin pigment cells) of an amazingly well preserved 180 million years old ichtyosaur (extinct marine reptile similar to whales) contributed in a multidisciplinary investigation to the new findings published today in Nature.