Scientific Highlights

A group of EMPA and ETH Zürich researchers have developed a new method to directly write ink made of silica aerogels in 3D. Thanks to X-ray phase contrast tomography at the TOMCAT beamline they characterized the resulting printed material with different compositions. Their results were published in Nature on August 18, 2020.

Metal-based nanoparticles are a promising tool in medicine – as a contrast agent, transporter of active substances, or to thermally kill tumor cells. Up to now, it has been hardly possible to study their distribution inside an organism. Researchers at the University of Basel in collaboration with the TOMCAT team have used phase contrast X-ray tomographic microscopy to take high-resolution captures of the nanoparticle aggregation inside zebrafish embryos.

The study was published in the journal Small and featured on the cover of its current issue.

The team of Prof. Thomas Hermans at the University of Strasbourg in France managed to create wall-less aqueous liquid channels called anti-tubes. Thanks to X-ray phase contrast tomography at the TOMCAT beamline those anti-tubes could be observed in 3D. The exciting results were published in Nature on May 6, 2020.

The TOMCAT beamline at the Swiss Light Source specializes in rapid high-resolution 3-dimensional tomographic microscopy measurements with a strong focus on biomedical imaging. The team has recently developed a technique to acquire micrometer-scale resolution datasets on the entire lung structure of a juvenile rat in its fresh natural state within the animal’s body and without the need for any fixation, staining or other alteration that would affect the observed structure (E. Borisova et al., 2020, Histochem Cell Biol).

The grating fabrication team of the X-ray tomography group has scored another record in etching technology of silicon by realizing a MacEtch process in gas phase. Ultra-high aspect ratios (up to 10 000 : 1) in the nanoscale regime (down to 10 nm) were achieved by platinum assisted chemical etching of silicon in the gas phase. The results were published in Nanoscale Horizons on February 17, 2020.

Detailed characterization of cellular structure and development of exceptionally preserved ancient tiny fossils from South China by synchrotron based X-ray tomographic microscopy at TOMCAT led an international team of researchers from the University of Bristol and Nanjing Institute of Geology and Palaeontology to the discovery that animal-like embryos evolved long before the first animals appear in the fossil record.

Researchers from the Helmholtz Zentrum Berlin (HZB) and the TOMCAT beamline have achieved a new world record in time-resolved tomography by measuring over 200 tomographies per second during heating of an evolving aluminium metal foam.