PSI Center for Life Sciences | PSI

From coral berries to new therapies: uncovering the molecular glue mechanism of natural compounds

Researchers at the Center for Life Sciences and the Center for Scientific Computing, Theory, and Data at the Paul Scherrer Institute have identified the mechanism by which certain natural compounds interfere with cellular signaling. These ‘molecular glues’ have a therapeutic potential for the treatment of specific cancer types. Their latest study on this topic has been published in the journal Proceedings of the National Academy of Sciences of the United States of America.

Tracing the secrets of life: The PSI Center for Life Sciences is pursuing research in the areas of structural biology, bioimaging and radiopharmacy.

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News & Scientific Highlights

17.03.2025

•Health Innovation

•5 min

A superlative milestone

Medical Science Industry Relations

PSI spin-off Araris Biotech AG achieves valuation at unicorn-level!

Volodymyr M. Korkhov (left) and Richard Kammerer of the Center for Life Sciences at PSI have made important advances towards understanding how botulinum neurotoxin, botox for short, enters our nerve cells.

11.02.2025

•Health Innovation

•6 min

How botox enters our cells

Biology Medical Science

Researchers at PSI have identified structural changes of the bacterial neurotoxin botox that are important for its uptake into nerve cells. This finding could allow a more targeted use of botox in medicine.