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Scientific Highlights

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3 February 2022
How to get chloride ions into the cell

How to get chloride ions into the cell

A molecular movie shot at PSI reveals the mechanism of a light-driven chloride pump

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26 January 2022
Camila Bacellar wins EU XFEL Young Scientist Award

EU XFEL Young Scientist Award for Camila Bacellar

Camila Bacellar, beamline scientist and group leader of the Alvra endstation at SwissFEL, has received the European XFEL Young Scientist Award. The award recognises the contribution of young scientists to research at the European XFEL.

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14 October 2020
Doming

A protein's unexpected "doming"

Health Innovation Medical Science Radiopharmacy

Researchers have coaxed a secret out of the vital protein cytochrome c that it kept well-hidden up to now. Measurements at the X-ray free-electron laser SwissFEL reveal structural changes that science had previously ruled out for this kind of biomolecule.

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17 September 2020
A2A protein

Advances in de novo protein structure determination using long-wavelength native-SAD phasing at SwissFEL

An international team of scientists from the Paul Scherrer Institute and members of the LeadXpro and Heptares pharmaceutical companies led by Karol Nass (Alvra group, SwissFEL) demonstrated a significant advancement in de novo protein structure determination at X-ray free-electron lasers. Their article, published recently in IUCrJ (DOI: 10.1107/S2052252520011379), describes structure determination of a membrane protein and an important drug target (A2A adenosine receptor) by native single-wavelength anomalous diffraction (native-SAD) at SwissFEL with up to ten fold reduction in the required number of indexed images.

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14 September 2020
Cyt C structure

Unraveling the structural dynamics of Heme proteins at SwissFEL

The results from the very first user experiment at SwissFEL have just been published in the Proceedings of the National Academy of Sciences (PNAS). The measurements probed the electron transport properties of the cytochrome c protein, which is found in cellular mitochondria. The measurements show that when the Fe atom at the centre of the protein undergoes electronic excitation, for example when it gains or loses and electron, the  active centre of the protein undergoes a doming structural rearrangement. This result raises interesting questions about how this structural change is involved in the electron transfer properties of cytochrome c.

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20 May 2020
Petr Skopintsev (links), Jörg Standfuss (Mitte) und Christopher Milne (rechts) an der Experimentierstation Alvra am Freie-Elektronen-Röntgenlaser SwissFEL

Elucidating the mechanism of a light-driven sodium pump

Media Releases SwissFEL Biology

Researchers at the Paul Scherrer Institute PSI have succeeded for the first time in recording a light-driven sodium pump from bacterial cells in action. The findings promise progress in developing new methods in neurobiology. The researchers used the new X-ray free-electron laser SwissFEL for their investigations.

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1 May 2020
CuPCP gives off an intense green glow not only when current is applied, but also under UV light.

In search of the lighting material of the future

Media Releases SwissFEL Future Technologies Large Research Facilities Research Using Synchrotron Light

At the Paul Scherrer Institute PSI, researchers have gained insights into a promising material for organic light-emitting diodes (OLEDs). This new understanding at the atomic level will help to develop new lighting materials that have higher light output and also are cost-efficient to manufacture.

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25 June 2019
Measured longitudinal phase space of the injected electron beam

First serial femtosecond crystallography experiment using SwissFEL’s large bandwidth X-ray pulses

The typical mode of operation at XFEL facilities uses the so-called self-amplified spontaneous emission (SASE) process to generate the short, bright X-ray pulses. This mode of operation is stochastic in nature, causing some variance in intensity and spectrum on a shot-to-shot basis, which makes certain types of crystallographic measurements much more challenging.

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1 March 2019
Figure 1. Layout depicting the experimental conditions at the Alvra experimental station. (b) Fresnel simulation of the Talbot carpet: intensity distribution of the experimental conditions for a 1D diamond phase grating with a 200 nm pitch and 2.985 keV photon energy. The inset (c) shows the detailed structure of the interference pattern in the vicinity of the sample where the pitch is 190 nm

Towards X-ray Transient Grating Spectroscopy at SwissFEL

The high brilliance of new X-ray sources such as X-ray Free Electron Laser opens the way to non-linear spectroscopies. These techniques can probe ultrafast matter dynamics that would otherwise be inaccessible. One of these techniques, Transient Grating, involves the creation of a transient excitation grating by crossing X-ray beams on the sample. Scientists at PSI have realized a demonstration of such crossing by using an innovative approach well suited for the hard X-ray regime.

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Dr. Camila Bacellar
Group Leader
Telephone: +41 56 310 4231
E-mail: camila.bacellar@psi.ch

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Laboratory for Synchrotron Radiation and Femtochemistry

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Synchrotron light large research facility.

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The new X-ray free electron laser facility.

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