Publications

PDB structures measured at X06DA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Abrami L, Audagnotto M, Ho S, Marcaida MJ, Mesquita FS, Anwar MU, et al.
    Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
    Nature Chemical Biology. 2021; 17(4): 438-447. https://doi.org/10.1038/s41589-021-00753-2
    DORA PSI
  • Aeschimann W, Kammer S, Staats S, Schneider P, Schneider G, Rimbach G, et al.
    Engineering of a functional γ-tocopherol transfer protein
    Redox Biology. 2021; 38: 101773 (11 pp.). https://doi.org/10.1016/j.redox.2020.101773
    DORA PSI
  • Alali A, Zhang L, Li J, Zuo C, Wassouf D, Yan X, et al.
    Biosynthesis of the tricyclic aromatic type II polyketide rishirilide: new potential third ring oxygenation after three cyclization steps
    Molecular Biotechnology. 2021; 23: 502-514. https://doi.org/10.1007/s12033-021-00314-x
    DORA PSI
  • Axer A, Jumde RP, Adam S, Faust A, Schäfers M, Fobker M, et al.
    Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
    Chemical Science. 2021; 12(4): 1286-1294. https://doi.org/10.1039/D0SC04297H
    DORA PSI
  • Bailleul G, Nicoll CR, Mascotti ML, Mattevi A, Fraaije MW
    Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties
    Journal of Biological Chemistry. 2021; 296: 100221 (13 pp.). https://doi.org/10.1074/jbc.RA120.016297
    DORA PSI
  • Bauer V, Schmidtgall B, Gógl G, Dolenc J, Osz J, Nominé Y, et al.
    Conformational editing of intrinsically disordered protein by α-methylation
    Chemical Science. 2021; 12(3): 1080-1089. https://doi.org/10.1039/D0SC04482B
    DORA PSI
  • Chaoprasid P, Lukat P, Mühlen S, Heidler T, Gazdag E-M, Dong S, et al.
    Crystal structure of bacterial cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication
    EMBO Journal. 2021; 40(4): e105202 (21 pp.). https://doi.org/10.15252/embj.2020105202
    DORA PSI
  • Conrady MC, Suarez I, Gogl G, Frecot DI, Bonhoure A, Kostmann C, et al.
    Structure of high-risk papillomavirus 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation
    Journal of Virology. 2021; 95(2): e00730-20 (15 pp.). https://doi.org/10.1128/JVI.00730-20
    DORA PSI
  • De Zitter E, Hugelier S, Duwé S, Vandenberg W, Tebo AG, Van Meervelt L, et al.
    Structure–function dataset reveals environment effects within a fluorescent protein model system
    Angewandte Chemie International Edition. 2021; 60(18): 10073-10081. https://doi.org/10.1002/anie.202015201
    DORA PSI
  • Doemling A, Sutanto F, Shaabani S, Oerlemans R, Deniz E, Patil P, et al.
    Marriage of high throughput synthesis and high throughput protein crystallography
    Angewandte Chemie International Edition. 2021. https://doi.org/10.1002/anie.202105584
    DORA PSI
  • Johansson E, Wu X, Yu B, Yang Z, Cao Z, Wiberg C, et al.
    Insulin binding to the analytical antibody sandwich pair OXI‐005 and HUI‐018: epitope mapping and binding properties
    Protein Science. 2021; 30(2): 485-496. https://doi.org/10.1002/pro.4009
    DORA PSI
  • Kannt A, Rajagopal S, Hallur MS, Swamy I, Kristam R, Dhakshinamoorthy S, et al.
    Novel inhibitors of nicotinamide-N-methyltransferase for the treatment of metabolic disorders
    Molecules. 2021; 26(4): 991 (22 pp.). https://doi.org/10.3390/molecules26040991
    DORA PSI
  • Kröger P, Shanmugaratnam S, Ferruz N, Schweimer K, Höcker B
    A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF
    Structure. 2021; 29(5): 433-443. https://doi.org/10.1016/j.str.2020.12.005
    DORA PSI
  • Lemaire ON, Wagner T
    Gas channel rerouting in a primordial enzyme: structural insights of the carbon-monoxide dehydrogenase/acetyl-CoA synthase complex from the acetogen Clostridium autoethanogenum
    Biochimica et Biophysica Acta: Bioenergetics. 2021; 1862(1): 148330 (14 pp.). https://doi.org/10.1016/j.bbabio.2020.148330
    DORA PSI
  • Li Y, Bedi RK, Wiedmer L, Sun X, Huang D, Caflisch A
    Atomistic and thermodynamic analysis of N6-methyladenosine (m6A) recognition by the reader domain of YTHDC1
    Journal of Chemical Theory and Computation. 2021; 17(2): 1240-1249. https://doi.org/10.1021/acs.jctc.0c01136
    DORA PSI
  • Ostertag E, Zheng L, Broger K, Stehle T, Li S-M, Zocher G
    Reprogramming substrate and catalytic promiscuity of tryptophan prenyltransferases
    Journal of Molecular Biology. 2021; 433(2): 166726 (14 pp.). https://doi.org/10.1016/j.jmb.2020.11.025
    DORA PSI
  • Palmerini V, Monzani S, Laurichesse Q, Loudhaief R, Mari S, Cecatiello V, et al.
    Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
    Nature Communications. 2021; 12(1): 2070 (12 pp.). https://doi.org/10.1038/s41467-021-22080-9
    DORA PSI
  • Persson BD, John L, Rafie K, Strebl M, Frängsmyr L, Ballmann MZ, et al.
    Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(3): e2020732118 (8 pp.). https://doi.org/10.1073/pnas.2020732118
    DORA PSI
  • Pott M, Tinzl M, Hayashi T, Ota Y, Dunkelmann D, Mittl PRE, et al.
    Noncanonical heme ligands steer carbene transfer reactivity in an artificial metalloenzyme
    Angewandte Chemie International Edition. 2021. https://doi.org/10.1002/anie.202103437
    DORA PSI
  • Ramharter J, Kessler D, Ettmayer P, Hofmann MH, Gerstberger T, Gmachl M, et al.
    One atom makes all the difference: Getting a foot in the door between SOS1 and KRAS
    Journal of Medicinal Chemistry. 2021; 64(10): 6569-6580. https://doi.org/10.1021/acs.jmedchem.0c01949
    DORA PSI
  • Ried MK, Wild R, Zhu J, Pipercevic J, Sturm K, Broger L, et al.
    Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis
    Nature Communications. 2021; 12: 348 (13 pp.). https://doi.org/10.1038/s41467-020-20681-4
    DORA PSI
  • Ruegenberg S, Mayr FAMC, Atanassov I, Baumann U, Denzel MS
    Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
    Nature Communications. 2021; 12: 2176 (14 pp.). https://doi.org/10.1038/s41467-021-22320-y
    DORA PSI
  • Röhrig UF, Majjigapu SR, Reynaud A, Pojer F, Dilek N, Reichenbach P, et al.
    Azole-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
    Journal of Medicinal Chemistry. 2021; 64(4): 2205-2227. https://doi.org/10.1021/acs.jmedchem.0c01968
    DORA PSI
  • Schnitzler A, Niefind K
    Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin
    European Journal of Medicinal Chemistry. 2021; 214: 113223 (9 pp.). https://doi.org/10.1016/j.ejmech.2021.113223
    DORA PSI
  • Schultenkämper K, Gütle DD, López MG, Keller LB, Zhang L, Einsle O, et al.
    Interrogating the role of the two distinct fructose-bisphosphate aldolases of Bacillus methanolicus by site-directed mutagenesis of key amino acids and gene repression by CRISPR interference
    Frontiers in Microbiology. 2021; 12: 669220 (15 pp.). https://doi.org/10.3389/fmicb.2021.669220
    DORA PSI
  • Shyp V, Dubey BN, Böhm R, Hartl J, Nesper J, Vorholt JA, et al.
    Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus
    Nature Microbiology. 2021; 6(1): 59-72. https://doi.org/10.1038/s41564-020-00809-4
    DORA PSI
  • Signor L, Paris T, Mas C, Picard A, Lutfalla G, Boeri Erba E, et al.
    Divalent cations influence the dimerization mode of murine S100A9 protein by modulating its disulfide bond pattern
    Journal of Structural Biology. 2021; 213(1): 107689 (16 pp.). https://doi.org/10.1016/j.jsb.2020.107689
    DORA PSI
  • Simeth NA, Kinateder T, Rajendran C, Nazet J, Merkl R, Sterner R, et al.
    Towards photochromic azobenzene-based inhibitors for tryptophan synthase
    Chemistry: A European Journal. 2021; 27(7): 2439-2451. https://doi.org/10.1002/chem.202004061
    DORA PSI
  • Soh Y-M, Basquin J, Gruber S
    A rod conformation of the Pyrococcus furiosus Rad50 coiled coil
    Proteins. 2021; 89(2): 251-255. https://doi.org/10.1002/prot.26005
    DORA PSI
  • Wagner TR, Ostertag E, Kaiser PD, Gramlich M, Ruetalo N, Junker D, et al.
    NeutrobodyPlex—monitoring SARS-CoV-2 neutralizing immune responses using nanobodies
    EMBO Reports. 2021; 22(5): e52325 (16 pp.). https://doi.org/10.15252/embr.202052325
    DORA PSI
  • Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, et al.
    Development of a potent and selective chemical probe for the pleiotropic kinase CK2
    Cell Chemical Biology. 2021; 28(4): 546-558. https://doi.org/10.1016/j.chembiol.2020.12.013
    DORA PSI
  • Wiese JG, Shanmugaratnam S, Höcker B
    Extension of a de novo TIM barrel with a rationally designed secondary structure element
    Protein Science. 2021. https://doi.org/10.1002/pro.4064
    DORA PSI
  • Yamamoto H, Sakai N, Ohte S, Sato T, Sekimata K, Matsumoto T, et al.
    Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva
    Bioorganic and Medicinal Chemistry Letters. 2021; 38: 127858 (5 pp.). https://doi.org/10.1016/j.bmcl.2021.127858
    DORA PSI
  • Yang C, Sesterhenn F, Bonet J, van Aalen EA, Scheller L, Abriata LA, et al.
    Bottom-up de novo design of functional proteins with complex structural features
    Nature Chemical Biology. 2021; 17: 492-500. https://doi.org/10.1038/s41589-020-00699-x
    DORA PSI
  • Zeelen J, van Straaten M, Verdi J, Hempelmann A, Hashemi H, Perez K, et al.
    Structure of trypanosome coat protein VSGsur and function in suramin resistance
    Nature Microbiology. 2021; 6: 392-400. https://doi.org/10.1038/s41564-020-00844-1
    DORA PSI
  • Zhang L, Bill E, Kroneck PMH, Einsle O
    A [3Cu:2S] cluster provides insight into the assembly and function of the CuZ site of nitrous oxide reductase
    Chemical Science. 2021; 12(9): 3239-3244. https://doi.org/10.1039/D0SC05204C
    DORA PSI
  • Zhang L, Bill E, Kroneck PMH, Einsle O
    Histidine-gated proton-coupled electron transfer to the CuA site of nitrous oxide reductase
    Journal of the American Chemical Society. 2021; 143(2): 830-838. https://doi.org/10.1021/jacs.0c10057
    DORA PSI
  • Zinzula L, Basquin J, Bohn S, Beck F, Klumpe S, Pfeifer G, et al.
    High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2
    Biochemical and Biophysical Research Communications. 2021; 538: 54-62. https://doi.org/10.1016/j.bbrc.2020.09.131
    DORA PSI
  • de Wijn R, Rollet K, Olieric V, Hennig O, Thome N, Noûs C, et al.
    Crystallization and structural determination of an enzyme: substrate complex by serial crystallography in a versatile microfluidic chip
    Journal of Visualized Experiments. 2021;(169): e61972 (15 pp.). https://doi.org/10.3791/61972
    DORA PSI
  • Aalbers FS, Fürst MJLJ, Rovida S, Trajkovic M, Rubén Gómez Castellanos J, Bartsch S, et al.
    Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering
    eLife. 2020; 9: e54639 (18 pp.). https://doi.org/10.7554/eLife.54639
    DORA PSI
  • Adhireksan Z, Sharma D, Lee PL, Davey CA
    Near-atomic resolution structures of interdigitated nucleosome fibres
    Nature Communications. 2020; 11(1): 4747 (13 pp.). https://doi.org/10.1038/s41467-020-18533-2
    DORA PSI
  • Arnold FM, Weber MS, Gonda I, Gallenito MJ, Adenau S, Egloff P, et al.
    The ABC exporter IrtAB imports and reduces mycobacterial siderophores
    Nature. 2020; 580(7803): 413-417. https://doi.org/10.1038/s41586-020-2136-9
    DORA PSI
  • Bakonyi D, Toelzer C, Stricker M, Hummel W, Niefind K, Gröger H
    Expanding the application range of microbial oxidoreductases by an alcohol dehydrogenase from Comamonas testosteroni with a broad substrate spectrum and pH profile
    Catalysts. 2020; 10(11): 1281 (14 pp.). https://doi.org/10.3390/catal10111281
    DORA PSI
  • Bedi RK, Huang D, Wiedmer L, Li Y, Dolbois A, Wojdyla JA, et al.
    Selectively disrupting m6A-dependent protein-RNA interactions with fragments
    ACS Chemical Biology. 2020; 15(3): 618-625. https://doi.org/10.1021/acschembio.9b00894
    DORA PSI
  • Bedi RK, Huang D, Eberle SA, Wiedmer L, Śledź P, Caflisch A
    Small-molecule inhibitors of METTL3, the major human epitranscriptomic writer
    ChemMedChem. 2020; 15(9): 744-748. https://doi.org/10.1002/cmdc.202000011
    DORA PSI
  • Binas O, Tants J-N, Peter SA, Janowski R, Davydova E, Braun J, et al.
    Structural basis for the recognition of transiently structured AU-rich elements by Roquin
    Nucleic Acids Research. 2020; 48(13): 7385-7403. https://doi.org/10.1093/nar/gkaa465
    DORA PSI
  • Boon M, De Zitter E, De Smet J, Wagemans J, Voet M, Pennemann FL, et al.
    'Drc', a structurally novel ssDNA-binding transcription regulator of N4-related bacterial viruses
    Nucleic Acids Research. 2020; 48(1): 445-459. https://doi.org/10.1093/nar/gkz1048
    DORA PSI
  • Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, et al.
    Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site
    eLife. 2020; 9: e51511 (19 pp.). https://doi.org/10.7554/eLife.51511
    DORA PSI
  • Braun NJ, Quek JP, Huber S, Kouretova J, Rogge D, Lang-Henkel H, et al.
    Structure-based macrocyclization of substrate analogue NS2B-NS3 protease inhibitors of Zika, West Nile and dengue viruses
    ChemMedChem. 2020; 15(15): 1439-1452. https://doi.org/10.1002/cmdc.202000237
    DORA PSI
  • Busetto V, Barbosa I, Basquin J, Marquenet É, Hocq R, Hennion M, et al.
    Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes
    Nucleic Acids Research. 2020; 48(10): 5670-5683. https://doi.org/10.1093/nar/gkaa267
    DORA PSI
  • Caldwell SJ, Haydon IC, Piperidou N, Huang P-S, Bick MJ, Sjöström HS, et al.
    Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(48): 30362-30369. https://doi.org/10.1073/pnas.2008535117
    DORA PSI
  • Chiniadis L, Bratsos I, Bethanis K, Karpusas M, Giastas P, Papakyriakou A
    High-resolution crystal structures of a "half sandwich"-type Ru(II) coordination compound bound to hen egg-white lysozyme and proteinase K
    Journal of Biological Inorganic Chemistry. 2020; 25: 635-645. https://doi.org/10.1007/s00775-020-01786-z
    DORA PSI
  • Cinquino M, Polimeno L, Lerario G, De Giorgi M, Moliterni A, Olieric V, et al.
    One-step synthesis at room temperature of low dimensional perovskite single crystals with high optical quality
    Journal of Luminescence. 2020; 221: 117079 (8 pp.). https://doi.org/10.1016/j.jlumin.2020.117079
    DORA PSI
  • Cottee MA, Letham SC, Young GR, Stoye JP, Taylor IA
    Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag
    Science Advances. 2020; 6(1): eaay6354 (12 pp.). https://doi.org/10.1126/sciadv.aay6354
    DORA PSI
  • Dolbois A, Batiste L, Wiedmer L, Dong J, Brütsch M, Huang D, et al.
    Hitting a moving target: simulation and crystallography study of ATAD2 bromodomain blockers
    ACS Medicinal Chemistry Letters. 2020; 11(8): 1573-1580. https://doi.org/10.1021/acsmedchemlett.0c00080
    DORA PSI
  • Draxler SW, Bauer M, Eickmeier C, Nadal S, Nar H, Rangel Rojas D, et al.
    Hybrid screening approach for very small fragments: X-ray and computational screening on FKBP51
    Journal of Medicinal Chemistry. 2020; 63(11): 5856-5864. https://doi.org/10.1021/acs.jmedchem.0c00120
    DORA PSI
  • Duarte DP, Lamontanara AJ, La Sala G, Jeong S, Sohn Y-K, Panjkovich A, et al.
    Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
    Nature Communications. 2020; 11(1): 2319 (15 pp.). https://doi.org/10.1038/s41467-020-16128-5
    DORA PSI
  • Dubey BN, Agustoni E, Böhm R, Kaczmarczyk A, Mangia F, von Arx C, et al.
    Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(2): 1000-1008. https://doi.org/10.1073/pnas.1911427117
    DORA PSI
  • Ebenhoch R, Prinz S, Kaltwasser S, Mills DJ, Meinecke R, Rübbelke M, et al.
    A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(50): 31838-31849. https://doi.org/10.1073/pnas.2013473117
    DORA PSI
  • Ecsédi P, Gógl G, Hóf H, Kiss B, Harmat V, Nyitray L
    Structure determination of the transactivation domain of p53 in complex with S100A4 using annexin A2 as a crystallization chaperone
    Structure. 2020; 28(8): 943-953. https://doi.org/10.1016/j.str.2020.05.001
    DORA PSI
  • Ernst S, Rovida S, Mattevi A, Fetzner S, Drees SL
    Photoinduced monooxygenation involving NAD(P)H-FAD sequential single-electron transfer
    Nature Communications. 2020; 11: 2600 (11 pp.). https://doi.org/10.1038/s41467-020-16450-y
    DORA PSI
  • Ernst P, Zosel F, Reichen C, Nettels D, Schuler B, Plückthun A
    Structure-guided design of a peptide lock for modular peptide binders
    ACS Chemical Biology. 2020; 15(2): 457-468. https://doi.org/10.1021/acschembio.9b00928
    DORA PSI
  • Flecken M, Wang H, Popilka L, Hartl FU, Bracher A, Hayer-Hartl M
    Dual functions of a Rubisco activase in metabolic repair and recruitment to carboxysomes
    Cell. 2020; 183(2): 457-473.e8. https://doi.org/10.1016/j.cell.2020.09.010
    DORA PSI
  • Fuenzalida Werner JP, Huang Y, Mishra K, Janowski R, Vetschera P, Heichler C, et al.
    Challenging a preconception: Optoacoustic spectrum differs from the optical absorption spectrum of proteins and dyes for molecular imaging
    Analytical Chemistry. 2020; 92(15): 10717-10724. https://doi.org/10.1021/acs.analchem.0c01902
    DORA PSI
  • Gao X, Zhu K, Wojdyl JA, Chen P, Qin B, Li Z, et al.
    Crystal structure of the NS3-like helicase from Alongshan virus
    IUCrJ. 2020; 7(3): 375-382. https://doi.org/10.1107/S2052252520003632
    DORA PSI
  • Garcia-Doval C, Schwede F, Berk C, Rostøl JT, Niewoehner O, Tejero O, et al.
    Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6
    Nature Communications. 2020; 11(1): 1596 (9 pp.). https://doi.org/10.1038/s41467-020-15334-5
    DORA PSI
  • Gharbi-Ayachi A, Santhanakrishnan S, Wong YH, Chan KWK, Tan ST, Bates RW, et al.
    Non-nucleoside inhibitors of Zika virus RNA-dependent RNA polymerase
    Journal of Virology. 2020; 94(21): e00794-20 (18 pp.). https://doi.org/10.1128/JVI.00794-20
    DORA PSI
  • Gogl G, Jane P, Caillet-Saguy C, Kostmann C, Bich G, Cousido-Siah A, et al.
    Dual specificity PDZ- and 14-3-3-binding motifs: a structural and interactomics study
    Structure. 2020; 28(7): 747-759.e3. https://doi.org/10.1016/j.str.2020.03.010
    DORA PSI
  • Grob P, Huber M, Walla B, Hermann J, Janowski R, Niessing D, et al.
    Crystal contact engineering enables efficient capture and purification of an oxidoreductase by technical crystallization
    Biotechnology Journal. 2020; 15(11): 2000010 (8 pp.). https://doi.org/10.1002/biot.202000010
    DORA PSI
  • Grädler U, Busch M, Leuthner B, Raba M, Burgdorf L, Lehmann M, et al.
    Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(22): 127551 (10 pp.). https://doi.org/10.1016/j.bmcl.2020.127551
    DORA PSI
  • Gstir T, Kahlenberg V, Krüger H, Penner S
    Synthesis and crystal structure of ABW-type SrFe1.40V0.60O4
    Acta Crystallographica Section E: Crystallographic Communications. 2020; 76: 664-667.sup-5. https://doi.org/10.1107/S205698902000496X
    DORA PSI
  • Guo B, Rodriguez-Gabin A, Prota AE, Mühlethaler T, Zhang N, Ye K, et al.
    Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence
    Molecular Pharmacology. 2020; 98(2): 156-167. https://doi.org/10.1124/mol.119.117457
    DORA PSI
  • Hanke T, Cheung S-Y, Kilu W, Heering J, Ni X, Planz V, et al.
    A selective modulator of peroxisome proliferator-activated receptor γ with an unprecedented binding mode
    Journal of Medicinal Chemistry. 2020; 63(9): 4555-4561. https://doi.org/10.1021/acs.jmedchem.9b01786
    DORA PSI
  • Heddi B, Cheong VV, Schmitt E, Mechulam Y, Phan AT
    Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3′-end tetrad of a DNA G-quadruplex
    Journal of Structural Biology. 2020; 209(1): 107399 (8 pp.). https://doi.org/10.1016/j.jsb.2019.10.001
    DORA PSI
  • Hemu X, El Sahili A, Hu S, Zhang X, Serra A, Goh BC, et al.
    Turning an asparaginyl endopeptidase into a peptide ligase
    ACS Catalysis. 2020; 10(15): 8825-8834. https://doi.org/10.1021/acscatal.0c02078
    DORA PSI
  • Himmelstoß M, Erharter K, Renard E, Ennifar E, Kreutz C, Micura R
    2′-O-trifluoromethylated RNA - a powerful modification for RNA chemistry and NMR spectroscopy
    Chemical Science. 2020; 11(41): 11322-11330. https://doi.org/10.1039/d0sc04520a
    DORA PSI
  • Hochstrasser R, Hutter CAJ, Arnold FM, Bärlocher K, Seeger MA, Hilbi H
    The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization
    Molecular Microbiology. 2020; 113(6): 1070-1084. https://doi.org/10.1111/mmi.14477
    DORA PSI
  • Hofmann R, Akimoto G, Wucherpfennig TG, Zeymer C, Bode JW
    Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins
    Nature Chemistry. 2020; 12(11): 1008-1015. https://doi.org/10.1038/s41557-020-0528-y
    DORA PSI
  • Hu Z, Wang C, Sitkoff D, Cheadle NL, Xu S, Muckelbauer JK, et al.
    Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(21): 127474 (6 pp.). https://doi.org/10.1016/j.bmcl.2020.127474
    DORA PSI
  • Hubálek F, Refsgaard HHF, Gram-Nielsen S, Madsen P, Nishimura E, Münzel M, et al.
    Molecular engineering of safe and efficacious oral basal insulin
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