Publications

PDB structures measured at X06DA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Aeschimann W, Kammer S, Staats S, Schneider P, Schneider G, Rimbach G, et al.
    Engineering of a functional γ-tocopherol transfer protein
    Redox Biology. 2021; 38: 101773 (11 pp.). https://doi.org/10.1016/j.redox.2020.101773
    DORA PSI
  • Bauer V, Schmidtgall B, Gógl G, Dolenc J, Osz J, Nominé Y, et al.
    Conformational editing of intrinsically disordered protein by α-methylation
    Chemical Science. 2021. https://doi.org/10.1039/D0SC04482B
    DORA PSI
  • Chaoprasid P, Lukat P, Mühlen S, Heidler T, Gazdag E-M, Dong S, et al.
    Crystal structure of bacterial cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication
    EMBO Journal. 2021; 40(4): e105202 (21 pp.). https://doi.org/10.15252/embj.2020105202
    DORA PSI
  • Conrady MC, Suarez I, Gogl G, Frecot DI, Bonhoure A, Kostmann C, et al.
    Structure of high-risk papillomavirus 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation
    Journal of Virology. 2021; 95(2): e00730-20 (15 pp.). https://doi.org/10.1128/JVI.00730-20
    DORA PSI
  • Johansson E, Wu X, Yu B, Yang Z, Cao Z, Wiberg C, et al.
    Insulin binding to the analytical antibody sandwich pair OXI‐005 and HUI‐018: epitope mapping and binding properties
    Protein Science. 2021; 30(2): 485-496. https://doi.org/10.1002/pro.4009
    DORA PSI
  • Kröger P, Shanmugaratnam S, Ferruz N, Schweimer K, Höcker B
    A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF
    Structure. 2021. https://doi.org/10.1016/j.str.2020.12.005
    DORA PSI
  • Lemaire ON, Wagner T
    Gas channel rerouting in a primordial enzyme: structural insights of the carbon-monoxide dehydrogenase/acetyl-CoA synthase complex from the acetogen Clostridium autoethanogenum
    Biochimica et Biophysica Acta: Bioenergetics. 2021; 1862(1): 148330 (14 pp.). https://doi.org/10.1016/j.bbabio.2020.148330
    DORA PSI
  • Li Y, Bedi RK, Wiedmer L, Sun X, Huang D, Caflisch A
    Atomistic and thermodynamic analysis of N6-methyladenosine (m6A) recognition by the reader domain of YTHDC1
    Journal of Chemical Theory and Computation. 2021. https://doi.org/10.1021/acs.jctc.0c01136
    DORA PSI
  • Ostertag E, Zheng L, Broger K, Stehle T, Li S-M, Zocher G
    Reprogramming substrate and catalytic promiscuity of tryptophan prenyltransferases
    Journal of Molecular Biology. 2021; 433(2): 166726 (14 pp.). https://doi.org/10.1016/j.jmb.2020.11.025
    DORA PSI
  • Persson BD, John L, Rafie K, Strebl M, Frängsmyr L, Ballmann MZ, et al.
    Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(3): e2020732118 (8 pp.). https://doi.org/10.1073/pnas.2020732118
    DORA PSI
  • Ried MK, Wild R, Zhu J, Pipercevic J, Sturm K, Broger L, et al.
    Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis
    Nature Communications. 2021; 12: 348 (13 pp.). https://doi.org/10.1038/s41467-020-20681-4
    DORA PSI
  • Röhrig UF, Majjigapu SR, Reynaud A, Pojer F, Dilek N, Reichenbach P, et al.
    Azole-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
    Journal of Medicinal Chemistry. 2021; 64(4): 2205-2227. https://doi.org/10.1021/acs.jmedchem.0c01968
    DORA PSI
  • Schnitzler A, Niefind K
    Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin
    European Journal of Medicinal Chemistry. 2021; 214: 113223 (9 pp.). https://doi.org/10.1016/j.ejmech.2021.113223
    DORA PSI
  • Shyp V, Dubey BN, Böhm R, Hartl J, Nesper J, Vorholt JA, et al.
    Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus
    Nature Microbiology. 2021; 6(1): 59-72. https://doi.org/10.1038/s41564-020-00809-4
    DORA PSI
  • Signor L, Paris T, Mas C, Picard A, Lutfalla G, Boeri Erba E, et al.
    Divalent cations influence the dimerization mode of murine S100A9 protein by modulating its disulfide bond pattern
    Journal of Structural Biology. 2021; 213(1): 107689 (16 pp.). https://doi.org/10.1016/j.jsb.2020.107689
    DORA PSI
  • Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, et al.
    Development of a potent and selective chemical probe for the pleiotropic kinase CK2
    Cell Chemical Biology. 2021. https://doi.org/10.1016/j.chembiol.2020.12.013
    DORA PSI
  • Yang C, Sesterhenn F, Bonet J, van Aalen EA, Scheller L, Abriata LA, et al.
    Bottom-up de novo design of functional proteins with complex structural features
    Nature Chemical Biology. 2021. https://doi.org/10.1038/s41589-020-00699-x
    DORA PSI
  • Zhang L, Bill E, Kroneck PMH, Einsle O
    A [3Cu:2S] cluster provides insight into the assembly and function of the CuZ site of nitrous oxide reductase
    Chemical Science. 2021. https://doi.org/10.1039/D0SC05204C
    DORA PSI
  • Zhang L, Bill E, Kroneck PMH, Einsle O
    Histidine-gated proton-coupled electron transfer to the CuA site of nitrous oxide reductase
    Journal of the American Chemical Society. 2021; 143(2): 830-838. https://doi.org/10.1021/jacs.0c10057
    DORA PSI
  • Adhireksan Z, Sharma D, Lee PL, Davey CA
    Near-atomic resolution structures of interdigitated nucleosome fibres
    Nature Communications. 2020; 11(1): 4747 (13 pp.). https://doi.org/10.1038/s41467-020-18533-2
    DORA PSI
  • Arnold FM, Weber MS, Gonda I, Gallenito MJ, Adenau S, Egloff P, et al.
    The ABC exporter IrtAB imports and reduces mycobacterial siderophores
    Nature. 2020; 580(7803): 413-417. https://doi.org/10.1038/s41586-020-2136-9
    DORA PSI
  • Axer A, Jumde RP, Adam S, Faust A, Schäfers M, Fobker M, et al.
    Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
    Chemical Science. 2020. https://doi.org/10.1039/D0SC04297H
    DORA PSI
  • Bakonyi D, Toelzer C, Stricker M, Hummel W, Niefind K, Gröger H
    Expanding the application range of microbial oxidoreductases by an alcohol dehydrogenase from Comamonas testosteroni with a broad substrate spectrum and pH profile
    Catalysts. 2020; 10(11): 1281 (14 pp.). https://doi.org/10.3390/catal10111281
    DORA PSI
  • Bedi RK, Huang D, Wiedmer L, Li Y, Dolbois A, Wojdyla JA, et al.
    Selectively disrupting m6A-dependent protein-RNA interactions with fragments
    ACS Chemical Biology. 2020; 15(3): 618-625. https://doi.org/10.1021/acschembio.9b00894
    DORA PSI
  • Bedi RK, Huang D, Eberle SA, Wiedmer L, Śledź P, Caflisch A
    Small-molecule inhibitors of METTL3, the major human epitranscriptomic writer
    ChemMedChem. 2020; 15(9): 744-748. https://doi.org/10.1002/cmdc.202000011
    DORA PSI
  • Binas O, Tants J-N, Peter SA, Janowski R, Davydova E, Braun J, et al.
    Structural basis for the recognition of transiently structured AU-rich elements by Roquin
    Nucleic Acids Research. 2020; 48(13): 7385-7403. https://doi.org/10.1093/nar/gkaa465
    DORA PSI
  • Boon M, De Zitter E, De Smet J, Wagemans J, Voet M, Pennemann FL, et al.
    'Drc', a structurally novel ssDNA-binding transcription regulator of N4-related bacterial viruses
    Nucleic Acids Research. 2020; 48(1): 445-459. https://doi.org/10.1093/nar/gkz1048
    DORA PSI
  • Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, et al.
    Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site
    eLife. 2020; 9: e51511 (19 pp.). https://doi.org/10.7554/eLife.51511
    DORA PSI
  • Braun NJ, Quek JP, Huber S, Kouretova J, Rogge D, Lang-Henkel H, et al.
    Structure-based macrocyclization of substrate analogue NS2B-NS3 protease inhibitors of Zika, West Nile and dengue viruses
    ChemMedChem. 2020; 15(15): 1439-1452. https://doi.org/10.1002/cmdc.202000237
    DORA PSI
  • Busetto V, Barbosa I, Basquin J, Marquenet É, Hocq R, Hennion M, et al.
    Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes
    Nucleic Acids Research. 2020; 48(10): 5670-5683. https://doi.org/10.1093/nar/gkaa267
    DORA PSI
  • Caldwell SJ, Haydon IC, Piperidou N, Huang P-S, Bick MJ, Sjöström HS, et al.
    Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(48): 30362-30369. https://doi.org/10.1073/pnas.2008535117
    DORA PSI
  • Chiniadis L, Bratsos I, Bethanis K, Karpusas M, Giastas P, Papakyriakou A
    High-resolution crystal structures of a "half sandwich"-type Ru(II) coordination compound bound to hen egg-white lysozyme and proteinase K
    Journal of Biological Inorganic Chemistry. 2020; 25: 635-645. https://doi.org/10.1007/s00775-020-01786-z
    DORA PSI
  • Cinquino M, Polimeno L, Lerario G, De Giorgi M, Moliterni A, Olieric V, et al.
    One-step synthesis at room temperature of low dimensional perovskite single crystals with high optical quality
    Journal of Luminescence. 2020; 221: 117079 (8 pp.). https://doi.org/10.1016/j.jlumin.2020.117079
    DORA PSI
  • Cottee MA, Letham SC, Young GR, Stoye JP, Taylor IA
    Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag
    Science Advances. 2020; 6(1): eaay6354 (12 pp.). https://doi.org/10.1126/sciadv.aay6354
    DORA PSI
  • Dolbois A, Batiste L, Wiedmer L, Dong J, Brütsch M, Huang D, et al.
    Hitting a moving target: simulation and crystallography study of ATAD2 bromodomain blockers
    ACS Medicinal Chemistry Letters. 2020; 11(8): 1573-1580. https://doi.org/10.1021/acsmedchemlett.0c00080
    DORA PSI
  • Draxler SW, Bauer M, Eickmeier C, Nadal S, Nar H, Rangel Rojas D, et al.
    Hybrid screening approach for very small fragments: X-ray and computational screening on FKBP51
    Journal of Medicinal Chemistry. 2020; 63(11): 5856-5864. https://doi.org/10.1021/acs.jmedchem.0c00120
    DORA PSI
  • Duarte DP, Lamontanara AJ, La Sala G, Jeong S, Sohn Y-K, Panjkovich A, et al.
    Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
    Nature Communications. 2020; 11(1): 2319 (15 pp.). https://doi.org/10.1038/s41467-020-16128-5
    DORA PSI
  • Dubey BN, Agustoni E, Böhm R, Kaczmarczyk A, Mangia F, von Arx C, et al.
    Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(2): 1000-1008. https://doi.org/10.1073/pnas.1911427117
    DORA PSI
  • Ebenhoch R, Prinz S, Kaltwasser S, Mills DJ, Meinecke R, Rübbelke M, et al.
    A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(50): 31838-31849. https://doi.org/10.1073/pnas.2013473117
    DORA PSI
  • Ecsédi P, Gógl G, Hóf H, Kiss B, Harmat V, Nyitray L
    Structure determination of the transactivation domain of p53 in complex with S100A4 using annexin A2 as a crystallization chaperone
    Structure. 2020; 28(8): 943-953. https://doi.org/10.1016/j.str.2020.05.001
    DORA PSI
  • Ernst P, Zosel F, Reichen C, Nettels D, Schuler B, Plückthun A
    Structure-guided design of a peptide lock for modular peptide binders
    ACS Chemical Biology. 2020; 15(2): 457-468. https://doi.org/10.1021/acschembio.9b00928
    DORA PSI
  • Flecken M, Wang H, Popilka L, Hartl FU, Bracher A, Hayer-Hartl M
    Dual functions of a Rubisco activase in metabolic repair and recruitment to carboxysomes
    Cell. 2020; 183(2): 457-473.e8. https://doi.org/10.1016/j.cell.2020.09.010
    DORA PSI
  • Fuenzalida Werner JP, Huang Y, Mishra K, Janowski R, Vetschera P, Heichler C, et al.
    Challenging a preconception: Optoacoustic spectrum differs from the optical absorption spectrum of proteins and dyes for molecular imaging
    Analytical Chemistry. 2020; 92(15): 10717-10724. https://doi.org/10.1021/acs.analchem.0c01902
    DORA PSI
  • Gao X, Zhu K, Wojdyl JA, Chen P, Qin B, Li Z, et al.
    Crystal structure of the NS3-like helicase from Alongshan virus
    IUCrJ. 2020; 7(3): 375-382. https://doi.org/10.1107/S2052252520003632
    DORA PSI
  • Garcia-Doval C, Schwede F, Berk C, Rostøl JT, Niewoehner O, Tejero O, et al.
    Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6
    Nature Communications. 2020; 11(1): 1596 (9 pp.). https://doi.org/10.1038/s41467-020-15334-5
    DORA PSI
  • Gharbi-Ayachi A, Santhanakrishnan S, Wong YH, Chan KWK, Tan ST, Bates RW, et al.
    Non-nucleoside inhibitors of Zika virus RNA-dependent RNA polymerase
    Journal of Virology. 2020; 94(21): e00794-20 (18 pp.). https://doi.org/10.1128/JVI.00794-20
    DORA PSI
  • Gogl G, Jane P, Caillet-Saguy C, Kostmann C, Bich G, Cousido-Siah A, et al.
    Dual specificity PDZ- and 14-3-3-binding motifs: a structural and interactomics study
    Structure. 2020; 28(7): 747-759.e3. https://doi.org/10.1016/j.str.2020.03.010
    DORA PSI
  • Grob P, Huber M, Walla B, Hermann J, Janowski R, Niessing D, et al.
    Crystal contact engineering enables efficient capture and purification of an oxidoreductase by technical crystallization
    Biotechnology Journal. 2020; 15(11): 2000010 (8 pp.). https://doi.org/10.1002/biot.202000010
    DORA PSI
  • Grädler U, Busch M, Leuthner B, Raba M, Burgdorf L, Lehmann M, et al.
    Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(22): 127551 (10 pp.). https://doi.org/10.1016/j.bmcl.2020.127551
    DORA PSI
  • Gstir T, Kahlenberg V, Krüger H, Penner S
    Synthesis and crystal structure of ABW-type SrFe1.40V0.60O4
    Acta Crystallographica Section E: Crystallographic Communications. 2020; 76: 664-667.sup-5. https://doi.org/10.1107/S205698902000496X
    DORA PSI
  • Guo B, Rodriguez-Gabin A, Prota AE, Mühlethaler T, Zhang N, Ye K, et al.
    Structural refinement of the tubulin ligand (+)-discodermolide to attenuate chemotherapy-mediated senescence
    Molecular Pharmacology. 2020; 98(2): 156-167. https://doi.org/10.1124/mol.119.117457
    DORA PSI
  • Hanke T, Cheung S-Y, Kilu W, Heering J, Ni X, Planz V, et al.
    A selective modulator of peroxisome proliferator-activated receptor γ with an unprecedented binding mode
    Journal of Medicinal Chemistry. 2020; 63(9): 4555-4561. https://doi.org/10.1021/acs.jmedchem.9b01786
    DORA PSI
  • Heddi B, Cheong VV, Schmitt E, Mechulam Y, Phan AT
    Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3′-end tetrad of a DNA G-quadruplex
    Journal of Structural Biology. 2020; 209(1): 107399 (8 pp.). https://doi.org/10.1016/j.jsb.2019.10.001
    DORA PSI
  • Hemu X, El Sahili A, Hu S, Zhang X, Serra A, Goh BC, et al.
    Turning an asparaginyl endopeptidase into a peptide ligase
    ACS Catalysis. 2020; 10(15): 8825-8834. https://doi.org/10.1021/acscatal.0c02078
    DORA PSI
  • Himmelstoß M, Erharter K, Renard E, Ennifar E, Kreutz C, Micura R
    2′-O-trifluoromethylated RNA - a powerful modification for RNA chemistry and NMR spectroscopy
    Chemical Science. 2020; 11(41): 11322-11330. https://doi.org/10.1039/d0sc04520a
    DORA PSI
  • Hochstrasser R, Hutter CAJ, Arnold FM, Bärlocher K, Seeger MA, Hilbi H
    The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization
    Molecular Microbiology. 2020; 113(6): 1070-1084. https://doi.org/10.1111/mmi.14477
    DORA PSI
  • Hofmann R, Akimoto G, Wucherpfennig TG, Zeymer C, Bode JW
    Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins
    Nature Chemistry. 2020; 12(11): 1008-1015. https://doi.org/10.1038/s41557-020-0528-y
    DORA PSI
  • Hu Z, Wang C, Sitkoff D, Cheadle NL, Xu S, Muckelbauer JK, et al.
    Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(21): 127474 (6 pp.). https://doi.org/10.1016/j.bmcl.2020.127474
    DORA PSI
  • Hubálek F, Refsgaard HHF, Gram-Nielsen S, Madsen P, Nishimura E, Münzel M, et al.
    Molecular engineering of safe and efficacious oral basal insulin
    Nature Communications. 2020; 11(1): 3746 (9 pp.). https://doi.org/10.1038/s41467-020-17487-9
    DORA PSI
  • Johansson E, Nielsen AD, Demuth H, Wiberg C, Schjødt CB, Huang T, et al.
    Identification of binding sites on human serum albumin for somapacitan, a long-acting growth hormone derivative
    Biochemistry. 2020; 59(14): 1410-1419. https://doi.org/10.1021/acs.biochem.0c00019
    DORA PSI
  • Juroszek R, Krüger B, Galuskina I, Krüger H, Vapnik Y, Galuskin E
    Siwaqaite, Ca6Al2(CrO4)3(OH)12·26H2O, a new mineral of the ettringite group from the pyrometamorphic Daba-Siwaqa complex, Jordan
    American Mineralogist. 2020; 105(3): 409-421. https://doi.org/10.2138/am-2020-7208
    DORA PSI
  • Kanamaru S, Uchida K, Nemoto M, Fraser A, Arisaka F, Leiman PG
    Structure and function of the T4 spackle protein Gp61.3
    Viruses. 2020; 12(10): 1070 (21 pp.). https://doi.org/10.3390/v12101070
    DORA PSI
  • Kanja M, Cappy P, Levy N, Oladosu O, Schmidt S, Rossolillo P, et al.
    NKNK: A new essential motif in the C-terminal domain of HIV-1 group M integrases
    Journal of Virology. 2020; 94(20): e01035-20 (23 pp.). https://doi.org/10.1128/JVI.01035-20
    DORA PSI
  • Karakus U, Sahin D, Mittl PRE, Mooij P, Koopman G, Boyman O
    Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species
    Science Translational Medicine. 2020; 12(574): eabb9283 (16 pp.). https://doi.org/10.1126/scitranslmed.abb9283
    DORA PSI
  • Kassube SA, Thomä NH
    Structural insights into Fe–S protein biogenesis by the CIA targeting complex
    Nature Structural and Molecular Biology. 2020; 27: 735-742. https://doi.org/10.1038/s41594-020-0454-0
    DORA PSI
  • Kessler D, Bergner A, Böttcher J, Fischer G, Döbel S, Hinkel M, et al.
    Drugging all RAS isoforms with one pocket
    Future Medicinal Chemistry. 2020; 12(21): 1911-1923. https://doi.org/10.4155/fmc-2020-0221
    DORA PSI
  • Kneuttinger AC, Rajendran C, Simeth NA, Bruckmann A, König B, Sterner R
    Significance of the protein interface configuration for allostery in imidazole glycerol phosphate synthase
    Biochemistry. 2020; 59(29): 2729-2742. https://doi.org/10.1021/acs.biochem.0c00332
    DORA PSI
  • Koiwai K, Inaba K, Morohashi K, Enya S, Arai R, Kojima H, et al.
    An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo
    Journal of Biological Chemistry. 2020; 295(20): 7154-7167. https://doi.org/10.1074/jbc.RA119.011463
    DORA PSI
  • Kong X-D, Moriya J, Carle V, Pojer F, Abriata LA, Deyle K, et al.
    De novo development of proteolytically resistant therapeutic peptides for oral administration
    Nature Biomedical Engineering. 2020; 4(5): 560-571. https://doi.org/10.1038/s41551-020-0556-3
    DORA PSI
  • Krausze J, Hercher TW, Archna A, Kruse T
    The structure of the Moco carrier protein from Rippkaea orientalis
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2020; 76(9): 453-463. https://doi.org/10.1107/S2053230X20011073
    DORA PSI
  • Kries H, Bloch JS, Bunzel HA, Pinkas DM, Hilvert D
    Contribution of oxyanion stabilization to kemp eliminase efficiency
    ACS Catalysis. 2020; 10(8): 4460-4464. https://doi.org/10.1021/acscatal.0c00575
    DORA PSI
  • Küssau T, Van Wyk N, Johansen MD, Alsarraf HMAB, Neyret A, Hamela C, et al.
    Functional characterization of the N-acetylmuramyl-L-alanine amidase, ami1, from Mycobacterium abscessus
    Cells. 2020; 9(11): 2410 (25 pp.). https://doi.org/10.3390/cells9112410
    DORA PSI
  • La Sala G, Michiels C, Kükenshöner T, Brandstoetter T, Maurer B, Koide A, et al.
    Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
    Nature Communications. 2020; 11(1): 4115 (16 pp.). https://doi.org/10.1038/s41467-020-17920-z
    DORA PSI
  • Larson ET, Brennan DL, Hickey ER, Ganesan R, Kroe‐Barrett R, Farrow NA
    X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains
    Protein Science. 2020; 29(7): 1679-1686. https://doi.org/10.1002/pro.3862
    DORA PSI
  • Li Y, Bedi RK, Moroz-Omori EV, Caflisch A
    Structural and dynamic insights into redundant function of YTHDF proteins
    Journal of Chemical Information and Modeling. 2020. https://doi.org/10.1021/acs.jcim.0c01029
    DORA PSI
  • Lindenblatt D, Nickelsen A, Applegate VM, Jose J, Niefind K
    Structural and mechanistic basis of the inhibitory potency of selected 2-aminothiazole compounds on protein kinase CK2
    Journal of Medicinal Chemistry. 2020; 63(14): 7766-7772. https://doi.org/10.1021/acs.jmedchem.0c00587
    DORA PSI
  • Ma B, Lucas B, Capacci A, Lin EY-S, Jones JH, Dechantsreiter M, et al.
    Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(4): 126852 (8 pp.). https://doi.org/10.1016/j.bmcl.2019.126852
    DORA PSI
  • Marasco M, Berteotti A, Weyershaeuser J, Thorausch N, Sikorska J, Krausze J, et al.
    Molecular mechanism of SHP2 activation by PD-1 stimulation
    Science Advances. 2020; 6(5): eaay4458 (15 pp.). https://doi.org/10.1126/sciadv.aay4458
    DORA PSI
  • Marcotte DJ, Spilker KA, Wen D, Hesson T, Patterson TA, Rajesh Kumar P, et al.
    The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2020; 76: 103-108. https://doi.org/10.1107/S2053230X2000031X
    DORA PSI
  • Marleaux M, Anand K, Latz E, Geyer M
    Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly
    FEBS Letters. 2020; 594(15): 2383-2395. https://doi.org/10.1002/1873-3468.13865
    DORA PSI
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    Identification of CNS-penetrant aryl sulfonamides as isoform-selective NaV1.6 inhibitors with efficacy in mouse models of epilepsy
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    Characterization of the pleiotropic LysR-type transcription regulator LeuO of Escherichia coli
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    Levantite, KCa3(Al2Si3)O11(PO4), a new latiumite group mineral from pyrometamorphic rock of the Hatrurim Basin, Negev Desert, Israel
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    Crystal structure of the leucine-rich repeat ectodomain of the plant immune receptor kinase SOBIR1
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    Crystal structure of phyllogen, a phyllody-inducing effector protein of phytoplasma
    Biochemical and Biophysical Research Communications. 2019; 513(4): 952-957. https://doi.org/10.1016/j.bbrc.2019.04.060
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    Structural elucidation of triclinic and monoclinic SFCA-III - killing two birds with one stone
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    Structural investigations on bredigite from the Hatrurim Complex
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    Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules
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    Structure and mechanism of ergothionase from Treponema denticola
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    Crystal structures and protein engineering of three different penicillin G acylases from Gram-positive bacteria with different thermostability
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