Publications

PDB structures measured at X06DA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Adam S, Zheng D, Klein A, Volz C, Mullen W, Shirran SL, et al.
    Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
    Nature Chemistry. 2023; 15(4): 560-568. https://doi.org/10.1038/s41557-023-01153-w
    DORA PSI
  • Anso I, Naegeli A, Cifuente JO, Orrantia A, Andersson E, Zenarruzabeitia O, et al.
    Turning universal O into rare Bombay type blood
    Nature Communications. 2023; 14(1): 1765 (16 pp.). https://doi.org/10.1038/s41467-023-37324-z
    DORA PSI
  • Arifi S, Marschner JA, Pollinger J, Isigkeit L, Heitel P, Kaiser A, et al.
    Targeting the alternative vitamin E metabolite binding site enables noncanonical PPARγ modulation
    Journal of the American Chemical Society. 2023; 145(27): 14802-14810. https://doi.org/10.1021/jacs.3c03417
    DORA PSI
  • Bashore FM, Marquez AB, Chaikuad A, Howell S, Dunn AS, Beltran AA, et al.
    Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
    Scientific Reports. 2023; 13(1): 6118 (17 pp.). https://doi.org/10.1038/s41598-023-32854-4
    DORA PSI
  • Bedi RK, Huang D, Li Y, Caflisch A
    Structure-based design of inhibitors of the m6A-RNA writer enzyme METTL3
    ACS Bio & Med Chem Au. 2023; 3(4): 359-370. https://doi.org/10.1021/acsbiomedchemau.3c00023
    DORA PSI
  • Billiald P, Slater A, Welin M, Clark JC, Loyau S, Pugnière M, et al.
    Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
    Blood Advances. 2023; 7(7): 1258-1268. https://doi.org/10.1182/bloodadvances.2022007863
    DORA PSI
  • Boiarska Z, Pérez-Peña H, Abel A-C, Marzullo P, Álvarez-Bernad B, Bonato F, et al.
    Maytansinol functionalization: towards useful probes for studying microtubule dynamics
    Chemistry: A European Journal. 2023; 29(5): e202203431 (12 pp.). https://doi.org/10.1002/chem.202203431
    DORA PSI
  • Brkic A, Leibundgut M, Jablonska J, Zanki V, Car Z, Petrovic Perokovic V, et al.
    Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
    Nature Communications. 2023; 14(1): 5498 (12 pp.). https://doi.org/10.1038/s41467-023-41244-3
    DORA PSI
  • Bui TYH, De Zitter E, Moeyaert B, Pecqueur L, Srinivasu BY, Economou A, et al.
    Oxygen-induced chromophore degradation in the photoswitchable red fluorescent protein rsCherry
    International Journal of Biological Macromolecules. 2023; 239: 124179 (9 pp.). https://doi.org/10.1016/j.ijbiomac.2023.124179
    DORA PSI
  • Busch MR, Rajendran C, Sterner R
    Structural and functional characterization of the ureidoacrylate amidohydrolase RutB from Escherichia coli
    Biochemistry. 2023; 62(3): 863-872. https://doi.org/10.1021/acs.biochem.2c00640
    DORA PSI
  • Cadoux C, Ratcliff D, Maslać N, Gu W, Tsakoumagkos I, Hoogendoorn S, et al.
    Nitrogen fixation and hydrogen evolution by sterically encumbered Mo-nitrogenase
    JACS Au. 2023; 3(5): 1521-1533. https://doi.org/10.1021/jacsau.3c00165
    DORA PSI
  • Chandra M, Đaković S, Foti K, Zeelen JP, van Straaten M, Aresta-Branco F, et al.
    Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome
    PLoS Neglected Tropical Diseases. 2023; 17(2): e0011093 (18 pp.). https://doi.org/10.1371/journal.pntd.0011093
    DORA PSI
  • Chmelova K, Gao T, Polak M, Schenkmayerova A, Croll TI, Shaikh TR, et al.
    Multimeric structure of a subfamily III haloalkane dehalogenase‐like enzyme solved by combination of cryo‐EM and x‐ray crystallography
    Protein Science. 2023; 32(10): e4751 (22 pp.). https://doi.org/10.1002/pro.4751
    DORA PSI
  • De Simone M, Alvigini L, Alonso-Cotchico L, Brissos V, Caroli J, Lucas MF, et al.
    Rationally guided improvement of NOV1 dioxygenase for the conversion of lignin-derived isoeugenol to vanillin
    Biochemistry. 2023; 62(2): 419-428. https://doi.org/10.1021/acs.biochem.2c00168
    DORA PSI
  • Denkhaus L, Siffert F, Einsle O
    An unusual active site architecture in cytochrome c nitrite reductase NrfA-1 from Geobacter metallireducens
    FEMS Microbiology Letters. 2023; 370: fnad068 (8 pp.). https://doi.org/10.1093/femsle/fnad068
    DORA PSI
  • Dubey BN, Shyp V, Fucile G, Sondermann H, Jenal U, Schirmer T
    Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization
    Scientific Reports. 2023; 13(1): 2727 (13 pp.). https://doi.org/10.1038/s41598-023-29110-0
    DORA PSI
  • Díaz-Perlas C, Ricken B, Farrera-Soler L, Guschin D, Pojer F, Lau K, et al.
    High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays
    Nature Communications. 2023; 14(1): 2774 (14 pp.). https://doi.org/10.1038/s41467-023-38075-7
    DORA PSI
  • Dürvanger Z, Juhász T, Liliom K, Harmat V
    Structures of calmodulin–melittin complexes show multiple binding modes lacking classical anchoring interactions
    Journal of Biological Chemistry. 2023; 299(4): 104596 (15 pp.). https://doi.org/10.1016/j.jbc.2023.104596
    DORA PSI
  • Emmert S, Quargnali G, Thallmair S, Rivera-Fuentes P
    A locally activatable sensor for robust quantification of organellar glutathione
    Nature Chemistry. 2023; 15: 1415-1421. https://doi.org/10.1038/s41557-023-01249-3
    DORA PSI
  • Engrola F, Correia MAS, Watson C, Romão CC, Veiros LF, Romão MJ, et al.
    Arsenite oxidase in complex with antimonite and arsenite oxyanions: insights into the catalytic mechanism
    Journal of Biological Chemistry. 2023; 299(8): 105036 (9 pp.). https://doi.org/10.1016/j.jbc.2023.105036
    DORA PSI
  • Estévez-Gallego J, Álvarez-Bernad B, Pera B, Wullschleger C, Raes O, Menche D, et al.
    Chemical modulation of microtubule structure through the laulimalide/peloruside site
    Structure. 2023; 31(1): 88-99.e5. https://doi.org/10.1016/j.str.2022.11.006
    DORA PSI
  • Farnung J, Muhar M, Liang JR, Tolmachova KA, Benoit RM, Corn JE, et al.
    Semisynthetic LC3 probes for autophagy pathways reveal a noncanonical LC3 interacting region motif crucial for the enzymatic activity of human ATG3
    ACS Central Science. 2023; 9(5): 1025-1034. https://doi.org/10.1021/acscentsci.3c00009
    DORA PSI
  • Gkeka A, Aresta-Branco F, Triller G, Vlachou EP, van Straaten M, Lilic M, et al.
    Immunodominant surface epitopes power immune evasion in the African trypanosome
    Cell Reports. 2023; 42(3): 112262 (21 pp.). https://doi.org/10.1016/j.celrep.2023.112262
    DORA PSI
  • Glögl M, Friedrich N, Cerutti G, Lemmin T, Kwon YD, Gorman J, et al.
    Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization
    Nature Structural and Molecular Biology. 2023; 30: 1323-1336. https://doi.org/10.1038/s41594-023-01062-z
    DORA PSI
  • Greisen PJ, Yi L, Zhou R, Zhou J, Johansson E, Dong T, et al.
    Computational design of N‐linked glycans for high throughput epitope profiling
    Protein Science. 2023; 32(10): e4726 (11 pp.). https://doi.org/10.1002/pro.4726
    DORA PSI
  • Hamed MM, Abdelsamie AS, Rox K, Schütz C, Kany AM, Röhrig T, et al.
    Towards translation of PqsR inverse agonists: from in vitro efficacy optimization to In vivo proof-of-principle
    Advanced Science. 2023; 10(5): 2204443 (14 pp.). https://doi.org/10.1002/advs.202204443
    DORA PSI
  • Hamid R, Adam S, Lacour A, Monjas L, Köhnke J, Hirsch AKH
    1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
    Journal of Biological Chemistry. 2023; 299(9): 105152 (11 pp.). https://doi.org/10.1016/j.jbc.2023.105152
    DORA PSI
  • Hasyeoui M, Lassagne F, Erb W, Nael M, Elokely KM, Chaikuad A, et al.
    Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells
    Bioorganic Chemistry. 2023; 134: 106456 (18 pp.). https://doi.org/10.1016/j.bioorg.2023.106456
    DORA PSI
  • Igareta NV, Tachibana R, Spiess DC, Peterson RL, Ward TR
    Spiers memorial lecture: shielding the active site: a streptavidin superoxide-dismutase chimera as a host protein for asymmetric transfer hydrogenation
    Faraday Discussions. 2023; 244: 9-20. https://doi.org/10.1039/d3fd00034f
    DORA PSI
  • Isaikina P, Petrovic I, Jakob RP, Sarma P, Ranjan A, Baruah M, et al.
    A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes
    Molecular Cell. 2023; 83(12): 2108-2121.e7. https://doi.org/10.1016/j.molcel.2023.05.002
    DORA PSI
  • Jespersen M, Pierik AJ, Wagner T
    Structures of the sulfite detoxifying F420-dependent enzyme from Methanococcales
    Nature Chemical Biology. 2023; 19: 695-702. https://doi.org/10.1038/s41589-022-01232-y
    DORA PSI
  • Juroszek R, Galuskina I, Krüger B, Krüger H, Vapnik Y, Kahlenberg V, et al.
    Minerals with a palmierite-type structure. Part I. Mazorite Ba3(PO4)2, a new mineral from the Hatrurim Complex in Israel
    Mineralogical Magazine. 2023. https://doi.org/10.1180/mgm.2023.57
    DORA PSI
  • Kirchgäßner S, Braun MB, Bartlick N, Koç C, Reinkemeier CD, Lemke EA, et al.
    Synthesis, biochemical characterization, and genetic encoding of a 1,2,4-triazole amino acid as an acetyllysine mimic for bromodomains of the BET Family
    Angewandte Chemie International Edition. 2023; 62(12): e202215460 (7 pp.). https://doi.org/10.1002/anie.202215460
    DORA PSI
  • Krüger B, Galuskina IO, Galuskin EV, Vapnik Y, Murashko MN
    Khurayyimite Ca7Zn4(Si2O7)2(OH)10·4H2O: a mineral with unusual loop-branched sechser single chains
    Mineralogy and Petrology. 2023; 117(2): 191-200. https://doi.org/10.1007/s00710-022-00804-z
    DORA PSI
  • Lemaire ON, Belhamri M, Wagner T
    Structural and biochemical elucidation of class I hybrid cluster protein natively extracted from a marine methanogenic archaeon
    Frontiers in Microbiology. 2023; 14: 1179204 (16 pp.). https://doi.org/10.3389/fmicb.2023.1179204
    DORA PSI
  • Lenza MP, Egia-Mendikute L, Antoñana-Vildosola A, Soares CO, Coelho H, Corzana F, et al.
    Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b
    Nature Communications. 2023; 14(1): 3496 (14 pp.). https://doi.org/10.1038/s41467-023-39119-8
    DORA PSI
  • Lenza MP, Atxabal U, Nycholat C, Oyenarte I, Franconetti A, Quintana JI, et al.
    Structures of the inhibitory receptor siglec-8 in complex with a high-affinity sialoside analogue and a therapeutic antibody
    JACS Au. 2023; 3(1): 204-215. https://doi.org/10.1021/jacsau.2c00592
    DORA PSI
  • Nemergut M, Marques SM, Uhrik L, Vanova T, Nezvedova M, Gadara DC, et al.
    Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s disease drug candidate
    Molecular Neurodegeneration. 2023; 18(1): 38 (25 pp.). https://doi.org/10.1186/s13024-023-00620-9
    DORA PSI
  • Nóbrega CS, Carvalho AL, Romão MJ, Pauleta SR
    Structural characterization of Neisseria gonorrhoeae bacterial peroxidase-insights into the catalytic cycle of bacterial peroxidases
    International Journal of Molecular Sciences. 2023; 24(7): 6246 (21 pp.). https://doi.org/10.3390/ijms24076246
    DORA PSI
  • Němec V, Khirsariya P, Janovská P, Moyano PM, Maier L, Procházková P, et al.
    Discovery of potent and exquisitely selective inhibitors of kinase CK1 with tunable isoform selectivity
    Angewandte Chemie International Edition. 2023; 62(11): e202217532 (7 pp.). https://doi.org/10.1002/anie.202217532
    DORA PSI
  • Personne H, Paschoud T, Fulgencio S, Baeriswyl S, Köhler T, van Delden C, et al.
    To fold or not to fold: diastereomeric optimization of an α-helical antimicrobial peptide
    Journal of Medicinal Chemistry. 2023; 66(11): 7570-7583. https://doi.org/10.1021/acs.jmedchem.3c00460
    DORA PSI
  • Prota AE, Lucena-Agell D, Ma Y, Estevez-Gallego J, Li S, Bargsten K, et al.
    Structural insight into the stabilization of microtubules by taxanes
    eLife. 2023; 12: e84791 (35 pp.). https://doi.org/10.7554/elife.84791
    DORA PSI
  • Qin B, Li Z, Tang K, Wang T, Xie Y, Aumonier S, et al.
    Identification of the SARS-unique domain of SARS-CoV-2 as an antiviral target
    Nature Communications. 2023; 14(1): 3999 (13 pp.). https://doi.org/10.1038/s41467-023-39709-6
    DORA PSI
  • Racle J, Guillaume P, Schmidt J, Michaux J, Larabi A, Lau K, et al.
    Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
    Immunity. 2023; 56(6): 1359-1375.e13. https://doi.org/10.1016/j.immuni.2023.03.009
    DORA PSI
  • Rahimova R, Nogaret P, Huteau V, Gelin M, Clément DA, Labesse G, et al.
    Structure-based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase
    FEBS Journal. 2023; 290(2): 482-501. https://doi.org/10.1111/febs.16604
    DORA PSI
  • Rodriguez I, Kocik-Krol J, Skalniak L, Musielak B, Wisniewska A, Ciesiołkiewicz A, et al.
    Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies
    Molecular Cancer. 2023; 22(1): 150 (8 pp.). https://doi.org/10.1186/s12943-023-01853-4
    DORA PSI
  • Sahu S, Ekundayo BE, Kumar A, Bleichert F
    A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin
    EMBO Journal. 2023; 42(18): e114654 (24 pp.). https://doi.org/10.15252/embj.2023114654
    DORA PSI
  • Salgado-Polo F, Borza R, Matsoukas M-T, Marsais F, Jagerschmidt C, Waeckel L, et al.
    Autotaxin facilitates selective LPA receptor signaling
    Cell Chemical Biology. 2023; 30(1): 69-84.e14. https://doi.org/10.1016/j.chembiol.2022.12.006
    DORA PSI
  • Schenkmayerova A, Toul M, Pluskal D, Baatallah R, Gagnot G, Pinto GP, et al.
    Catalytic mechanism for Renilla-type luciferases
    Nature Catalysis. 2023; 6(1): 23-38. https://doi.org/10.1038/s41929-022-00895-z
    DORA PSI
  • Smith KML, Panepucci E, Kaminski JW, Aumonier S, Huang C-Y, Eris D, et al.
    SDU - software for high-throughput automated data collection at the Swiss Light Source
    Journal of Synchrotron Radiation. 2023; 30: 538-545. https://doi.org/10.1107/S1600577523002631
    DORA PSI
  • Sorin MN, Di Maio A, Silva LM, Ebert D, Delannoy CP, Nguyen N-K, et al.
    Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus
    Cell Reports. 2023; 42(2): 112114 (18 pp.). https://doi.org/10.1016/j.celrep.2023.112114
    DORA PSI
  • Stasiak AC, Gogler K, Borisova M, Fink P, Mayer C, Stehle T, et al.
    N-acetylmuramic acid recognition by MurK kinase from the MurNAc auxotrophic oral pathogen Tannerella forsythia
    Journal of Biological Chemistry. 2023; 299(9): 105076 (13 pp.). https://doi.org/10.1016/j.jbc.2023.105076
    DORA PSI
  • Stegmann DP, Steuber J, Fritz G, Wojdyla JA, Sharpe ME
    Fast fragment and compound screening pipeline at the Swiss Light Source
    In: Methods in enzymology. sine loco: Elsevier; 2023. https://doi.org/10.1016/bs.mie.2023.08.005
    DORA PSI
  • Takase S, Hiroyama T, Shirai F, Maemoto Y, Nakata A, Arata M, et al.
    A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression
    Nature Communications. 2023; 14(1): 23 (18 pp.). https://doi.org/10.1038/s41467-022-35404-0
    DORA PSI
  • Taylor G, Cui H, Leodolter J, Giese C, Weber-Ban E
    ClpC2 protects mycobacteria against a natural antibiotic targeting ClpC1-dependent protein degradation
    Communications Biology. 2023; 6(1): 301 (13 pp.). https://doi.org/10.1038/s42003-023-04658-9
    DORA PSI
  • Triller G, Vlachou EP, Hashemi H, van Straaten M, Zeelen JP, Kelemen Y, et al.
    A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl
    Cell Reports. 2023; 42(2): 112049 (27 pp.). https://doi.org/10.1016/j.celrep.2023.112049
    DORA PSI
  • Trncik C, Detemple F, Einsle O
    Iron-only Fe-nitrogenase underscores common catalytic principles in biological nitrogen fixation
    Nature Catalysis. 2023; 6(5): 415-424. https://doi.org/10.1038/s41929-023-00952-1
    DORA PSI
  • Wirtz DA, Schneberger N, Klöppel S, Richarz R, Geyer M, König GM, et al.
    Adenylation domain-guided recruitment of trans-acting nonheme monooxygenases in nonribosomal peptide biosynthesis
    ACS Chemical Biology. 2023; 18: 1748-1759. https://doi.org/10.1021/acschembio.3c00106
    DORA PSI
  • Abiko LA, Dias Teixeira R, Engilberge S, Grahl A, Mühlethaler T, Sharpe T, et al.
    Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol
    Nature Chemistry. 2022; 14: 1133-1141. https://doi.org/10.1038/s41557-022-01009-9
    DORA PSI
  • Alsarraf HMAB, Ung KL, Johansen MD, Dimon J, Olieric V, Kremer L, et al.
    Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N‐acetyltransferase
    FEBS Letters. 2022; 596(12): 1516-1532. https://doi.org/10.1002/1873-3468.14360
    DORA PSI
  • Bereiter R, Renard E, Breuker K, Kreutz C, Ennifar E, Micura R
    1-deazaguanosine-modified RNA: the missing piece for functional RNA atomic mutagenesis
    Journal of the American Chemical Society. 2022; 144(23): 10344-10352. https://doi.org/10.1021/jacs.2c01877
    DORA PSI
  • Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, et al.
    NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
    Molecular Cell. 2022; 82(3): 555-569.e7. https://doi.org/10.1016/j.molcel.2021.12.031
    DORA PSI
  • Bleuler-Martinez S, Varrot A, Olieric V, Schubert M, Vogt E, Fetz C, et al.
    Structure–function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity
    Glycobiology. 2022; 32(7): 600-615. https://doi.org/10.1093/glycob/cwac020
    DORA PSI
  • Bobrovs R, Basens EE, Drunka L, Kanepe I, Matisone S, Velins KK, et al.
    Exploring aspartic protease inhibitor binding to design selective antimalarials
    Journal of Chemical Information and Modeling. 2022; 62(13): 3263-3273. https://doi.org/10.1021/acs.jcim.2c00422
    DORA PSI
  • Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, et al.
    Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRASG12C inhibitor
    Journal of Medicinal Chemistry. 2022; 65(21): 14614-14629. https://doi.org/10.1021/acs.jmedchem.2c01120
    DORA PSI
  • Burnett GL, Yang YC, Aggen JB, Pitzen J, Gliedt MK, Semko CM, et al.
    Discovery of RMC-5552, a selective bi-steric inhibitor of mTORC1, for the treatment of mTORC1-activated tumors
    Journal of Medicinal Chemistry. 2022; 66(1): 149-169. https://doi.org/10.1021/acs.jmedchem.2c01658
    DORA PSI
  • Camus A, Truong G, Mittl PRE, Markert G, Hilvert D
    Reprogramming nonribosomal peptide synthetases for site-specific insertion of α-hydroxy acids
    Journal of the American Chemical Society. 2022; 144(38): 17567-17575. https://doi.org/10.1021/jacs.2c07013
    DORA PSI
  • Chaikuad A, Zhubi R, Tredup C, Knapp S
    Comparative structural analyses of the NHL domains from the human E3 ligase TRIM-NHL family
    IUCrJ. 2022; 9(6): 720-727. https://doi.org/10.1107/S2052252522008582
    DORA PSI
  • Chen P, Wojdyla JA, Colasanti O, Li Z, Qin B, Wang M, et al.
    Biochemical and structural characterization of hepatitis A virus 2C reveals an unusual ribonuclease activity on single-stranded RNA
    Nucleic Acids Research. 2022; 50(16): 9470-9489. https://doi.org/10.1093/nar/gkac671
    DORA PSI
  • Clark JM, Salgado-Polo F, Macdonald SJF, Barrett TN, Perrakis A, Jamieson C
    Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators
    Journal of Medicinal Chemistry. 2022; 65(8): 6338-6351. https://doi.org/10.1021/acs.jmedchem.2c00368
    DORA PSI
  • Collu G, Bierig T, Krebs A-S, Engilberge S, Varma N, Guixà-González R, et al.
    Chimeric single α-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology
    Structure. 2022; 30(1): 95-106. https://doi.org/10.1016/j.str.2021.09.002
    DORA PSI
  • Conchou L, Doumèche B, Galisson F, Violot S, Dugelay C, Diesis E, et al.
    Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium
    Communications Biology. 2022; 5(1): 1158 (13 pp.). https://doi.org/10.1038/s42003-022-04091-4
    DORA PSI
  • Cousido-Siah A, Carneiro L, Kostmann C, Ecsedi P, Nyitray L, Trave G, et al.
    A scalable strategy to solve structures of PDZ domains and their complexes
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 509-516. https://doi.org/10.1107/S2059798322001784
    DORA PSI
  • Cullati SN, Chaikuad A, Chen J-S, Gebel J, Tesmer L, Zhubi R, et al.
    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
    Molecular Cell. 2022; 82(11): 2006-2020.e8. https://doi.org/10.1016/j.molcel.2022.03.005
    DORA PSI
  • Dammann M, Stahlecker J, Zimmermann MO, Klett T, Rotzinger K, Kramer M, et al.
    Screening of a Halogen-Enriched Fragment Library leads to unconventional binding modes
    Journal of Medicinal Chemistry. 2022; 65(21): 14539-14552. https://doi.org/10.1021/acs.jmedchem.2c00951
    DORA PSI
  • De Vries T, Martelly W, Campagne S, Sabath K, Sarnowski CP, Wong J, et al.
    Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2022; 119(6): e2114092119 (11 pp.). https://doi.org/10.1073/pnas.2114092119
    DORA PSI
  • Ekström F, Gottinger A, Forsgren N, Catto M, Iacovino LG, Pisani L, et al.
    Dual reversible coumarin inhibitors mutually bound to monoamine oxidase B and acetylcholinesterase crystal structures
    ACS Medicinal Chemistry Letters. 2022; 13(3): 499-506. https://doi.org/10.1021/acsmedchemlett.2c00001
    DORA PSI
  • Fraley AE, Dieterich CL, Mabesoone MFJ, Minas HA, Meoded RA, Hemmerling F, et al.
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