Publications

PDB structures measured at X06DA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Abiko LA, Dias Teixeira R, Engilberge S, Grahl A, Mühlethaler T, Sharpe T, et al.
    Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol
    Nature Chemistry. 2022: (11 pp.). https://doi.org/10.1038/s41557-022-01009-9
    DORA PSI
  • Alsarraf HMAB, Ung KL, Johansen MD, Dimon J, Olieric V, Kremer L, et al.
    Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N‐acetyltransferase
    FEBS Letters. 2022; 596(12): 1516-1532. https://doi.org/10.1002/1873-3468.14360
    DORA PSI
  • Bereiter R, Renard E, Breuker K, Kreutz C, Ennifar E, Micura R
    1-deazaguanosine-modified RNA: the missing piece for functional RNA atomic mutagenesis
    Journal of the American Chemical Society. 2022; 144(23): 10344-10352. https://doi.org/10.1021/jacs.2c01877
    DORA PSI
  • Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, et al.
    NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
    Molecular Cell. 2022; 82(3): 555-569.e7. https://doi.org/10.1016/j.molcel.2021.12.031
    DORA PSI
  • Bleuler-Martinez S, Varrot A, Olieric V, Schubert M, Vogt E, Fetz C, et al.
    Structure–function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity
    Glycobiology. 2022; 32(7): 600-615. https://doi.org/10.1093/glycob/cwac020
    DORA PSI
  • Bobrovs R, Basens EE, Drunka L, Kanepe I, Matisone S, Velins KK, et al.
    Exploring aspartic protease inhibitor binding to design selective antimalarials
    Journal of Chemical Information and Modeling. 2022; 62(13): 3263-3273. https://doi.org/10.1021/acs.jcim.2c00422
    DORA PSI
  • Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, et al.
    Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRASG12C inhibitor
    Journal of Medicinal Chemistry. 2022; 65(21): 14614-14629. https://doi.org/10.1021/acs.jmedchem.2c01120
    DORA PSI
  • Camus A, Truong G, Mittl PRE, Markert G, Hilvert D
    Reprogramming nonribosomal peptide synthetases for site-specific insertion of α-hydroxy acids
    Journal of the American Chemical Society. 2022; 144(38): 17567-17575. https://doi.org/10.1021/jacs.2c07013
    DORA PSI
  • Chen P, Wojdyla JA, Colasanti O, Li Z, Qin B, Wang M, et al.
    Biochemical and structural characterization of hepatitis A virus 2C reveals an unusual ribonuclease activity on single-stranded RNA
    Nucleic Acids Research. 2022; 50(16): 9470-9489. https://doi.org/10.1093/nar/gkac671
    DORA PSI
  • Clark JM, Salgado-Polo F, Macdonald SJF, Barrett TN, Perrakis A, Jamieson C
    Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators
    Journal of Medicinal Chemistry. 2022; 65(8): 6338-6351. https://doi.org/10.1021/acs.jmedchem.2c00368
    DORA PSI
  • Collu G, Bierig T, Krebs A-S, Engilberge S, Varma N, Guixà-González R, et al.
    Chimeric single α-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology
    Structure. 2022; 30(1): 95-106. https://doi.org/10.1016/j.str.2021.09.002
    DORA PSI
  • Cousido-Siah A, Carneiro L, Kostmann C, Ecsedi P, Nyitray L, Trave G, et al.
    A scalable strategy to solve structures of PDZ domains and their complexes
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 509-516. https://doi.org/10.1107/S2059798322001784
    DORA PSI
  • Cullati SN, Chaikuad A, Chen J-S, Gebel J, Tesmer L, Zhubi R, et al.
    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
    Molecular Cell. 2022; 82(11): 2006-2020.e8. https://doi.org/10.1016/j.molcel.2022.03.005
    DORA PSI
  • Dammann M, Stahlecker J, Zimmermann MO, Klett T, Rotzinger K, Kramer M, et al.
    Screening of a Halogen-Enriched Fragment Library leads to unconventional binding modes
    Journal of Medicinal Chemistry. 2022; 65(21): 14539-14552. https://doi.org/10.1021/acs.jmedchem.2c00951
    DORA PSI
  • De Vries T, Martelly W, Campagne S, Sabath K, Sarnowski CP, Wong J, et al.
    Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2022; 119(6): e2114092119 (11 pp.). https://doi.org/10.1073/pnas.2114092119
    DORA PSI
  • Ekström F, Gottinger A, Forsgren N, Catto M, Iacovino LG, Pisani L, et al.
    Dual reversible coumarin inhibitors mutually bound to monoamine oxidase B and acetylcholinesterase crystal structures
    ACS Medicinal Chemistry Letters. 2022; 13(3): 499-506. https://doi.org/10.1021/acsmedchemlett.2c00001
    DORA PSI
  • Fraley AE, Dieterich CL, Mabesoone MFJ, Minas HA, Meoded RA, Hemmerling F, et al.
    Structure of a promiscuous thioesterase domain responsible for branching acylation in polyketide biosynthesis
    Angewandte Chemie International Edition. 2022; 61(39): e202206385 (9 pp.). https://doi.org/10.1002/anie.202206385
    DORA PSI
  • Fruergaard MU, Dach I, Andersen JL, Ozol M, Shahsavar A, Quistgaard EM, et al.
    The Na+,K+-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state
    Journal of Biological Chemistry. 2022; 298(9): 102317 (12 pp.). https://doi.org/10.1016/j.jbc.2022.102317
    DORA PSI
  • Galazzo L, Meier G, Januliene D, Parey K, De Vecchis D, Striednig B, et al.
    The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells
    Science Advances. 2022; 8(41): eabn6845 (14 pp.). https://doi.org/10.1126/sciadv.abn6845
    DORA PSI
  • García-Alija M, Du JJ, Ordóñez I, Diz-Vallenilla A, Moraleda-Montoya A, Sultana N, et al.
    Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE
    Nature Communications. 2022; 13(1): 1137 (17 pp.). https://doi.org/10.1038/s41467-022-28722-w
    DORA PSI
  • Hermanns T, Pichlo C, Baumann U, Hofmann K
    A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family
    Nature Communications. 2022; 13(1): 401 (14 pp.). https://doi.org/10.1038/s41467-022-28049-6
    DORA PSI
  • Herzog D, Jansen J, Mißun M, Diederichs K, Stengel F, Marx A
    Chemical proteomics of the tumor suppressor fhit covalently bound to the cofactor Ap3A elucidates its inhibitory action on translation
    Journal of the American Chemical Society. 2022; 144(19): 8613-8623. https://doi.org/10.1021/jacs.2c00815
    DORA PSI
  • Iacovino LG, Rossi M, Di Stefano G, Rossi V, Binda C, Brigotti M, et al.
    Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme
    Biochimie. 2022; 199: 23-35. https://doi.org/10.1016/j.biochi.2022.03.008
    DORA PSI
  • Iijima D, Sugama H, Takahashi Y, Hirai M, Togashi Y, Xie J, et al.
    Discovery of SPH3127: a novel, highly potent, and orally active direct renin inhibitor
    Journal of Medicinal Chemistry. 2022; 65(16): 10882-10897. https://doi.org/10.1021/acs.jmedchem.2c00834
    DORA PSI
  • Jones AN, Tikhaia E, Mourão A, Sattler M
    Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1
    Nucleic Acids Research. 2022; 50(4): 2350-2362. https://doi.org/10.1093/nar/gkac080
    DORA PSI
  • Kaminski JW, Vera L, Stegmann DP, Vering J, Eris D, Smith KML, et al.
    Fast fragment- and compound-screening pipeline at the Swiss Light Source
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 328-336. https://doi.org/10.1107/S2059798322000705
    DORA PSI
  • Koda Y, Sato S, Yamamoto H, Niwa H, Watanabe H, Watanabe C, et al.
    Design and synthesis of tranylcypromine-derived LSD1 inhibitors with improved hERG and microsomal stability profiles
    ACS Medicinal Chemistry Letters. 2022; 13(5): 848-854. https://doi.org/10.1021/acsmedchemlett.2c00120
    DORA PSI
  • Lambey P, Otun O, Cong X, Hoh F, Brunel L, Verdié P, et al.
    Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins
    eLife. 2022; 11: e72555 (29 pp.). https://doi.org/10.7554/eLife.72555
    DORA PSI
  • Landskron L, Bak J, Adamopoulos A, Kaplani K, Moraiti M, van den Hengel LG, et al.
    Posttranslational modification of microtubules by the MATCAP detyrosinase
    Science. 2022; 376(6595): abn6020 (13 pp.). https://doi.org/10.1126/science.abn6020
    DORA PSI
  • Li Y, Bedi RK, Nai F, von Roten V, Dolbois A, Zálešák F, et al.
    Structure-based design of ligands of the m6A-RNA reader YTHDC1
    European Journal of Medicinal Chemistry Reports. 2022; 5: 100057 (11 pp.). https://doi.org/10.1016/j.ejmcr.2022.100057
    DORA PSI
  • Margreiter MA, Witzenberger M, Wasser Y, Davydova E, Janowski R, Metz J, et al.
    Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death
    Computational and Structural Biotechnology Journal. 2022; 20: 443-458. https://doi.org/10.1016/j.csbj.2021.12.029
    DORA PSI
  • Marineau JJ, Hamman KB, Hu S, Alnemy S, Mihalich J, Kabro A, et al.
    Discovery of SY-5609: a selective, noncovalent inhibitor of CDK7
    Journal of Medicinal Chemistry. 2022; 65(2): 1458-1480. https://doi.org/10.1021/acs.jmedchem.1c01171
    DORA PSI
  • Marzullo P, Boiarska Z, Pérez-Peña H, Abel AC, Álvarez-Bernad B, Lucena-Agell D, et al.
    Maytansinol derivatives: side reactions as a chance for new tubulin binders
    Chemistry: A European Journal. 2022; 28(2): e202103520 (10 pp.). https://doi.org/10.1002/chem.202103520
    DORA PSI
  • Maso L, Vascon F, Chinellato M, Goormaghtigh F, Bellio P, Campagnaro E, et al.
    Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway
    Structure. 2022; 30(11): 1479-1493.e9. https://doi.org/10.1016/j.str.2022.09.004
    DORA PSI
  • Menna M, Fiorentino F, Marrocco B, Lucidi A, Tomassi S, Cilli D, et al.
    Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models
    European Journal of Medicinal Chemistry. 2022; 237: 114410 (23 pp.). https://doi.org/10.1016/j.ejmech.2022.114410
    DORA PSI
  • Mertens V, Abi Saad MJ, Coudevylle N, Wälti MA, Finke A, Marsh M, et al.
    Elucidation of a nutlin-derivative-HDM2 complex structure at the interaction site by NMR molecular replacement: a straightforward derivation
    Journal of Magnetic Resonance Open. 2022; 10-11: 100032 (5 pp.). https://doi.org/10.1016/j.jmro.2022.100032
    DORA PSI
  • Metzner FJ, Huber E, Hopfner K-P, Lammens K
    Structural and biochemical characterization of human Schlafen 5
    Nucleic Acids Research. 2022; 50(2): 1147-1161. https://doi.org/10.1093/nar/gkab1278
    DORA PSI
  • Mishra K, Fuenzalida-Werner JP, Pennacchietti F, Janowski R, Chmyrov A, Huang Y, et al.
    Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging
    Nature Biotechnology. 2022; 40: 598-605. https://doi.org/10.1038/s41587-021-01100-5
    DORA PSI
  • Muckenfuss LM, Migenda Herranz AC, Boneberg FM, Clerici M, Jinek M
    Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis
    eLife. 2022; 11: e80332 (29 pp.). https://doi.org/10.7554/eLife.80332
    DORA PSI
  • Mühlethaler T, Milanos L, Ortega JA, Blum TB, Gioia D, Roy B, et al.
    Rational design of a novel tubulin inhibitor with a unique mechanism of action
    Angewandte Chemie International Edition. 2022; 61(25): e202204052 (11 pp.). https://doi.org/10.1002/anie.202204052
    DORA PSI
  • Nai F, Nachawati R, Zálešák F, Wang X, Li Y, Caflisch A
    Fragment ligands of the m6A-RNA reader YTHDF2
    ACS Medicinal Chemistry Letters. 2022; 13(9): 1500-1509. https://doi.org/10.1021/acsmedchemlett.2c00303
    DORA PSI
  • Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, et al.
    Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses
    Cell Chemical Biology. 2022; 29(5): 774-784.e8. https://doi.org/10.1016/j.chembiol.2021.11.006
    DORA PSI
  • Niwa H, Watanabe C, Sato S, Harada T, Watanabe H, Tabusa R, et al.
    Structure-activity relationship and in silico evaluation of cis- and trans-PCPA-derived inhibitors of LSD1 and LSD2
    ACS Medicinal Chemistry Letters. 2022; 13(9): 1485-1492. https://doi.org/10.1021/acsmedchemlett.2c00294
    DORA PSI
  • Pacesa M, Loeff L, Querques I, Muckenfuss LM, Sawicka M, Jinek M
    R-loop formation and conformational activation mechanisms of Cas9
    Nature. 2022; 609: 191-196. https://doi.org/10.1038/s41586-022-05114-0
    DORA PSI
  • Pacesa M, Lin C-H, Cléry A, Saha A, Arantes PR, Bargsten K, et al.
    Structural basis for Cas9 off-target activity
    Cell. 2022; 185(22): 4067-4081.e21. https://doi.org/10.1016/j.cell.2022.09.026
    DORA PSI
  • Qiao Z, Kong Q, Tee WT, Lim ARQ, Teo MX, Olieric V, et al.
    Molecular basis of the key regulator WRINKLED1 in plant oil biosynthesis
    Science Advances. 2022; 8(34): eabq1211 (10 pp.). https://doi.org/10.1126/sciadv.abq1211
    DORA PSI
  • Qin B, Craven GB, Hou P, Chesti J, Lu X, Child ES, et al.
    Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease
    Acta Pharmaceutica Sinica B. 2022; 12(10): 3924-3933. https://doi.org/10.1016/j.apsb.2022.06.002
    DORA PSI
  • Ragotte RJ, Pulido D, Lias AM, Quinkert D, Alanine DGW, Jamwal A, et al.
    Heterotypic interactions drive antibody synergy against a malaria vaccine candidate
    Nature Communications. 2022; 13(1): 933 (12 pp.). https://doi.org/10.1038/s41467-022-28601-4
    DORA PSI
  • Ramanadane K, Straub MS, Dutzler R, Manatschal C
    Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family
    eLife. 2022; 11: e74589 (29 pp.). https://doi.org/10.7554/eLife.74589
    DORA PSI
  • Roman A-O, Jimenez-Sandoval P, Augustin S, Broyart C, Hothorn LA, Santiago J
    HSL1 and BAM1/2 impact epidermal cell development by sensing distinct signaling peptides
    Nature Communications. 2022; 13(1): 876 (13 pp.). https://doi.org/10.1038/s41467-022-28558-4
    DORA PSI
  • Röhrig UF, Majjigapu SR, Vogel P, Reynaud A, Pojer F, Dilek N, et al.
    Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
    Journal of Enzyme Inhibition and Medicinal Chemistry. 2022; 37(1): 1773-1811. https://doi.org/10.1080/14756366.2022.2089665
    DORA PSI
  • Santos MFA, Sciortino G, Correia I, Fernandes ACP, Santos-Silva T, Pisanu F, et al.
    Binding of VIVO2+, VIVOL, VIVOL2 and VVO2L moieties to proteins: X-ray/theoretical characterization and biological implications
    Chemistry: A European Journal. 2022; 28(40): e202200105 (8 pp.). https://doi.org/10.1002/chem.202200105
    DORA PSI
  • Scaletti ER, Gustafsson Westergren R, Andersson Y, Wiita E, Henriksson M, Homan EJ, et al.
    The first structure of human MTHFD2L and its implications for the development of isoform-selective inhibitors
    ChemMedChem. 2022; 17(18): e202200274 (10 pp.). https://doi.org/10.1002/cmdc.202200274
    DORA PSI
  • Tan YB, Lello L S, Liu X, Law Y-S, Kang C, Lescar J, et al.
    Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
    Nucleic Acids Research. 2022; 50(2): 1000-1016. https://doi.org/10.1093/nar/gkab1302
    DORA PSI
  • Veggi D, Malito E, Lo Surdo P, Pansegrau W, Rippa V, Wahome N, et al.
    Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096
    Computational and Structural Biotechnology Journal. 2022; 20: 2070-2081. https://doi.org/10.1016/j.csbj.2022.04.011
    DORA PSI
  • Wang L, Moreira EA, Kempf G, Miyake Y, Oliveira Esteves BI, Fahmi A, et al.
    Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways
    Cell Reports. 2022; 39(4): 110736 (20 pp.). https://doi.org/10.1016/j.celrep.2022.110736
    DORA PSI
  • Zeinyeh W, Esvan YJ, Josselin B, Defois M, Baratte B, Knapp S, et al.
    Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity
    European Journal of Medicinal Chemistry. 2022; 236: 114369 (11 pp.). https://doi.org/10.1016/j.ejmech.2022.114369
    DORA PSI
  • Zetterberg FR, MacKinnon A, Brimert T, Gravelle L, Johnsson RE, Kahl-Knutson B, et al.
    Discovery and optimization of the first highly effective and orally available galectin-3 inhibitors for treatment of fibrotic disease
    Journal of Medicinal Chemistry. 2022; 65(19): 12626-12638. https://doi.org/10.1021/acs.jmedchem.2c00660
    DORA PSI
  • Zhang C, Yang F, Wojdyla JA, Qin B, Zhang W, Zheng M, et al.
    An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein
    Cell Reports. 2022; 40(1): 111030 (21 pp.). https://doi.org/10.1016/j.celrep.2022.111030
    DORA PSI
  • de la Roche NM, Mühlethaler T, Di Martino RMC, Ortega JA, Gioia D, Roy B, et al.
    Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
    European Journal of Medicinal Chemistry. 2022; 241: 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614
    DORA PSI
  • Abraham ET, Oecal S, Mörgelin M, Schmid PWN, Buchner J, Baumann U, et al.
    Collagen's primary structure determines collagen:HSP47 complex stoichiometry
    Journal of Biological Chemistry. 2021; 297(6): 101169 (13 pp.). https://doi.org/10.1016/j.jbc.2021.101169
    DORA PSI
  • Abrami L, Audagnotto M, Ho S, Marcaida MJ, Mesquita FS, Anwar MU, et al.
    Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
    Nature Chemical Biology. 2021; 17(4): 438-447. https://doi.org/10.1038/s41589-021-00753-2
    DORA PSI
  • Adhireksan Z, Sharma D, Lee PL, Bao Q, Padavattan S, Shum WK, et al.
    Engineering nucleosomes for generating diverse chromatin assemblies
    Nucleic Acids Research. 2021; 49(9): E52 (12 pp.). https://doi.org/10.1093/nar/gkab070
    DORA PSI
  • Aeschimann W, Kammer S, Staats S, Schneider P, Schneider G, Rimbach G, et al.
    Engineering of a functional γ-tocopherol transfer protein
    Redox Biology. 2021; 38: 101773 (11 pp.). https://doi.org/10.1016/j.redox.2020.101773
    DORA PSI
  • Alali A, Zhang L, Li J, Zuo C, Wassouf D, Yan X, et al.
    Biosynthesis of the tricyclic aromatic type II polyketide rishirilide: new potential third ring oxygenation after three cyclization steps
    Molecular Biotechnology. 2021; 23: 502-514. https://doi.org/10.1007/s12033-021-00314-x
    DORA PSI
  • Alvigini L, Gran-Scheuch A, Guo Y, Trajkovic M, Saifuddin M, Fraaije MW, et al.
    Discovery, biocatalytic exploration and structural analysis of a 4-ethylphenol oxidase from Gulosibacter chungangensis
    ChemBioChem. 2021; 22(22): 3225-3233. https://doi.org/10.1002/cbic.202100457
    DORA PSI
  • Axer A, Jumde RP, Adam S, Faust A, Schäfers M, Fobker M, et al.
    Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
    Chemical Science. 2021; 12(4): 1286-1294. https://doi.org/10.1039/D0SC04297H
    DORA PSI
  • Baeriswyl S, Personne H, Di Bonaventura I, Köhler T, Van Delden C, Stocker A, et al.
    A mixed chirality α-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography
    RSC Chemical Biology. 2021; 2(6): 1608-1617. https://doi.org/10.1039/d1cb00124h
    DORA PSI
  • Bailleul G, Nicoll CR, Mascotti ML, Mattevi A, Fraaije MW
    Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties
    Journal of Biological Chemistry. 2021; 296: 100221 (13 pp.). https://doi.org/10.1074/jbc.RA120.016297
    DORA PSI
  • Banaś AM, Bocian-Ostrzycka KM, Dunin-Horkawicz S, Ludwiczak J, Wilk P, Orlikowska M, et al.
    Interplay between DsbA1, DsbA2 and C8J_1298 periplasmic oxidoreductases of Campylobacter jejuni and their impact on bacterial physiology and pathogenesis
    International Journal of Molecular Sciences. 2021; 22(24): 13451 (37 pp.). https://doi.org/10.3390/ijms222413451
    DORA PSI
  • Basler S, Studer S, Zou Y, Mori T, Ota Y, Camus A, et al.
    Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold
    Nature Chemistry. 2021; 13(3): 231-235. https://doi.org/10.1038/s41557-020-00628-4
    DORA PSI
  • Bauer V, Schmidtgall B, Gógl G, Dolenc J, Osz J, Nominé Y, et al.
    Conformational editing of intrinsically disordered protein by α-methylation
    Chemical Science. 2021; 12(3): 1080-1089. https://doi.org/10.1039/D0SC04482B
    DORA PSI
  • Brullo C, Rapetti F, Abbate S, Prosdocimi T, Torretta A, Semrau M, et al.
    Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors
    European Journal of Medicinal Chemistry. 2021; 223: 113638 (13 pp.). https://doi.org/10.1016/j.ejmech.2021.113638
    DORA PSI
  • Böhringer N, Green R, Liu Y, Mettal U, Marner M, Modaresi SM, et al.
    Mutasynthetic production and antimicrobial characterization of darobactin analogs
    Microbiology Spectrum. 2021; 9(3): e01535 (14 pp.). https://doi.org/10.1128/SPECTRUM.01535-21
    DORA PSI
  • Chaoprasid P, Lukat P, Mühlen S, Heidler T, Gazdag E-M, Dong S, et al.
    Crystal structure of bacterial cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication
    EMBO Journal. 2021; 40(4): e105202 (21 pp.). https://doi.org/10.15252/embj.2020105202
    DORA PSI
  • Conrady MC, Suarez I, Gogl G, Frecot DI, Bonhoure A, Kostmann C, et al.
    Structure of high-risk papillomavirus 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation
    Journal of Virology. 2021; 95(2): e00730-20 (15 pp.). https://doi.org/10.1128/JVI.00730-20
    DORA PSI
  • De Zitter E, Hugelier S, Duwé S, Vandenberg W, Tebo AG, Van Meervelt L, et al.
    Structure–function dataset reveals environment effects within a fluorescent protein model system
    Angewandte Chemie International Edition. 2021; 60(18): 10073-10081. https://doi.org/10.1002/anie.202015201
    DORA PSI
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