Publications

PDB structures measured at X06DA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Akichika S, Hirano S, Shichino Y, Suzuki T, Nishimasu H, Ishitani R, et al.
    Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase
    Science. 2019; 363(6423): eaav0080 (7 pp.). https://doi.org/10.1126/science.aav0080
    DORA PSI
  • Andreou A, Giastas P, Arnaouteli S, Tzanodaskalaki M, Tzartos SJ, Bethanis K, et al.
    The putative polysaccharide deacetylase Ba0331: cloning, expression, crystallization and structure determination
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2019; 75(4): 312-320. https://doi.org/10.1107/S2053230X19001766
    DORA PSI
  • André C, Martiel I, Wolff P, Landolfo M, Lorber B, Silva da Veiga C, et al.
    Interaction of a model peptide on gram negative and gram positive bacterial sliding clamps
    ACS Infectious Diseases. 2019; 5: 1022-1034. https://doi.org/10.1021/acsinfecdis.9b00089
    DORA PSI
  • Apel A-K, Cheng RKY, Tautermann CS, Brauchle M, Huang C-Y, Pautsch A, et al.
    Crystal structure of CC chemokine receptor 2A in complex with an orthosteric antagonist provides insights for the design of selective antagonists
    Structure. 2019; 27(3): 427-438.e5. https://doi.org/10.1016/j.str.2018.10.027
    DORA PSI
  • Bachmaier S, Volpato Santos Y, Kramer S, Githure GB, Klöckner T, Pepperl J, et al.
    Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
    Nature Communications. 2019; 10(1): 1421 (14 pp.). https://doi.org/10.1038/s41467-019-09338-z
    DORA PSI
  • Baeriswyl S, Gan B-H, Siriwardena TN, Visini R, Robadey M, Javor S, et al.
    X-ray crystal structures of short antimicrobial peptides as Pseudomonas aeruginosa lectin B complexes
    ACS Chemical Biology. 2019; 14(4): 758-766. https://doi.org/10.1021/acschembio.9b00047
    DORA PSI
  • Baier M, Rustmeier NH, Harr J, Cyrus N, Reiss GJ, Grafmüller A, et al.
    Divalent sialylated precision glycooligomers binding to Polyomaviruses and the effect of different linkers
    Macromolecular Bioscience. 2019; 19(5): 1800426 (7 pp.). https://doi.org/10.1002/mabi.201800426
    DORA PSI
  • Basu S, Olieric V, Leonarski F, Matsugaki N, Kawano Y, Takashi T, et al.
    Long-wavelength native-SAD phasing: opportunities and challenges
    IUCrJ. 2019; 6(3): 1-14. https://doi.org/10.1107/S2052252519002756
    DORA PSI
  • Basu S, Finke A, Vera L, Wang M, Olieric V
    Making routine native SAD a reality: lessons from beamline X06DA at the Swiss Light Source
    Acta Crystallographica Section D: Structural Biology. 2019; 75(3): 262-271. https://doi.org/10.1107/S2059798319003103
    DORA PSI
  • Bergner A, Cockcroft X, Fischer G, Gollner A, Hela W, Kousek R, et al.
    KRAS binders hidden in nature
    Chemistry: A European Journal. 2019; 25(52): 12037-12041. https://doi.org/10.1002/chem.201902810
    DORA PSI
  • Boneberg FM, Brandmann T, Kobel L, van den Heuvel J, Bargsten K, Bammert L, et al.
    Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis
    RNA. 2019; 25(6): 685-701. https://doi.org/10.1261/rna.069609.118
    DORA PSI
  • Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, et al.
    Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
    European Journal of Medicinal Chemistry. 2019; 162: 290-320. https://doi.org/10.1016/j.ejmech.2018.11.004
    DORA PSI
  • Bunzel HA, Kries H, Marchetti L, Zeymer C, Mittl PRE, Mulholland AJ, et al.
    Emergence of a negative activation heat capacity during evolution of a designed enzyme
    Journal of the American Chemical Society. 2019; 141(30): 11745-11748. https://doi.org/10.1021/jacs.9b02731
    DORA PSI
  • Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, et al.
    Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)
    Biochemical Journal. 2019; 476(5): 875-887. https://doi.org/10.1042/BCJ20190038
    DORA PSI
  • Clarke DE, Noguchi H, Gryspeerdt J-LAG, De Feyter S, Voet ARD
    Artificial β-propeller protein-based hydrolases
    Chemical Communications. 2019; 55(60): 8880-8883. https://doi.org/10.1039/c9cc04388h
    DORA PSI
  • Damm-Ganamet KL, Arora N, Becart S, Edwards JP, Lebsack AD, McAllister HM, et al.
    Accelerating lead identification by high throughput virtual screening: prospective case studies from the pharmaceutical industry
    Journal of Chemical Information and Modeling. 2019; 59(5): 2046-2062. https://doi.org/10.1021/acs.jcim.8b00941
    DORA PSI
  • Dohle W, Prota AE, Menchon G, Hamel E, Steinmetz MO, Potter BVL
    Tetrahydroisoquinoline sulfamates as potent microtubule disruptors: synthesis, antiproliferative and antitubulin activity of dichlorobenzyl-based derivatives, and a Tubulin cocrystal structure.
    ACS Omega. 2019; 4: 755-764. https://doi.org/10.1021/acsomega.8b02879
    DORA PSI
  • Ejby M, Guskov A, Pichler MJ, Zanten GC, Schoof E, Saburi W, et al.
    Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β-mannan possess distinct manno-oligosaccharide-binding profiles
    Molecular Microbiology. 2019; 112(1): 114-130. https://doi.org/10.1111/mmi.14257
    DORA PSI
  • Faltova L, Jiang K, Frey D, Wu Y, Capitani G, Prota AE, et al.
    Crystal structure of a heterotetrameric katanin p60:p80 complex
    Structure. 2019; 27(9): 1375-1383.e3. https://doi.org/10.1016/j.str.2019.07.002
    DORA PSI
  • Fragel SM, Montada A, Heermann R, Baumann U, Schacherl M, Schnetz K
    Characterization of the pleiotropic LysR-type transcription regulator LeuO of Escherichia coli
    Nucleic Acids Research. 2019; 47(14): 7363-7379. https://doi.org/10.1093/nar/gkz506
    DORA PSI
  • Friedel K, Popp MA, Matern JCJ, Gazdag EM, Thiel IV, Volkmann G, et al.
    A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine
    Chemical Science. 2019; 10(1): 239-251. https://doi.org/10.1039/C8SC01074A
    DORA PSI
  • Fujimoto K, Matsuoka E, Asada N, Tadano G, Yamamoto T, Nakahara K, et al.
    Structure-based design of selective β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: targeting the flap to gain selectivity over BACE2
    Journal of Medicinal Chemistry. 2019; 62(10): 5080-5095. https://doi.org/10.1021/acs.jmedchem.9b00309
    DORA PSI
  • Galuskin EV, Krüger B, Galuskina IO, Krüger H, Vapnik Y, Pauluhn A, et al.
    Levantite, KCa3(Al2Si3)O11(PO4), a new latiumite group mineral from pyrometamorphic rock of the Hatrurim Basin, Negev Desert, Israel
    Mineralogical Magazine. 2019; 83(5): 713-721. https://doi.org/10.1180/mgm.2019.37
    DORA PSI
  • Grāve K, Lambert W, Berggren G, Griese JJ, Bennett MD, Logan DT, et al.
    Redox-induced structural changes in the di-iron and di-manganese forms of Bacillus anthracis ribonucleotide reductase subunit NrdF suggest a mechanism for gating of radical access
    Journal of Biological Inorganic Chemistry. 2019; 24(6): 849-861. https://doi.org/10.1007/s00775-019-01703-z
    DORA PSI
  • Guillon R, Rahimova R, Preeti P, Egron D, Rouanet S, Dumontet C, et al.
    Lead optimization and biological evaluation of fragment-based cN-II inhibitors
    European Journal of Medicinal Chemistry. 2019; 168: 28-44. https://doi.org/10.1016/j.ejmech.2019.02.040
    DORA PSI
  • Hegge JW, Swarts DC, Chandradoss SD, Cui TJ, Kneppers J, Jinek M, et al.
    DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute
    Nucleic Acids Research. 2019; 47(11): 5809-5821. https://doi.org/10.1093/nar/gkz306
    DORA PSI
  • Heinrich T, Seenisamy J, Blume B, Bomke J, Calderini M, Eckert U, et al.
    Discovery and structure-based optimization of next-generation reversible methionine aminopeptidase-2 (MetAP-2) inhibitors
    Journal of Medicinal Chemistry. 2019; 62(10): 5025-5039. https://doi.org/10.1021/acs.jmedchem.9b00041
    DORA PSI
  • Hohmann U, Hothorn M
    Crystal structure of the leucine-rich repeat ectodomain of the plant immune receptor kinase SOBIR1
    Acta Crystallographica Section D: Structural Biology. 2019; 75(5): 488-497. https://doi.org/10.1107/S2059798319005291
    DORA PSI
  • Hutter CAJ, Timachi MH, Hürlimann LM, Zimmermann I, Egloff P, Göddeke H, et al.
    The extracellular gate shapes the energy profile of an ABC exporter
    Nature Communications. 2019; 10(1): 2260 (13 pp.). https://doi.org/10.1038/s41467-019-09892-6
    DORA PSI
  • Iwabuchi N, Maejima K, Kitazawa Y, Miyatake H, Nishikawa M, Tokuda R, et al.
    Crystal structure of phyllogen, a phyllody-inducing effector protein of phytoplasma
    Biochemical and Biophysical Research Communications. 2019; 513(4): 952-957. https://doi.org/10.1016/j.bbrc.2019.04.060
    DORA PSI
  • Javitt G, Calvo MLG, Albert L, Reznik N, Ilani T, Diskin R, et al.
    Intestinal gel-forming mucins polymerize by disulfide-mediated dimerization of D3 domains
    Journal of Molecular Biology. 2019; 431(19): 3740-3752. https://doi.org/10.1016/j.jmb.2019.07.018
    DORA PSI
  • Kahlenberg V, Schmidmair D, Krüger H, Krüger B, Pauluhn A
    Structural studies on Ca3Al4MgO10 (C3A2M) - a ternary phase in the system CaO-Al2O3-MgO
    Journal of the American Ceramic Society. 2019; 102: 2084. https://doi.org/10.1111/jace.16001
    DORA PSI
  • Kessler D, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, et al.
    Drugging an undruggable pocket on KRAS
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(32): 15823-15829. https://doi.org/10.1073/pnas.1904529116
    DORA PSI
  • Klamt A, Nagarathinam K, Tanabe M, Kumar A, Balbach J
    Hyperbolic pressure-temperature phase diagram of the zinc-finger protein apoKti11 detected by NMR spectroscopy
    Journal of Physical Chemistry B. 2019; 123(4): 792-801. https://doi.org/10.1021/acs.jpcb.8b11019
    DORA PSI
  • Klünemann T, Preuß A, Adamczack J, Rosa LFM, Harnisch F, Layer G, et al.
    Crystal structure of dihydro-heme d1 dehydrogenase NirN from Pseudomonas aeruginosa reveals amino acid residues essential for catalysis
    Journal of Molecular Biology. 2019; 431(17): 3246-3260. https://doi.org/10.1016/j.jmb.2019.05.046
    DORA PSI
  • Korntner-Vetter M, Lefèvre S, Hu X-W, George R, Singleton MR
    Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex
    Life Science Alliance. 2019; 2(4): e201900408 (11 pp.). https://doi.org/10.26508/lsa.201900408
    DORA PSI
  • Kroupova A, Ivaşcu A, Reimão-Pinto MM, Ameres SL, Jinek M
    Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor
    Nucleic Acids Research. 2019; 47(2): 1030-1042. https://doi.org/10.1093/nar/gky1164
    DORA PSI
  • Kutnowski N, Shmulevich F, Davidov G, Shahar A, Bar-Zvi D, Eichler J, et al.
    Specificity of protein-DNA interactions in hypersaline environment: structural studies on complexes of Halobacterium salinarum oxidative stress-dependent protein hsRosR
    Nucleic Acids Research. 2019; 47(16): 8860-8873. https://doi.org/10.1093/nar/gkz604
    DORA PSI
  • Lach M, Künzle M, Beck T
    Proteins as sustainable building blocks for the next generation of bioinorganic nanomaterials
    Biochemistry. 2019; 58(3): 140-141. https://doi.org/10.1021/acs.biochem.8b00966
    DORA PSI
  • Lau K, Podolec R, Chappuis R, Ulm R, Hothorn M
    Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs
    EMBO Journal. 2019; 38(18): e102140 (18 pp.). https://doi.org/10.15252/embj.2019102140
    DORA PSI
  • Leisinger F, Burn R, Meury M, Lukat P, Seebeck FP
    Structural and mechanistic basis for anaerobic ergothioneine biosynthesis
    Journal of the American Chemical Society. 2019; 141(17): 6906-6914. https://doi.org/10.1021/jacs.8b12596
    DORA PSI
  • Leopold K, Stirpe A, Schalch T
    Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1
    Genes and Development. 2019. https://doi.org/10.1101/gad.320440.118
    DORA PSI
  • Levy N, Bruneau J-M, Le Rouzic E, Bonnard D, Le Strat F, Caravano A, et al.
    Structural Basis for E. coli penicillin binding protein (PBP) 2 inhibition, a platform for drug design
    Journal of Medicinal Chemistry. 2019; 62(9): 4742-4754. https://doi.org/10.1021/acs.jmedchem.9b00338
    DORA PSI
  • Li H, Huang C-Y, Govorunova EG, Schafer CT, Sineshchekov OA, Wang M, et al.
    Crystal structure of a natural light-gated anion channelrhodopsin
    eLife. 2019; 8: e41741 (21 pp.). https://doi.org/10.7554/eLife.41741
    DORA PSI
  • Lingaraju M, Johnsen D, Schlundt A, Langer LM, Basquin J, Sattler M, et al.
    The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs
    Nature Communications. 2019; 10(1): 3393 (11 pp.). https://doi.org/10.1038/s41467-019-11339-x
    DORA PSI
  • Liu X, An T, Li D, Fan Z, Xiang P, Li C, et al.
    Structure of the heterophilic interaction between the nectin-like 4 and nectin-like 1 molecules
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(6): 2068-2077. https://doi.org/10.1073/pnas.1810969116
    DORA PSI
  • Lončar N, Fiorentini F, Bailleul G, Savino S, Romero E, Mattevi A, et al.
    Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO)
    Applied Microbiology and Biotechnology. 2019; 103(4): 1755-1764. https://doi.org/10.1007/s00253-018-09579-w
    DORA PSI
  • Lorenzo-Orts L, Hohmann U, Zhu J, Hothorn M
    Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules
    Life Science Alliance. 2019; 2(3): e201900385 (14 pp.). https://doi.org/10.26508/lsa.201900385
    DORA PSI
  • Luxenburger A, Schmidt D, Ianes C, Pichlo C, Krüger M, von Drathen T, et al.
    Design, synthesis and biological evaluation of isoxazole-based CK1 inhibitors modified with chiral pyrrolidine scaffolds
    Molecules. 2019; 24(5): 873 (34 pp.). https://doi.org/10.3390/molecules24050873
    DORA PSI
  • Maurer A, Leisinger F, Lim D, Seebeck FP
    Structure and mechanism of ergothionase from Treponema denticola
    Chemistry: A European Journal. 2019; 25(44): 10298-10303. https://doi.org/10.1002/chem.201901866
    DORA PSI
  • Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, et al.
    KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells
    Nature Structural and Molecular Biology. 2019; 26(5): 361-371. https://doi.org/10.1038/s41594-019-0219-9
    DORA PSI
  • Meyer M, Walbott H, Oliéric V, Kondo J, Costa M, Masquida B
    Conformational adaptation of UNCG loops upon crowding
    RNA. 2019; 25(11): 1522-1531. https://doi.org/10.1261/rna.072694.119
    DORA PSI
  • Nakamura R, Hikita M, Ogawa S, Takahashi Y, Fujishiro T
    Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes
    FEBS Journal. 2019. https://doi.org/10.1111/febs.15081
    DORA PSI
  • Netzer-El SY, Caspy I, Nelson N
    Crystal structure of Photosystem i monomer from Synechocystis PCC 6803
    Frontiers in Plant Science. 2019; 9: 1865 (7 pp.). https://doi.org/10.3389/fpls.2018.01865
    DORA PSI
  • Pabis M, Popowicz GM, Stehle R, Fernández-Ramos D, Asami S, Warner L, et al.
    HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
    Nucleic Acids Research. 2019; 47(2): 1011-1029. https://doi.org/10.1093/nar/gky1138
    DORA PSI
  • Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, et al.
    VISAGE reveals a targetable mitotic spindle vulnerability in cancer cells
    Cell Systems. 2019; 9(1): 74-92.e8. https://doi.org/10.1016/j.cels.2019.05.009
    DORA PSI
  • Perez C, Mehdipour AR, Hummer G, Locher KP
    Structure of outward-facing PglK and molecular dynamics of lipid-linked oligosaccharide recognition and translocation
    Structure. 2019; 27(4): 669-678.e5. https://doi.org/10.1016/j.str.2019.01.013
    DORA PSI
  • Pichlo C, Juetten L, Wojtalla F, Schacherl M, Diaz D, Baumann U
    Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1
    Journal of Biological Chemistry. 2019; 294(30): 11525-11535. https://doi.org/10.1074/jbc.RA119.009029
    DORA PSI
  • Popow J, Arnhof H, Bader G, Berger H, Ciulli A, Covini D, et al.
    Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions
    Journal of Medicinal Chemistry. 2019; 62(5): 2508-2520. https://doi.org/10.1021/acs.jmedchem.8b01826
    DORA PSI
  • Rebelein JG, Cotelle Y, Garabedian B, Ward TR
    Chemical optimization of whole-cell transfer hydrogenation using carbonic anhydrase as host protein
    ACS Catalysis. 2019; 9(5): 4173-4178. https://doi.org/10.1021/acscatal.9b01006
    DORA PSI
  • Robinson GC, Kaufmann M, Roux C, Martinez-Font J, Hothorn M, Thore S, et al.
    Crystal structure of the pseudoenzyme PDX1.2 in complex with its cognate enzyme PDX1.3: a total eclipse
    Acta Crystallographica Section D: Structural Biology. 2019; 75(4): 400-415. https://doi.org/10.1107/S2059798319002912
    DORA PSI
  • Sauer MM, Jakob RP, Luber T, Canonica F, Navarra G, Ernst B, et al.
    Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets
    Journal of the American Chemical Society. 2019; 141(2): 936-944. https://doi.org/10.1021/jacs.8b10736
    DORA PSI
  • Schulte M, Frick K, Gnandt E, Jurkovic S, Burschel S, Labatzke R, et al.
    A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I
    Nature Communications. 2019; 10(1): 2551 (9 pp.). https://doi.org/10.1038/s41467-019-10429-0
    DORA PSI
  • Semmelmann F, Straub K, Nazet J, Rajendran C, Merkl R, Sterner R
    Mapping the allosteric communication network of aminodeoxychorismate synthase
    Journal of Molecular Biology. 2019; 431(15): 2718-2728. https://doi.org/10.1016/j.jmb.2019.05.021
    DORA PSI
  • Solarczek J, Klünemann T, Brandt F, Schrepfer P, Wolter M, Jacob CR, et al.
    Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity
    Scientific Reports. 2019; 9(1): 5106 (10 pp.). https://doi.org/10.1038/s41598-019-41498-2
    DORA PSI
  • Stampfli AR, Goncharenko KV, Meury M, Dubey BN, Schirmer T, Seebeck FP
    An alternative active site architecture for O2 activation in the ergothioneine biosynthetic EgtB from Chloracidobacterium thermophilum
    Journal of the American Chemical Society. 2019; 141(13): 5275-5285. https://doi.org/10.1021/jacs.8b13023
    DORA PSI
  • Stazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, et al.
    Development of alkyl glycerone phosphate synthase inhibitors: structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
    European Journal of Medicinal Chemistry. 2019; 163: 722-735. https://doi.org/10.1016/j.ejmech.2018.11.050
    DORA PSI
  • Swarts DC, Jinek M
    Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a
    Molecular Cell. 2019; 73(3): 589-600. https://doi.org/10.1016/j.molcel.2018.11.021
    DORA PSI
  • Trautermann CS, Binder F, Büttner FH, Eickmeier C, Fiegen D, Gross U, et al.
    Allosteric activation of striatal-enriched protein tyrosine phosphatase (STEP, PTPN5) by a fragment-like molecule
    Journal of Medicinal Chemistry. 2019; 62(1): 306-316. https://doi.org/10.1021/acs.jmedchem.8b00857
    DORA PSI
  • Ung KL, Alsarraf HMAB, Olieric V, Kremer L, Blaise M
    Crystal structure of the aminoglycosides N‐acetyltransferase Eis2 from Mycobacterium abscessus
    FEBS Journal. 2019; 286(21): 4342-4355. https://doi.org/10.1111/febs.14975
    DORA PSI
  • Vaattovaara A, Brandt B, Rajaraman S, Safronov O, Veidenberg A, Luklová M, et al.
    Mechanistic insights into the evolution of DUF26-containing proteins in land plants
    Communications Biology. 2019; 2(1): 56 (18 pp.). https://doi.org/10.1038/s42003-019-0306-9
    DORA PSI
  • Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, et al.
    Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle
    Nature. 2019; 568(7753): 571-575. https://doi.org/10.1038/s41586-019-1095-5
    DORA PSI
  • Wachter S, Jung J, Shafiq S, Basquin J, Fort C, Bastin P, et al.
    Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly
    EMBO Journal. 2019; 38(9): e101251 (18 pp.). https://doi.org/10.15252/embj.2018101251
    DORA PSI
  • Wang W, Yu L-J, Xu C, Tomizaki T, Zhao S, Umena Y, et al.
    Structural basis for blue-green light harvesting and energy dissipation in diatoms
    Science. 2019; 363(6427): eaav0365 (8 pp.). https://doi.org/10.1126/science.aav0365
    DORA PSI
  • Wang N, Bosc C, Ryul Choi S, Boulan B, Peris L, Olieric N, et al.
    Structural basis of tubulin detyrosination by the vasohibin–SVBP enzyme complex
    Nature Structural and Molecular Biology. 2019; 26(7): 571-582. https://doi.org/10.1038/s41594-019-0241-y
    DORA PSI
  • Watterson SH, Liu Q, Beaudoin Bertrand M, Batt DG, Li L, Pattoli MA, et al.
    Discovery of branebrutinib (BMS-986195): a strategy for identifying a highly potent and selective covalent inhibitor providing rapid in vivo inactivation of Bruton's tyrosine kinase (BTK)
    Journal of Medicinal Chemistry. 2019; 62(7): 3228-3250. https://doi.org/10.1021/acs.jmedchem.9b00167
    DORA PSI
  • Weinstabl H, Treu M, Rinnenthal J, Zahn SK, Ettmayer P, Bader G, et al.
    Intracellular trapping of the selective phosphoglycerate dehydrogenase (PHGDH) inhibitor BI-4924 disrupts serine biosynthesis
    Journal of Medicinal Chemistry. 2019; 62(17): 7976-7997. https://doi.org/10.1021/acs.jmedchem.9b00718
    DORA PSI
  • Wiedmer L, Schärer C, Spiliotopoulos D, Hürzeler M, Śledź P, Caflisch A
    Ligand retargeting by binding site analogy
    European Journal of Medicinal Chemistry. 2019; 175: 107-113. https://doi.org/10.1016/j.ejmech.2019.04.037
    DORA PSI
  • Zhang L, Wüst A, Prasser B, Müller C, Einsle O
    Functional assembly of nitrous oxide reductase provides insights into copper site maturation
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(26): 12822-12827. https://doi.org/10.1073/pnas.1903819116
    DORA PSI
  • Zhong W, Guo J, Cui L, Chionh YH, Li K, El Sahili A, et al.
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    Direct observation of the ZrIV interaction with the carboxamide bond in a noncovalent complex between Hen Egg White Lysozyme and a Zr-substituted Keggin polyoxometalate
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