Publications

PDB structures measured at X10SA


 

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Pedrini B, Finke AD, Marsh M, Luporini P, Vallesi A, Alimenti C
    Crystal structure of the pheromone Er-13 from the ciliate Euplotes raikovi, with implications for a protein–protein association model in pheromone/receptor interactions
    Journal of Structural Biology. 2022; 214(1): 107812 (10 pp.). https://doi.org/10.1016/j.jsb.2021.107812
    DORA PSI
  • Babu M, Favretto F, de Opakua AI, Rankovic M, Becker S, Zweckstetter M
    Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis
    Nature Communications. 2021; 12(1): 3396 (7 pp.). https://doi.org/10.1038/s41467-021-23691-y
    DORA PSI
  • Beale JH, Marsh ME
    Optimizing the growth of endothiapepsin crystals for serial crystallography experiments
    Journal of Visualized Experiments. 2021; 168: e61896 (30 pp.). https://doi.org/10.3791/61896
    DORA PSI
  • Benz J, Rufer AC, Huber S, Ehler A, Hug M, Topp A, et al.
    Novel β-Glucocerebrosidase activators that bind to a new pocket at a dimer interface and induce dimerization
    Angewandte Chemie International Edition. 2021; 60(10): 5436-5442. https://doi.org/10.1002/anie.202013890
    DORA PSI
  • Buchstaller H-P, Anlauf U, Dorsch D, Kögler S, Kuhn D, Lehmann M, et al.
    Optimization of a screening hit toward M2912, an oral tankyrase inhibitor with antitumor activity in colorectal cancer models
    Journal of Medicinal Chemistry. 2021; 64(14): 10371-10392. https://doi.org/10.1021/acs.jmedchem.1c00800
    DORA PSI
  • Cretu C, Gee P, Liu X, Agrawal A, Nguyen TV, Ghosh AK, et al.
    Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
    Nature Communications. 2021; 12(1): 4491 (15 pp.). https://doi.org/10.1038/s41467-021-24741-1
    DORA PSI
  • Dekker C, Mattes H, Wright M, Boettcher A, Hinniger A, Hughes N, et al.
    Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition
    Journal of Molecular Biology. 2021; 433(24): 167309 (11 pp.). https://doi.org/10.1016/j.jmb.2021.167309
    DORA PSI
  • Dietl A, Barends TRM
    Dynamics in an unusual acyl carrier protein from a ladderane lipid-synthesizing organism
    Proteins. 2021. https://doi.org/10.1002/prot.26187
    DORA PSI
  • Fuchs ACD, Ammelburg M, Martin J, Schmitz RA, Hartmann MD, Lupas AN
    Archaeal Connectase is a specific and efficient protein ligase related to proteasome β subunits
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(11): e2017871118 (9 pp.). https://doi.org/10.1073/pnas.2017871118
    DORA PSI
  • Fujimoto K, Yoshida S, Tadano G, Asada N, Fuchino K, Suzuki S, et al.
    Structure-based approaches to improving selectivity through utilizing explicit water molecules: discovery of selective β-secretase (BACE1) inhibitors over BACE2
    Journal of Medicinal Chemistry. 2021; 64(6): 3075-3085. https://doi.org/10.1021/acs.jmedchem.0c01858
    DORA PSI
  • Güttler T, Aksu M, Dickmanns A, Stegmann KM, Gregor K, Rees R, et al.
    Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies
    EMBO Journal. 2021. https://doi.org/10.15252/embj.2021107985
    DORA PSI
  • Hart P 't., Hommen P, Noisier A, Krzyzanowski A, Schüler D, Porfetye AT, et al.
    Structure based design of bicyclic Peptide inhibitors of RbAp48
    Angewandte Chemie International Edition. 2021; 60(4): 1813-1820. https://doi.org/10.1002/anie.202009749
    DORA PSI
  • Herud-Sikimić O, Stiel AC, Kolb M, Shanmugaratnam S, Berendzen KW, Feldhaus C, et al.
    A biosensor for the direct visualization of auxin
    Nature. 2021; 592: 768-772. https://doi.org/10.1038/s41586-021-03425-2
    DORA PSI
  • Ibrahim A, Papin C, Mohideen-Abdul K, Gras SL, Stoll I, Bronner C, et al.
    MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion
    Science. 2021; 372(6549): eabd5581 (14 pp.). https://doi.org/10.1126/science.abd5581
    DORA PSI
  • Jiang B, Jiang J, Kaltheuner IH, Iniguez AB, Anand K, Ferguson FM, et al.
    Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma
    European Journal of Medicinal Chemistry. 2021; 221: 113481 (16 pp.). https://doi.org/10.1016/j.ejmech.2021.113481
    DORA PSI
  • Johansson E, Wu X, Yu B, Yang Z, Cao Z, Wiberg C, et al.
    Insulin binding to the analytical antibody sandwich pair OXI‐005 and HUI‐018: epitope mapping and binding properties
    Protein Science. 2021; 30(2): 485-496. https://doi.org/10.1002/pro.4009
    DORA PSI
  • Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klügel M, et al.
    CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation
    Nature Chemical Biology. 2021. https://doi.org/10.1038/s41589-021-00858-8
    DORA PSI
  • Krzyzanowski A, Gasper R, Adihou H, Hart P ’t, Waldmann H
    Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5–MEP50 Complex
    ChemBioChem. 2021; 22(11): 1908-1914. https://doi.org/10.1002/cbic.202100079
    DORA PSI
  • Larraufie M-H, Gao X, Xia X, Devine PJ, Kallen J, Liu D, et al.
    Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
    Cell Chemical Biology. 2021. https://doi.org/10.1016/j.chembiol.2021.04.001
    DORA PSI
  • Ma EJ, Siirola E, Moore C, Kummer A, Stoeckli M, Faller M, et al.
    Machine-directed evolution of an imine reductase for activity and stereoselectivity
    ACS Catalysis. 2021; 11(20): 12433-12445. https://doi.org/10.1021/acscatal.1c02786
    DORA PSI
  • Markert C, Thoma G, Srinivas H, Bollbuck B, Lüönd RM, Miltz W, et al.
    Discovery of LYS006, a potent and highly selective inhibitor of leukotriene A4 hydrolase
    Journal of Medicinal Chemistry. 2021; 64(4): 1889-1903. https://doi.org/10.1021/acs.jmedchem.0c01955
    DORA PSI
  • Martiel I, Beale JH, Karpik A, Huang C-Y, Vera L, Olieric N, et al.
    Versatile microporous polymer-based supports for serial macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2021; 77(9): 1153-1167. https://doi.org/10.1107/S2059798321007324
    DORA PSI
  • Mata G, Miles DH, Drew SL, Fournier J, Lawson KV, Mailyan AK, et al.
    Design, synthesis, and structure–activity relationship optimization of pyrazolopyrimidine amide Inhibitors of phosphoinositide 3-kinase γ (PI3Kγ)
    Journal of Medicinal Chemistry. 2021. https://doi.org/10.1021/acs.jmedchem.1c01153
    DORA PSI
  • Mieczkowski M, Steinmetzger C, Bessi I, Lenz AK, Schmiedel A, Holzapfel M, et al.
    Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine
    Nature Communications. 2021; 12(1): 3549 (11 pp.). https://doi.org/10.1038/s41467-021-23932-0
    DORA PSI
  • Murayama K, Kato-Murayama M, Sato T, Hosaka T, Ishiguro K, Mizuno T, et al.
    Anthocyanin 5,3′-aromatic acyltransferase from Gentiana triflora, a structural insight into biosynthesis of a blue anthocyanin
    Phytochemistry. 2021; 186: 112727 (8 pp.). https://doi.org/10.1016/j.phytochem.2021.112727
    DORA PSI
  • Perez-Borrajero C, Podvalnaya N, Holleis K, Lichtenberger R, Karaulanov E, Simon B, et al.
    Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans
    Genes and Development. 2021; 35(17-18): 1304-1323. https://doi.org/10.1101/gad.348648.121
    DORA PSI
  • Ptacin JL, Caffaro CE, Ma L, San Jose Gall KM, Aerni HR, Acuff NV, et al.
    An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
    Nature Communications. 2021; 12(1): 4785 (14 pp.). https://doi.org/10.1038/s41467-021-24987-9
    DORA PSI
  • Quambusch L, Depta L, Landel I, Lubeck M, Kirschner T, Nabert J, et al.
    Cellular model system to dissect the isoform-selectivity of Akt inhibitors
    Nature Communications. 2021; 12(1): 5297 (14 pp.). https://doi.org/10.1038/s41467-021-25512-8
    DORA PSI
  • Ramharter J, Kessler D, Ettmayer P, Hofmann MH, Gerstberger T, Gmachl M, et al.
    One atom makes all the difference: Getting a foot in the door between SOS1 and KRAS
    Journal of Medicinal Chemistry. 2021; 64(10): 6569-6580. https://doi.org/10.1021/acs.jmedchem.0c01949
    DORA PSI
  • Rombouts FJR, Kusakabe K-I, Alexander R, Austin N, Borghys H, De Cleyn M, et al.
    JNJ-67569762, A 2-aminotetrahydropyridine-based selective BACE1 inhibitor targeting the S3 pocket: from discovery to clinical candidate
    Journal of Medicinal Chemistry. 2021; 64(19): 14175-14191. https://doi.org/10.1021/acs.jmedchem.1c00935
    DORA PSI
  • Romero-Romero S, Costas M, Silva Manzano D-A, Kordes S, Rojas-Ortega E, Tapia C, et al.
    The stability landscape of de novo TIM barrels explored by a modular design approach
    Journal of Molecular Biology. 2021; 433(18): 167153 (20 pp.). https://doi.org/10.1016/j.jmb.2021.167153
    DORA PSI
  • Ross B, Krapp S, Geiss-Friedlander R, Littmann W, Huber R, Kiefersauer R
    Aerosol-based ligand soaking of reservoir-free protein crystals
    Journal of Applied Crystallography. 2021; 54: 895-902. https://doi.org/10.1107/S1600576721003551
    DORA PSI
  • Rueeger H, Lueoend R, Machauer R, Veenstra SJ, Holzer P, Hurth K, et al.
    Synthesis of the potent, selective, and efficacious β-secretase (BACE1) inhibitor NB-360
    Journal of Medicinal Chemistry. 2021; 64(8): 4677-4696. https://doi.org/10.1021/acs.jmedchem.0c02143
    DORA PSI
  • Röhrig UF, Majjigapu SR, Reynaud A, Pojer F, Dilek N, Reichenbach P, et al.
    Azole-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
    Journal of Medicinal Chemistry. 2021; 64(4): 2205-2227. https://doi.org/10.1021/acs.jmedchem.0c01968
    DORA PSI
  • Schneider AFL, Kallen J, Ottl J, Reid PC, Ripoche S, Ruetz S, et al.
    Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
    RSC Chemical Biology. 2021. https://doi.org/10.1039/D1CB00056J
    DORA PSI
  • Schutzius G, Kolter C, Bergling S, Tortelli F, Fuchs F, Renner S, et al.
    BET bromodomain inhibitors regulate keratinocyte plasticity
    Nature Chemical Biology. 2021; 17: 280-290. https://doi.org/10.1038/s41589-020-00716-z
    DORA PSI
  • Selim KA, Tremiño L, Marco-Marín C, Alva V, Espinosa J, Contreras A, et al.
    Functional and structural characterization of PII-like protein CutA does not support involvement in heavy metal tolerance and hints at a small-molecule carrying/signaling role
    FEBS Journal. 2021; 288(4): 1142-1162. https://doi.org/10.1111/febs.15464
    DORA PSI
  • Sheng Q, D'Alessio JA, Menezes DL, Karim C, Tang Y, Tam A, et al.
    PCA062, a P-cadherin targeting antibody-drug-conjugate, displays potent anti-tumor activity against P-cadherin-expressing malignancies
    Molecular Cancer Therapeutics. 2021; 20(7): 1270-1282. https://doi.org/10.1158/1535-7163.MCT-20-0708
    DORA PSI
  • Sherpa D, Chrustowicz J, Qiao S, Langlois CR, Hehl LA, Gottemukkala KV, et al.
    GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
    Molecular Cell. 2021; 81(11): 2445-2459. https://doi.org/10.1016/j.molcel.2021.03.025
    DORA PSI
  • Sorigué D, Hadjidemetriou K, Blangy S, Gotthard G, Bonvalet A, Coquelle N, et al.
    Mechanism and dynamics of fatty acid photodecarboxylase
    Science. 2021; 372(6538): eabd5687 (11 pp.). https://doi.org/10.1126/science.abd5687
    DORA PSI
  • Taschner M, Basquin J, Steigenberger B, Schäfer IB, Soh YM, Basquin C, et al.
    Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding
    EMBO Journal. 2021; 40(15): e107807 (23 pp.). https://doi.org/10.15252/embj.2021107807
    DORA PSI
  • Thomson CG, Le Grand D, Dowling M, Beattie D, Elphick L, Faller M, et al.
    Development of autotaxin inhibitors: a series of tetrazole cinnamides
    Bioorganic and Medicinal Chemistry Letters. 2021; 31: 127663 (7 pp.). https://doi.org/10.1016/j.bmcl.2020.127663
    DORA PSI
  • Vara BA, Levi SM, Achab A, Candito DA, Fradera X, Lesburg CA, et al.
    Discovery of diaminopyrimidine carboxamide HPK1 inhibitors as preclinical immunotherapy tool compounds
    ACS Medicinal Chemistry Letters. 2021; 12(4): 653-661. https://doi.org/10.1021/acsmedchemlett.1c00096
    DORA PSI
  • Wilhelm J, Kühn S, Tarnawski M, Gotthard G, Tünnermann J, Tänzer T, et al.
    Kinetic and structural characterization of the self-labeling protein tags HaloTag7, SNAP-tag, and CLIP-tag
    Biochemistry. 2021; 60(33): 2560-2575. https://doi.org/10.1021/acs.biochem.1c00258
    DORA PSI
  • Yu EC, Methot JL, Fradera X, Lesburg CA, Lacey BM, Siliphaivanh P, et al.
    Identification of potent reverse indazole inhibitors for HPK1
    ACS Medicinal Chemistry Letters. 2021; 12(3): 459-466. https://doi.org/10.1021/acsmedchemlett.0c00672
    DORA PSI
  • Østergaard H, Lund J, Greisen PJ, Kjellev S, Henriksen A, Lorenzen N, et al.
    FVIIIa-mimetic bispecific antibody (Mim8) ameliorates bleeding upon severe vascular challenge in hemophilia A mice
    Blood. 2021. https://doi.org/10.1182/blood.2020010331
    DORA PSI
  • Adihou H, Gopalakrishnan R, Förster T, Guéret SM, Gasper R, Geschwindner S, et al.
    A protein tertiary structure mimetic modulator of the Hippo signalling pathway
    Nature Communications. 2020; 11(1): 5425 (10 pp.). https://doi.org/10.1038/s41467-020-19224-8
    DORA PSI
  • Ajam T, De I, Petkau N, Whelan G, Pena V, Eichele G
    Alternative catalytic residues in the active site of Esco acetyltransferases
    Scientific Reports. 2020; 10(1): 9828 (13 pp.). https://doi.org/10.1038/s41598-020-66795-z
    DORA PSI
  • Angst D, Gessier F, Janser P, Vulpetti A, Wälchli R, Beerli C, et al.
    Discovery of LOU064 (remibrutinib), a potent and highly selective covalent inhibitor of Bruton's tyrosine kinase
    Journal of Medicinal Chemistry. 2020; 63(10): 5102-5118. https://doi.org/10.1021/acs.jmedchem.9b01916
    DORA PSI
  • Bokhovchuk F, Mesrouze Y, Delaunay C, Martin T, Villard F, Meyerhofer M, et al.
    Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors
    Protein Science. 2020; 29(2): 509-520. https://doi.org/10.1002/pro.3775
    DORA PSI
  • Borreschmidt Hansen B, Jepsen TH, Larsen M, Sindet R, Vifian T, Nørreskov Burhardt M, et al.
    Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity
    Journal of Medicinal Chemistry. 2020; 63(3): 7008-7032. https://doi.org/10.1021/acs.jmedchem.0c00359
    DORA PSI
  • Buonfiglio R, Prati F, Bischetti M, Cavarischia C, Furlotti G, Ombrato R
    Discovery of novel imidazopyridine GSK-3β inhibitors supported by cmputational approaches
    Molecules. 2020; 25(9): 2163 (29 pp.). https://doi.org/10.3390/molecules25092163
    DORA PSI
  • Cheng R, Huang C-Y, Hennig M, Nar H, Schnapp G
    In situ crystallography as an emerging method for structure solution of membrane proteins: the case of CCR2A
    FEBS Journal. 2020; 287(5): 866-873. https://doi.org/10.1111/febs.15098
    DORA PSI
  • Cuozzo JW, Clark MA, Keefe AD, Kohlmann A, Mulvihill M, Ni H, et al.
    Novel autotaxin inhibitor for the treatment of idiopathic pulmonary fibrosis: a clinical candidate discovered using DNA-encoded chemistry
    Journal of Medicinal Chemistry. 2020; 63(14): 7840-7856. https://doi.org/10.1021/acs.jmedchem.0c00688
    DORA PSI
  • DeRatt LG, Pietsch EC, Tanner A, Shaffer P, Jacoby E, Wang W, et al.
    A carboxylic acid isostere screen of the DHODH inhibitor Brequinar
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(22): 127589 (5 pp.). https://doi.org/10.1016/j.bmcl.2020.127589
    DORA PSI
  • Dengl S, Mayer K, Bormann F, Duerr H, Hoffmann E, Nussbaum B, et al.
    Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
    Nature Communications. 2020; 11(1): 4974 (11 pp.). https://doi.org/10.1038/s41467-020-18477-7
    DORA PSI
  • Dodonova SO, Zhu F, Dienemann C, Taipale J, Cramer P
    Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function
    Nature. 2020; 580(7805): 669-672. https://doi.org/10.1038/s41586-020-2195-y
    DORA PSI
  • Drew SL, Thomas-Tran R, Beatty JW, Fournier J, Lawson KV, Miles DH, et al.
    Discovery of potent and selective PI3Kγ inhibitors
    Journal of Medicinal Chemistry. 2020; 63(19): 11235-11257. https://doi.org/10.1021/acs.jmedchem.0c01203
    DORA PSI
  • Du X, Moore J, Blank BR, Eksterowicz J, Sutimantanapi D, Yuen N, et al.
    Orally bioavailable small-molecule CD73 inhibitor (OP-5244) reverses immunosuppression through blockade of adenosine production
    Journal of Medicinal Chemistry. 2020; 63(18): 10433-10459. https://doi.org/10.1021/acs.jmedchem.0c01086
    DORA PSI
  • Ebenhoch R, Prinz S, Kaltwasser S, Mills DJ, Meinecke R, Rübbelke M, et al.
    A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(50): 31838-31849. https://doi.org/10.1073/pnas.2013473117
    DORA PSI
  • Erdogan M, Fabritius A, Basquin J, Griesbeck O
    Targeted in situ protein diversification and intra-organelle validation in mammalian cells
    Cell Chemical Biology. 2020; 27(5): 610-621. https://doi.org/10.1016/j.chembiol.2020.02.004
    DORA PSI
  • Ernst C, Kayastha K, Koch T, Venceslau SS, Pereira IAC, Demmer U, et al.
    Structural and spectroscopic characterization of a HdrA-like subunit from Hyphomicrobium denitrificans
    FEBS Journal. 2020. https://doi.org/10.1111/febs.15505
    DORA PSI
  • Farrants H, Tarnawski M, Müller TG, Otsuka S, Hiblot J, Koch B, et al.
    Chemogenetic control of nanobodies
    Nature Methods. 2020; 17(3): 279-282. https://doi.org/10.1038/s41592-020-0746-7
    DORA PSI
  • Favretto F, Baker JD, Strohäker T, Andreas LB, Blair LJ, Becker S, et al.
    The molecular basis of the interaction of cyclophilin A with α-synuclein
    Angewandte Chemie International Edition. 2020; 59(14): 5692-5695. https://doi.org/10.1002/anie.201914878
    DORA PSI
  • Fuchs A-L, Wurm JP, Neu A, Sprangers R
    Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(32): 19237-19244. https://doi.org/10.1073/pnas.2009362117
    DORA PSI
  • Gasser C, Delazer I, Neuner E, Pascher K, Brillet K, Klotz S, et al.
    Thioguanosine conversion enables mRNA-lifetime evaluation by RNA sequencing using double metabolic labeling (TUC-seq DUAL)
    Angewandte Chemie International Edition. 2020; 59(17): 6881-6886. https://doi.org/10.1002/anie.201916272
    DORA PSI
  • Goepfert A, Lehmann S, Blank J, Kolbinger F, Rondeau JM
    Structural analysis reveals that the cytokine IL-17F forms a homodimeric complex with receptor IL-17RC to drive IL-17RA-independent signaling
    Immunity. 2020; 52(3): 499-512. https://doi.org/10.1016/j.immuni.2020.02.004
    DORA PSI
  • Haltenhof T, Kotte A, De Bortoli F, Schiefer S, Meinke S, Emmerichs A-K, et al.
    A conserved kinase-based body-temperature sensor globally controls alternative splicing and gene expression
    Molecular Cell. 2020; 78(1): 57-69.e4. https://doi.org/10.1016/j.molcel.2020.01.028
    DORA PSI
  • He Q, Toh JD, Ero R, Qiao Z, Kumar V, Serra A, et al.
    The unusual di-domain structure of Dunaliella salina glycerol-3-phosphate dehydrogenase enables direct conversion of dihydroxyacetone phosphate to glycerol
    Plant Journal. 2020; 102(1): 153-164. https://doi.org/10.1111/tpj.14619
    DORA PSI
  • Hough MA, Conradie J, Strange RW, Antonyuk SV, Eady RR, Ghosh A, et al.
    Nature of the copper-nitrosyl intermediates of copper nitrite reductases during catalysis
    Chemical Science. 2020; 11(46): 12485-12492. https://doi.org/10.1039/d0sc04797j
    DORA PSI
  • Hu Z, Wang C, Glunz PW, Li J, Cheadle NL, Chen AY, et al.
    Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(21): 127495 (4 pp.). https://doi.org/10.1016/j.bmcl.2020.127495
    DORA PSI
  • Huang C-Y, Olieric V, Caffrey M, Wang M
    In meso in situ serial X-Ray crystallography (IMISX): a protocol for membrane protein structure determination at the Swiss Light Source
    In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:293-319. https://doi.org/10.1007/978-1-0716-0373-4_20
    DORA PSI
  • Huang G, Wagner T, Demmer U, Warkentin E, Ermler U, Shima S
    The hydride transfer process in NADP-dependent methylene-tetrahydromethanopterin dehydrogenase
    Journal of Molecular Biology. 2020; 432(7): 2042-2054. https://doi.org/10.1016/j.jmb.2020.01.042
    DORA PSI
  • Hughes N, Erbel P, Bornancin F, Wiesmann C, Schiering N, Villard F, et al.
    Stabilizing inactive conformations of MALT1 as an effective approach to inhibit its protease activity
    Advanced Therapeutics. 2020; 3(9): 2000078 (8 pp.). https://doi.org/10.1002/adtp.202000078
    DORA PSI
  • Huwald D, Duda S, Gasper R, Olieric V, Hofmann E, Hemschemeier A
    Distinctive structural properties of THB11, a pentacoordinate Chlamydomonas reinhardtii truncated hemoglobin with N- and C-terminal extensions
    Journal of Biological Inorganic Chemistry. 2020; 25: 267-283. https://doi.org/10.1007/s00775-020-01759-2
    DORA PSI
  • Kalliokoski T, Rummakko P, Rantanen M, Blaesse M, Augustin M, Ummenthala GR, et al.
    Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(8): 127060 (6 pp.). https://doi.org/10.1016/j.bmcl.2020.127060
    DORA PSI
  • Katayama K, Ishii K, Tsuda E, Yotsumoto K, Hiramoto K, Suzuki M, et al.
    Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(20): 127475 (5 pp.). https://doi.org/10.1016/j.bmcl.2020.127475
    DORA PSI
  • Kawanami T, Karki RG, Cody E, Liu Q, Liang G, Ksander GM, et al.
    Structure-guided design of substituted biphenyl butanoic acid derivatives as neprilysin inhibitors
    ACS Medicinal Chemistry Letters. 2020; 11(2): 188-194. https://doi.org/10.1021/acsmedchemlett.9b00578
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