Publications

PDB structures measured at X10SA


 

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Adlakha J, Karamichali I, Sangwallek J, Deiss S, Bär K, Coles M, et al.
    Characterization of MCU-Binding Proteins MCUR1 and CCDC90B — Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles
    Structure. 2019; 27(3): 464-475. https://doi.org/10.1016/j.str.2018.11.004
    DORA PSI
  • Akram M, Dietl A, Mersdorf U, Prinz S, Maalcke W, Keltjens J, et al.
    A 192-heme electron transfer network in the hydrazine dehydrogenase complex
    Science Advances. 2019; 5(4): eaav4310 (7 pp.). https://doi.org/10.1126/sciadv.aav4310
    DORA PSI
  • Aksu M, Trakhanov S, Vera Rodriguez A, Görlich D
    Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122
    Journal of Cell Biology. 2019; 218(6): 1839-1852. https://doi.org/10.1083/jcb.201812093
    DORA PSI
  • Apel A-K, Cheng RKY, Tautermann CS, Brauchle M, Huang C-Y, Pautsch A, et al.
    Crystal structure of CC chemokine receptor 2A in complex with an orthosteric antagonist provides insights for the design of selective antagonists
    Structure. 2019; 27(3): 427-438.e5. https://doi.org/10.1016/j.str.2018.10.027
    DORA PSI
  • Bartolini D, Bührmann M, Barreca ML, Manfroni G, Cecchetti V, Rauh D, et al.
    Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors
    Biochemical and Biophysical Research Communications. 2019; 511(3): 579-586. https://doi.org/10.1016/j.bbrc.2019.02.063
    DORA PSI
  • Basu S, Kaminski JW, Panepucci E, Huang C-Y, Warshamanage R, Wang M, et al.
    Automated data collection and real-time data analysis suite for serial synchrotron crystallography
    Journal of Synchrotron Radiation. 2019; 26(1): 244-252. https://doi.org/10.1107/S1600577518016570
    DORA PSI
  • Bokhovchuk F, Mesrouze Y, Izaac A, Meyerhofer M, Zimmermann C, Fontana P, et al.
    Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
    FEBS Journal. 2019; 286(12): 2381-2398. https://doi.org/10.1111/febs.14817
    DORA PSI
  • Chen Y, Cramer P
    Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo-and heterodimerization
    Journal of Biological Chemistry. 2019; 294(27): 10663-10673. https://doi.org/10.1074/jbc.RA119.008577
    DORA PSI
  • Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, et al.
    Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy
    Science Translational Medicine. 2019; 11(496): eaav5989 (12 pp.). https://doi.org/10.1126/scitranslmed.aav5989
    DORA PSI
  • Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, et al.
    BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
    Nature Chemical Biology. 2019; 15(7): 672-680. https://doi.org/10.1038/s41589-019-0294-6
    DORA PSI
  • Fournier J, Chen K, Mailyan AK, Jackson JJ, Buckman BO, Emayan K, et al.
    Total synthesis of covalent cysteine protease inhibitor N-desmethyl thalassospiramide C and crystallographic evidence for its mode of action
    Organic Letters. 2019; 21(2): 508-512. https://doi.org/10.1021/acs.orglett.8b03821
    DORA PSI
  • Friedel K, Popp MA, Matern JCJ, Gazdag EM, Thiel IV, Volkmann G, et al.
    A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine
    Chemical Science. 2019; 10(1): 239-251. https://doi.org/10.1039/C8SC01074A
    DORA PSI
  • Furet P, Salem B, Mesrouze Y, Schmelzle T, Lewis I, Kallen J, et al.
    Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence
    Bioorganic and Medicinal Chemistry Letters. 2019; 29(16): 2316-2319. https://doi.org/10.1016/j.bmcl.2019.06.022
    DORA PSI
  • Greenidge PA, Blommers MJJ, Priestle JP, Hunziker J
    How to computationally stack the deck for hit-to-lead generation: in silico molecular interaction energy profiling for de novo siRNA guide strand surrogate selection
    Journal of Chemical Information and Modeling. 2019; 59(5): 1897-1908. https://doi.org/10.1021/acs.jcim.8b00892
    DORA PSI
  • Heim C, Pliatsika D, Mousavizadeh F, Bär K, Hernandez Alvarez B, Giannis A, et al.
    De-novo design of cereblon (CRBN) effectors guided by natural hydrolysis products of thalidomide derivatives
    Journal of Medicinal Chemistry. 2019; 62(14): 6615-6629. https://doi.org/10.1021/acs.jmedchem.9b00454
    DORA PSI
  • Kallen J, Izaac A, Chau S, Wirth E, Schoepfer J, Mah R, et al.
    Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
    ChemMedChem. 2019; 14(14): 1305-1314. https://doi.org/10.1002/cmdc.201900201
    DORA PSI
  • Karki RG, Powers J, Mainolfi N, Anderson K, Belanger DB, Liu D, et al.
    Design, synthesis, and preclinical characterization of selective factor D inhibitors targeting the alternative complement pathway
    Journal of Medicinal Chemistry. 2019; 62(9): 4656-4668. https://doi.org/10.1021/acs.jmedchem.9b00271
    DORA PSI
  • Keskeny C, Raisch T, Sgromo A, Igreja C, Bhandari D, Weichenrieder O, et al.
    A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex
    Genes and Development. 2019; 33(3-4): 236-252. https://doi.org/10.1101/gad.320952.118
    DORA PSI
  • Koch AW, Schiering N, Melkko S, Ewert S, Salter J, Zhang Y, et al.
    MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans
    Blood. 2019; 133(13): 1507-1516. https://doi.org/10.1182/blood-2018-10-880849
    DORA PSI
  • Koizumi Y, Tanaka Y, Matsumura T, Kadoh Y, Miyoshi H, Hongu M, et al.
    Discovery of a pyrazolo[1,5-α]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety
    Bioorganic and Medicinal Chemistry. 2019; 27(15): 3440-3450. https://doi.org/10.1016/j.bmc.2019.06.021
    DORA PSI
  • Kramer A
    Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine.
    Biochimica et Biophysica Acta: General Subjects. 2019; 1863: 577-585. https://doi.org/10.1016/j.bbagen.2019.01.001
    DORA PSI
  • Laraia L, Friese A, Corkery DP, Konstantinidis G, Erwin N, Hofer W, et al.
    The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis
    Nature Chemical Biology. 2019; 15(7): 710-720. https://doi.org/10.1038/s41589-019-0307-5
    DORA PSI
  • McNally R, Li Q, Li K, Dekker C, Vangrevelinghe E, Jones M, et al.
    Discovery and structural characterization of ATP-site ligands for the wild-type and V617F mutant JAK2 pseudokinase domain
    ACS Chemical Biology. 2019; 14(4): 587-593. https://doi.org/10.1021/acschembio.8b00722
    DORA PSI
  • Nguyen D, Lemos C, Wortmann L, Eis K, Holton SJ, Boemer U, et al.
    Discovery and characterization of the potent and highly selective (piperidin-4-yl)pyrido[3,2-d]pyrimidine based in vitro probe BAY-885 for the kinase ERK5.
    Journal of Medicinal Chemistry. 2019; 62(2): 928-940. https://doi.org/10.1021/acs.jmedchem.8b01606
    DORA PSI
  • Quancard J, Klein T, Fung S-Y, Renatus M, Hughes N, Israël L, et al.
    An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient
    Nature Chemical Biology. 2019; 15(3): 304-313. https://doi.org/10.1038/s41589-018-0222-1
    DORA PSI
  • Richter H, Satz AL, Bedoucha M, Buettelmann B, Petersen AC, Harmeier A, et al.
    DNA-encoded library-derived DDR1 inhibitor prevents fibrosis and renal function loss in a genetic mouse model of Alport syndrome
    ACS Chemical Biology. 2019; 14(1): 37-49. https://doi.org/10.1021/acschembio.8b00866
    DORA PSI
  • Ripin N, Boudet J, Duszczyk MM, Hinniger A, Faller M, Krepl M, et al.
    Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(8): 2935-2944. https://doi.org/10.1073/pnas.1808696116
    DORA PSI
  • Sauer MM, Jakob RP, Luber T, Canonica F, Navarra G, Ernst B, et al.
    Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets
    Journal of the American Chemical Society. 2019; 141(2): 936-944. https://doi.org/10.1021/jacs.8b10736
    DORA PSI
  • Schehr M, Ianes C, Weisner J, Heintze L, Müller MP, Pichlo C, et al.
    2-azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach
    Photochemical and Photobiological Sciences. 2019; 18(6): 1398-1407. https://doi.org/10.1039/c9pp00010k
    DORA PSI
  • Sommerkamp JA, Frankenberg-Dinkel N, Hofmann E
    Crystal structure of the first eukaryotic bilin reductase GtPEBB reveals a flipped binding mode of dihydrobiliverdin
    Journal of Biological Chemistry. 2019; 294(38): 13889-13901. https://doi.org/10.1074/jbc.RA119.009306
    DORA PSI
  • Straw ML, Hough MA, Wilson MT, Worrall JAR
    A histidine residue and a tetranuclear cuprous-thiolate cluster dominate the copper loading landscape of a copper storage protein from Streptomyces lividans
    Chemistry: A European Journal. 2019; 25(45): 10678-10688. https://doi.org/10.1002/chem.201901411
    DORA PSI
  • Uhlenbrock N, Smith S, Weisner J, Landel I, Lindemann M, Le TA, et al.
    Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt
    Chemical Science. 2019; 10(12): 3573-3585. https://doi.org/10.1039/c8sc05212c
    DORA PSI
  • Watanabe T, Wagner T, Huang G, Kahnt J, Ataka K, Ermler U, et al.
    The bacterial [Fe]-hydrogenase paralog HmdII uses tetrahydrofolate derivatives as substrates
    Angewandte Chemie International Edition. 2019; 58(11): 3506-3510. https://doi.org/10.1002/anie.201813465
    DORA PSI
  • Weisner J, Landel I, Reintjes C, Uhlenbrock N, Trajkovic-Arsic M, Dienstbier N, et al.
    Preclinical efficacy of covalent-allosteric AKT inhibitor borussertib in combination with trametinib in KRAS-mutant pancreatic and colorectal cancer
    Cancer Research. 2019; 79(9): 2367-2378. https://doi.org/10.1158/0008-5472.CAN-18-2861
    DORA PSI
  • Willistein M, Bechtel DF, Müller CS, Demmer U, Heimann L, Kayastha K, et al.
    Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
    Nature Communications. 2019; 10(1): 2074 (10 pp.). https://doi.org/10.1038/s41467-019-10078-3
    DORA PSI
  • Wolle P, Engel J, Smith S, Goebel L, Hennes E, Lategahn J, et al.
    Characterization of covalent pyrazolopyrimidine-MKK7 complexes and a report on a unique DFG-in/Leu-in conformation of mitogen-activated protein kinase kinase 7 (MKK7)
    Journal of Medicinal Chemistry. 2019; 62(11): 5541-5546. https://doi.org/10.1021/acs.jmedchem.9b00472
    DORA PSI
  • Wolle P, Hardick J, Cronin SJF, Engel J, Baumann M, Lategahn J, et al.
    Targeting the MKK7-JNK (mitogen-activated protein kinase kinase 7-c-Jun N-terminal kinase) pathway with covalent inhibitors
    Journal of Medicinal Chemistry. 2019; 62(5): 2843-2848. https://doi.org/10.1021/acs.jmedchem.9b00102
    DORA PSI
  • Zakrzewska S, Mehdipour AR, Malviya VN, Nonaka T, Koepke J, Muenke C, et al.
    Inward-facing conformation of a multidrug resistance MATE family transporter
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(25): 12275-12284. https://doi.org/10.1073/pnas.1904210116
    DORA PSI
  • Żyła DS, Prota AE, Capitani G, Glockshuber R
    Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria
    Journal of Biological Chemistry. 2019; 294(27): 10553-10563. https://doi.org/10.1074/jbc.RA119.008610
    DORA PSI
  • Aichem A, Anders S, Catone N, Rößler P, Stotz S, Berg A, et al.
    The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation
    Nature Communications. 2018; 9(1): 3321 (14 pp.). https://doi.org/10.1038/s41467-018-05776-3
    DORA PSI
  • Ali I, Eu S, Koch D, Bleimling N, Goody RS, Müller MP
    Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2018; 74(5): 315-321. https://doi.org/10.1107/S2053230X18005915
    DORA PSI
  • Andrei SA, Meijer FA, Neves JF, Brunsveld L, Landrieu I, Ottmann C, et al.
    Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes
    ACS Chemical Neuroscience. 2018; 9(11): 2639-2654. https://doi.org/10.1021/acschemneuro.8b00118
    DORA PSI
  • Bier D, Kaiser M
    Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins
    Chemistry: A European Journal. 2018; 24(52): 13807-13814. https://doi.org/10.1002/chem.201801074
    DORA PSI
  • Born D, Reuter L, Mersdorf U, Mueller M, Fischer MG, Meinhart A, et al.
    Capsid protein structure, self-assembly, and processing reveal morphogenesis of the marine virophage mavirus
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(28): 7332-7337. https://doi.org/10.1073/pnas.1805376115
    DORA PSI
  • Boubia B, Poupardin O, Barth M, Binet J, Peralba P, Mounier L, et al.
    Design, synthesis, and evaluation of a novel series of indole sulfonamide peroxisome proliferator activated receptor (PPAR) α/γ/δ triple activators: discovery of lanifibranor, a new antifibrotic clinical candidate
    Journal of Medicinal Chemistry. 2018; 61(6): 2246-2265. https://doi.org/10.1021/acs.jmedchem.7b01285
    DORA PSI
  • Brieke C, Tarnawski M, Greule A, Cryle MJ
    Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach
    Journal of Inorganic Biochemistry. 2018; 185: 43-51. https://doi.org/10.1016/j.jinorgbio.2018.05.001
    DORA PSI
  • Carcache D, Vulpetti A, Kallen J, Mattes H, Orain D, Stringer R, et al.
    Optimizing a weakly binding fragment into a potent RORγt inverse agonist with efficacy in an in vivo inflammation model
    Journal of Medicinal Chemistry. 2018; 61(15): 6724-6735. https://doi.org/10.1021/acs.jmedchem.8b00529
    DORA PSI
  • Cretu C, Agrawal AA, Cook A, Will CL, Fekkes P, Smith PG, et al.
    Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds
    Molecular Cell. 2018; 70(2): 265-273. https://doi.org/10.1016/j.molcel.2018.03.011
    DORA PSI
  • Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, et al.
    Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin
    Scientific Reports. 2018; 8(1): 10705 (15 pp.). https://doi.org/10.1038/s41598-018-29058-6
    DORA PSI
  • Demmer JK, Bertsch J, Öppinger C, Wohlers H, Kayastha K, Demmer U, et al.
    Molecular basis of the flavin-based electron-bifurcating caffeyl-CoA reductase reaction
    FEBS Letters. 2018; 592(3): 332-342. https://doi.org/10.1002/1873-3468.12971
    DORA PSI
  • Duan J, Senger M, Esselborn J, Engelbrecht V, Wittkamp F, Apfel U-P, et al.
    Crystallographic and spectroscopic assignment of the proton transfer pathway in [FeFe]-hydrogenases
    Nature Communications. 2018; 9(1): 4726 (11 pp.). https://doi.org/10.1038/s41467-018-07140-x
    DORA PSI
  • Elgamacy M, Coles M, Ernst P, Zhu H, Hartmann MD, Plückthun A, et al.
    An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture
    ACS Synthetic Biology. 2018; 7(9): 2226-2235. https://doi.org/10.1021/acssynbio.8b00224
    DORA PSI
  • Evers A, Bossart M, Pfeiffer-Marek S, Elvert R, Schreuder H, Kurz M, et al.
    Dual glucagon-like peptide 1 (GLP-1)/glucagon receptor agonists specifically optimized for multidose formulations
    Journal of Medicinal Chemistry. 2018; 61(13): 5580-5593. https://doi.org/10.1021/acs.jmedchem.8b00292
    DORA PSI
  • Frey S, Rees R, Schünemann J, Ng SC, Fünfgeld K, Huyton T, et al.
    Surface properties determining passage rates of proteins through nuclear pores
    Cell. 2018; 174(1): 202-217.e9. https://doi.org/10.1016/j.cell.2018.05.045
    DORA PSI
  • Fuchs ACD, Maldoner L, Wojtynek M, Hartmann MD, Martin J
    Rpn11-mediated ubiquitin processing in an ancestral archaeal ubiquitination system
    Nature Communications. 2018; 9(1): 2696 (12 pp.). https://doi.org/10.1038/s41467-018-05198-1
    DORA PSI
  • Fuchs ACD, Maldoner L, Hipp K, Hartmann MD, Martin J
    Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties
    Journal of Biological Chemistry. 2018; 293(3): 920-930. https://doi.org/10.1074/jbc.M117.815258
    DORA PSI
  • Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, et al.
    Repurposing a library of human cathepsin L ligands: identification of macrocyclic lactams as potent rhodesain and trypanosoma brucei inhibitors
    Journal of Medicinal Chemistry. 2018; 61(8): 3350-3369. https://doi.org/10.1021/acs.jmedchem.7b01869
    DORA PSI
  • Gruner S, Weber R, Peter D, Chung M-Y, Igreja C, Valkov E, et al.
    Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast
    Nucleic Acids Research. 2018; 46(13): 6893-6908. https://doi.org/10.1093/nar/gky542
    DORA PSI
  • Gudim I, Hammerstad M, Lofstad M, Hersleth H-P
    The Characterization of Different Flavodoxin Reductase-Flavodoxin (FNR-Fld) Interactions Reveals an Efficient FNR-Fld Redox Pair and Identifies a Novel FNR Subclass
    Biochemistry. 2018; 57(37): 5427-5436. https://doi.org/10.1021/acs.biochem.8b00674
    DORA PSI
  • Haeussler K, Fritz-Wolf K, Reichmann M, Rahlfs S, Becker K
    Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target
    Journal of Molecular Biology. 2018; 430(21): 4049-4067. https://doi.org/10.1016/j.jmb.2018.07.030
    DORA PSI
  • Hansen S, Ernst P, König SLB, Reichen C, Ewald C, Nettels D, et al.
    Curvature of designed armadillo repeat proteins allows modular peptide binding
    Journal of Structural Biology. 2018; 201(2): 108-117. https://doi.org/10.1016/j.jsb.2017.08.009
    DORA PSI
  • Hohmann U, Santiago J, Nicolet J, Olsson V, Spiga FM, Hothorn LA, et al.
    Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(13): 3488-3493. https://doi.org/10.1073/pnas.1714972115
    DORA PSI
  • Horrell S, Kekilli D, Sen K, Owen RL, Dworkowski FSN, Antonyuk SV, et al.
    Enzyme catalysis captured using multiple structures from one crystal at varying temperatures
    IUCrJ. 2018; 5: 283-292. https://doi.org/10.1107/S205225251800386X
    DORA PSI
  • Jahn B, Pol A, Lumpe H, Barends TRM, Dietl A, Hogendoorn C, et al.
    Similar but not the same: first kinetic and structural analyses of a methanol dehydrogenase containing a europium ion in the active site
    ChemBioChem. 2018; 19(11): 1147-1153. https://doi.org/10.1002/cbic.v19.11
    DORA PSI
  • Kallen J, Izaac A, Kaufmann M, Roethlisberger P
    X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome
    ChemMedChem. 2018; 13(18): 1997-2007. https://doi.org/10.1002/cmdc.201800344
    DORA PSI
  • Khazina E, Weichenrieder O
    Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p
    eLife. 2018; 7: e34960 (29 pp.). https://doi.org/10.7554/eLife.34960
    DORA PSI
  • Kuhlee A
    Tc toxin activation requires unfolding and refolding of a beta-propeller
    Nature. 2018; 563(7730): 209. https://doi.org/10.1038/s41586-018-0556-6
    DORA PSI
  • Kumari P, Aeschimann F, Gaidatzis D, Keusch JJ, Ghosh P, Neagu A, et al.
    Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
    Nature Communications. 2018; 9(1): 1549 (15 pp.). https://doi.org/10.1038/s41467-018-03920-7
    DORA PSI
  • Lazzaretti D, Bandholz-Cajamarca L, Emmerich C, Schaaf K, Basquin C, Irion U, et al.
    The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity
    Life Science Alliance. 2018; 1(5): e201800187 (15 pp.). https://doi.org/10.26508/lsa.201800187
    DORA PSI
  • Lebugle M, Dworkowski F, Pauluhn A, Guzenko VA, Romano L, Meier N, et al.
    High-intensity x-ray microbeam for macromolecular crystallography using silicon kinoform diffractive lenses
    Applied Optics. 2018; 57(30): 9032-9039. https://doi.org/10.1364/AO.57.009032
    DORA PSI
  • Liu S, Yang H, Kuhn B, Rudolph MG
    D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies
    Journal of Computer-Aided Molecular Design. 2018; 32(1): 1-20. https://doi.org/10.1007/s10822-017-0088-4
    DORA PSI
  • Liu W, Liu A, Gao H, Wang Q, Wang L, Warkentin E, et al.
    Structural properties of the peroxiredoxin AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus
    Biochimica et Biophysica Acta: General Subjects. 2018; 1862(12): 2797-2805. https://doi.org/10.1016/j.bbagen.2018.08.017
    DORA PSI
  • Ma X, Liu K, Li J, Li H, Li J, Liu Y, et al.
    A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning
    Journal of Biological Chemistry. 2018; 293(36): 14155-14164. https://doi.org/10.1074/jbc.RA118.001854
    DORA PSI
  • Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, et al.
    Ligand channel in pharmacologically stabilized rhodopsin
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(14): 3640-3645. https://doi.org/10.1073/pnas.1718084115
    DORA PSI
  • Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton J-M, Alzari PM
    Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
    Journal of Structural Biology. 2018; 204(2): 165-171. https://doi.org/10.1016/j.jsb.2018.08.001
    DORA PSI
  • Mesrouze Y, Bokhovchuk F, Izaac A, Meyerhofer M, Zimmermann C, Fontana P, et al.
    Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface
    Protein Science. 2018; 27(10): 1810-1820. https://doi.org/10.1002/pro.3493
    DORA PSI
  • Mortuza GB, Hermida D, Pedersen A-K, Segura-Bayona S, López-Méndez B, Redondo P, et al.
    Molecular basis of Tousled-like kinase 2 activation
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