Publications

PDB structures measured at X10SA


 

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Altegoer F, Quax TEF, Weiland P, Nußbaum P, Giammarinaro PI, Patro M, et al.
    Structural insights into the mechanism of archaellar rotational switching
    Nature Communications. 2022; 13(1): 2857 (12 pp.). https://doi.org/10.1038/s41467-022-30358-9
    DORA PSI
  • Aziz I, Kaltwasser S, Kayastha K, Khera R, Vonck J, Ermler U
    The molybdenum storage protein forms and deposits distinct polynuclear tungsten oxygen aggregates
    Journal of Inorganic Biochemistry. 2022; 234: 111904 (9 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111904
    DORA PSI
  • Botte M, Ni D, Schenck S, Zimmermann I, Chami M, Bocquet N, et al.
    Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
    Nature Communications. 2022; 13(1): 1826 (10 pp.). https://doi.org/10.1038/s41467-022-29459-2
    DORA PSI
  • Chakrabarti KS, Olsson S, Pratihar S, Giller K, Overkamp K, Lee KO, et al.
    A litmus test for classifying recognition mechanisms of transiently binding proteins
    Nature Communications. 2022; 13(1): 3792 (11 pp.). https://doi.org/10.1038/s41467-022-31374-5
    DORA PSI
  • Chrustowicz J, Sherpa D, Teyra J, Loke MS, Popowicz GM, Basquin J, et al.
    Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases
    Journal of Molecular Biology. 2022; 434(2): 167347 (22 pp.). https://doi.org/10.1016/j.jmb.2021.167347
    DORA PSI
  • Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, et al.
    N-heterocyclic 3-pyridyl carboxamide inhibitors of DHODH for the treatment of acute myelogenous leukemia
    Journal of Medicinal Chemistry. 2022; 65(16): 11241-11256. https://doi.org/10.1021/acs.jmedchem.2c00788
    DORA PSI
  • Dahms SO, Schnapp G, Winter M, Büttner FH, Schlepütz M, Gnamm C, et al.
    Dichlorophenylpyridine-based molecules inhibit furin through an induced-fit mechanism
    ACS Chemical Biology. 2022; 17(4): 816-821. https://doi.org/10.1021/acschembio.2c00103
    DORA PSI
  • Davies C, Dötsch L, Ciulla MG, Hennes E, Yoshida K, Gasper R, et al.
    Identification of a novel pseudo‐natural product type IV IDO1 inhibitor chemotype
    Angewandte Chemie International Edition. 2022; 61(40): e202209374 (12 pp.). https://doi.org/10.1002/anie.202209374
    DORA PSI
  • Diaz E, Adhikary S, Tepper AWJW, Riley D, Ortiz-Meoz R, Krosky D, et al.
    Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor
    Communications Biology. 2022; 5(1): 787 (14 pp.). https://doi.org/10.1038/s42003-022-03735-9
    DORA PSI
  • Fairhurst RA, Furet P, Imbach-Weese P, Stauffer F, Rueeger H, McCarthy C, et al.
    Identification of NVP-CLR457 as an orally bioavailable Non-CNS-Penetrant pan-class IA phosphoinositol-3-kinase inhibitor
    Journal of Medicinal Chemistry. 2022; 65(12): 8345-8379. https://doi.org/10.1021/acs.jmedchem.2c00267
    DORA PSI
  • Frei MS, Tarnawski M, Roberti MJ, Koch B, Hiblot J, Johnsson K
    Engineered HaloTag variants for fluorescence lifetime multiplexing
    Nature Methods. 2022; 19(1): 65-70. https://doi.org/10.1038/s41592-021-01341-x
    DORA PSI
  • Fritz-Wolf K, Bathke J, Rahlfs S, Becker K
    Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites
    Current Research in Structural Biology. 2022; 4: 87-95. https://doi.org/10.1016/j.crstbi.2022.03.004
    DORA PSI
  • Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, et al.
    In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M
    Journal of the American Chemical Society. 2022; 144(12): 5614-5628. https://doi.org/10.1021/jacs.2c01020
    DORA PSI
  • Gehrtz P, Marom S, Bührmann M, Hardick J, Kleinbölting S, Shraga A, et al.
    Optimization of covalent MKK7 inhibitors via crude nanomole-scale libraries
    Journal of Medicinal Chemistry. 2022; 65(15): 10341-10356. https://doi.org/10.1021/acs.jmedchem.1c02206
    DORA PSI
  • Heim C, Hartmann MD
    High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 290-298. https://doi.org/10.1107/S2059798322000092
    DORA PSI
  • Heimsch KC, Gertzen CGW, Schuh AK, Nietzel T, Rahlfs S, Przyborski JM, et al.
    Structure and function of redox-sensitive superfolder green fluorescent protein variant
    Antioxidants and Redox Signaling. 2022; 37(1-3): 1-18. https://doi.org/10.1089/ars.2021.0234
    DORA PSI
  • Huang Y, Sendzik M, Zhang J, Gao Z, Sun Y, Wang L, et al.
    Discovery of the clinical candidate MAK683: an EED-directed, allosteric, and selective PRC2 inhibitor for the treatment of advanced malignancies
    Journal of Medicinal Chemistry. 2022; 65(7): 5317-5333. https://doi.org/10.1021/acs.jmedchem.1c02148
    DORA PSI
  • Huang C-Y, Aumonier S, Engilberge S, Eris D, Smith KML, Leonarski F, et al.
    Probing ligand binding of endothiapepsin by 'temperature-resolved' macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 964-974. https://doi.org/10.1107/S205979832200612X
    DORA PSI
  • Iskhakova ZI, Zhuravleva DE, Heim C, Hartmann MD, Laykov AV, Forchhammer K, et al.
    PotN represents a novel energy-state sensing PII subfamily, occurring in firmicutes
    FEBS Journal. 2022; 289(17): 5305-5321. https://doi.org/10.1111/febs.16431
    DORA PSI
  • Kemble AM, Hornsperger B, Ruf I, Richter H, Benz J, Kuhn B, et al.
    A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature
    PLoS One. 2022; 17(9): e0268590 (24 pp.). https://doi.org/10.1371/journal.pone.0268590
    DORA PSI
  • Krasavin M, Bubyrev A, Kazantsev A, Heim C, Maiwald S, Zhukovsky D, et al.
    Replacing the phthalimide core in thalidomide with benzotriazole
    Journal of Enzyme Inhibition and Medicinal Chemistry. 2022; 37(1): 527-530. https://doi.org/10.1080/14756366.2021.2024525
    DORA PSI
  • Kubacka D, Kozarski M, Baranowski MR, Wojcik R, Panecka‐Hofman J, Strzelecka D, et al.
    Substrate‐based design of cytosolic nucleotidase IIIB inhibitors and structural insights into inhibition mechanism
    Pharmaceuticals. 2022; 15(5): 554 (27 pp.). https://doi.org/10.3390/ph15050554
    DORA PSI
  • Langlois CR, Beier V, Karayel O, Chrustowicz J, Sherpa D, Mann M, et al.
    A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters
    EMBO Reports. 2022; 23(6): e53835 (17 pp.). https://doi.org/10.15252/embr.202153835
    DORA PSI
  • Lategahn J, Tumbrink HL, Schultz-Fademrecht C, Heimsoeth A, Werr L, Niggenaber J, et al.
    Insight into targeting exon20 insertion mutations of the epidermal growth factor receptor with wild type-sparing inhibitors
    Journal of Medicinal Chemistry. 2022; 65(9): 6643-6655. https://doi.org/10.1021/acs.jmedchem.1c02080
    DORA PSI
  • Li D, Sloman DL, Achab A, Zhou H, McGowan MA, White C, et al.
    Oxetane promise delivered: discovery of long-acting IDO1 inhibitors suitable for Q3W oral or parenteral dosing
    Journal of Medicinal Chemistry. 2022; 65(8): 6001-6016. https://doi.org/10.1021/acs.jmedchem.1c01670
    DORA PSI
  • Luebben AV, Bender D, Becker S, Crowther LM, Erven I, Hofmann K, et al.
    Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration
    Science Advances. 2022; 8(15): eabj8633 (10 pp.). https://doi.org/10.1126/sciadv.abj8633
    DORA PSI
  • Mata G, Miles DH, Drew SL, Fournier J, Lawson KV, Mailyan AK, et al.
    Design, synthesis, and structure-activity relationship optimization of pyrazolopyrimidine amide inhibitors of phosphoinositide 3-kinase γ (PI3Kγ)
    Journal of Medicinal Chemistry. 2022; 65(2): 1418-1444. https://doi.org/10.1021/acs.jmedchem.1c01153
    DORA PSI
  • Milder FJ, Jongeneelen M, Ritschel T, Bouchier P, Bisschop IJM, de Man M, et al.
    Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2022; 119(6): e2115379119 (8 pp.). https://doi.org/10.1073/pnas.2115379119
    DORA PSI
  • Overbeck JH, Stelzig D, Fuchs AL, Wurm JP, Sprangers R
    Observation of conformational changes that underlie the catalytic cycle of Xrn2
    Nature Chemical Biology. 2022; 18: 1152-1160. https://doi.org/10.1038/s41589-022-01111-6
    DORA PSI
  • Pedrini B, Finke AD, Marsh M, Luporini P, Vallesi A, Alimenti C
    Crystal structure of the pheromone Er-13 from the ciliate Euplotes raikovi, with implications for a protein-protein association model in pheromone/receptor interactions
    Journal of Structural Biology. 2022; 214(1): 107812 (10 pp.). https://doi.org/10.1016/j.jsb.2021.107812
    DORA PSI
  • Rai A, Singh AK, Bleimling N, Posern G, Vetter IR, Goody RS
    Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector
    Nature Communications. 2022; 13(1): 4262 (17 pp.). https://doi.org/10.1038/s41467-022-31831-1
    DORA PSI
  • Rigamonti N, Veitonmäki N, Domke C, Barsin S, Jetzer S, Abdelmotaleb O, et al.
    A multispecific anti-CD40 DARPin construct induces tumor-selective CD40 activation and tumor regression
    Cancer Immunology Research. 2022; 10(5): 626-640. https://doi.org/10.1158/2326-6066.CIR-21-0553
    DORA PSI
  • Vulpetti A, Lingel A, Dalvit C, Schiering N, Oberer L, Henry C, et al.
    Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19F NMR Binding Assay with Predicted 19F NMR Chemical Shifts
    ChemMedChem. 2022; 17(13): e202200163 (9 pp.). https://doi.org/10.1002/cmdc.202200163
    DORA PSI
  • Weidenweber S, Schühle K, Lippert ML, Mock J, Seubert A, Demmer U, et al.
    Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism
    FEBS Journal. 2022; 289(18): 5599-5616. https://doi.org/10.1111/febs.16443
    DORA PSI
  • Weisberg E, Chowdhury B, Meng C, Case AE, Ni W, Garg S, et al.
    BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma
    Blood Cancer Journal. 2022; 12(7): 110 (10 pp.). https://doi.org/10.1038/s41408-022-00704-7
    DORA PSI
  • Weiss A, Lorthiois E, Barys L, Beyer KS, Bomio-Confaglia C, Burks H, et al.
    Discovery, preclinical characterization, and early clinical activity of JDQ443, a structurally novel, potent, and selective covalent oral inhibitor of KRASG12C
    Cancer Discovery. 2022; 12(6): 1500-1517. https://doi.org/10.1158/2159-8290.CD-22-0158
    DORA PSI
  • Wilson A, Andreeva EA, Niziński S, Talbot L, Hartmann E, Schlichting I, et al.
    Structure-function-dynamics relationships in the peculiar Planktothrix PCC7805 OCP1: impact of his-tagging and carotenoid type
    Biochimica et Biophysica Acta: Bioenergetics. 2022; 1863(7): 148584 (24 pp.). https://doi.org/10.1016/j.bbabio.2022.148584
    DORA PSI
  • Xu G, Liu Z, Wang X, Lu T, Desjarlais RL, Thieu T, et al.
    Discovery of potent and orally bioavailable pyridine N-oxide-based factor XIa inhibitors through exploiting nonclassical interactions
    Journal of Medicinal Chemistry. 2022; 65(15): 10419-10440. https://doi.org/10.1021/acs.jmedchem.2c00442
    DORA PSI
  • de la Roche NM, Mühlethaler T, Di Martino RMC, Ortega JA, Gioia D, Roy B, et al.
    Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
    European Journal of Medicinal Chemistry. 2022; 241: 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614
    DORA PSI
  • Augsberger C, Hänel G, Xu W, Pulko V, Hanisch LJ, Augustin A, et al.
    Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody
    Blood. 2021; 138(25): 2655 (15 pp.)-2669. https://doi.org/10.1182/blood.2020010477
    DORA PSI
  • Babu M, Favretto F, de Opakua AI, Rankovic M, Becker S, Zweckstetter M
    Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis
    Nature Communications. 2021; 12(1): 3396 (7 pp.). https://doi.org/10.1038/s41467-021-23691-y
    DORA PSI
  • Beale JH, Marsh ME
    Optimizing the growth of endothiapepsin crystals for serial crystallography experiments
    Journal of Visualized Experiments. 2021; 168: e61896 (30 pp.). https://doi.org/10.3791/61896
    DORA PSI
  • Benz J, Rufer AC, Huber S, Ehler A, Hug M, Topp A, et al.
    Novel β-Glucocerebrosidase activators that bind to a new pocket at a dimer interface and induce dimerization
    Angewandte Chemie International Edition. 2021; 60(10): 5436-5442. https://doi.org/10.1002/anie.202013890
    DORA PSI
  • Betschart C, Faller M, Zink F, Hemmig R, Blank J, Vangrevelinghe E, et al.
    Structure-based optimization of a fragment-like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist
    ACS Medicinal Chemistry Letters. 2021; 13(4): 658-664. https://doi.org/10.1021/acsmedchemlett.1c00696
    DORA PSI
  • Buchstaller H-P, Anlauf U, Dorsch D, Kögler S, Kuhn D, Lehmann M, et al.
    Optimization of a screening hit toward M2912, an oral tankyrase inhibitor with antitumor activity in colorectal cancer models
    Journal of Medicinal Chemistry. 2021; 64(14): 10371-10392. https://doi.org/10.1021/acs.jmedchem.1c00800
    DORA PSI
  • Centola M, van Pee K, Betz H, Yildiz Ö
    Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases
    Nature Communications. 2021; 12(1): 6982 (13 pp.). https://doi.org/10.1038/s41467-021-27281-w
    DORA PSI
  • Cretu C, Gee P, Liu X, Agrawal A, Nguyen TV, Ghosh AK, et al.
    Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
    Nature Communications. 2021; 12(1): 4491 (15 pp.). https://doi.org/10.1038/s41467-021-24741-1
    DORA PSI
  • Dekker C, Mattes H, Wright M, Boettcher A, Hinniger A, Hughes N, et al.
    Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition
    Journal of Molecular Biology. 2021; 433(24): 167309 (11 pp.). https://doi.org/10.1016/j.jmb.2021.167309
    DORA PSI
  • Dietl A, Barends TRM
    Dynamics in an unusual acyl carrier protein from a ladderane lipid-synthesizing organism
    Proteins. 2021; 90(1): 73-82. https://doi.org/10.1002/prot.26187
    DORA PSI
  • Ebenhoch R, Bauer M, Reinert D, Kersting A, Huber S, Schmid A, et al.
    Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP
    Journal of Structural Biology. 2021; 213(1): 107691. https://doi.org/10.1016/j.jsb.2020.107691
    DORA PSI
  • Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, et al.
    ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR
    Nature Chemical Biology. 2021; 17(11): 1148-1156. https://doi.org/10.1038/s41589-021-00852-0
    DORA PSI
  • Fuchs ACD, Ammelburg M, Martin J, Schmitz RA, Hartmann MD, Lupas AN
    Archaeal Connectase is a specific and efficient protein ligase related to proteasome β subunits
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(11): e2017871118 (9 pp.). https://doi.org/10.1073/pnas.2017871118
    DORA PSI
  • Fujimoto K, Yoshida S, Tadano G, Asada N, Fuchino K, Suzuki S, et al.
    Structure-based approaches to improving selectivity through utilizing explicit water molecules: discovery of selective β-secretase (BACE1) inhibitors over BACE2
    Journal of Medicinal Chemistry. 2021; 64(6): 3075-3085. https://doi.org/10.1021/acs.jmedchem.0c01858
    DORA PSI
  • Güttler T, Aksu M, Dickmanns A, Stegmann KM, Gregor K, Rees R, et al.
    Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies
    EMBO Journal. 2021; 40(19): e107985 (26 pp.). https://doi.org/10.15252/embj.2021107985
    DORA PSI
  • Hart P 't., Hommen P, Noisier A, Krzyzanowski A, Schüler D, Porfetye AT, et al.
    Structure based design of bicyclic Peptide inhibitors of RbAp48
    Angewandte Chemie International Edition. 2021; 60(4): 1813-1820. https://doi.org/10.1002/anie.202009749
    DORA PSI
  • He Y, Schild M, Grether U, Benz J, Leibrock L, Heer D, et al.
    Development of high brain-penetrant and reversible monoacylglycerol lipase PET tracers for neuroimaging
    Journal of Medicinal Chemistry. 2021; 65(3): 2191-2207. https://doi.org/10.1021/acs.jmedchem.1c01706
    DORA PSI
  • Herud-Sikimić O, Stiel AC, Kolb M, Shanmugaratnam S, Berendzen KW, Feldhaus C, et al.
    A biosensor for the direct visualization of auxin
    Nature. 2021; 592: 768-772. https://doi.org/10.1038/s41586-021-03425-2
    DORA PSI
  • Ibrahim A, Papin C, Mohideen-Abdul K, Gras SL, Stoll I, Bronner C, et al.
    MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion
    Science. 2021; 372(6549): eabd5581 (14 pp.). https://doi.org/10.1126/science.abd5581
    DORA PSI
  • Jiang B, Jiang J, Kaltheuner IH, Iniguez AB, Anand K, Ferguson FM, et al.
    Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma
    European Journal of Medicinal Chemistry. 2021; 221: 113481 (16 pp.). https://doi.org/10.1016/j.ejmech.2021.113481
    DORA PSI
  • Johansson E, Wu X, Yu B, Yang Z, Cao Z, Wiberg C, et al.
    Insulin binding to the analytical antibody sandwich pair OXI‐005 and HUI‐018: epitope mapping and binding properties
    Protein Science. 2021; 30(2): 485-496. https://doi.org/10.1002/pro.4009
    DORA PSI
  • Kolos JM, Pomplun S, Jung S, Rieß B, Purder PL, Voll AM, et al.
    Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides
    Chemical Science. 2021; 12(44): 14758-14765. https://doi.org/10.1039/d1sc04638a
    DORA PSI
  • Konia E, Chatzicharalampous K, Drakonaki A, Muenke C, Ermler U, Tsiotis G, et al.
    Rational engineering of Luminiphilus syltensis (R)-selective amine transaminase for the acceptance of bulky substrates
    Chemical Communications. 2021; 57(96): 12948-12951. https://doi.org/10.1039/d1cc04664k
    DORA PSI
  • Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klügel M, et al.
    CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation
    Nature Chemical Biology. 2021; 17: 1075-1083. https://doi.org/10.1038/s41589-021-00858-8
    DORA PSI
  • Krzyzanowski A, Gasper R, Adihou H, Hart P ’t, Waldmann H
    Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5–MEP50 Complex
    ChemBioChem. 2021; 22(11): 1908-1914. https://doi.org/10.1002/cbic.202100079
    DORA PSI
  • Kröger P, Shanmugaratnam S, Scheib U, Höcker B
    Fine-tuning spermidine binding modes in the putrescine binding protein PotF
    Journal of Biological Chemistry. 2021; 297(6): 101419 (12 pp.). https://doi.org/10.1016/j.jbc.2021.101419
    DORA PSI
  • Kung JW, Meier AK, Willistein M, Weidenweber S, Demmer U, Ermler U, et al.
    Structural basis of cyclic 1,3-diene forming acyl-coenzyme a dehydrogenases
    ChemBioChem. 2021; 22(22): 3173-3177. https://doi.org/10.1002/cbic.202100421
    DORA PSI
  • Larraufie M-H, Gao X, Xia X, Devine PJ, Kallen J, Liu D, et al.
    Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
    Cell Chemical Biology. 2021; 28(9): 1271-1282. https://doi.org/10.1016/j.chembiol.2021.04.001
    DORA PSI
  • Lemaire ON, Müller MC, Kahnt J, Wagner T
    Structural rearrangements of a dodecameric ketol-acid reductoisomerase isolated from a marine thermophilic methanogen
    Biomolecules. 2021; 11(11): 1679 (12 pp.). https://doi.org/10.3390/biom11111679
    DORA PSI
  • Ma B, Zhang L, Sun L, Xin Z, Kumaravel G, Marcotte D, et al.
    Discovery of potent selective nonzinc binding autotaxin inhibitor BIO-32546
    ACS Medicinal Chemistry Letters. 2021; 12(7): 1124-1129. https://doi.org/10.1021/acsmedchemlett.1c00211
    DORA PSI
  • Ma EJ, Siirola E, Moore C, Kummer A, Stoeckli M, Faller M, et al.
    Machine-directed evolution of an imine reductase for activity and stereoselectivity
    ACS Catalysis. 2021; 11(20): 12433-12445. https://doi.org/10.1021/acscatal.1c02786
    DORA PSI
  • Markert C, Thoma G, Srinivas H, Bollbuck B, Lüönd RM, Miltz W, et al.
    Discovery of LYS006, a potent and highly selective inhibitor of leukotriene A4 hydrolase
    Journal of Medicinal Chemistry. 2021; 64(4): 1889-1903. https://doi.org/10.1021/acs.jmedchem.0c01955
    DORA PSI
  • Martiel I, Beale JH, Karpik A, Huang C-Y, Vera L, Olieric N, et al.
    Versatile microporous polymer-based supports for serial macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2021; 77(9): 1153-1167. https://doi.org/10.1107/S2059798321007324
    DORA PSI
  • Mieczkowski M, Steinmetzger C, Bessi I, Lenz AK, Schmiedel A, Holzapfel M, et al.
    Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine
    Nature Communications. 2021; 12(1): 3549 (11 pp.). https://doi.org/10.1038/s41467-021-23932-0
    DORA PSI
  • Murayama K, Kato-Murayama M, Sato T, Hosaka T, Ishiguro K, Mizuno T, et al.
    Anthocyanin 5,3′-aromatic acyltransferase from Gentiana triflora, a structural insight into biosynthesis of a blue anthocyanin
    Phytochemistry. 2021; 186: 112727 (8 pp.). https://doi.org/10.1016/j.phytochem.2021.112727
    DORA PSI
  • Perez-Borrajero C, Podvalnaya N, Holleis K, Lichtenberger R, Karaulanov E, Simon B, et al.
    Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans
    Genes and Development. 2021; 35(17-18): 1304-1323. https://doi.org/10.1101/gad.348648.121
    DORA PSI
  • Ptacin JL, Caffaro CE, Ma L, San Jose Gall KM, Aerni HR, Acuff NV, et al.
    An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
    Nature Communications. 2021; 12(1): 4785 (14 pp.). https://doi.org/10.1038/s41467-021-24987-9
    DORA PSI
  • Quambusch L, Depta L, Landel I, Lubeck M, Kirschner T, Nabert J, et al.
    Cellular model system to dissect the isoform-selectivity of Akt inhibitors
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