Publications

PDB structures measured at X10SA


 

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Bokhovchuk F, Mesrouze Y, Delaunay C, Martin T, Villard F, Meyerhofer M, et al.
    Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors
    Protein Science. 2020; 29(2): 509-520. https://doi.org/10.1002/pro.3775
    DORA PSI
  • Rondelet A, Lin Y-C, Singh D, Porfetye AT, Thakur HC, Hecker A, et al.
    Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis
    Journal of Cell Biology. 2020; 219(2): e201907083. https://doi.org/10.1083/jcb.201907083
    DORA PSI
  • Wiseman B, Högbom M
    Conformational changes in apolipoprotein N-acyltransferase (Lnt)
    Scientific Reports. 2020; 10(1): 639 (11 pp.). https://doi.org/10.1038/s41598-020-57419-7
    DORA PSI
  • Adlakha J, Karamichali I, Sangwallek J, Deiss S, Bär K, Coles M, et al.
    Characterization of MCU-binding proteins MCUR1 and CCDC90B — representatives of a protein family conserved in prokaryotes and eukaryotic organelles
    Structure. 2019; 27(3): 464-475.e6. https://doi.org/10.1016/j.str.2018.11.004
    DORA PSI
  • Afanasieva E, Chaudhuri I, Martin J, Hertle E, Ursinus A, Alva V, et al.
    Structural diversity of oligomeric β-propellers with different numbers of identical blades
    eLife. 2019; 8: e49853 (15 pp.). https://doi.org/10.7554/eLife.49853
    DORA PSI
  • Akram M, Dietl A, Mersdorf U, Prinz S, Maalcke W, Keltjens J, et al.
    A 192-heme electron transfer network in the hydrazine dehydrogenase complex
    Science Advances. 2019; 5(4): eaav4310 (7 pp.). https://doi.org/10.1126/sciadv.aav4310
    DORA PSI
  • Akram M, Reimann J, Dietl A, Menzel A, Versantvoort W, Kartal B, et al.
    A nitric oxide-binding heterodimeric cytochrome c complex from the anammox bacterium Kuenenia stuttgartiensis binds to hydrazine synthase
    Journal of Biological Chemistry. 2019; 294(45): 16712-16728. https://doi.org/10.1074/jbc.RA119.008788
    DORA PSI
  • Aksu M, Trakhanov S, Vera Rodriguez A, Görlich D
    Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122
    Journal of Cell Biology. 2019; 218(6): 1839-1852. https://doi.org/10.1083/jcb.201812093
    DORA PSI
  • Apel A-K, Cheng RKY, Tautermann CS, Brauchle M, Huang C-Y, Pautsch A, et al.
    Crystal structure of CC chemokine receptor 2A in complex with an orthosteric antagonist provides insights for the design of selective antagonists
    Structure. 2019; 27(3): 427-438.e5. https://doi.org/10.1016/j.str.2018.10.027
    DORA PSI
  • Bartolini D, Bührmann M, Barreca ML, Manfroni G, Cecchetti V, Rauh D, et al.
    Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors
    Biochemical and Biophysical Research Communications. 2019; 511(3): 579-586. https://doi.org/10.1016/j.bbrc.2019.02.063
    DORA PSI
  • Basu S, Kaminski JW, Panepucci E, Huang C-Y, Warshamanage R, Wang M, et al.
    Automated data collection and real-time data analysis suite for serial synchrotron crystallography
    Journal of Synchrotron Radiation. 2019; 26(1): 244-252. https://doi.org/10.1107/S1600577518016570
    DORA PSI
  • Bokhovchuk F, Mesrouze Y, Izaac A, Meyerhofer M, Zimmermann C, Fontana P, et al.
    Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
    FEBS Journal. 2019; 286(12): 2381-2398. https://doi.org/10.1111/febs.14817
    DORA PSI
  • Brünle S, Eisinger ML, Poppe J, Mills DJ, Langer JD, Vonck J, et al.
    Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(52): 26497-26504. https://doi.org/10.1073/pnas.1913031116
    DORA PSI
  • Chaikuad A, Thangaratnarajah C, von Delft F, Bullock AN
    Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension
    Scientific Reports. 2019; 9(1): 18351 (10 pp.). https://doi.org/10.1038/s41598-019-54830-7
    DORA PSI
  • Chen Y, Cramer P
    Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo-and heterodimerization
    Journal of Biological Chemistry. 2019; 294(27): 10663-10673. https://doi.org/10.1074/jbc.RA119.008577
    DORA PSI
  • Cheng R, Huang C-Y, Hennig M, Nar H, Schnapp G
    In situ crystallography as an emerging method for structure solution of membrane proteins: the case of CCR2A
    FEBS Journal. 2019: (8 pp.). https://doi.org/10.1111/febs.15098
    DORA PSI
  • Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, et al.
    Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy
    Science Translational Medicine. 2019; 11(496): eaav5989 (12 pp.). https://doi.org/10.1126/scitranslmed.aav5989
    DORA PSI
  • Darowski D, Jost C, Stubenrauch K, Wessels U, Benz J, Ehler A, et al.
    P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation
    Protein Engineering Design & Selection. 2019. https://doi.org/10.1093/protein/gzz027
    DORA PSI
  • Deshpande I, Keusch JJ, Challa K, Iesmantavicius V, Gasser SM, Gut H
    The Sir4 H-BRCT domain interacts with phospho-proteins to sequester and repress yeast heterochromatin
    EMBO Journal. 2019; 38(20): e101744 (18 pp.). https://doi.org/10.15252/embj.2019101744
    DORA PSI
  • Ebenhoch R, Akhdar A, Reboll MR, Korf-Klingebiel M, Gupta P, Armstrong J, et al.
    Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair
    Nature Communications. 2019; 10(1): 5379 (10 pp.). https://doi.org/10.1038/s41467-019-13343-7
    DORA PSI
  • Engelhardt H, Böse D, Petronczki M, Scharn D, Bader G, Baum A, et al.
    Start selective and rigidify: the discovery path toward a next generation of EGFR tyrosine kinase inhibitors
    Journal of Medicinal Chemistry. 2019; 62(22): 10272-10293. https://doi.org/10.1021/acs.jmedchem.9b01169
    DORA PSI
  • Ernst P, Honegger A, van der Valk F, Ewald C, Mittl PRE, Plückthun A
    Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts
    Scientific Reports. 2019; 9(1): 16162 (10 pp.). https://doi.org/10.1038/s41598-019-52121-9
    DORA PSI
  • Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, et al.
    BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
    Nature Chemical Biology. 2019; 15(7): 672-680. https://doi.org/10.1038/s41589-019-0294-6
    DORA PSI
  • Fournier J, Chen K, Mailyan AK, Jackson JJ, Buckman BO, Emayan K, et al.
    Total synthesis of covalent cysteine protease inhibitor N-desmethyl thalassospiramide C and crystallographic evidence for its mode of action
    Organic Letters. 2019; 21(2): 508-512. https://doi.org/10.1021/acs.orglett.8b03821
    DORA PSI
  • Friedel K, Popp MA, Matern JCJ, Gazdag EM, Thiel IV, Volkmann G, et al.
    A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine
    Chemical Science. 2019; 10(1): 239-251. https://doi.org/10.1039/C8SC01074A
    DORA PSI
  • Furet P, Salem B, Mesrouze Y, Schmelzle T, Lewis I, Kallen J, et al.
    Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence
    Bioorganic and Medicinal Chemistry Letters. 2019; 29(16): 2316-2319. https://doi.org/10.1016/j.bmcl.2019.06.022
    DORA PSI
  • Greenidge PA, Blommers MJJ, Priestle JP, Hunziker J
    How to computationally stack the deck for hit-to-lead generation: in silico molecular interaction energy profiling for de novo siRNA guide strand surrogate selection
    Journal of Chemical Information and Modeling. 2019; 59(5): 1897-1908. https://doi.org/10.1021/acs.jcim.8b00892
    DORA PSI
  • He Q, Toh JD, Ero R, Qiao Z, Kumar V, Serra A, et al.
    The unusual di-domain structure of Dunaliella salina glycerol-3-phosphate dehydrogenase enables direct conversion of dihydroxyacetone phosphate to glycerol
    The Plant Journal. 2019. https://doi.org/10.1111/tpj.14619
    DORA PSI
  • Heim C, Pliatsika D, Mousavizadeh F, Bär K, Hernandez Alvarez B, Giannis A, et al.
    De-novo design of cereblon (CRBN) effectors guided by natural hydrolysis products of thalidomide derivatives
    Journal of Medicinal Chemistry. 2019; 62(14): 6615-6629. https://doi.org/10.1021/acs.jmedchem.9b00454
    DORA PSI
  • Hemmann JL, Wagner T, Shima S, Vorholt JA
    Methylofuran is a prosthetic group of the formyltransferase/hydrolase complex and shuttles one-carbon units between two active sites
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(51): 25583-25590. https://doi.org/10.1073/pnas.1911595116
    DORA PSI
  • Himmelbauer MK, Xin Z, Jones JH, Enyedy I, King K, Marcotte DJ, et al.
    Rational design and optimization of a novel class of macrocyclic apoptosis signal-regulating kinase 1 inhibitors
    Journal of Medicinal Chemistry. 2019; 62(23): 10740-10756. https://doi.org/10.1021/acs.jmedchem.9b01206
    DORA PSI
  • Hoegenauer K, Kallen J, Jiménez-Núñez E, Strang R, Ertl P, Cooke NG, et al.
    Structure-based and property-driven optimization of N-aryl imidazoles toward potent and selective oral RORγt inhibitors
    Journal of Medicinal Chemistry. 2019; 62(23): 10816-10832. https://doi.org/10.1021/acs.jmedchem.9b01291
    DORA PSI
  • Jeganathan S, Wendt M, Kiehstaller S, Brancaccio D, Kuepper A, Pospiech N, et al.
    Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly
    Angewandte Chemie International Edition. 2019; 58(48): 17351-17358. https://doi.org/10.1002/anie.201907901
    DORA PSI
  • Kallen J, Izaac A, Chau S, Wirth E, Schoepfer J, Mah R, et al.
    Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
    ChemMedChem. 2019; 14(14): 1305-1314. https://doi.org/10.1002/cmdc.201900201
    DORA PSI
  • Karki RG, Powers J, Mainolfi N, Anderson K, Belanger DB, Liu D, et al.
    Design, synthesis, and preclinical characterization of selective factor D inhibitors targeting the alternative complement pathway
    Journal of Medicinal Chemistry. 2019; 62(9): 4656-4668. https://doi.org/10.1021/acs.jmedchem.9b00271
    DORA PSI
  • Kawase T, Nakazawa T, Eguchi T, Tsuzuki H, Ueno Y, Amano Y, et al.
    Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells
    Oncotarget. 2019; 10(58): 6111-6123. https://doi.org/10.18632/oncotarget.27222
    DORA PSI
  • Keskeny C, Raisch T, Sgromo A, Igreja C, Bhandari D, Weichenrieder O, et al.
    A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex
    Genes and Development. 2019; 33(3-4): 236-252. https://doi.org/10.1101/gad.320952.118
    DORA PSI
  • Koch AW, Schiering N, Melkko S, Ewert S, Salter J, Zhang Y, et al.
    MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans
    Blood. 2019; 133(13): 1507-1516. https://doi.org/10.1182/blood-2018-10-880849
    DORA PSI
  • Koizumi Y, Tanaka Y, Matsumura T, Kadoh Y, Miyoshi H, Hongu M, et al.
    Discovery of a pyrazolo[1,5-α]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety
    Bioorganic and Medicinal Chemistry. 2019; 27(15): 3440-3450. https://doi.org/10.1016/j.bmc.2019.06.021
    DORA PSI
  • Kutin Y, Kositzki R, Branca RMM, Srinivas V, Lundin D, Haumann M, et al.
    Chemical flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins
    Journal of Biological Chemistry. 2019; 294(48): 18372-18386. https://doi.org/10.1074/jbc.RA119.010570
    DORA PSI
  • Laraia L, Friese A, Corkery DP, Konstantinidis G, Erwin N, Hofer W, et al.
    The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis
    Nature Chemical Biology. 2019; 15(7): 710-720. https://doi.org/10.1038/s41589-019-0307-5
    DORA PSI
  • Lategahn J, Keul M, Klövekorn P, Tumbrink HL, Niggenaber J, Müller MP, et al.
    Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S
    Chemical Science. 2019; 10(46): 10789-10801. https://doi.org/10.1039/c9sc03445e
    DORA PSI
  • McNally R, Li Q, Li K, Dekker C, Vangrevelinghe E, Jones M, et al.
    Discovery and structural characterization of ATP-site ligands for the wild-type and V617F mutant JAK2 pseudokinase domain
    ACS Chemical Biology. 2019; 14(4): 587-593. https://doi.org/10.1021/acschembio.8b00722
    DORA PSI
  • Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, et al.
    Influenza virus uses transportin 1 for vRNP debundling during cell entry
    Nature Microbiology. 2019; 4(4): 578-586. https://doi.org/10.1038/s41564-018-0332-2
    DORA PSI
  • Muth M, Jänsch N, Kopranovic A, Krämer A, Wössner N, Jung M, et al.
    Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
    Biochimica et Biophysica Acta: General Subjects. 2019; 1863(3): 577-585. https://doi.org/10.1016/j.bbagen.2019.01.001
    DORA PSI
  • Nguyen D, Lemos C, Wortmann L, Eis K, Holton SJ, Boemer U, et al.
    Discovery and characterization of the potent and highly selective (piperidin-4-yl)pyrido[3,2-d]pyrimidine based in vitro probe BAY-885 for the kinase ERK5.
    Journal of Medicinal Chemistry. 2019; 62(2): 928-940. https://doi.org/10.1021/acs.jmedchem.8b01606
    DORA PSI
  • Peter D, Ruscica V, Bawankar P, Weber R, Helms S, Valkov E, et al.
    Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression
    Genes and Development. 2019; 33(19-20): 1355-1360. https://doi.org/10.1101/gad.329219.119
    DORA PSI
  • Pulz R, Angst D, Dawson J, Gessier F, Gutmann S, Hersperger R, et al.
    Design of potent and selective covalent inhibitors of Bruton's tyrosine kinase targeting an inactive conformation
    ACS Medicinal Chemistry Letters. 2019; 10(10): 1467-1472. https://doi.org/10.1021/acsmedchemlett.9b00317
    DORA PSI
  • Quambusch L, Landel I, Depta L, Weisner J, Uhlenbrock N, Müller MP, et al.
    Covalent-allosteric inhibitors to achieve Akt isoform-selectivity
    Angewandte Chemie International Edition. 2019; 58(52): 18823-18829. https://doi.org/10.1002/anie.201909857
    DORA PSI
  • Quancard J, Klein T, Fung S-Y, Renatus M, Hughes N, Israël L, et al.
    An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient
    Nature Chemical Biology. 2019; 15(3): 304-313. https://doi.org/10.1038/s41589-018-0222-1
    DORA PSI
  • Richter H, Satz AL, Bedoucha M, Buettelmann B, Petersen AC, Harmeier A, et al.
    DNA-encoded library-derived DDR1 inhibitor prevents fibrosis and renal function loss in a genetic mouse model of Alport syndrome
    ACS Chemical Biology. 2019; 14(1): 37-49. https://doi.org/10.1021/acschembio.8b00866
    DORA PSI
  • Ripin N, Boudet J, Duszczyk MM, Hinniger A, Faller M, Krepl M, et al.
    Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(8): 2935-2944. https://doi.org/10.1073/pnas.1808696116
    DORA PSI
  • Roderer D, Schubert E, Sitsel O, Raunser S
    Towards the application of Tc toxins as a universal protein translocation system
    Nature Communications. 2019; 10(1): 5263 (11 pp.). https://doi.org/10.1038/s41467-019-13253-8
    DORA PSI
  • Röhrig UF, Reynaud A, Majjigapu SR, Vogel P, Pojer F, Zoete V
    Inhibition mechanisms of indoleamine 2,3-dioxygenase 1 (IDO1)
    Journal of Medicinal Chemistry. 2019; 62(19): 8784-8795. https://doi.org/10.1021/acs.jmedchem.9b00942
    DORA PSI
  • Sauer MM, Jakob RP, Luber T, Canonica F, Navarra G, Ernst B, et al.
    Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets
    Journal of the American Chemical Society. 2019; 141(2): 936-944. https://doi.org/10.1021/jacs.8b10736
    DORA PSI
  • Schehr M, Ianes C, Weisner J, Heintze L, Müller MP, Pichlo C, et al.
    2-azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach
    Photochemical and Photobiological Sciences. 2019; 18(6): 1398-1407. https://doi.org/10.1039/c9pp00010k
    DORA PSI
  • Schubart A, Anderson K, Mainolfi N, Sellner H, Ehara T, Adams CM, et al.
    Small-molecule factor B inhibitor for the treatment of complement-mediated diseases
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(16): 7926-7931. https://doi.org/10.1073/pnas.1820892116
    DORA PSI
  • Soh Y-M, Davidson IF, Zamuner S, Basquin J, Bock FP, Taschner M, et al.
    Self-organization of parS centromeres by the ParB CTP hydrolase
    Science. 2019; 366(6469): 1129-1133. https://doi.org/10.1126/science.aay3965
    DORA PSI
  • Sommerkamp JA, Frankenberg-Dinkel N, Hofmann E
    Crystal structure of the first eukaryotic bilin reductase GtPEBB reveals a flipped binding mode of dihydrobiliverdin
    Journal of Biological Chemistry. 2019; 294(38): 13889-13901. https://doi.org/10.1074/jbc.RA119.009306
    DORA PSI
  • Stauffer F, Weiss A, Scheufler C, Möbitz H, Ragot C, Beyer KS, et al.
    New potent DOT1L inhibitors for in vivo evaluation in mouse
    ACS Medicinal Chemistry Letters. 2019; 10(12): 1655-1660. https://doi.org/10.1021/acsmedchemlett.9b00452
    DORA PSI
  • Straw ML, Hough MA, Wilson MT, Worrall JAR
    A histidine residue and a tetranuclear cuprous-thiolate cluster dominate the copper loading landscape of a copper storage protein from Streptomyces lividans
    Chemistry: A European Journal. 2019; 25(45): 10678-10688. https://doi.org/10.1002/chem.201901411
    DORA PSI
  • Trigo-Mourino P, Thestrup T, Griesbeck O, Griesinger C, Becker S
    Dynamic tuning of FRET in a green fluorescent protein biosensor
    Science Advances. 2019; 5(8): eaaw4988 (8 pp.). https://doi.org/10.1126/sciadv.aaw4988
    DORA PSI
  • Uhlenbrock N, Smith S, Weisner J, Landel I, Lindemann M, Le TA, et al.
    Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt
    Chemical Science. 2019; 10(12): 3573-3585. https://doi.org/10.1039/c8sc05212c
    DORA PSI
  • Watanabe T, Wagner T, Huang G, Kahnt J, Ataka K, Ermler U, et al.
    The bacterial [Fe]-hydrogenase paralog HmdII uses tetrahydrofolate derivatives as substrates
    Angewandte Chemie International Edition. 2019; 58(11): 3506-3510. https://doi.org/10.1002/anie.201813465
    DORA PSI
  • Weisner J, Landel I, Reintjes C, Uhlenbrock N, Trajkovic-Arsic M, Dienstbier N, et al.
    Preclinical efficacy of covalent-allosteric AKT inhibitor borussertib in combination with trametinib in KRAS-mutant pancreatic and colorectal cancer
    Cancer Research. 2019; 79(9): 2367-2378. https://doi.org/10.1158/0008-5472.CAN-18-2861
    DORA PSI
  • Willistein M, Bechtel DF, Müller CS, Demmer U, Heimann L, Kayastha K, et al.
    Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
    Nature Communications. 2019; 10(1): 2074 (10 pp.). https://doi.org/10.1038/s41467-019-10078-3
    DORA PSI
  • Wolle P, Engel J, Smith S, Goebel L, Hennes E, Lategahn J, et al.
    Characterization of covalent pyrazolopyrimidine-MKK7 complexes and a report on a unique DFG-in/Leu-in conformation of mitogen-activated protein kinase kinase 7 (MKK7)
    Journal of Medicinal Chemistry. 2019; 62(11): 5541-5546. https://doi.org/10.1021/acs.jmedchem.9b00472
    DORA PSI
  • Wolle P, Hardick J, Cronin SJF, Engel J, Baumann M, Lategahn J, et al.
    Targeting the MKK7-JNK (mitogen-activated protein kinase kinase 7-c-Jun N-terminal kinase) pathway with covalent inhibitors
    Journal of Medicinal Chemistry. 2019; 62(5): 2843-2848. https://doi.org/10.1021/acs.jmedchem.9b00102
    DORA PSI
  • Zakrzewska S, Mehdipour AR, Malviya VN, Nonaka T, Koepke J, Muenke C, et al.
    Inward-facing conformation of a multidrug resistance MATE family transporter
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(25): 12275-12284. https://doi.org/10.1073/pnas.1904210116
    DORA PSI
  • Żyła DS, Prota AE, Capitani G, Glockshuber R
    Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria
    Journal of Biological Chemistry. 2019; 294(27): 10553-10563. https://doi.org/10.1074/jbc.RA119.008610
    DORA PSI
  • Aichem A, Anders S, Catone N, Rößler P, Stotz S, Berg A, et al.
    The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation
    Nature Communications. 2018; 9(1): 3321 (14 pp.). https://doi.org/10.1038/s41467-018-05776-3
    DORA PSI
  • Ali I, Eu S, Koch D, Bleimling N, Goody RS, Müller MP
    Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2018; 74(5): 315-321. https://doi.org/10.1107/S2053230X18005915
    DORA PSI
  • Andrei SA, Meijer FA, Neves JF, Brunsveld L, Landrieu I, Ottmann C, et al.
    Inhibition of 14-3-3/Tau by hybrid small-molecule peptides operating via two different binding modes
    ACS Chemical Neuroscience. 2018; 9(11): 2639-2654. https://doi.org/10.1021/acschemneuro.8b00118
    DORA PSI
  • Boichenko I, Bär K, Deiss S, Heim C, Albrecht R, Lupas AN, et al.
    Chemical ligand space of cereblon
    ACS Omega. 2018; 3(9): 11163-11171. https://doi.org/10.1021/acsomega.8b00959
    DORA PSI
  • Born D, Reuter L, Mersdorf U, Mueller M, Fischer MG, Meinhart A, et al.
    Capsid protein structure, self-assembly, and processing reveal morphogenesis of the marine virophage mavirus
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(28): 7332-7337. https://doi.org/10.1073/pnas.1805376115
    DORA PSI
  • Boubia B, Poupardin O, Barth M, Binet J, Peralba P, Mounier L, et al.
    Design, synthesis, and evaluation of a novel series of indole sulfonamide peroxisome proliferator activated receptor (PPAR) α/γ/δ triple activators: discovery of lanifibranor, a new antifibrotic clinical candidate
    Journal of Medicinal Chemistry. 2018; 61(6): 2246-2265. https://doi.org/10.1021/acs.jmedchem.7b01285
    DORA PSI
  • Brieke C, Tarnawski M, Greule A, Cryle MJ
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