Publications

PDB structures measured at X10SA


 

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Adlakha J, Karamichali I, Sangwallek J, Deiss S, Bär K, Coles M, et al.
    Characterization of MCU-Binding Proteins MCUR1 and CCDC90B — Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles
    Structure. 2019; 27(3): 464-475. https://doi.org/10.1016/j.str.2018.11.004
    DORA PSI
  • Apel A-K, Cheng RKY, Tautermann CS, Brauchle M, Huang C-Y, Pautsch A, et al.
    Crystal structure of CC chemokine receptor 2A in complex with an orthosteric antagonist provides insights for the design of selective antagonists
    Structure. 2019; 27(3): 427-438.e5. https://doi.org/10.1016/j.str.2018.10.027
    DORA PSI
  • Basu S, Kaminski JW, Panepucci E, Huang C-Y, Warshamanage R, Wang M, et al.
    Automated data collection and real-time data analysis suite for serial synchrotron crystallography
    Journal of Synchrotron Radiation. 2019; 26(1): 244-252. https://doi.org/10.1107/S1600577518016570
    DORA PSI
  • Friedel K, Popp MA, Matern JCJ, Gazdag EM, Thiel IV, Volkmann G, et al.
    A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine
    Chemical Science. 2019; 10(1): 239-251. https://doi.org/10.1039/C8SC01074A
    DORA PSI
  • Kramer A
    Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine.
    Biochimica et Biophysica Acta: General Subjects. 2019; 1863: 577-585. https://doi.org/10.1016/j.bbagen.2019.01.001
    DORA PSI
  • Nguyen D, Lemos C, Wortmann L, Eis K, Holton SJ, Boemer U, et al.
    Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
    Journal of Medicinal Chemistry. 2019; 62: 928.
    DORA PSI
  • Quancard J, Klein T, Fung S-Y, Renatus M, Hughes N, Israël L, et al.
    An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient
    Nature Chemical Biology. 2019; 15(3): 304-313. https://doi.org/10.1038/s41589-018-0222-1
    DORA PSI
  • Raisch T, Sgromo A, Weichenrieder O, Izaurralde E
    A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex.
    Genes and Development. 2019; 33: 236.
    DORA PSI
  • Richter H, Hochstrasser R, Burger D, Gasser R, Huber S, Kuhn B, et al.
    DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.
    ACS Chemical Biology. 2019; 14: 37.
    DORA PSI
  • Watanabe T, Wagner T, Ermler U, Shima S
    The Bacterial [Fe]-Hydrogenase Paralog HmdII Uses Tetrahydrofolate Derivatives as Substrates.
    Angewandte Chemie International Edition. 2019; 58: 3506.
    DORA PSI
  • Wolle P, Baumann M, Rauh D
    Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.
    Journal of Medicinal Chemistry. 2019; 62: 2843.
    DORA PSI
  • Aichem A, Anders S, Catone N, Rößler P, Stotz S, Berg A, et al.
    The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.
    Nature Communications. 2018; 9: 3321. https://doi.org/10.1038/s41467-018-05776-3
    DORA PSI
  • Ali I, Eu S, Koch D, Bleimling N, Goody RS, Müller MP
    Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2018; 74(5): 315-321. https://doi.org/10.1107/S2053230X18005915
    DORA PSI
  • Andrei SA, Meijer FA, Neves JF, Brunsveld L, Landrieu I, Ottmann C, et al.
    Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes
    ACS Chemical Neuroscience. 2018; 9(11): 2639-2654. https://doi.org/10.1021/acschemneuro.8b00118
    DORA PSI
  • Bier D, Kaiser M
    Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins
    Chemistry: A European Journal. 2018; 24(52): 13807-13814. https://doi.org/10.1002/chem.201801074
    DORA PSI
  • Born D, Reuter L, Mersdorf U, Mueller M, Fischer MG, Meinhart A, et al.
    Capsid protein structure, self-assembly, and processing reveal morphogenesis of the marine virophage mavirus
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(28): 7332-7337. https://doi.org/10.1073/pnas.1805376115
    DORA PSI
  • Boubia B, Poupardin O, Barth M, Binet J, Peralba P, Mounier L, et al.
    Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) alpha/gamma/delta Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate
    Journal of Medicinal Chemistry. 2018; 61(6): 2246-2265. https://doi.org/10.1021/acs.jmedchem.7b01285
    DORA PSI
  • Brieke C, Tarnawski M, Greule A, Cryle MJ
    Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach
    Journal of Inorganic Biochemistry. 2018; 185: 43-51. https://doi.org/10.1016/j.jinorgbio.2018.05.001
    DORA PSI
  • Cretu C, Agrawal AA, Cook A, Will CL, Fekkes P, Smith PG, et al.
    Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds
    Molecular Cell. 2018; 70(2): 265-273. https://doi.org/10.1016/j.molcel.2018.03.011
    DORA PSI
  • Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, et al.
    Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin
    Scientific Reports. 2018; 8(1): 10705. https://doi.org/10.1038/s41598-018-29058-6
    DORA PSI
  • Demmer JK, Bertsch J, Öppinger C, Wohlers H, Kayastha K, Demmer U, et al.
    Molecular basis of the flavin-based electron-bifurcating caffeyl-CoA reductase reaction
    FEBS Letters. 2018; 592(3): 332-342. https://doi.org/10.1002/1873-3468.12971
    DORA PSI
  • Elgamacy M, Coles M, Ernst P, Zhu H, Hartmann MD, Plückthun A, et al.
    An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture
    ACS Synthetic Biology. 2018; 7(9): 2226-2235. https://doi.org/10.1021/acssynbio.8b00224
    DORA PSI
  • Esselborn J, Hofmann E
    Crystallographic and spectroscopic assignment of the proton transfer pathway in [FeFe]-hydrogenases
    Nature Communications. 2018; 9: 4726. https://doi.org/10.1038/s41467-018-07140-x
    DORA PSI
  • Evers A, Bossart M, Pfeiffer-Marek S, Elvert R, Schreuder H, Kurz M, et al.
    Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations
    Journal of Medicinal Chemistry. 2018; 61(13): 5580-5593. https://doi.org/10.1021/acs.jmedchem.8b00292
    DORA PSI
  • Fuchs ACD, Maldoner L, Wojtynek M, Hartmann MD, Martin J
    Rpn11-mediated ubiquitin processing in an ancestral archaeal ubiquitination system
    Nature Communications. 2018; 9(1): 2696. https://doi.org/10.1038/s41467-018-05198-1
    DORA PSI
  • Fuchs ACD, Maldoner L, Hipp K, Hartmann MD, Martin J
    Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties
    Journal of Biological Chemistry. 2018; 293(3): 920-930. https://doi.org/10.1074/jbc.M117.815258
    DORA PSI
  • Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, et al.
    Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors
    Journal of Medicinal Chemistry. 2018; 61(8): 3350-3369. https://doi.org/10.1021/acs.jmedchem.7b01869
    DORA PSI
  • Gruner S, Weber R, Peter D, Chung M-Y, Igreja C, Valkov E, et al.
    Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast
    Nucleic Acids Research. 2018; 46(13): 6893-6908. https://doi.org/10.1093/nar/gky542
    DORA PSI
  • Gudim I, Hammerstad M, Lofstad M, Hersleth H-P
    The Characterization of Different Flavodoxin Reductase-Flavodoxin (FNR-Fld) Interactions Reveals an Efficient FNR-Fld Redox Pair and Identifies a Novel FNR Subclass
    Biochemistry. 2018; 57(37): 5427-5436. https://doi.org/10.1021/acs.biochem.8b00674
    DORA PSI
  • Haeussler K, Fritz-Wolf K, Reichmann M, Rahlfs S, Becker K
    Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target
    Journal of Molecular Biology. 2018; 430(21): 4049-4067. https://doi.org/10.1016/j.jmb.2018.07.030
    DORA PSI
  • Hansen S, Ernst P, König SLB, Reichen C, Ewald C, Nettels D, et al.
    Curvature of designed armadillo repeat proteins allows modular peptide binding
    Journal of Structural Biology. 2018; 201(2): 108-117. https://doi.org/10.1016/j.jsb.2017.08.009
    DORA PSI
  • Hohmann U, Santiago J, Nicolet J, Olsson V, Spiga FM, Hothorn LA, et al.
    Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(13): 3488-3493. https://doi.org/10.1073/pnas.1714972115
    DORA PSI
  • Horrell S, Kekilli D, Sen K, Owen RL, Dworkowski FSN, Antonyuk SV, et al.
    Enzyme catalysis captured using multiple structures from one crystal at varying temperatures
    IUCrJ. 2018; 5: 283-292. https://doi.org/10.1107/S205225251800386X
    DORA PSI
  • Kallen J, Stringer R, Wolf RM, Wagner J
    Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model
    Journal of Medicinal Chemistry. 2018; 61(15): 6724-6735. https://doi.org/10.1021/acs.jmedchem.8b00529
    DORA PSI
  • Kallen J, Izaac A, Kaufmann M, Roethlisberger P
    X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome
    ChemMedChem. 2018; 13(18): 1997-2007. https://doi.org/10.1002/cmdc.201800344
    DORA PSI
  • Kuhlee A
    Tc toxin activation requires unfolding and refolding of a beta-propeller
    Nature. 2018; 563(7730): 209. https://doi.org/10.1038/s41586-018-0556-6
    DORA PSI
  • Kumari P, Aeschimann F, Gaidatzis D, Keusch JJ, Ghosh P, Neagu A, et al.
    Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
    Nature Communications. 2018; 9(1): 1549. https://doi.org/10.1038/s41467-018-03920-7
    DORA PSI
  • Lebugle M, Dworkowski F, Pauluhn A, Guzenko VA, Romano L, Meier N, et al.
    High-intensity x-ray microbeam for macromolecular crystallography using silicon kinoform diffractive lenses
    Applied Optics. 2018; 57(30): 9032-9039. https://doi.org/10.1364/AO.57.009032
    DORA PSI
  • Liu S, Yang H, Kuhn B, Rudolph MG
    D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies
    Journal of Computer-Aided Molecular Design. 2018; 32(1): 1-20. https://doi.org/10.1007/s10822-017-0088-4
    DORA PSI
  • Liu W, Liu A, Gao H, Wang Q, Wang L, Warkentin E, et al.
    Structural properties of the peroxiredoxin AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus
    Biochimica et Biophysica Acta: General Subjects. 2018; 1862(12): 2797-2805. https://doi.org/10.1016/j.bbagen.2018.08.017
    DORA PSI
  • Ma X, Liu K, Li J, Li H, Li J, Liu Y, et al.
    A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning
    Journal of Biological Chemistry. 2018; 293(36): 14155-14164. https://doi.org/10.1074/jbc.RA118.001854
    DORA PSI
  • Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, et al.
    Ligand channel in pharmacologically stabilized rhodopsin
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(14): 3640-3645. https://doi.org/10.1073/pnas.1718084115
    DORA PSI
  • Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton J-M, Alzari PM
    Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
    Journal of Structural Biology. 2018; 204(2): 165-171. https://doi.org/10.1016/j.jsb.2018.08.001
    DORA PSI
  • Mesrouze Y, Bokhovchuk F, Izaac A, Meyerhofer M, Zimmermann C, Fontana P, et al.
    Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface
    Protein Science. 2018; 27(10): 1810-1820. https://doi.org/10.1002/pro.3493
    DORA PSI
  • Mortuza GB, Hermida D, Pedersen A-K, Segura-Bayona S, López-Méndez B, Redondo P, et al.
    Molecular basis of Tousled-Like Kinase 2 activation
    Nature Communications. 2018; 9(1): 2535. https://doi.org/10.1038/s41467-018-04941-y
    DORA PSI
  • Murakami M, Kallen J
    Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201
    Cancer Research. 2018; 78(21): 6257-6267. https://doi.org/10.1158/0008-5472.CAN-18-0338
    DORA PSI
  • Nakaoku T, Kohno T, Araki M, Niho S, Chauhan R, Knowles PP, et al.
    A secondary RET mutation in the activation loop conferring resistance to vandetanib
    Nature Communications. 2018; 9(1): 625. https://doi.org/10.1038/s41467-018-02994-7
    DORA PSI
  • Namoto K, Sirockin F, Sellner H, Wiesmann C, Villard F, Moreau RJ, et al.
    Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2018; 28(5): 906-909. https://doi.org/10.1016/j.bmcl.2018.01.064
    DORA PSI
  • Poppe J, Brünle S, Hail R, Wiesemann K, Schneider K, Ermler U
    The Molybdenum Storage Protein: A soluble ATP hydrolysis-dependent molybdate pump
    FEBS Journal. 2018; 285(24): 4602-4616. https://doi.org/10.1111/febs.14684
    DORA PSI
  • Poppe J, Ermler U
    The molybdenum storage protein - A bionanolab for creating experimentally alterable polyoxomolybdate clusters
    Journal of Inorganic Biochemistry. 2018; 189: 172-179. https://doi.org/10.1016/j.jinorgbio.2018.09.011
    DORA PSI
  • Pries V, Nöcker C, Khan D, Johnen P, Hong Z, Tripathi A, et al.
    Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties
    Cell Chemical Biology. 2018; 25(3): 279-290. https://doi.org/10.1016/j.chembiol.2017.12.007
    DORA PSI
  • Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, et al.
    Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD
    Journal of the American Society of Nephrology. 2018; 29(5): 1525-1535. https://doi.org/10.1681/asn.2017080856
    DORA PSI
  • Qiu H, Liu-Bujalski L, Caldwell RD, Follis AV, Gardberg A, Goutopoulos A, et al.
    Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit
    Bioorganic and Medicinal Chemistry Letters. 2018; 28(17): 2939-2944. https://doi.org/10.1016/j.bmcl.2018.07.008
    DORA PSI
  • Raisch T, Sandmeir F, Weichenrieder O, Valkov E, Izaurralde E
    Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex
    Journal of Structural Biology. 2018; 204(3): 388-395. https://doi.org/10.1016/j.jsb.2018.10.009
    DORA PSI
  • Regula JT, Imhof-Jung S, Mølhøj M, Benz J, Ehler A, Bujotzek A, et al.
    Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly
    Protein Engineering Design & Selection. 2018; 31(7-8): 289-299. https://doi.org/10.1093/protein/gzy021
    DORA PSI
  • Rocker A, Peschke M, Kittilä T, Sakson R, Brieke C, Meinhart A
    The ng-ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis
    Nature Communications. 2018; 9(1): 1686. https://doi.org/10.1038/s41467-018-03652-8
    DORA PSI
  • Rufer AC, Kusznir E, Burger D, Stihle M, Ruf A, Rudolph MG
    Domain swap in the C-terminal ubiquitin-like domain of human doublecortin
    Acta Crystallographica Section D: Structural Biology. 2018; 74(5): 450-462. https://doi.org/10.1107/S2059798318004813
    DORA PSI
  • Schoepfer J, Jahnke W, Berellini G, Buonamici S, Cotesta S, Cowan-Jacob SW, et al.
    Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
    Journal of Medicinal Chemistry. 2018; 61(18): 8120-8135. https://doi.org/10.1021/acs.jmedchem.8b01040
    DORA PSI
  • Schubert E, Vetter IR, Prumbaum D, Penczek PA, Raunser S
    Membrane insertion of alpha-xenorhabdolysin in near-atomic detail
    eLife. 2018; 7: e38017. https://doi.org/10.7554/eLife.38017
    DORA PSI
  • Schuetz DA, Richter L, Amaral M, Grandits M, Grädler U, Musil D, et al.
    Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors
    Journal of Medicinal Chemistry. 2018; 61(10): 4397-4411. https://doi.org/10.1021/acs.jmedchem.8b00080
    DORA PSI
  • Sgromo A, Raisch T, Backhaus C, Keskeny C, Alva V, Weichenrieder O, et al.
    Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4–NOT complex to elicit repression of mRNA targets
    RNA. 2018; 24(3): 381-395. https://doi.org/10.1261/rna.064584.117
    DORA PSI
  • Stevers LM, De Vink PJ, Ottmann C, Huskens J, Brunsveld L
    A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions
    Journal of the American Chemical Society. 2018; 140: 14498. https://doi.org/10.1021/jacs.8b09618
    DORA PSI
  • Stollmaier C, Maspero E
    beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation
    Journal of Molecular Biology. 2018; 430(18): 3218-3233. https://doi.org/10.1016/j.jmb.2018.06.044
    DORA PSI
  • Tesch R, Becker C, Müller MP, Beck ME, Quambusch L, Getlik M, et al.
    An Unusual Intramolecular Halogen Bond Guides Conformational Selection
    Angewandte Chemie International Edition. 2018; 57(31): 9970-9975. https://doi.org/10.1002/anie.201804917
    DORA PSI
  • Vaupel A, Holzer P, Ferretti S, Guagnano V, Kallen J, Mah R, et al.
    In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor
    Bioorganic and Medicinal Chemistry Letters. 2018; 28(20): 3404-3408. https://doi.org/10.1016/j.bmcl.2018.08.027
    DORA PSI
  • Veenstra SJ, Rueeger H, Voegtle M, Lueoend R, Holzer P, Hurth K, et al.
    Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2018; 28(12): 2195-2200. https://doi.org/10.1016/j.bmcl.2018.05.003
    DORA PSI
  • Vergara A, Caterino M, Merlino A
    Raman-markers of X-ray radiation damage of proteins
    International Journal of Biological Macromolecules. 2018; 111: 1194-1205. https://doi.org/10.1016/j.ijbiomac.2018.01.135
    DORA PSI
  • Vos SM, Farnung L, Boehning M, Wigge C, Linden A, Urlaub H, et al.
    Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
    Nature. 2018; 560(7720): 607-612. https://doi.org/10.1038/s41586-018-0440-4
    DORA PSI
  • Vulpetti A, Ostermann N, Randl S, Yoon T, Mac Sweeney A, Cumin F, et al.
    Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D
    ACS Medicinal Chemistry Letters. 2018; 9(5): 490-495. https://doi.org/10.1021/acsmedchemlett.8b00104
    DORA PSI
  • Wagner T, Ermler U, Shima S
    Dioxygen Sensitivity of [Fe]-Hydrogenase in the Presence of Reducing Substrates
    Angewandte Chemie International Edition. 2018; 57(18): 4917-4920. https://doi.org/10.1002/anie.201712293
    DORA PSI
  • Wojdyla JA, Kaminski JW, Panepucci E, Ebner S, Wang X, Gabadinho J, et al.
    DA+ data acquisition and analysis software at the Swiss Light Source macromolecular crystallography beamlines
    Journal of Synchrotron Radiation. 2018; 25(1): 293-303. https://doi.org/10.1107/S1600577517014503
    DORA PSI
  • de Moura TR, Mozaffari-Jovin S, Szabó CZK, Schmitzová J, Dybkov O, Cretu C, et al.
    Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors
    Molecular Cell. 2018; 69(6): 979-992. https://doi.org/10.1016/j.molcel.2018.02.022
    DORA PSI
  • Ahmed S, Ayscough A, Barker GR, Canning HE, Davenport R, Downham R, et al.
    1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors with a Novel Monodentate Binding Interaction
    Journal of Medicinal Chemistry. 2017; 60(13): 5663-5672. https://doi.org/10.1021/acs.jmedchem.7b00352
    DORA PSI
  • Aigner H, Wilson RH, Bracher A, Calisse L, Bhat JY, Hartl FU, et al.
    Plant RuBisCo assembly in E. coli with five chloroplast chaperones including BSD2
    Science. 2017; 358(6368): 1272-1278. https://doi.org/10.1126/science.aap9221
    DORA PSI
  • Altmann E, Erbel P, Renatus M, Schaefer M, Schlierf A, Druet A, et al.
    Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5
    Angewandte Chemie International Edition. 2017; 56(5): 1294-1297. https://doi.org/10.1002/anie.201608672
    DORA PSI
  • Bai L, Wagner T, Xu T, Hu X, Ermler U, Shima S
    A Water-Bridged H-Bonding Network Contributes to the Catalysis of the SAM-Dependent C-Methyltransferase HcgC
    Angewandte Chemie International Edition. 2017; 56(36): 10806-10809. https://doi.org/10.1002/anie.201705605
    DORA PSI
  • Bai L, Fujishiro T, Huang G, Koch J, Takabayashi A, Yokono M, et al.
    Towards artificial methanogenesis: Biosynthesis of the [Fe]-hydrogenase cofactor and characterization of the semi-synthetic hydrogenase
    Faraday Discussions. 2017; 198: 37-58. https://doi.org/10.1039/c6fd00209a
    DORA PSI
  • Bier D, Mittal S, Bravo-Rodriguez K, Sowislok A, Guillory X, Briels J, et al.
    The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface
    Journal of the American Chemical Society. 2017; 139(45): 16256-16263. https://doi.org/10.1021/jacs.7b07939
    DORA PSI
  • Bloch JS, Ruetz M, Kräutler B, Locher KP
    Structure of the human transcobalamin beta domain in four distinct states
    PLoS One. 2017; 12(9): e0184932. https://doi.org/10.1371/journal.pone.0184932
    DORA PSI
  • Bührmann M, Hardick J, Weisner J, Quambusch L, Rauh D
    Covalent Lipid Pocket Ligands Targeting p38α MAPK Mutants
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