Publications

PDB structures measured at X10SA


 

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Chen X-R, Poudel L, Hong Z, Johnen P, Katti S, Tripathi A, et al.
    Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity
    Journal of Biological Chemistry. 2023; 299(2): 102861 (21 pp.). https://doi.org/10.1016/j.jbc.2022.102861
    DORA PSI
  • Fedir B, Yannick M, Marco M, Patrizia F, Catherine Z, Frédéric V, et al.
    N‐terminal β‐strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor
    Protein Science. 2023; 32(1): e4545 (13 pp.). https://doi.org/10.1002/pro.4545
    DORA PSI
  • Krasavin M, Adamchik M, Bubyrev A, Heim C, Maiwald S, Zhukovsky D, et al.
    Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines
    European Journal of Medicinal Chemistry. 2023; 246: 114990 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114990
    DORA PSI
  • Mauxion F, Basquin J, Ozgur S, Rame M, Albrecht J, Schäfer I, et al.
    The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
    Cell Reports. 2023; 42. https://doi.org/10.1016/j.celrep.2022.111902
    DORA PSI
  • Rutz S, Deneka D, Dittmann A, Sawicka M, Dutzler R
    Structure of a volume-regulated heteromeric LRRC8A/C channel
    Nature Structural and Molecular Biology. 2023; 30: 52-61. https://doi.org/10.1038/s41594-022-00899-0
    DORA PSI
  • Altegoer F, Quax TEF, Weiland P, Nußbaum P, Giammarinaro PI, Patro M, et al.
    Structural insights into the mechanism of archaellar rotational switching
    Nature Communications. 2022; 13(1): 2857 (12 pp.). https://doi.org/10.1038/s41467-022-30358-9
    DORA PSI
  • Astashkin R, Kovalev K, Bukhdruker S, Vaganova S, Kuzmin A, Alekseev A, et al.
    Structural insights into light-driven anion pumping in cyanobacteria
    Nature Communications. 2022; 13(1): 6460 (13 pp.). https://doi.org/10.1038/s41467-022-34019-9
    DORA PSI
  • Aziz I, Kaltwasser S, Kayastha K, Khera R, Vonck J, Ermler U
    The molybdenum storage protein forms and deposits distinct polynuclear tungsten oxygen aggregates
    Journal of Inorganic Biochemistry. 2022; 234: 111904 (9 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111904
    DORA PSI
  • Berneburg I, Rahlfs S, Becker K, Fritz-Wolf K
    Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain
    Communications Biology. 2022; 5(1): 1353 (14 pp.). https://doi.org/10.1038/s42003-022-04307-7
    DORA PSI
  • Botte M, Ni D, Schenck S, Zimmermann I, Chami M, Bocquet N, et al.
    Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
    Nature Communications. 2022; 13(1): 1826 (10 pp.). https://doi.org/10.1038/s41467-022-29459-2
    DORA PSI
  • Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, et al.
    Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRASG12C inhibitor
    Journal of Medicinal Chemistry. 2022; 65(21): 14614-14629. https://doi.org/10.1021/acs.jmedchem.2c01120
    DORA PSI
  • Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, et al.
    Chemoproteomics-enabled identification of 4-Oxo-β-lactams as inhibitors of dipeptidyl peptidases 8 and 9
    Angewandte Chemie International Edition. 2022; 61(47): e202210498 (10 pp.). https://doi.org/10.1002/anie.202210498
    DORA PSI
  • Chakrabarti KS, Olsson S, Pratihar S, Giller K, Overkamp K, Lee KO, et al.
    A litmus test for classifying recognition mechanisms of transiently binding proteins
    Nature Communications. 2022; 13(1): 3792 (11 pp.). https://doi.org/10.1038/s41467-022-31374-5
    DORA PSI
  • Chrustowicz J, Sherpa D, Teyra J, Loke MS, Popowicz GM, Basquin J, et al.
    Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases
    Journal of Molecular Biology. 2022; 434(2): 167347 (22 pp.). https://doi.org/10.1016/j.jmb.2021.167347
    DORA PSI
  • Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, et al.
    N-heterocyclic 3-pyridyl carboxamide inhibitors of DHODH for the treatment of acute myelogenous leukemia
    Journal of Medicinal Chemistry. 2022; 65(16): 11241-11256. https://doi.org/10.1021/acs.jmedchem.2c00788
    DORA PSI
  • Dahms SO, Schnapp G, Winter M, Büttner FH, Schlepütz M, Gnamm C, et al.
    Dichlorophenylpyridine-based molecules inhibit furin through an induced-fit mechanism
    ACS Chemical Biology. 2022; 17(4): 816-821. https://doi.org/10.1021/acschembio.2c00103
    DORA PSI
  • Davies C, Dötsch L, Ciulla MG, Hennes E, Yoshida K, Gasper R, et al.
    Identification of a novel pseudo‐natural product type IV IDO1 inhibitor chemotype
    Angewandte Chemie International Edition. 2022; 61(40): e202209374 (12 pp.). https://doi.org/10.1002/anie.202209374
    DORA PSI
  • Diaz E, Adhikary S, Tepper AWJW, Riley D, Ortiz-Meoz R, Krosky D, et al.
    Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor
    Communications Biology. 2022; 5(1): 787 (14 pp.). https://doi.org/10.1038/s42003-022-03735-9
    DORA PSI
  • Dillenberger M, Rahlfs S, Becker K, Fritz-Wolf K
    Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity
    Structure. 2022; 30(10): 1452-1461.e3. https://doi.org/10.1016/j.str.2022.08.001
    DORA PSI
  • Fairhurst RA, Furet P, Imbach-Weese P, Stauffer F, Rueeger H, McCarthy C, et al.
    Identification of NVP-CLR457 as an orally bioavailable Non-CNS-Penetrant pan-class IA phosphoinositol-3-kinase inhibitor
    Journal of Medicinal Chemistry. 2022; 65(12): 8345-8379. https://doi.org/10.1021/acs.jmedchem.2c00267
    DORA PSI
  • Frei MS, Tarnawski M, Roberti MJ, Koch B, Hiblot J, Johnsson K
    Engineered HaloTag variants for fluorescence lifetime multiplexing
    Nature Methods. 2022; 19(1): 65-70. https://doi.org/10.1038/s41592-021-01341-x
    DORA PSI
  • Fritz-Wolf K, Bathke J, Rahlfs S, Becker K
    Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites
    Current Research in Structural Biology. 2022; 4: 87-95. https://doi.org/10.1016/j.crstbi.2022.03.004
    DORA PSI
  • Furet P, Bordas V, Le Douget M, Salem B, Mesrouze Y, Imbach-Weese P, et al.
    The first class of small molecules potently disrupting the YAP-TEAD interaction by direct competition
    ChemMedChem. 2022; 17(19): e202200303 (14 pp.). https://doi.org/10.1002/cmdc.202200303
    DORA PSI
  • Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, et al.
    In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M
    Journal of the American Chemical Society. 2022; 144(12): 5614-5628. https://doi.org/10.1021/jacs.2c01020
    DORA PSI
  • Gehrtz P, Marom S, Bührmann M, Hardick J, Kleinbölting S, Shraga A, et al.
    Optimization of covalent MKK7 inhibitors via crude nanomole-scale libraries
    Journal of Medicinal Chemistry. 2022; 65(15): 10341-10356. https://doi.org/10.1021/acs.jmedchem.1c02206
    DORA PSI
  • Goepfert A, Barske C, Lehmann S, Wirth E, Willemsen J, Gudjonsson JE, et al.
    IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling
    Cell Reports. 2022; 41(3): 111489 (19 pp.). https://doi.org/10.1016/j.celrep.2022.111489
    DORA PSI
  • Grethe C, Schmidt M, Kipka G-M, O’Dea R, Gallant K, Janning P, et al.
    Structural basis for specific inhibition of the deubiquitinase UCHL1
    Nature Communications. 2022; 13(1): 5950 (17 pp.). https://doi.org/10.1038/s41467-022-33559-4
    DORA PSI
  • Heim C, Hartmann MD
    High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 290-298. https://doi.org/10.1107/S2059798322000092
    DORA PSI
  • Heim C, Spring AK, Kirchgäßner S, Schwarzer D, Hartmann MD
    Identification and structural basis of C-terminal cyclic imides as natural degrons for cereblon
    Biochemical and Biophysical Research Communications. 2022; 637: 66 (7 pp.)-72. https://doi.org/10.1016/j.bbrc.2022.11.001
    DORA PSI
  • Heimsch KC, Gertzen CGW, Schuh AK, Nietzel T, Rahlfs S, Przyborski JM, et al.
    Structure and function of redox-sensitive superfolder green fluorescent protein variant
    Antioxidants and Redox Signaling. 2022; 37(1-3): 1-18. https://doi.org/10.1089/ars.2021.0234
    DORA PSI
  • Hernández Lozada NJ, Hong B, Wood JC, Caputi L, Basquin J, Chuang L, et al.
    Biocatalytic routes to stereo-divergent iridoids
    Nature Communications. 2022; 13(1): 4718 (13 pp.). https://doi.org/10.1038/s41467-022-32414-w
    DORA PSI
  • Huang Y, Sendzik M, Zhang J, Gao Z, Sun Y, Wang L, et al.
    Discovery of the clinical candidate MAK683: an EED-directed, allosteric, and selective PRC2 inhibitor for the treatment of advanced malignancies
    Journal of Medicinal Chemistry. 2022; 65(7): 5317-5333. https://doi.org/10.1021/acs.jmedchem.1c02148
    DORA PSI
  • Huang C-Y, Aumonier S, Engilberge S, Eris D, Smith KML, Leonarski F, et al.
    Probing ligand binding of endothiapepsin by 'temperature-resolved' macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 964-974. https://doi.org/10.1107/S205979832200612X
    DORA PSI
  • Huyton T, Jaiswal M, Taxer W, Fischer M, Görlich D
    Crystal structures of FNIP/FGxxFN motif-containing leucine-rich repeat proteins
    Scientific Reports. 2022; 12(1): 16430 (12 pp.). https://doi.org/10.1038/s41598-022-20758-8
    DORA PSI
  • Iskhakova ZI, Zhuravleva DE, Heim C, Hartmann MD, Laykov AV, Forchhammer K, et al.
    PotN represents a novel energy-state sensing PII subfamily, occurring in firmicutes
    FEBS Journal. 2022; 289(17): 5305-5321. https://doi.org/10.1111/febs.16431
    DORA PSI
  • Kemble AM, Hornsperger B, Ruf I, Richter H, Benz J, Kuhn B, et al.
    A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature
    PLoS One. 2022; 17(9): e0268590 (24 pp.). https://doi.org/10.1371/journal.pone.0268590
    DORA PSI
  • Kofink C, Trainor N, Mair B, Wöhrle S, Wurm M, Mischerikow N, et al.
    A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
    Nature Communications. 2022; 13(1): 5969 (15 pp.). https://doi.org/10.1038/s41467-022-33430-6
    DORA PSI
  • Krasavin M, Bubyrev A, Kazantsev A, Heim C, Maiwald S, Zhukovsky D, et al.
    Replacing the phthalimide core in thalidomide with benzotriazole
    Journal of Enzyme Inhibition and Medicinal Chemistry. 2022; 37(1): 527-530. https://doi.org/10.1080/14756366.2021.2024525
    DORA PSI
  • Kubacka D, Kozarski M, Baranowski MR, Wojcik R, Panecka‐Hofman J, Strzelecka D, et al.
    Substrate‐based design of cytosolic nucleotidase IIIB inhibitors and structural insights into inhibition mechanism
    Pharmaceuticals. 2022; 15(5): 554 (27 pp.). https://doi.org/10.3390/ph15050554
    DORA PSI
  • Langley C, Tatsis E, Hong B, Nakamura Y, Paetz C, Stevenson CEM, et al.
    Expansion of the catalytic repertoire of alcohol dehydrogenases in plant metabolism
    Angewandte Chemie International Edition. 2022; 61(48): e202210934 (7 pp.). https://doi.org/10.1002/anie.202210934
    DORA PSI
  • Langlois CR, Beier V, Karayel O, Chrustowicz J, Sherpa D, Mann M, et al.
    A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters
    EMBO Reports. 2022; 23(6): e53835 (17 pp.). https://doi.org/10.15252/embr.202153835
    DORA PSI
  • Lategahn J, Tumbrink HL, Schultz-Fademrecht C, Heimsoeth A, Werr L, Niggenaber J, et al.
    Insight into targeting exon20 insertion mutations of the epidermal growth factor receptor with wild type-sparing inhibitors
    Journal of Medicinal Chemistry. 2022; 65(9): 6643-6655. https://doi.org/10.1021/acs.jmedchem.1c02080
    DORA PSI
  • Li D, Sloman DL, Achab A, Zhou H, McGowan MA, White C, et al.
    Oxetane promise delivered: discovery of long-acting IDO1 inhibitors suitable for Q3W oral or parenteral dosing
    Journal of Medicinal Chemistry. 2022; 65(8): 6001-6016. https://doi.org/10.1021/acs.jmedchem.1c01670
    DORA PSI
  • Lorthiois E, Gerspacher M, Beyer KS, Vaupel A, Leblanc C, Stringer R, et al.
    JDQ443, a structurally novel, pyrazole-based, covalent inhibitor of KRASG12C for the treatment of solid tumors
    Journal of Medicinal Chemistry. 2022; 65(24): 16173-16203. https://doi.org/10.1021/acs.jmedchem.2c01438
    DORA PSI
  • Luebben AV, Bender D, Becker S, Crowther LM, Erven I, Hofmann K, et al.
    Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration
    Science Advances. 2022; 8(15): eabj8633 (10 pp.). https://doi.org/10.1126/sciadv.abj8633
    DORA PSI
  • Mata G, Miles DH, Drew SL, Fournier J, Lawson KV, Mailyan AK, et al.
    Design, synthesis, and structure-activity relationship optimization of pyrazolopyrimidine amide inhibitors of phosphoinositide 3-kinase γ (PI3Kγ)
    Journal of Medicinal Chemistry. 2022; 65(2): 1418-1444. https://doi.org/10.1021/acs.jmedchem.1c01153
    DORA PSI
  • Milder FJ, Jongeneelen M, Ritschel T, Bouchier P, Bisschop IJM, de Man M, et al.
    Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2022; 119(6): e2115379119 (8 pp.). https://doi.org/10.1073/pnas.2115379119
    DORA PSI
  • Moore KP, Schwaid AG, Tudor M, Park S, Beshore DC, Converso A, et al.
    A phenotypic screen identifies potent DPP9 inhibitors capable of killing HIV-1 infected cells
    ACS Chemical Biology. 2022; 17(9): 2595-2604. https://doi.org/10.1021/acschembio.2c00515
    DORA PSI
  • Obst-Sander U, Ricci A, Kuhn B, Friess T, Koldewey P, Kuglstatter A, et al.
    Discovery of novel allosteric EGFR L858R inhibitors for the treatment of non-small-cell lung cancer as a single agent or in combination with Osimertinib
    Journal of Medicinal Chemistry. 2022; 65(19): 13052-13073. https://doi.org/10.1021/acs.jmedchem.2c00893
    DORA PSI
  • Overbeck JH, Stelzig D, Fuchs AL, Wurm JP, Sprangers R
    Observation of conformational changes that underlie the catalytic cycle of Xrn2
    Nature Chemical Biology. 2022; 18: 1152-1160. https://doi.org/10.1038/s41589-022-01111-6
    DORA PSI
  • Pedrini B, Finke AD, Marsh M, Luporini P, Vallesi A, Alimenti C
    Crystal structure of the pheromone Er-13 from the ciliate Euplotes raikovi, with implications for a protein-protein association model in pheromone/receptor interactions
    Journal of Structural Biology. 2022; 214(1): 107812 (10 pp.). https://doi.org/10.1016/j.jsb.2021.107812
    DORA PSI
  • Rai A, Singh AK, Bleimling N, Posern G, Vetter IR, Goody RS
    Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector
    Nature Communications. 2022; 13(1): 4262 (17 pp.). https://doi.org/10.1038/s41467-022-31831-1
    DORA PSI
  • Rigamonti N, Veitonmäki N, Domke C, Barsin S, Jetzer S, Abdelmotaleb O, et al.
    A multispecific anti-CD40 DARPin construct induces tumor-selective CD40 activation and tumor regression
    Cancer Immunology Research. 2022; 10(5): 626-640. https://doi.org/10.1158/2326-6066.CIR-21-0553
    DORA PSI
  • Smith CR, Kulyk S, Ahmad MUD, Arkhipova V, Christensen JG, Gunn RJ, et al.
    Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits
    RSC Medicinal Chemistry. 2022; 13(12): 1549-1564. https://doi.org/10.1039/d2md00163b
    DORA PSI
  • Tosstorff A, Rudolph MG, Cole JC, Reutlinger M, Kramer C, Schaffhauser H, et al.
    A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios
    Journal of Computer-Aided Molecular Design. 2022; 36(10): 753-765. https://doi.org/10.1007/s10822-022-00478-x
    DORA PSI
  • Vollheyde K, Kühnel K, Lambrecht F, Kawelke S, Herrfurth C, Feussner I
    Crystal structure of the bifunctional wax synthase 1 from Acinetobacter baylyi suggests a conformational change upon substrate binding and formation of additional substrate binding sites
    ACS Catalysis. 2022; 12(15): 9753-9765. https://doi.org/10.1021/acscatal.2c01712
    DORA PSI
  • Vulpetti A, Lingel A, Dalvit C, Schiering N, Oberer L, Henry C, et al.
    Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19F NMR Binding Assay with Predicted 19F NMR Chemical Shifts
    ChemMedChem. 2022; 17(13): e202200163 (9 pp.). https://doi.org/10.1002/cmdc.202200163
    DORA PSI
  • Weidenweber S, Schühle K, Lippert ML, Mock J, Seubert A, Demmer U, et al.
    Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism
    FEBS Journal. 2022; 289(18): 5599-5616. https://doi.org/10.1111/febs.16443
    DORA PSI
  • Weisberg E, Chowdhury B, Meng C, Case AE, Ni W, Garg S, et al.
    BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma
    Blood Cancer Journal. 2022; 12(7): 110 (10 pp.). https://doi.org/10.1038/s41408-022-00704-7
    DORA PSI
  • Weiss A, Lorthiois E, Barys L, Beyer KS, Bomio-Confaglia C, Burks H, et al.
    Discovery, preclinical characterization, and early clinical activity of JDQ443, a structurally novel, potent, and selective covalent oral inhibitor of KRASG12C
    Cancer Discovery. 2022; 12(6): 1500-1517. https://doi.org/10.1158/2159-8290.CD-22-0158
    DORA PSI
  • Wen X, Leisinger F, Leopold V, Seebeck FP
    Synthetic reagents for enzyme-catalyzed methylation
    Angewandte Chemie International Edition. 2022; 61: e202208746 (7 pp.). https://doi.org/10.1002/anie.202208746
    DORA PSI
  • Wilson A, Andreeva EA, Niziński S, Talbot L, Hartmann E, Schlichting I, et al.
    Structure-function-dynamics relationships in the peculiar Planktothrix PCC7805 OCP1: impact of his-tagging and carotenoid type
    Biochimica et Biophysica Acta: Bioenergetics. 2022; 1863(7): 148584 (24 pp.). https://doi.org/10.1016/j.bbabio.2022.148584
    DORA PSI
  • Xu G, Liu Z, Wang X, Lu T, Desjarlais RL, Thieu T, et al.
    Discovery of potent and orally bioavailable pyridine N-oxide-based factor XIa inhibitors through exploiting nonclassical interactions
    Journal of Medicinal Chemistry. 2022; 65(15): 10419-10440. https://doi.org/10.1021/acs.jmedchem.2c00442
    DORA PSI
  • de la Roche NM, Mühlethaler T, Di Martino RMC, Ortega JA, Gioia D, Roy B, et al.
    Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
    European Journal of Medicinal Chemistry. 2022; 241: 114614 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114614
    DORA PSI
  • Augsberger C, Hänel G, Xu W, Pulko V, Hanisch LJ, Augustin A, et al.
    Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody
    Blood. 2021; 138(25): 2655 (15 pp.)-2669. https://doi.org/10.1182/blood.2020010477
    DORA PSI
  • Babu M, Favretto F, de Opakua AI, Rankovic M, Becker S, Zweckstetter M
    Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis
    Nature Communications. 2021; 12(1): 3396 (7 pp.). https://doi.org/10.1038/s41467-021-23691-y
    DORA PSI
  • Beale JH, Marsh ME
    Optimizing the growth of endothiapepsin crystals for serial crystallography experiments
    Journal of Visualized Experiments. 2021; 168: e61896 (30 pp.). https://doi.org/10.3791/61896
    DORA PSI
  • Benz J, Rufer AC, Huber S, Ehler A, Hug M, Topp A, et al.
    Novel β-Glucocerebrosidase activators that bind to a new pocket at a dimer interface and induce dimerization
    Angewandte Chemie International Edition. 2021; 60(10): 5436-5442. https://doi.org/10.1002/anie.202013890
    DORA PSI
  • Betschart C, Faller M, Zink F, Hemmig R, Blank J, Vangrevelinghe E, et al.
    Structure-based optimization of a fragment-like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist
    ACS Medicinal Chemistry Letters. 2021; 13(4): 658-664. https://doi.org/10.1021/acsmedchemlett.1c00696
    DORA PSI
  • Buchstaller H-P, Anlauf U, Dorsch D, Kögler S, Kuhn D, Lehmann M, et al.
    Optimization of a screening hit toward M2912, an oral tankyrase inhibitor with antitumor activity in colorectal cancer models
    Journal of Medicinal Chemistry. 2021; 64(14): 10371-10392. https://doi.org/10.1021/acs.jmedchem.1c00800
    DORA PSI
  • Centola M, van Pee K, Betz H, Yildiz Ö
    Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases
    Nature Communications. 2021; 12(1): 6982 (13 pp.). https://doi.org/10.1038/s41467-021-27281-w
    DORA PSI
  • Chicano TM, Dietrich L, de Almeida NM, Akram M, Hartmann E, Leidreiter F, et al.
    Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex
    Nature Microbiology. 2021; 6(9): 1129-1139. https://doi.org/10.1038/s41564-021-00934-8
    DORA PSI
  • Cretu C, Gee P, Liu X, Agrawal A, Nguyen TV, Ghosh AK, et al.
    Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
    Nature Communications. 2021; 12(1): 4491 (15 pp.). https://doi.org/10.1038/s41467-021-24741-1
    DORA PSI
  • DeSelm L, Huck B, Lan R, Neagu C, Potnick J, Xiao Y, et al.
    Identification of clinical candidate M2698, a dual p70S6K and akt inhibitor, for treatment of PAM pathway-altered cancers
    Journal of Medicinal Chemistry. 2021; 64(19): 14603-14619. https://doi.org/10.1021/acs.jmedchem.1c01087
    DORA PSI
  • Dekker C, Mattes H, Wright M, Boettcher A, Hinniger A, Hughes N, et al.
    Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition
    Journal of Molecular Biology. 2021; 433(24): 167309 (11 pp.). https://doi.org/10.1016/j.jmb.2021.167309
    DORA PSI
  • Dietl A, Barends TRM
    Dynamics in an unusual acyl carrier protein from a ladderane lipid-synthesizing organism
    Proteins. 2021; 90(1): 73-82. https://doi.org/10.1002/prot.26187
    DORA PSI
  • Ebenhoch R, Bauer M, Reinert D, Kersting A, Huber S, Schmid A, et al.
    Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP
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