Publications

PDB structures measured at X10SA


 

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Abe-Sato K, Tabuse H, Kanazawa H, Kamitani M, Endo M, Tokura S, et al.
    Structure-based optimization and biological evaluation of potent and selective MMP-7 inhibitors for kidney fibrosis
    Journal of Medicinal Chemistry. 2023; 66(21): 14653-14668. https://doi.org/10.1021/acs.jmedchem.3c01166
    DORA PSI
  • Adam S, Zheng D, Klein A, Volz C, Mullen W, Shirran SL, et al.
    Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
    Nature Chemistry. 2023; 15(4): 560-568. https://doi.org/10.1038/s41557-023-01153-w
    DORA PSI
  • Alper P, Betschart C, André C, Boulay T, Cheng D, Deane J, et al.
    Discovery of the TLR7/8 antagonist MHV370 for treatment of systemic autoimmune diseases
    ACS Medicinal Chemistry Letters. 2023; 14(8): 1054-1062. https://doi.org/10.1021/acsmedchemlett.3c00136
    DORA PSI
  • Berneburg I, Stumpf M, Velten A-S, Rahlfs S, Przyborski J, Becker K, et al.
    Structure of Leishmania donovani 6-phosphogluconate dehydrogenase and inhibition by phosphine gold(I) complexes: a potential approach to leishmaniasis treatment
    International Journal of Molecular Sciences. 2023; 24(10): 8615 (20 pp.). https://doi.org/10.3390/ijms24108615
    DORA PSI
  • Blum A, Dorsch D, Linde N, Brandstetter S, Buchstaller H-P, Busch M, et al.
    Identification of M4205 - a highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors
    Journal of Medicinal Chemistry. 2023; 66(4): 2386-2395. https://doi.org/10.1021/acs.jmedchem.2c00851
    DORA PSI
  • Boland C, Huang C-Y, Shanker Kaki S, Wang M, Olieric V, Caffrey M
    Se-MAG is a convenient additive for experimental phasing and structure determination of membrane proteins crystallised by the lipid cubic phase (in meso) method
    Crystals. 2023; 13(9): 1402 (20 pp.). https://doi.org/10.3390/cryst13091402
    DORA PSI
  • Buchstaller H-P, Sala-Hojman A, Leiendecker M, Albers J, Anlauf U, Berges N, et al.
    Discovery of cycloalkyl[c]thiophenes as novel scaffolds for hypoxia-inducible factor-2α inhibitors
    Journal of Medicinal Chemistry. 2023; 66(13): 8666-8686. https://doi.org/10.1021/acs.jmedchem.3c00332
    DORA PSI
  • Bührmann M, Kallepu S, Warmuth JD, Wiese JN, Ehrt C, Vatheuer H, et al.
    FRAGTORY: pharmacophore-focused design, synthesis, and evaluation of an sp3-enriched fragment library
    Journal of Medicinal Chemistry. 2023; 66(9): 6297-6314. https://doi.org/10.1021/acs.jmedchem.3c00187
    DORA PSI
  • Chen X-R, Poudel L, Hong Z, Johnen P, Katti S, Tripathi A, et al.
    Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity
    Journal of Biological Chemistry. 2023; 299(2): 102861 (21 pp.). https://doi.org/10.1016/j.jbc.2022.102861
    DORA PSI
  • Claff T, Schlegel JG, Voss JH, Vaaßen VJ, Weiße RH, Cheng RKY, et al.
    Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction
    Communications Chemistry. 2023; 6(1): 106 (10 pp.). https://doi.org/10.1038/s42004-023-00894-6
    DORA PSI
  • Cumming JG, Kreis L, Kühne H, Wermuth R, Vercruysse M, Kramer C, et al.
    Discovery of a series of indane-containing NBTIs with activity against multidrug-resistant gram-negative pathogens
    ACS Medicinal Chemistry Letters. 2023; 14(7): 993-998. https://doi.org/10.1021/acsmedchemlett.3c00187
    DORA PSI
  • Demin S, Peschiulli A, Velter AI, Vos A, De Boeck B, Miller B, et al.
    Macrocyclic carbon-linked pyrazoles as novel inhibitors of MCL-1
    ACS Medicinal Chemistry Letters. 2023; 14(7): 955-961. https://doi.org/10.1021/acsmedchemlett.3c00141
    DORA PSI
  • Dietl A, Wellach K, Mahadevan P, Mertes N, Winter SL, Kutsch T, et al.
    Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference
    Journal of Biological Chemistry. 2023; 299(5): 104602 (15 pp.). https://doi.org/10.1016/j.jbc.2023.104602
    DORA PSI
  • Dillenberger M, Werner A-D, Velten A-S, Rahlfs S, Becker K, Fritz-Wolf K
    Structural analysis of Plasmodium falciparum hexokinase provides novel information about catalysis due to a Plasmodium-specific insertion
    International Journal of Molecular Sciences. 2023; 24(16): 12739 (20 pp.). https://doi.org/10.3390/ijms241612739
    DORA PSI
  • Duan J, Hemschemeier A, Burr DJ, Stripp ST, Hofmann E, Happe T
    Cyanide binding to [FeFe]-hydrogenase stabilizes the alternative configuration of the proton transfer pathway
    Angewandte Chemie International Edition. 2023; 62(7): e202216903 (4 pp.). https://doi.org/10.1002/anie.202216903
    DORA PSI
  • Duvall JR, Thomas JD, Bukhalid RA, Catcott KC, Bentley KW, Collins SD, et al.
    Discovery and optimization of a STING agonist platform for application in antibody drug conjugates
    Journal of Medicinal Chemistry. 2023; 66(15): 10715-10733. https://doi.org/10.1021/acs.jmedchem.3c00907
    DORA PSI
  • Ebenhoch R, Bauer M, Romig H, Gottschling D, Kley JT, Heine N, et al.
    Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design
    Acta Crystallographica Section D: Structural Biology. 2023; 79(10): 871-880. https://doi.org/10.1107/S2059798323006137
    DORA PSI
  • Fedir B, Yannick M, Marco M, Patrizia F, Catherine Z, Frédéric V, et al.
    N‐terminal β‐strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor
    Protein Science. 2023; 32(1): e4545 (13 pp.). https://doi.org/10.1002/pro.4545
    DORA PSI
  • Fischman S, Levin I, Rondeau J-M, Štrajbl M, Lehmann S, Huber T, et al.
    "Redirecting an anti-IL-1β antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A"
    Communications Biology. 2023; 6(1): 997 (13 pp.). https://doi.org/10.1038/s42003-023-05369-x
    DORA PSI
  • Gehl M, Demmer U, Ermler U, Shima S
    Crystal structure of FAD-independent methylene-tetrahydrofolate reductase from Mycobacterium hassiacum
    Proteins. 2023. https://doi.org/10.1002/prot.26504
    DORA PSI
  • Goebel L, Kirschner T, Koska S, Rai A, Janning P, Maffini S, et al.
    Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
    eLife. 2023; 12: e82184 (22 pp.). https://doi.org/10.7554/elife.82184
    DORA PSI
  • Grädler U, Schwarz D, Wegener A, Eichhorn T, Bandeiras TM, Freitas MC, et al.
    Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding
    Journal of Biological Chemistry. 2023; 299(11): 105328 (14 pp.). https://doi.org/10.1016/j.jbc.2023.105328
    DORA PSI
  • Guerlavais V, Sawyer TK, Carvajal L, Chang YS, Graves B, Ren J-G, et al.
    Discovery of sulanemadlin (ALRN-6924), the first cell-permeating, stabilized α-helical peptide in clinical development
    Journal of Medicinal Chemistry. 2023; 66(14): 9401-9417. https://doi.org/10.1021/acs.jmedchem.3c00623
    DORA PSI
  • Heim C, Spring A-K, Kirchgäßner S, Schwarzer D, Hartmann MD
    Cereblon neo-substrate binding mimics the recognition of the cyclic imide degron
    Biochemical and Biophysical Research Communications. 2023; 646: 30-35. https://doi.org/10.1016/j.bbrc.2023.01.051
    DORA PSI
  • Hellweg L, Edenhofer A, Barck L, Huppertz MC, Frei MS, Tarnawski M, et al.
    A general method for the development of multicolor biosensors with large dynamic ranges
    Nature Chemical Biology. 2023; 19: 1147-1157. https://doi.org/10.1038/s41589-023-01350-1
    DORA PSI
  • Hiemstra IH, Santegoets KCM, Janmaat ML, De Goeij BECG, Ten Hagen W, van Dooremalen S, et al.
    Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity
    EBioMedicine. 2023; 93: 104663 (19 pp.). https://doi.org/10.1016/j.ebiom.2023.104663
    DORA PSI
  • Hommel U, Hurth K, Rondeau J-M, Vulpetti A, Ostermeier D, Boettcher A, et al.
    Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β
    Nature Communications. 2023; 14(1): 5497 (13 pp.). https://doi.org/10.1038/s41467-023-41190-0
    DORA PSI
  • Imai Y, Suzuki R, Wakasugi D, Matsuda D, Tanaka-Yamamoto N, Ohki Y, et al.
    Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor
    Bioorganic and Medicinal Chemistry. 2023; 93: 117460 (15 pp.). https://doi.org/10.1016/j.bmc.2023.117460
    DORA PSI
  • Kalliokoski T, Kettunen H, Kumpulainen E, Kettunen E, Thieulin-Pardo G, Neumann L, et al.
    Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening
    Bioorganic and Medicinal Chemistry Letters. 2023; 94: 129450 (8 pp.). https://doi.org/10.1016/j.bmcl.2023.129450
    DORA PSI
  • Kim D, Herdeis L, Rudolph D, Zhao Y, Böttcher J, Vides A, et al.
    Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
    Nature. 2023; 619(7968): 160-166. https://doi.org/10.1038/s41586-023-06123-3
    DORA PSI
  • Kompa J, Bruins J, Glogger M, Wilhelm J, Frei MS, Tarnawski M, et al.
    Exchangeable HaloTag ligands for super-resolution fluorescence microscopy
    Journal of the American Chemical Society. 2023; 145(5): 3075-3083. https://doi.org/10.1021/jacs.2c11969
    DORA PSI
  • Krasavin M, Adamchik M, Bubyrev A, Heim C, Maiwald S, Zhukovsky D, et al.
    Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines
    European Journal of Medicinal Chemistry. 2023; 246: 114990 (12 pp.). https://doi.org/10.1016/j.ejmech.2022.114990
    DORA PSI
  • Krieger J, Sorrell FJ, Wegener AA, Leuthner B, Machrouhi-Porcher F, Hecht M, et al.
    Systematic potency and property assessment of VHL ligands and implications on PROTAC design
    ChemMedChem. 2023; 18(8): e202200615 (11 pp.). https://doi.org/10.1002/cmdc.202200615
    DORA PSI
  • Kuhn B, Ritter M, Benz J, Kocer B, Sarie JC, Hochstrasser R, et al.
    Novel potent and highly selective DDR1 inhibitors from integrated lead finding
    Medicinal Chemistry Research. 2023; 32(7): 1400-1425. https://doi.org/10.1007/s00044-023-03066-2
    DORA PSI
  • Leit S, Greenwood J, Carriero S, Mondal S, Abel R, Ashwell M, et al.
    Discovery of a potent and selective tyrosine kinase 2 inhibitor: TAK-279
    Journal of Medicinal Chemistry. 2023; 66: 10473-10496. https://doi.org/10.1021/acs.jmedchem.3c00600
    DORA PSI
  • Liu J, Chiang H-C, Xiong W, Laurent V, Griffiths SC, Dülfer J, et al.
    A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer
    Journal for ImmunoTherapy of Cancer. 2023; 11(6): e006720 (14 pp.). https://doi.org/10.1136/jitc-2023-006720
    DORA PSI
  • Martinelli P, Schaaf O, Mantoulidis A, Martin LJ, Fuchs JE, Bader G, et al.
    Discovery of a chemical probe to study implications of BPTF bromodomain inhibition in cellular and in vivo experiments
    ChemMedChem. 2023; 18(6): e202200686 (8 pp.). https://doi.org/10.1002/cmdc.202200686
    DORA PSI
  • Mauxion F, Basquin J, Ozgur S, Rame M, Albrecht J, Schäfer I, et al.
    The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
    Cell Reports. 2023; 42(1): 111902 (18 pp.). https://doi.org/10.1016/j.celrep.2022.111902
    DORA PSI
  • Mesrouze Y, Gubler H, Villard F, Boesch R, Ottl J, Kallen J, et al.
    Biochemical and structural characterization of a peptidic inhibitor of the YAP:TEAD interaction that binds to the α-Helix Pocket on TEAD
    ACS Chemical Biology. 2023; 18(3): 643-651. https://doi.org/10.1021/acschembio.2c00936
    DORA PSI
  • Mhaindarkar VP, Rasche R, Kümmel D, Rudolph MG, Klostermeier D
    Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain
    Acta Crystallographica Section D: Structural Biology. 2023; 79(6): 498-507. https://doi.org/10.1107/S2059798323002565
    DORA PSI
  • Miyagi H, Suzuki M, Yasunaga M, Asada H, Iwata S, Saito J-ichi
    Structural insight into an anti-BRIL Fab as a G-protein-coupled receptor crystallization chaperone
    Acta Crystallographica Section D: Structural Biology. 2023; 79(5): 435-441. https://doi.org/10.1107/S205979832300311X
    DORA PSI
  • Nain-Perez A, Nilsson O, Lulla A, Håversen L, Brear P, Liljenberg S, et al.
    Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators
    European Journal of Medicinal Chemistry. 2023; 250: 115177 (18 pp.). https://doi.org/10.1016/j.ejmech.2023.115177
    DORA PSI
  • Ohta A, Tanada M, Shinohara S, Morita Y, Nakano K, Yamagishi Y, et al.
    Validation of a new methodology to create oral drugs beyond the rule of 5 for intracellular tough targets
    Journal of the American Chemical Society. 2023; 145(44): 24035-24051. https://doi.org/10.1021/jacs.3c07145
    DORA PSI
  • O’Dea R, Kazi N, Hoffmann-Benito A, Zhao Z, Recknagel S, Wendrich K, et al.
    Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36
    Nature Chemical Biology. 2023; 19(11): 1394-1405. https://doi.org/10.1038/s41589-023-01388-1
    DORA PSI
  • Roehrig S, Ackerstaff J, Jiménez Núñez E, Teller H, Ellerbrock P, Meier K, et al.
    Design and preclinical characterization program toward Asundexian (BAY 2433334), an oral factor XIa inhibitor for the prevention and treatment of thromboembolic disorders
    Journal of Medicinal Chemistry. 2023; 66(17): 12203-12224. https://doi.org/10.1021/acs.jmedchem.3c00795
    DORA PSI
  • Rutz S, Deneka D, Dittmann A, Sawicka M, Dutzler R
    Structure of a volume-regulated heteromeric LRRC8A/C channel
    Nature Structural and Molecular Biology. 2023; 30: 52-61. https://doi.org/10.1038/s41594-022-00899-0
    DORA PSI
  • Schmeing S, Amrahova G, Bigler K, Chang JY, Openy J, Pal S, et al.
    Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding
    Chemical Science. 2023; 14(31): 8269-8278. https://doi.org/10.1039/d3sc00985h
    DORA PSI
  • Schröder M, Leiendecker M, Grädler U, Braun J, Blum A, Wanior M, et al.
    MSC-1186, a highly selective Pan-SRPK inhibitor based on an exceptionally decorated benzimidazole-pyrimidine core
    Journal of Medicinal Chemistry. 2023; 66(1): 837-854. https://doi.org/10.1021/acs.jmedchem.2c01705
    DORA PSI
  • Selim KA, Haffner M, Mantovani O, Albrecht R, Zhu H, Hagemann M, et al.
    Carbon signaling protein SbtB possesses atypical redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2023; 120(8): e2205882120 (11 pp.). https://doi.org/10.1073/pnas.2205882120
    DORA PSI
  • Sellner H, Chapeau E, Furet P, Voegtle M, Salem B, Le Douget M, et al.
    Optimization of a class of dihydrobenzofurane analogs toward orally efficacious YAP-TEAD protein-protein interaction inhibitors
    ChemMedChem. 2023; 18(11): e202300051 (23 pp.). https://doi.org/10.1002/cmdc.202300051
    DORA PSI
  • Sikandar A, Popoff A, Jumde RP, Mándi A, Kaur A, Elgaher WAM, et al.
    Revision of the absolute configurations of chelocardin and amidochelocardin
    Angewandte Chemie International Edition. 2023; 62(40): e202306437 (5 pp.). https://doi.org/10.1002/anie.202306437
    DORA PSI
  • Smith KML, Panepucci E, Kaminski JW, Aumonier S, Huang C-Y, Eris D, et al.
    SDU - software for high-throughput automated data collection at the Swiss Light Source
    Journal of Synchrotron Radiation. 2023; 30: 538-545. https://doi.org/10.1107/S1600577523002631
    DORA PSI
  • Stegmann DP, Steuber J, Fritz G, Wojdyla JA, Sharpe ME
    Fast fragment and compound screening pipeline at the Swiss Light Source
    In: Methods in enzymology. sine loco: Elsevier; 2023. https://doi.org/10.1016/bs.mie.2023.08.005
    DORA PSI
  • Steinebach C, Bricelj A, Murgai A, Sosič I, Bischof L, Ng YLD, et al.
    Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs
    Journal of medicinal chemistry (NOT FOUND). 2023; 66(21): 14513-14543. https://doi.org/10.1021/acs.jmedchem.3c00851
    DORA PSI
  • Stephan P, Langley C, Winkler D, Basquin J, Caputi L, O'Connor SE, et al.
    Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase**
    Angewandte Chemie International Edition. 2023; 62(35): e202304843 (6 pp.). https://doi.org/10.1002/anie.202304843
    DORA PSI
  • Toure M, Johnson T, Li B, Schmidt R, Ma H, Neagu C, et al.
    Discovery of quinazoline HPK1 inhibitors with high cellular potency
    Bioorganic and Medicinal Chemistry. 2023; 92: 117423 (16 pp.). https://doi.org/10.1016/j.bmc.2023.117423
    DORA PSI
  • Valiente-Gabioud AA, Garteizgogeascoa Suñer I, Idziak A, Fabritius A, Basquin J, Angibaud J, et al.
    Fluorescent sensors for imaging of interstitial calcium
    Nature Communications. 2023; 14(1): 6220 (15 pp.). https://doi.org/10.1038/s41467-023-41928-w
    DORA PSI
  • Vulpetti A, Holzer P, Schmiedeberg N, Imbach-Weese P, Pissot-Soldermann C, Hollingworth GJ, et al.
    Discovery of new binders for DCAF1, an emerging ligase target in the targeted protein degradation field
    ACS Medicinal Chemistry Letters. 2023; 14(7): 949-954. https://doi.org/10.1021/acsmedchemlett.3c00104
    DORA PSI
  • Zhao Z, O’Dea R, Wendrich K, Kazi N, Gersch M
    Native semisynthesis of isopeptide-linked substrates for specificity analysis of deubiquitinases and Ubl proteases
    Journal of the American Chemical Society. 2023; 145(38): 20801-20812. https://doi.org/10.1021/jacs.3c04062
    DORA PSI
  • Altegoer F, Quax TEF, Weiland P, Nußbaum P, Giammarinaro PI, Patro M, et al.
    Structural insights into the mechanism of archaellar rotational switching
    Nature Communications. 2022; 13(1): 2857 (12 pp.). https://doi.org/10.1038/s41467-022-30358-9
    DORA PSI
  • Astashkin R, Kovalev K, Bukhdruker S, Vaganova S, Kuzmin A, Alekseev A, et al.
    Structural insights into light-driven anion pumping in cyanobacteria
    Nature Communications. 2022; 13(1): 6460 (13 pp.). https://doi.org/10.1038/s41467-022-34019-9
    DORA PSI
  • Aziz I, Kaltwasser S, Kayastha K, Khera R, Vonck J, Ermler U
    The molybdenum storage protein forms and deposits distinct polynuclear tungsten oxygen aggregates
    Journal of Inorganic Biochemistry. 2022; 234: 111904 (9 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111904
    DORA PSI
  • Berneburg I, Rahlfs S, Becker K, Fritz-Wolf K
    Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain
    Communications Biology. 2022; 5(1): 1353 (14 pp.). https://doi.org/10.1038/s42003-022-04307-7
    DORA PSI
  • Beroza P, Crawford JJ, Ganichkin O, Gendelev L, Harris SF, Klein R, et al.
    Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
    Nature Communications. 2022; 13(1): 6447 (10 pp.). https://doi.org/10.1038/s41467-022-33981-8
    DORA PSI
  • Botte M, Ni D, Schenck S, Zimmermann I, Chami M, Bocquet N, et al.
    Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
    Nature Communications. 2022; 13(1): 1826 (10 pp.). https://doi.org/10.1038/s41467-022-29459-2
    DORA PSI
  • Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, et al.
    Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRASG12C inhibitor
    Journal of Medicinal Chemistry. 2022; 65(21): 14614-14629. https://doi.org/10.1021/acs.jmedchem.2c01120
    DORA PSI
  • Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, et al.
    Chemoproteomics-enabled identification of 4-Oxo-β-lactams as inhibitors of dipeptidyl peptidases 8 and 9
    Angewandte Chemie International Edition. 2022; 61(47): e202210498 (10 pp.). https://doi.org/10.1002/anie.202210498
    DORA PSI
  • Chakrabarti KS, Olsson S, Pratihar S, Giller K, Overkamp K, Lee KO, et al.
    A litmus test for classifying recognition mechanisms of transiently binding proteins
    Nature Communications. 2022; 13(1): 3792 (11 pp.). https://doi.org/10.1038/s41467-022-31374-5
    DORA PSI
  • Chrustowicz J, Sherpa D, Teyra J, Loke MS, Popowicz GM, Basquin J, et al.
    Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases
    Journal of Molecular Biology. 2022; 434(2): 167347 (22 pp.). https://doi.org/10.1016/j.jmb.2021.167347
    DORA PSI
  • Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, et al.
    N-heterocyclic 3-pyridyl carboxamide inhibitors of DHODH for the treatment of acute myelogenous leukemia
    Journal of Medicinal Chemistry. 2022; 65(16): 11241-11256. https://doi.org/10.1021/acs.jmedchem.2c00788
    DORA PSI
  • Dahms SO, Schnapp G, Winter M, Büttner FH, Schlepütz M, Gnamm C, et al.
    Dichlorophenylpyridine-based molecules inhibit furin through an induced-fit mechanism
    ACS Chemical Biology. 2022; 17(4): 816-821. https://doi.org/10.1021/acschembio.2c00103
    DORA PSI
  • Davies C, Dötsch L, Ciulla MG, Hennes E, Yoshida K, Gasper R, et al.
    Identification of a novel pseudo‐natural product type IV IDO1 inhibitor chemotype
    Angewandte Chemie International Edition. 2022; 61(40): e202209374 (12 pp.). https://doi.org/10.1002/anie.202209374
    DORA PSI
  • Diaz E, Adhikary S, Tepper AWJW, Riley D, Ortiz-Meoz R, Krosky D, et al.
    Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor
    Communications Biology. 2022; 5(1): 787 (14 pp.). https://doi.org/10.1038/s42003-022-03735-9
    DORA PSI
  • Dillenberger M, Rahlfs S, Becker K, Fritz-Wolf K
    Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity
    Structure. 2022; 30(10): 1452-1461.e3. https://doi.org/10.1016/j.str.2022.08.001
    DORA PSI
  • Fairhurst RA, Furet P, Imbach-Weese P, Stauffer F, Rueeger H, McCarthy C, et al.
    Identification of NVP-CLR457 as an orally bioavailable Non-CNS-Penetrant pan-class IA phosphoinositol-3-kinase inhibitor
    Journal of Medicinal Chemistry. 2022; 65(12): 8345-8379. https://doi.org/10.1021/acs.jmedchem.2c00267
    DORA PSI
  • Frei MS, Tarnawski M, Roberti MJ, Koch B, Hiblot J, Johnsson K
    Engineered HaloTag variants for fluorescence lifetime multiplexing
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