Publications

PDB structures measured at X06SA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Berger B-T, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, et al.
    Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
    Cell Chemical Biology. 2021. https://doi.org/10.1016/j.chembiol.2021.01.003
    DORA PSI
  • Delfosse V, Huet T, Harrus D, Granell M, Bourguet M, Gardia-Parège C, et al.
    Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(1): e2020551118 (10 pp.). https://doi.org/10.1073/PNAS.2020551118
    DORA PSI
  • Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, et al.
    Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism
    Science Advances. 2021; 7(5): eabe5504 (15 pp.). https://doi.org/10.1126/sciadv.abe5504
    DORA PSI
  • Dimovasili C, Fadouloglou VE, Kefala A, Providaki M, Kotsifaki D, Kanavouras K, et al.
    Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology
    Journal of Neurochemistry. 2021. https://doi.org/10.1111/jnc.15296
    DORA PSI
  • Focht D, Neumann C, Lyons J, Eguskiza Bilbao A, Blunck R, Malinauskaite L, et al.
    A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition
    EMBO Journal. 2021; 40(1): e105164 (13 pp.). https://doi.org/10.15252/embj.2020105164
    DORA PSI
  • Ostertag E, Zheng L, Broger K, Stehle T, Li S-M, Zocher G
    Reprogramming substrate and catalytic promiscuity of tryptophan prenyltransferases
    Journal of Molecular Biology. 2021; 433(2): 166726 (14 pp.). https://doi.org/10.1016/j.jmb.2020.11.025
    DORA PSI
  • Peter MF, Gebhardt C, Glaenzer J, Schneberger N, de Boer M, Thomas GH, et al.
    Triggering closure of a sialic acid TRAP transporter substrate binding protein through binding of natural or artificial substrates
    Journal of Molecular Biology. 2021; 433(3): 166756 (15 pp.). https://doi.org/10.1016/j.jmb.2020.166756
    DORA PSI
  • Shen Y, Kalograiaki I, Prunotto A, Dunne M, Boulos S, Taylor NMI, et al.
    Structural basis for recognition of bacterial cell wall teichoic acid by pseudo-symmetric SH3b-like repeats of a viral peptidoglycan hydrolase
    Chemical Science. 2021; 12(2): 576-589. https://doi.org/10.1039/d0sc04394j
    DORA PSI
  • Tomašič T, Rabbani S, Jakob RP, Reisner A, Jakopin Ž, Maier T, et al.
    Does targeting Arg98 of FimH lead to high affinity antagonists?
    European Journal of Medicinal Chemistry. 2021; 211: 113093 (16 pp.). https://doi.org/10.1016/j.ejmech.2020.113093
    DORA PSI
  • Zhang L, Bill E, Kroneck PMH, Einsle O
    A [3Cu:2S] cluster provides insight into the assembly and function of the CuZ site of nitrous oxide reductase
    Chemical Science. 2021. https://doi.org/10.1039/D0SC05204C
    DORA PSI
  • Zhang L, Bill E, Kroneck PMH, Einsle O
    Histidine-gated proton-coupled electron transfer to the CuA site of nitrous oxide reductase
    Journal of the American Chemical Society. 2021; 143(2): 830-838. https://doi.org/10.1021/jacs.0c10057
    DORA PSI
  • Arnold FM, Weber MS, Gonda I, Gallenito MJ, Adenau S, Egloff P, et al.
    The ABC exporter IrtAB imports and reduces mycobacterial siderophores
    Nature. 2020; 580(7803): 413-417. https://doi.org/10.1038/s41586-020-2136-9
    DORA PSI
  • Badmann T, Groll M
    Structures in tetrahydrofolate methylation in desulfitobacterial glycine betaine metabolism at atomic resolution
    ChemBioChem. 2020; 21(6): 776-779. https://doi.org/10.1002/cbic.201900515
    DORA PSI
  • Bao C, Bajrami B, Marcotte DJ, Chodaparambil JV, Kerns HM, Henderson J, et al.
    Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms
    Cellular and Molecular Neurobiology. 2020. https://doi.org/10.1007/s10571-020-00875-6
    DORA PSI
  • Bauer MR, Krämer A, Settanni G, Jones RN, Ni X, Khan Tareque R, et al.
    Targeting cavity-creating p53 cancer mutations with small-molecule stabilizers: the Y220X paradigm
    ACS Chemical Biology. 2020; 15(3): 657-668. https://doi.org/10.1021/acschembio.9b00748
    DORA PSI
  • Bracco P, Wijma HJ, Nicolai B, Rodriguez Buitrago JA, Klünemann T, Vila A, et al.
    CYP154C5 regioselectivity in steroid hydroxylation explored by substrate modifications and protein engineering
    ChemBioChem. 2020. https://doi.org/10.1002/cbic.202000735
    DORA PSI
  • Brunner JD, Jakob RP, Schulze T, Neldner Y, Moroni A, Thiel G, et al.
    Structural basis for ion selectivity in TMEM175 K+ channels
    eLife. 2020; 9: e53683 (24 pp.). https://doi.org/10.7554/eLife.53683
    DORA PSI
  • Bräuer A, Zhou Q, Grammbitter GLC, Schmalhofer M, Rühl M, Kaila VRI, et al.
    Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis
    Nature Chemistry. 2020; 12(8): 755-763. https://doi.org/10.1038/s41557-020-0491-7
    DORA PSI
  • Buonfiglio R, Prati F, Bischetti M, Cavarischia C, Furlotti G, Ombrato R
    Discovery of novel imidazopyridine GSK-3β inhibitors supported by cmputational approaches
    Molecules. 2020; 25(9): 2163 (29 pp.). https://doi.org/10.3390/molecules25092163
    DORA PSI
  • Caldwell SJ, Haydon IC, Piperidou N, Huang P-S, Bick MJ, Sjöström HS, et al.
    Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(48): 30362-30369. https://doi.org/10.1073/pnas.2008535117
    DORA PSI
  • Chaikuad A, Pollinger J, Rühl M, Ni X, Kilu W, Heering J, et al.
    Comprehensive set of tertiary complex structures and palmitic acid binding provide molecular insights into ligand design for RXR isoforms
    International Journal of Molecular Sciences. 2020; 21(22): 1-13. https://doi.org/10.3390/ijms21228457
    DORA PSI
  • Colarusso S, De Simone D, Frattarelli T, Andreini M, Cerretani M, Missineo A, et al.
    Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction
    Bioorganic and Medicinal Chemistry. 2020; 28(21): 115738 (12 pp.). https://doi.org/10.1016/j.bmc.2020.115738
    DORA PSI
  • Collie GW, Michaelides IN, Embrey K, Stubbs CJ, Börjesson U, Dale IL, et al.
    Structural basis for targeting the folded P-loop conformation of c-MET
    ACS Medicinal Chemistry Letters. 2020. https://doi.org/10.1021/acsmedchemlett.0c00392
    DORA PSI
  • Crack JC, Amara P, Volbeda A, Mouesca J-M, Rohac R, Pellicer Martinez MT, et al.
    Electron and proton transfers modulate DNA binding by the transcription regulator RsrR
    Journal of the American Chemical Society. 2020; 142(11): 5104-5116. https://doi.org/10.1021/jacs.9b12250
    DORA PSI
  • Dolbois A, Batiste L, Wiedmer L, Dong J, Brütsch M, Huang D, et al.
    Hitting a moving target: simulation and crystallography study of ATAD2 bromodomain blockers
    ACS Medicinal Chemistry Letters. 2020; 11(8): 1573-1580. https://doi.org/10.1021/acsmedchemlett.0c00080
    DORA PSI
  • Draxler SW, Bauer M, Eickmeier C, Nadal S, Nar H, Rangel Rojas D, et al.
    Hybrid screening approach for very small fragments: X-ray and computational screening on FKBP51
    Journal of Medicinal Chemistry. 2020; 63(11): 5856-5864. https://doi.org/10.1021/acs.jmedchem.0c00120
    DORA PSI
  • Du D, Katsuyama Y, Horiuchi M, Fushinobu S, Chen A, Davis TD, et al.
    Structural basis for selectivity in a highly reducing type II polyketide synthase
    Nature Chemical Biology. 2020; 16: 776-782. https://doi.org/10.1038/s41589-020-0530-0
    DORA PSI
  • Ernst S, Ecker F, Kaspers MS, Ochtrop P, Hedberg C, Groll M, et al.
    Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination
    Science Advances. 2020; 6(20): eaaz8041 (14 pp.). https://doi.org/10.1126/sciadv.aaz8041
    DORA PSI
  • Ernst P, Zosel F, Reichen C, Nettels D, Schuler B, Plückthun A
    Structure-guided design of a peptide lock for modular peptide binders
    ACS Chemical Biology. 2020; 15(2): 457-468. https://doi.org/10.1021/acschembio.9b00928
    DORA PSI
  • Exner TE, Becker S, Becker S, Boniface-Guiraud A, Delepelaire P, Diederichs K, et al.
    Binding of HasA by its transmembrane receptor HasR follows a conformational funnel mechanism
    European Biophysics Journal. 2020; 49(1): 39-57. https://doi.org/10.1007/s00249-019-01411-1
    DORA PSI
  • Fairhurst RA, Knoepfel T, Buschmann N, Leblanc C, Mah R, Todorov M, et al.
    Discovery of roblitinib (FGF401) as a reversible-covalent inhibitor of the kinase activity of fibroblast growth factor receptor 4
    Journal of Medicinal Chemistry. 2020; 63(21): 12542-12573. https://doi.org/10.1021/acs.jmedchem.0c01019
    DORA PSI
  • Ferri E, Le Thomas A, Ackerly Wallweber H, Day ES, Walters BT, Kaufman SE, et al.
    Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
    Nature Communications. 2020; 11(1): 6387 (15 pp.). https://doi.org/10.1038/s41467-020-19974-5
    DORA PSI
  • Gandini R, Reichenbach T, Spadiut O, Tan T-C, Kalyani DC, Divne C
    A transmembrane crenarchaeal mannosyltransferase is involved in N-glycan biosynthesis and displays an unexpected minimal cellulose-synthase-like fold
    Journal of Molecular Biology. 2020; 432(16): 4658-4672. https://doi.org/10.1016/j.jmb.2020.06.016
    DORA PSI
  • Gao L, Meiring JCM, Kraus Y, Wranik M, Weinert T, Pritzl SD, et al.
    A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
    Cell Chemical Biology. 2020. https://doi.org/10.1016/j.chembiol.2020.11.007
    DORA PSI
  • Ge P, Scholl D, Prokhorov NS, Avaylon J, Shneider MM, Browning C, et al.
    Action of a minimal contractile bactericidal nanomachine
    Nature. 2020; 580(7805): 658-662. https://doi.org/10.1038/s41586-020-2186-z
    DORA PSI
  • Gebel J, Tuppi M, Chaikuad A, Hötte K, Schröder M, Schulz L, et al.
    p63 uses a switch-like mechanism to set the threshold for induction of apoptosis
    Nature Chemical Biology. 2020; 16: 1078-1086. https://doi.org/10.1038/s41589-020-0600-3
    DORA PSI
  • Gellrich L, Heitel P, Heering J, Kilu W, Pollinger J, Goebel T, et al.
    L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ
    Journal of Medicinal Chemistry. 2020; 63(13): 6727-6740. https://doi.org/10.1021/acs.jmedchem.9b02150
    DORA PSI
  • Gotfryd K, Boesen T, Mortensen JS, Khelashvili G, Quick M, Terry DS, et al.
    X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
    Nature Communications. 2020; 11(1): 1005 (14 pp.). https://doi.org/10.1038/s41467-020-14735-w
    DORA PSI
  • Grob P, Huber M, Walla B, Hermann J, Janowski R, Niessing D, et al.
    Crystal contact engineering enables efficient capture and purification of an oxidoreductase by technical crystallization
    Biotechnology Journal. 2020; 15(11): 2000010 (8 pp.). https://doi.org/10.1002/biot.202000010
    DORA PSI
  • Grāve K, Griese JJ, Berggren G, Bennett MD, Högbom M
    The Bacillus anthracis class Ib ribonucleotide reductase subunit NrdF intrinsically selects manganese over iron
    Journal of Biological Inorganic Chemistry. 2020; 25: 571-582. https://doi.org/10.1007/s00775-020-01782-3
    DORA PSI
  • Görlich S, Samuel AJ, Best RJ, Seidel R, Vacelet J, Leonarski FK, et al.
    Natural hybrid silica/protein superstructure at atomic resolution
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(49): 31088-31093. https://doi.org/10.1073/pnas.2019140117
    DORA PSI
  • Hanke T, Cheung S-Y, Kilu W, Heering J, Ni X, Planz V, et al.
    A selective modulator of peroxisome proliferator-activated receptor γ with an unprecedented binding mode
    Journal of Medicinal Chemistry. 2020; 63(9): 4555-4561. https://doi.org/10.1021/acs.jmedchem.9b01786
    DORA PSI
  • Hepp S, Trauth J, Hasenjäger S, Bezold F, Essen L-O, Taxis C
    An optogenetic tool for induced protein stabilization based on the Phaeodactylum tricornutum aureochrome 1a light-oxygen-voltage domain
    Journal of Molecular Biology. 2020; 432(7): 1880-1900. https://doi.org/10.1016/j.jmb.2020.02.019
    DORA PSI
  • Himmelstoß M, Erharter K, Renard E, Ennifar E, Kreutz C, Micura R
    2′-O-trifluoromethylated RNA - a powerful modification for RNA chemistry and NMR spectroscopy
    Chemical Science. 2020; 11(41): 11322-11330. https://doi.org/10.1039/d0sc04520a
    DORA PSI
  • Hofmann MH, Mani R, Engelhardt H, Impagnatiello MA, Carotta S, Kerenyi M, et al.
    Selective and potent CDK8/19 inhibitors enhance NK-cell activity and promote tumor surveillance
    Molecular Cancer Therapeutics. 2020; 19(4): 1018-1030. https://doi.org/10.1158/1535-7163.MCT-19-0789
    DORA PSI
  • Hortschansky P, Misslinger M, Mörl J, Gsaller F, Bromley MJ, Brakhage AA, et al.
    Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus
    Life Science Alliance. 2020; 3(7): e202000729 (12 pp.). https://doi.org/10.26508/lsa.202000729
    DORA PSI
  • Huang C-Y, Olieric V, Caffrey M, Wang M
    In meso in situ serial X-Ray crystallography (IMISX): a protocol for membrane protein structure determination at the Swiss Light Source
    In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:293-319. https://doi.org/10.1007/978-1-0716-0373-4_20
    DORA PSI
  • Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, et al.
    An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5
    Autophagy. 2020; 16(2): 256-270. https://doi.org/10.1080/15548627.2019.1606637
    DORA PSI
  • Hügle M, Regenass P, Warstat R, Hau M, Schmidtkunz K, Lucas X, et al.
    4-acyl pyrroles as dual BET-BRD7/9 bromodomain inhibitors address BETi insensitive human cancer cell lines
    Journal of Medicinal Chemistry. 2020. https://doi.org/10.1021/acs.jmedchem.0c00478
    DORA PSI
  • Iacovino LG, Savino S, Borg AJE, Binda C, Nidetzky B, Mattevi A
    Crystallographic snapshots of UDP-glucuronic acid 4-epimerase ligand binding, rotation, and reduction
    Journal of Biological Chemistry. 2020; 295(35): 12461-12473. https://doi.org/10.1074/jbc.ra120.014692
    DORA PSI
  • Jespers W, Verdon G, Azuaje J, Majellaro M, Keränen H, García-Mera X, et al.
    X-Ray crystallography and free energy calculations reveal the binding mechanism of A2A adenosine receptor antagonists
    Angewandte Chemie International Edition. 2020; 59(38): 16536-16543. https://doi.org/10.1002/anie.202003788
    DORA PSI
  • Kaiser M, Wurm JP, Märtens B, Bläsi U, Pogoryelov D, Wöhnert J
    Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus
    FEBS Open Bio. 2020; 10(2): 221-228. https://doi.org/10.1002/2211-5463.12772
    DORA PSI
  • Karpik A, Martiel I, Kristiansen PM, Padeste C
    Fabrication of ultrathin suspended polymer membranes as supports for serial protein crystallography
    Micro and Nano Engineering. 2020; 7: 100053 (6 pp.). https://doi.org/10.1016/j.mne.2020.100053
    DORA PSI
  • Kessler D, Bergner A, Böttcher J, Fischer G, Döbel S, Hinkel M, et al.
    Drugging all RAS isoforms with one pocket
    Future Medicinal Chemistry. 2020; 12(21): 1911-1923. https://doi.org/10.4155/fmc-2020-0221
    DORA PSI
  • Kessler D, Gollner A, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, et al.
    Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(7): 3365-3367. https://doi.org/10.1073/pnas.1921236117
    DORA PSI
  • Kisgeropoulos EC, Griese JJ, Smith ZR, Branca RMM, Schneider CR, Högbom M, et al.
    Key structural motifs balance metal binding and oxidative reactivity in a heterobimetallic Mn/Fe protein
    ACS Applied Materials and Interfaces. 2020; 142(11): 5338-5354. https://doi.org/10.1021/jacs.0c00333
    DORA PSI
  • Klatt F, Leitner A, Kim IV, Ho-Xuan H, Schneider EV, Langhammer F, et al.
    A precisely positioned MED12 activation helix stimulates CDK8 kinase activity
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(6): 2894-2905. https://doi.org/10.1073/pnas.1917635117
    DORA PSI
  • Knez D, Colettis N, Iacovino LG, Sova M, Pišlar A, Konc J, et al.
    Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and B
    Journal of Medicinal Chemistry. 2020; 63(3): 1361-1387. https://doi.org/10.1021/acs.jmedchem.9b01886
    DORA PSI
  • Kries H, Bloch JS, Bunzel HA, Pinkas DM, Hilvert D
    Contribution of oxyanion stabilization to kemp eliminase efficiency
    ACS Catalysis. 2020; 10(8): 4460-4464. https://doi.org/10.1021/acscatal.0c00575
    DORA PSI
  • Leger PR, Hu DX, Biannic B, Bui M, Han X, Karbarz E, et al.
    Discovery of potent, selective, and orally bioavailable inhibitors of USP7 with in vivo antitumor activity
    Journal of Medicinal Chemistry. 2020; 63(10): 5398-5420. https://doi.org/10.1021/acs.jmedchem.0c00245
    DORA PSI
  • Leonarski F, Mozzanica A, Brückner M, Lopez-Cuenca C, Redford S, Sala L, et al.
    JUNGFRAU detector for brighter x-ray sources: solutions for IT and data science challenges in macromolecular crystallography
    Structural Dynamics. 2020; 7(1): 014305 (13 pp.). https://doi.org/10.1063/1.5143480
    DORA PSI
  • Ma B, Bohnert T, Otipoby KL, Tien E, Arefayene M, Bai J, et al.
    Discovery of BIIB068: a selective, potent, reversible Bruton's tyrosine kinase inhibitor as an orally efficacious agent for autoimmune diseases
    Journal of Medicinal Chemistry. 2020; 63(21): 12526-12541. https://doi.org/10.1021/acs.jmedchem.0c00702
    DORA PSI
  • Macdonald DS, Garrabou X, Klaus C, Verez R, Mori T, Hilvert D
    Engineered artificial carboligases facilitate regioselective preparation of enantioenriched aldol adducts
    Journal of the American Chemical Society. 2020; 142(23): 10250-10254. https://doi.org/10.1021/jacs.0c02351
    DORA PSI
  • Magiera‐Mularz K, Kuska K, Skalniak L, Grudnik P, Musielak B, Plewka J, et al.
    Macrocyclic peptide inhibitor of PD‐1/PD‐L1 immune checkpoint
    Advanced Therapeutics. 2020. https://doi.org/10.1002/adtp.202000195
    DORA PSI
  • Maliar N, Kovalev K, Baeken C, Balandin T, Astashkin R, Rulev M, et al.
    Crystal structure of the N112A mutant of the light-driven sodium pump KR2
    Crystals. 2020; 10(6): 496 (15 pp.). https://doi.org/10.3390/cryst10060496
    DORA PSI
  • Malik IT, Pereira R, Vielberg M-T, Mayer C, Straetener J, Thomy D, et al.
    Functional characterisation of ClpP mutations conferring resistance to acyldepsipeptide antibiotics in firmicutes
    ChemBioChem. 2020; 21(14): 1997-2012. https://doi.org/10.1002/cbic.201900787
    DORA PSI
  • Martiel I, Huang C-Y, Villanueva-Perez P, Panepucci E, Basu S, Caffrey M, et al.
    Low-dose in situ prelocation of protein microcrystals by 2D X-ray phase-contrast imaging for serial crystallography
    IUCrJ. 2020; 7(6): 1131-1141. https://doi.org/10.1107/S2052252520013238
    DORA PSI
  • Martiel I, Buntschu D, Meier N, Gobbo A, Panepucci E, Schneider R, et al.
    The TELL automatic sample changer for macromolecular crystallography
    Journal of Synchrotron Radiation. 2020; 27: 860-863. https://doi.org/10.1107/S1600577520002416
    DORA PSI
  • Martiel I, Mozzanica A, Opara NL, Panepucci E, Leonarski F, Redford S, et al.
    X-ray fluorescence detection for serial macromolecular crystallography using a JUNGFRAU pixel detector
    Journal of Synchrotron Radiation. 2020; 27: 329-339. https://doi.org/10.1107/S1600577519016758
    DORA PSI
  • Matthews A, Saleem-Batcha R, Sanders JN, Stull F, Houk KN, Teufel R
    Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases
    Nature Chemical Biology. 2020; 16(5): 556-563. https://doi.org/10.1038/s41589-020-0476-2
    DORA PSI
  • Medits I, Vaney M-C, Rouvinski A, Rey M, Chamot-Rooke J, Rey FA, et al.
    Extensive flavivirus E trimer breathing accompanies stem zippering of the post-fusion hairpin
    EMBO Reports. 2020; 21: e50069 (17 pp.). https://doi.org/10.15252/embr.202050069
    DORA PSI
  • Methot JL, Achab A, Christopher M, Zhou H, McGowan MA, Trotter BW, et al.
    Optimization of versatile oxindoles as selective PI3Kδ inhibitors
    ACS Medicinal Chemistry Letters. 2020; 11(12): 2461-2469. https://doi.org/10.1021/acsmedchemlett.0c00441
    DORA PSI
  • Metje-Sprink J, Groffmann J, Neumann P, Barg-Kues B, Ficner R, Kühnel K, et al.
    Crystal structure of the Rab33B/Atg16L1 effector complex
    Scientific Reports. 2020; 10(1): 12956 (13 pp.). https://doi.org/10.1038/s41598-020-69637-0
    DORA PSI
  • Metrick CM, Peterson EA, Santoro JC, Enyedy IJ, Murugan P, Chen TY, et al.
    Human PLD structures enable drug design and characterization of isoenzyme selectivity
    Nature Chemical Biology. 2020; 16: 391-399. https://doi.org/10.1038/s41589-019-0458-4
    DORA PSI
  • Moosmann P, Ecker F, Leopold-Messer S, Cahn JKB, Dieterich CL, Groll M, et al.
    A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds
    Nature Chemistry. 2020; 12(10): 968-972. https://doi.org/10.1038/s41557-020-0515-3
    DORA PSI
  • Munzel L, Neumann P, Otto FB, Krick R, Metje-Sprink J, Kroppen B, et al.
    Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore
    Autophagy. 2020. https://doi.org/10.1080/15548627.2020.1766332
    DORA PSI
  • Nakamura R, Hikita M, Ogawa S, Takahashi Y, Fujishiro T
    Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes
    FEBS Journal. 2020; 287(6): 1138-1154. https://doi.org/10.1111/febs.15081
    DORA PSI
  • Ni X, Knapp S, Chaikuad A
    Comparative structural analyses and nucleotide-binding characterization of the four KH domains of FUBP1
    Scientific Reports. 2020; 10: 13459 (10 pp.). https://doi.org/10.1038/s41598-020-69832-z
    DORA PSI
  • Nicoll CR, Bailleul G, Fiorentini F, Mascotti ML, Fraaije MW, Mattevi A
    Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs
    Nature Structural and Molecular Biology. 2020; 27(1): 14-24. https://doi.org/10.1038/s41594-019-0347-2
    DORA PSI
  • Olatunji S, Yu X, Bailey J, Huang C-Y, Zapotoczna M, Bowen K, et al.
    Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
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