Publications

PDB structures measured at X06SA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Albert L, Nagpal J, Steinchen W, Zhang L, Werel L, Djokovic N, et al.
    Bistable photoswitch allows in vivo control of hematopoiesis
    ACS Central Science. 2022; 8(1): 57-66. https://doi.org/10.1021/acscentsci.1c00434
    DORA PSI
  • Astro V, Ramirez-Calderon G, Pennucci R, Caroli J, Saera-Vila A, Cardona-Londoño K, et al.
    Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
    iScience. 2022; 25(7): 104665 (32 pp.). https://doi.org/10.1016/j.isci.2022.104665
    DORA PSI
  • Auman D, Ecker F, Mader SL, Dorst KM, Bräuer A, Widmalm G, et al.
    Peroxy intermediate drives carbon bond activation in the dioxygenase AsqJ
    Journal of the American Chemical Society. 2022; 144(34): 15622-15632. https://doi.org/10.1021/jacs.2c05650
    DORA PSI
  • Baudrexl M, Fida T, Berk B, Schwarz WH, Zverlov VV, Groll M, et al.
    Biochemical and structural characterization of thermostable GH159 glycoside hydrolases exhibiting α-L-arabinofuranosidase activity
    Frontiers in Molecular Biosciences. 2022; 9: 907439 (15 pp.). https://doi.org/10.3389/fmolb.2022.907439
    DORA PSI
  • Beaumet M, Dose A, Bräuer A, Mahy JP, Ghattas W, Groll M, et al.
    An artificial metalloprotein with metal-adaptive coordination sites and Ni-dependent quercetinase activity
    Journal of Inorganic Biochemistry. 2022; 235: 111914 (5 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111914
    DORA PSI
  • Begnini F, Geschwindner S, Johansson P, Wissler L, Lewis RJ, Danelius E, et al.
    Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction
    Journal of Medicinal Chemistry. 2022; 65(4): 3473-3517. https://doi.org/10.1021/acs.jmedchem.1c01975
    DORA PSI
  • Bloch JS, Sequeira JM, Ramírez AS, Quadros EV, Locher KP
    Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route
    FASEB Journal. 2022; 36(4): e22222 (11 pp.). https://doi.org/10.1096/fj.202101376RR
    DORA PSI
  • Bonagas N, Gustafsson NMS, Henriksson M, Marttila P, Gustafsson R, Wiita E, et al.
    Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
    Nature Cancer. 2022; 3(2): 156-172. https://doi.org/10.1038/s43018-022-00331-y
    DORA PSI
  • Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, et al.
    Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRASG12C inhibitor
    Journal of Medicinal Chemistry. 2022; 65(21): 14614-14629. https://doi.org/10.1021/acs.jmedchem.2c01120
    DORA PSI
  • Bärland N, Rueff A-S, Cebrero G, Hutter CAJ, Seeger MA, Veening JW, et al.
    Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification
    Science Advances. 2022; 8(9): eabm1122 (14 pp.). https://doi.org/10.1126/sciadv.abm1122
    DORA PSI
  • Cansfield AD, Ator MA, Banerjee J, Bestwick M, Bortolato A, Brown GA, et al.
    Novel macrocyclic antagonists of the calcitonin gene-related peptide receptor: design, realization, and structural characterization of protein-ligand complexes
    ACS Chemical Neuroscience. 2022; 13(6): 751-765. https://doi.org/10.1021/acschemneuro.1c00696
    DORA PSI
  • Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, et al.
    Chemoproteomics-enabled identification of 4-Oxo-β-lactams as inhibitors of dipeptidyl peptidases 8 and 9
    Angewandte Chemie International Edition. 2022; 61(47): e202210498 (10 pp.). https://doi.org/10.1002/anie.202210498
    DORA PSI
  • Cellini A, Shankar MK, Wahlgren WY, Nimmrich A, Furrer A, James D, et al.
    Structural basis of the radical pair state in photolyases and cryptochromes
    Chemical Communications. 2022; 58(31): 4889-4892. https://doi.org/10.1039/D2CC00376G
    DORA PSI
  • Chen Y, Tso K, Heckrodt TJ, Li H, Yen R, Lin N, et al.
    Bicyclic pyrimidine compounds as potent IRAK4 inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2022; 73: 128900 (5 pp.). https://doi.org/10.1016/j.bmcl.2022.128900
    DORA PSI
  • Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, et al.
    N-heterocyclic 3-pyridyl carboxamide inhibitors of DHODH for the treatment of acute myelogenous leukemia
    Journal of Medicinal Chemistry. 2022; 65(16): 11241-11256. https://doi.org/10.1021/acs.jmedchem.2c00788
    DORA PSI
  • Cullati SN, Chaikuad A, Chen J-S, Gebel J, Tesmer L, Zhubi R, et al.
    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
    Molecular Cell. 2022; 82(11): 2006-2020.e8. https://doi.org/10.1016/j.molcel.2022.03.005
    DORA PSI
  • Daniels MH, Malojcic G, Clugston SL, Williams B, Coeffet-Le Gal M, Pan-Zhou X-R, et al.
    Discovery and optimization of highly selective inhibitors of CDK5
    Journal of Medicinal Chemistry. 2022; 65(4): 3575-3596. https://doi.org/10.1021/acs.jmedchem.1c02069
    DORA PSI
  • Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, et al.
    Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition
    Nature Communications. 2022; 13(1): 382. https://doi.org/10.1038/s41467-021-27911-3
    DORA PSI
  • Diamanti R, Srinivas V, Johansson AI, Nordström A, Griese JJ, Lebrette H, et al.
    Comparative structural analysis provides new insights into the function of R2-like ligand-binding oxidase
    FEBS Letters. 2022; 569(12): 1600-1610. https://doi.org/10.1002/1873-3468.14319
    DORA PSI
  • Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, et al.
    Identification of pyrimidine-based lead compounds for understudied kinases implicated in driving neurodegeneration
    Journal of Medicinal Chemistry. 2022; 65(2): 1313-1328. https://doi.org/10.1021/acs.jmedchem.1c00440
    DORA PSI
  • Funck D, Sinn M, Fleming JR, Stanoppi M, Dietrich J, López-Igual R, et al.
    Discovery of a Ni2+-dependent guanidine hydrolase in bacteria
    Nature. 2022; 603(7901): 515-521. https://doi.org/10.1038/s41586-022-04490-x
    DORA PSI
  • Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, et al.
    In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M
    Journal of the American Chemical Society. 2022; 144(12): 5614-5628. https://doi.org/10.1021/jacs.2c01020
    DORA PSI
  • Ghosh P, Kropp HM, Betz K, Ludmann S, Diederichs K, Marx A, et al.
    Microenvironment-sensitive fluorescent nucleotide probes from benzofuran, benzothiophene, and selenophene as substrates for DNA polymerases
    Journal of the American Chemical Society. 2022; 144(23): 10556-10569. https://doi.org/10.1021/jacs.2c03454
    DORA PSI
  • Gilzer D, Schreiner M, Niemann HH
    Direct interaction of a chaperone-bound type III secretion substrate with the export gate
    Nature Communications. 2022; 13(1): 2858 (13 pp.). https://doi.org/10.1038/s41467-022-30487-1
    DORA PSI
  • Gude F, Molloy EM, Horch T, Dell M, Dunbar KL, Krabbe J, et al.
    A specialized polythioamide-binding protein confers antibiotic self-resistance in anaerobic bacteria
    Angewandte Chemie International Edition. 2022; 61(37): e202206168 (9 pp.). https://doi.org/10.1002/anie.202206168
    DORA PSI
  • Heinrich T, Peterson C, Schneider R, Garg S, Schwarz D, Gunera J, et al.
    Optimization of TEAD P-site binding fragment hit into in vivo active lead MSC-4106
    Journal of Medicinal Chemistry. 2022; 65(13): 9206-9229. https://doi.org/10.1021/acs.jmedchem.2c00403
    DORA PSI
  • Huang C-Y, Aumonier S, Engilberge S, Eris D, Smith KML, Leonarski F, et al.
    Probing ligand binding of endothiapepsin by 'temperature-resolved' macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 964-974. https://doi.org/10.1107/S205979832200612X
    DORA PSI
  • Huber EM, Hortschansky P, Scheven MT, Misslinger M, Haas H, Brakhage AA, et al.
    Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX
    Structure. 2022; 30(7): 934-946.e4. https://doi.org/10.1016/j.str.2022.04.001
    DORA PSI
  • Kaminski JW, Vera L, Stegmann DP, Vering J, Eris D, Smith KML, et al.
    Fast fragment- and compound-screening pipeline at the Swiss Light Source
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 328-336. https://doi.org/10.1107/S2059798322000705
    DORA PSI
  • Kaplan E, Greene NP, Jepson AE, Koronakis V
    Structural basis of lipoprotein recognition by the bacterial Lol trafficking chaperone LolA
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2022; 119(36): e2208662119 (9 pp.). https://doi.org/10.1073/pnas.2208662119
    DORA PSI
  • Kepa MW, Tomizaki T, Sato Y, Ozerov D, Sekiguchi H, Yasuda N, et al.
    Acoustic levitation and rotation of thin films and their application for room temperature protein crystallography
    Scientific Reports. 2022; 12: 5349 (14 pp.). https://doi.org/10.1038/s41598-022-09167-z
    DORA PSI
  • Kroef V, Ruegenberg S, Horn M, Allmeroth K, Ebert L, Bozkus S, et al.
    GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway
    eLife. 2022; 11: e69223 (29 pp.). https://doi.org/10.7554/eLife.69223
    DORA PSI
  • Kurz CG, Preuss F, Tjaden A, Cusack M, Amrhein JA, Chatterjee D, et al.
    Illuminating the dark: highly selective inhibition of serine/threonine kinase 17A with pyrazolo[1,5-a]pyrimidine-Based macrocycles
    Journal of Medicinal Chemistry. 2022; 65(11): 7799-7817. https://doi.org/10.1021/acs.jmedchem.2c00173
    DORA PSI
  • Leit S, Greenwood JR, Mondal S, Carriero S, Dahlgren M, Harriman GC, et al.
    Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
    Bioorganic and Medicinal Chemistry Letters. 2022; 73: 128891 (10 pp.). https://doi.org/10.1016/j.bmcl.2022.128891
    DORA PSI
  • Li P, Nayeri N, Górecki K, Becares ER, Wang K, Mahato DR, et al.
    PcoB is a defense outer membrane protein that facilitates cellular uptake of copper
    Protein Science. 2022; 31(7): e4364 (16 pp.). https://doi.org/10.1002/pro.4364
    DORA PSI
  • Li Y, Bedi RK, Nai F, von Roten V, Dolbois A, Zálešák F, et al.
    Structure-based design of ligands of the m6A-RNA reader YTHDC1
    European Journal of Medicinal Chemistry Reports. 2022; 5: 100057 (11 pp.). https://doi.org/10.1016/j.ejmcr.2022.100057
    DORA PSI
  • Maire AL, Rey M, Vivat V, Guée L, Blanc P, Malosse C, et al.
    Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids
    Journal of Molecular Endocrinology. 2022; 69(3): 377-390. https://doi.org/10.1530/JME-22-0021
    DORA PSI
  • Mehta V, Khanppnavar B, Schuster D, Kantarci I, Vercellino I, Kosturanova A, et al.
    Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
    eLife. 2022; 11: e77032 (21 pp.). https://doi.org/10.7554/ELIFE.77032
    DORA PSI
  • Metzner FJ, Huber E, Hopfner K-P, Lammens K
    Structural and biochemical characterization of human Schlafen 5
    Nucleic Acids Research. 2022; 50(2): 1147-1161. https://doi.org/10.1093/nar/gkab1278
    DORA PSI
  • Molina R, Garcia-Martin R, López-Méndez B, Grøn Jensen A L, Ciges-Tomas J R, Marchena-Hurtado J, et al.
    Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases
    Nucleic Acids Research. 2022; 50(19): 11199-11213. https://doi.org/10.1093/nar/gkac923
    DORA PSI
  • Mous S, Gotthard G, Ehrenberg D, Sen S, Weinert T, Johnson PJM, et al.
    Dynamics and mechanism of a light-driven chloride pump
    Science. 2022; 375(6583): 845-851. https://doi.org/10.1126/science.abj6663
    DORA PSI
  • Muckenfuss LM, Migenda Herranz AC, Boneberg FM, Clerici M, Jinek M
    Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis
    eLife. 2022; 11: e80332 (29 pp.). https://doi.org/10.7554/eLife.80332
    DORA PSI
  • Nass KJ, Ilie IM, Saller MJ, Driessen AJM, Caflisch A, Kammerer RA, et al.
    The role of the N-terminal amphipathic helix in bacterial YidC: insights from functional studies, the crystal structure and molecular dynamics simulations
    Biochimica et Biophysica Acta: Biomembranes. 2022; 1864(3): 183825 (9 pp.). https://doi.org/10.1016/j.bbamem.2021.183825
    DORA PSI
  • Ng S, Brueckner AC, Bahmanjah S, Deng Q, Johnston JM, Ge L, et al.
    Discovery and structure-based design of macrocyclic peptides targeting STUB1
    Journal of Medicinal Chemistry. 2022; 65(14): 9789-9801. https://doi.org/10.1021/acs.jmedchem.2c00406
    DORA PSI
  • Nozal V, Martínez-González L, Gomez-Almeria M, Gonzalo-Consuegra C, Santana P, Chaikuad A, et al.
    TDP-43 Modulation by Tau-Tubulin kinase 1 inhibitors: a new avenue for future amyotrophic lateral sclerosis therapy
    Journal of Medicinal Chemistry. 2022; 65(2): 1585-1607. https://doi.org/10.1021/acs.jmedchem.1c01942
    DORA PSI
  • Pacesa M, Lin C-H, Cléry A, Saha A, Arantes PR, Bargsten K, et al.
    Structural basis for Cas9 off-target activity
    Cell. 2022; 185(22): 4067-4081.e21. https://doi.org/10.1016/j.cell.2022.09.026
    DORA PSI
  • Priyanka A, Tisi D, Sixma TK
    Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain
    Journal of Structural Biology. 2022; 214(3): 107862 (9 pp.). https://doi.org/10.1016/j.jsb.2022.107862
    DORA PSI
  • Ramanadane K, Straub MS, Dutzler R, Manatschal C
    Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family
    eLife. 2022; 11: e74589 (29 pp.). https://doi.org/10.7554/eLife.74589
    DORA PSI
  • Rohac R, Crack JC, de Rosny E, Gigarel O, Le Brun NE, Fontecilla-Camps JC, et al.
    Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors
    Communications Biology. 2022; 5(1): 769 (11 pp.). https://doi.org/10.1038/s42003-022-03745-7
    DORA PSI
  • Rossetti GG, Ossorio MA, Rempel S, Kratzel A, Dionellis VS, Barriot S, et al.
    Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits
    Scientific Reports. 2022; 12(1): 2505 (9 pp.). https://doi.org/10.1038/s41598-022-06306-4
    DORA PSI
  • Salustros N, Grønberg C, Abeyrathna NS, Lyu P, Orädd F, Wang K, et al.
    Structural basis of ion uptake in copper-transporting P1B-type ATPases
    Nature Communications. 2022; 13(1): 5121 (11 pp.). https://doi.org/10.1038/s41467-022-32751-w
    DORA PSI
  • Shi Y-M, Hirschmann M, Shi Y-N, Ahmed S, Abebew D, Tobias NJ, et al.
    Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria
    Nature Chemistry. 2022; 14(6): 701-712. https://doi.org/10.1038/s41557-022-00923-2
    DORA PSI
  • Stauffer M, Jeckelmann J-M, Ilgü H, Ucurum Z, Boggavarapu R, Fotiadis D
    Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor
    Communications Chemistry. 2022; 5(1): 23 (10 pp.). https://doi.org/10.1038/s42004-022-00636-0
    DORA PSI
  • Stephenson Clarke JR, Douglas LR, Duriez PJ, Balourdas D-I, Joerger AC, Khadiullina R, et al.
    Discovery of nanomolar-affinity pharmacological chaperones stabilizing the oncogenic p53 mutant Y220C
    ACS Pharmacology & Translational Science. 2022; 5(11): 1169-1180. https://doi.org/10.1021/acsptsci.2c00164
    DORA PSI
  • Takeuchi K, Ikeda Y, Senda M, Harada A, Okuwaki K, Fukuzawa K, et al.
    The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity
    Structure. 2022; 30(6): 886-899.e4. https://doi.org/10.1016/j.str.2022.04.004
    DORA PSI
  • Tao H, Lauterbach L, Bian G, Chen R, Hou A, Mori T, et al.
    Discovery of non-squalene triterpenes
    Nature. 2022; 606(7913): 414-419. https://doi.org/10.1038/s41586-022-04773-3
    DORA PSI
  • Trottmann F, Ishida K, Ishida-Ito M, Kries H, Groll M, Hertweck C
    Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead
    Nature Chemistry. 2022; 14(8): 884-890. https://doi.org/10.1038/s41557-022-01005-z
    DORA PSI
  • Tsugita A, Uehara S, Matsui T, Yokoyama T, Ostash I, Deneka M, et al.
    The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK
    FEBS Journal. 2022; 289(19): 6038-6057. https://doi.org/10.1111/febs.16460
    DORA PSI
  • Vollheyde K, Kühnel K, Lambrecht F, Kawelke S, Herrfurth C, Feussner I
    Crystal structure of the bifunctional wax synthase 1 from Acinetobacter baylyi suggests a conformational change upon substrate binding and formation of additional substrate binding sites
    ACS Catalysis. 2022; 12(15): 9753-9765. https://doi.org/10.1021/acscatal.2c01712
    DORA PSI
  • Wiuf A, Steffen JH, Becares ER, Grønberg C, Mahato DR, Rasmussen SGF, et al.
    The two-domain elevator-type mechanism of zinc-transporting ZIP proteins
    Science Advances. 2022; 8(28): eabn4331 (14 pp.). https://doi.org/10.1126/sciadv.abn4331
    DORA PSI
  • Zhang Q, Balourdas D-I, Baron B, Senitzki A, Haran TE, Wiman KG, et al.
    Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
    Cell Death & Disease. 2022; 13(3): 214 (11 pp.). https://doi.org/10.1038/s41419-022-04653-8
    DORA PSI
  • Akaki T, Bessho Y, Ito T, Fujioka S, Ubukata M, Mori G, et al.
    Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases
    Bioorganic and Medicinal Chemistry. 2021; 44: 116283 (15 pp.). https://doi.org/10.1016/j.bmc.2021.116283
    DORA PSI
  • Akram M, Dietl A, Müller M, Barends TRM
    Purification of the key enzyme complexes of the anammox pathway from DEMON sludge
    Biopolymers. 2021; 112(6): e23428 (11 pp.). https://doi.org/10.1002/bip.23428
    DORA PSI
  • Akram M, Bock J, Dietl A, Barends TRM
    Specificity of small c-type cytochromes in anaerobic ammonium oxidation
    ACS Omega. 2021; 6(33): 21457 (8 pp.)-21464. https://doi.org/10.1021/acsomega.1c02275
    DORA PSI
  • Alali A, Zhang L, Li J, Zuo C, Wassouf D, Yan X, et al.
    Biosynthesis of the tricyclic aromatic type II polyketide rishirilide: new potential third ring oxygenation after three cyclization steps
    Molecular Biotechnology. 2021; 23: 502-514. https://doi.org/10.1007/s12033-021-00314-x
    DORA PSI
  • Alvigini L, Gran-Scheuch A, Guo Y, Trajkovic M, Saifuddin M, Fraaije MW, et al.
    Discovery, biocatalytic exploration and structural analysis of a 4-ethylphenol oxidase from Gulosibacter chungangensis
    ChemBioChem. 2021; 22(22): 3225-3233. https://doi.org/10.1002/cbic.202100457
    DORA PSI
  • Amelia T, van Veldhoven JPD, Falsini M, Liu R, Heitman LH, van Westen GJP, et al.
    Crystal structure and subsequent ligand design of a nonriboside partial agonist bound to the adenosine A2A receptor
    Journal of Medicinal Chemistry. 2021; 64(7): 3827-3842. https://doi.org/10.1021/acs.jmedchem.0c01856
    DORA PSI
  • Bailleul G, Nicoll CR, Mascotti ML, Mattevi A, Fraaije MW
    Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties
    Journal of Biological Chemistry. 2021; 296: 100221 (13 pp.). https://doi.org/10.1074/jbc.RA120.016297
    DORA PSI
  • Bao C, Bajrami B, Marcotte DJ, Chodaparambil JV, Kerns HM, Henderson J, et al.
    Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms
    Cellular and Molecular Neurobiology. 2021; 41: 669-685. https://doi.org/10.1007/s10571-020-00875-6
    DORA PSI
  • Bartsch A, Ives CM, Kattner C, Pein F, Diehn M, Tanabe M, et al.
    An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding
    Biochimica et Biophysica Acta: Biomembranes. 2021; 1863(6): 183601 (11 pp.). https://doi.org/10.1016/j.bbamem.2021.183601
    DORA PSI
  • Basler S, Studer S, Zou Y, Mori T, Ota Y, Camus A, et al.
    Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold
    Nature Chemistry. 2021; 13(3): 231-235. https://doi.org/10.1038/s41557-020-00628-4
    DORA PSI
  • Basse Hansen S, Dyla M, Neumann C, Quistgaard EMH, Andersen JL, Kjaergaard M, et al.
    The crystal structure of the Ca2+-ATPase 1 from Listeria monocytogenes reveals a pump primed for dephosphorylation
    Journal of Molecular Biology. 2021; 433(16): 167015 (11 pp.). https://doi.org/10.1016/j.jmb.2021.167015
    DORA PSI
  • Bauder M, Meyners C, Purder PL, Merz S, Sugiarto WO, Voll AM, et al.
    Structure-based design of high-affinity macrocyclic FKBP51 inhibitors
    Journal of Medicinal Chemistry. 2021; 64(6): 3320-3349. https://doi.org/10.1021/acs.jmedchem.0c02195
    DORA PSI
  • Baumgart M, Röpke M, Mühlbauer ME, Asami S, Mader SL, Fredriksson K, et al.
    Design of buried charged networks in artificial proteins
    Nature Communications. 2021; 12: 1895 (9 pp.). https://doi.org/10.1038/s41467-021-21909-7
    DORA PSI
  • Beliaeva MA, Leisinger F, Seebeck FP
    In vitro reconstitution of a five-step pathway for bacterial ergothioneine catabolism
    ACS Chemical Biology. 2021; 16(2): 397-403. https://doi.org/10.1021/acschembio.0c00968
    DORA PSI
  • Bereiter R, Himmelstoß M, Renard E, Mairhofer E, Egger M, Breuker K, et al.
    Impact of 3-deazapurine nucleobases on RNA properties
    Nucleic Acids Research. 2021; 49(8): 4281-4293. https://doi.org/10.1093/nar/gkab256
    DORA PSI
  • Berger B-T, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, et al.
    Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
    Cell Chemical Biology. 2021; 28(5): 686-698. https://doi.org/10.1016/j.chembiol.2021.01.003
    DORA PSI
  • Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis D
    The making of a potent L-lactate transport inhibitor
    Communications Chemistry. 2021; 4(1): 128 (9 pp.). https://doi.org/10.1038/s42004-021-00564-5
    DORA PSI
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