Publications

PDB structures measured at X06SA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Antoshvili M, Caspy I, Hippler M, Nelson N
    Structure and function of photosystem I in Cyanidioschyzon merolae
    Photosynthesis Research. 2019; 139(1-3): 499-508. https://doi.org/10.1007/s11120-018-0501-4
    DORA PSI
  • Apel A-K, Cheng RKY, Tautermann CS, Brauchle M, Huang C-Y, Pautsch A, et al.
    Crystal structure of CC chemokine receptor 2A in complex with an orthosteric antagonist provides insights for the design of selective antagonists
    Structure. 2019; 27(3): 427-438.e5. https://doi.org/10.1016/j.str.2018.10.027
    DORA PSI
  • Basu S, Kaminski JW, Panepucci E, Huang C-Y, Warshamanage R, Wang M, et al.
    Automated data collection and real-time data analysis suite for serial synchrotron crystallography
    Journal of Synchrotron Radiation. 2019; 26(1): 244-252. https://doi.org/10.1107/S1600577518016570
    DORA PSI
  • Bayliss R
    Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease.
    Journal of Medicinal Chemistry. 2019; 62: 2447.
    DORA PSI
  • Bogdanovic X, Schneider S, Wirth C, Hunte C
    A cysteine protease-like domain enhances the cytotoxic effects of thePhotorhabdus asymbioticatoxin PaTox.
    Journal of Biological Chemistry. 2019; 294: 1035.
    DORA PSI
  • Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, et al.
    Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)
    Biochemical Journal. 2019; 476(5): 875-887. https://doi.org/10.1042/BCJ20190038
    DORA PSI
  • Chaikuad A, Knapp S
    Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
    Biochemical Journal. 2019; 476: 875.
    DORA PSI
  • Falchetto M, Ciossani G, Scolari F, Di Cosimo A, Nenci S, Field LM, et al.
    Structural and biochemical evaluation of Ceratitis capitata odorant-binding protein 22 affinity for odorants involved in intersex communication
    Insect Molecular Biology. 2019; 28(3): 431-443. https://doi.org/10.1111/imb.12559
    DORA PSI
  • Griese JJ, Kositzki R, Haumann M, Högbom M
    Assembly of a heterodinuclear Mn/Fe cofactor is coupled to tyrosine-valine ether cross-link formation in the R2-like ligand-binding oxidase
    Journal of Biological Inorganic Chemistry. 2019; 24(2): 211-221. https://doi.org/10.1007/s00775-019-01639-4
    DORA PSI
  • Jaeger K, Bruenle S, Weinert T, Guba W, Muehle J, Miyazaki T, et al.
    Structural basis for allosteric ligand recognition in the human CC chemokine receptor 7
    Cell. 2019; 178(5): 1222-1230. https://doi.org/10.1016/j.cell.2019.07.028
    DORA PSI
  • Lach M, Künzle M, Beck T
    Proteins as sustainable building blocks for the next generation of bioinorganic nanomaterials
    Biochemistry. 2019; 58(3): 140-141. https://doi.org/10.1021/acs.biochem.8b00966
    DORA PSI
  • Mittl PRE
    Drug Design Inspired by Nature: Crystallographic Detection of an Auto-Tailored Protease Inhibitor Template.
    Angewandte Chemie International Edition. 2019; 58: 4051.
    DORA PSI
  • Nguyen D, Lemos C, Wortmann L, Eis K, Holton SJ, Boemer U, et al.
    Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
    Journal of Medicinal Chemistry. 2019; 62: 928.
    DORA PSI
  • Rudolph D
    Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors.
    ChemMedChem. 2019; 14: 88.
    DORA PSI
  • Schöppe J, Ehrenmann J, Klenk C, Rucktooa P, Schütz M, Doré AS, et al.
    Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
    Nature Communications. 2019; 10(1): 17 (11 pp.). https://doi.org/10.1038/s41467-018-07939-8
    DORA PSI
  • Tomizaki T, Shinoda A, Tsujino S
    Single crystal time-lapse measurement using ultrasonic acoustic levitation
    In: Gwo S, Huang D-J, Wei D-H, eds. Proceedings of the 13th international conference on synchrotron radiation instrumentation – SRI2018. Vol. 2054. AIP conference proceedings. Melville, New York: AIP Publishing; 2019. https://doi.org/10.1063/1.5084703
    DORA PSI
  • Tsujino S, Shinoda A, Tomizaki T
    On-demand droplet loading of ultrasonic acoustic levitator and its application for protein crystallography experiments
    Applied Physics Letters. 2019; 114(21): 213702 (5 pp.). https://doi.org/10.1063/1.5095574
    DORA PSI
  • Tsujino S, Sato Y, Takeda Y, Tomizaki T
    Oscillation resonances and anisotropic damping of the motion of acoustically levitated droplets in single-axis acoustic levitators
    Applied Physics Letters. 2019; 115: 053702 (5 pp.). https://doi.org/10.1063/1.5112109
    DORA PSI
  • Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, et al.
    Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle
    Nature. 2019; 568(7753): 571-575. https://doi.org/10.1038/s41586-019-1095-5
    DORA PSI
  • Watts E, Heidenreich D, Tucker E, Raab M, Strebhardt K, Chesler L, et al.
    Designing dual inhibitors of anaplastic lymphoma kinase (ALK) and bromodomain-4 (BRD4) by tuning kinase selectivity
    Journal of Medicinal Chemistry. 2019; 62(5): 2618-2637. https://doi.org/10.1021/acs.jmedchem.8b01947
    DORA PSI
  • Weinert T, Skopintsev P, James D, Dworkowski F, Panepucci E, Kekilli D, et al.
    Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography
    Science. 2019; 365(6448): 61-65. https://doi.org/10.1126/science.aaw8634
    DORA PSI
  • Zhang AT, Montgomery MG, Leslie AGW, Cook GM, Walker JE
    The structure of the catalytic domain of the ATP synthase from Mycobacterium smegmatis is a target for developing antitubercular drugs
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(10): 4206-4211. https://doi.org/10.1073/pnas.1817615116
    DORA PSI
  • Andersen JL, Gesser B, Funder ED, Nielsen CJF, Gotfred-Rasmussen H, Rasmussen MK, et al.
    Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
    Nature Communications. 2018; 9(1): 4344 (8 pp.). https://doi.org/10.1038/s41467-018-06787-w
    DORA PSI
  • Apetri A, Crespo R, Juraszek J, Pascual G, Janson R, Zhu X, et al.
    A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities
    Acta Neuropathologica. 2018; 6: 43 (17 pp.). https://doi.org/10.1186/s40478-018-0543-z
    DORA PSI
  • Argy N, Le Gal S, Coppée R, Song Z, Vindrios W, Massias L, et al.
    Pneumocystis cytochrome B mutants associated with atovaquone prophylaxis failure as the cause of pneumocystis infection outbreak among heart transplant recipients
    Clinical Infectious Diseases. 2018; 67(6): 913-919. https://doi.org/10.1093/cid/ciy154
    DORA PSI
  • Batiste L, Unzue A, Dolbois A, Hassler F, Wang X, Deerain N, et al.
    Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple)
    ACS Central Science. 2018; 4(2): 180-188. https://doi.org/10.1021/acscentsci.7b00401
    DORA PSI
  • Bauer D, Meinhold S, Jakob RP, Stigler J, Merkel U, Maier T, et al.
    A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(18): 4666-4671. https://doi.org/10.1073/pnas.1716899115
    DORA PSI
  • Bhatia S, Krieger V, Groll M, Osko JD, Reßing N, Ahlert H, et al.
    Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor
    Journal of Medicinal Chemistry. 2018; 61(22): 10299-10309. https://doi.org/10.1021/acs.jmedchem.8b01487
    DORA PSI
  • Bräuning B, Groll M
    Structural and mechanistic features of ClyA-like α-pore-forming toxins
    Toxins. 2018; 10(9): 343. https://doi.org/10.3390/toxins10090343
    DORA PSI
  • Bräuning B, Bertosin E, Praetorius F, Ihling C, Schatt A, Adler A, et al.
    Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
    Nature Communications. 2018; 9(1): 1806 (14 pp.). https://doi.org/10.1038/s41467-018-04139-2
    DORA PSI
  • Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-Sanjuan A, et al.
    High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design
    Scientific Reports. 2018; 8(1): 4242. https://doi.org/10.1038/s41598-018-22382-x
    DORA PSI
  • Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, et al.
    Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
    Nature Communications. 2018; 9(1): 4500 (10 pp.). https://doi.org/10.1038/s41467-018-06955-y
    DORA PSI
  • Caldwell R, Liu-Bujalski L, Qiu H, Mochalkin I, Jones R, Neagu C, et al.
    Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk
    Bioorganic and Medicinal Chemistry Letters. 2018; 28(21): 3419-3424. https://doi.org/10.1016/j.bmcl.2018.09.033
    DORA PSI
  • Crawford JJ, Johnson AR, Misner DL, Belmont LD, Castanedo G, Choy R, et al.
    Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development
    Journal of Medicinal Chemistry. 2018; 61(6): 2227-2245. https://doi.org/10.1021/acs.jmedchem.7b01712
    DORA PSI
  • Dalle Vedove A, Spiliotopoulos D, D'Agostino VG, Marchand J-R, Unzue A, Nevado C, et al.
    Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains
    ChemMedChem. 2018; 13(14): 1479-1487. https://doi.org/10.1002/cmdc.201800234
    DORA PSI
  • Dohle W, Jourdan FL, Menchon G, Prota AE, Foster PA, Mannion P, et al.
    Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure
    Journal of Medicinal Chemistry. 2018; 61(3): 1031-1044. https://doi.org/10.1021/acs.jmedchem.7b01474
    DORA PSI
  • Dubay KH, Iwan K, Osorio-Planes L, Geissler PL, Groll M, Trauner D, et al.
    A Predictive Approach for the Optical Control of Carbonic Anhydrase II Activity
    ACS Chemical Biology. 2018; 13(3): 793-800. https://doi.org/10.1021/acschembio.7b00862
    DORA PSI
  • Dunne M, Denyes JM, Arndt H, Loessner MJ, Leiman PG, Klumpp J
    Salmonella Phage S16 Tail Fiber Adhesin Features a Rare Polyglycine Rich Domain for Host Recognition
    Structure. 2018; 26(12): 1573-1580. https://doi.org/10.1016/j.str.2018.07.017
    DORA PSI
  • Ecker F, Haas H, Groll M, Huber EM
    Iron Scavenging in Aspergillus Species: Structural and Biochemical Insights into Fungal Siderophore Esterases
    Angewandte Chemie International Edition. 2018; 57(44): 14624-14629. https://doi.org/10.1002/anie.201807093
    DORA PSI
  • Edwardson TGW, Mori T, Hilvert D
    Rational Engineering of a Designed Protein Cage for siRNA Delivery
    Journal of the American Chemical Society. 2018; 140(33): 10439-10442. https://doi.org/10.1021/jacs.8b06442
    DORA PSI
  • Ehrenmann J, Schöppe J, Klenk C, Rappas M, Kummer L, Doré AS, et al.
    High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist
    Nature Structural and Molecular Biology. 2018; 25(12): 1086-1092. https://doi.org/10.1038/s41594-018-0151-4
    DORA PSI
  • Einsle O
    Another twist on nitrogenases
    Nature Microbiology. 2018; 3(3): 263-264. https://doi.org/10.1038/s41564-018-0116-8
    DORA PSI
  • El Ghachi M, Howe N, Huang C-Y, Olieric V, Warshamanage R, Touzé T, et al.
    Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis
    Nature Communications. 2018; 9(1): 1078 (13 pp.). https://doi.org/10.1038/s41467-018-03477-5
    DORA PSI
  • Elgamacy M, Coles M, Ernst P, Zhu H, Hartmann MD, Plückthun A, et al.
    An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture
    ACS Synthetic Biology. 2018; 7(9): 2226-2235. https://doi.org/10.1021/acssynbio.8b00224
    DORA PSI
  • Erra M, Taltavull J, Bernal FJ, Caturla JF, Carrascal M, Pages L, et al.
    Discovery of a Novel Inhaled PI3K delta Inhibitor for the Treatment of Respiratory Diseases
    Journal of Medicinal Chemistry. 2018; 61(21): 9551-9567. https://doi.org/10.1021/acs.jmedchem.8b00873
    DORA PSI
  • Esposito C, Wiedmer L, Caflisch A
    In Silico Identification of JMJD3 Demethylase Inhibitors
    Journal of Chemical Information and Modeling. 2018; 58(10): 2151-2163. https://doi.org/10.1021/acs.jcim.8b00539
    DORA PSI
  • Esposito D, Günster RA, Martino L, Omari KE, Wagner A, Thurston TLM, et al.
    Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3
    Journal of Biological Chemistry. 2018; 293(14): 5064-5078. https://doi.org/10.1074/jbc.RA118.001796
    DORA PSI
  • Field JJ, Pera B, Estévez Gallego J, Calvo E, Rodríguez-Salarichs J, Sáez-Calvo G, et al.
    Zampanolide binding to tubulin indicates cross-talk of taxane site with colchicine and nucleotide sites
    Journal of Natural Products. 2018; 81(3): 494-505. https://doi.org/10.1021/acs.jnatprod.7b00704
    DORA PSI
  • Frouws TD, Barth PD, Richmond TJ
    Site-Specific Disulfide Crosslinked Nucleosomes with Enhanced Stability
    Journal of Molecular Biology. 2018; 430(1): 45-57. https://doi.org/10.1016/j.jmb.2017.10.029
    DORA PSI
  • Fuenzalida-Werner JP, Janowski R, Mishra K, Weidenfeld I, Niessing D, Ntziachristos V, et al.
    Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation
    Journal of Structural Biology. 2018; 204(3): 519-522. https://doi.org/10.1016/j.jsb.2018.09.013
    DORA PSI
  • Geuijen CAW, De Nardis C, Maussang D, Rovers E, Gallenne T, Hendriks LJA, et al.
    Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
    Cancer Cell. 2018; 33(5): 922-936. https://doi.org/10.1016/j.ccell.2018.04.003
    DORA PSI
  • Gotfryd K, Mósca AF, Missel JW, Truelsen SF, Wang K, Spulber M, et al.
    Human adipose glycerol flux is regulated by a pH gate in AQP10
    Nature Communications. 2018; 9(1): 4749 (11 pp.). https://doi.org/10.1038/s41467-018-07176-z
    DORA PSI
  • Griese JJ, Branca RMM, Srinivas V, Högbom M
    Ether cross-link formation in the R2-like ligand-binding oxidase
    Journal of Biological Inorganic Chemistry. 2018; 23(6): 879-886. https://doi.org/10.1007/s00775-018-1583-3
    DORA PSI
  • Groll M
    Design, synthesis, and evaluation of cystargolide-based beta-lactones as potent proteasome inhibitors
    European Journal of Medicinal Chemistry. 2018; 157: 962-977. https://doi.org/10.1016/j.ejmech.2018.08.052
    DORA PSI
  • Groll M, Nguyen H, Vellalath S, Romo D
    Homosalinosporamide A and its mode of proteasome inhibition: An X-ray crystallographic study
    Marine Drugs. 2018; 16(7): 24. https://doi.org/10.3390/md16070240
    DORA PSI
  • Grötzinger SW, Karan R, Strillinger E, Bader S, Frank A, Al Rowaihi IS, et al.
    Identification and Experimental Characterization of an Extremophilic Brine Pool Alcohol Dehydrogenase from Single Amplified Genomes
    ACS Chemical Biology. 2018; 13(1): 161-170. https://doi.org/10.1021/acschembio.7b00792
    DORA PSI
  • Hamaguchi H, Amano Y, Moritomo A, Shirakami S, Nakajima Y, Nakai K, et al.
    Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
    Bioorganic and Medicinal Chemistry. 2018; 26(18): 4971-4983. https://doi.org/10.1016/j.bmc.2018.08.005
    DORA PSI
  • Hansen S, Ernst P, König SLB, Reichen C, Ewald C, Nettels D, et al.
    Curvature of designed armadillo repeat proteins allows modular peptide binding
    Journal of Structural Biology. 2018; 201(2): 108-117. https://doi.org/10.1016/j.jsb.2017.08.009
    DORA PSI
  • Herbst DA, Huitt-Roehl CR, Jakob RP, Kravetz JM, Storm PA, Alley JR, et al.
    The structural organization of substrate loading in iterative polyketide synthases
    Nature Chemical Biology. 2018; 14(5): 474-479. https://doi.org/10.1038/s41589-018-0026-3
    DORA PSI
  • Hoegl A, Nodwell MB, Kirsch VC, Bach NC, Pfanzelt M, Stahl M, et al.
    Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics
    Nature Chemistry. 2018. https://doi.org/10.1038/s41557-018-0144-2
    DORA PSI
  • Huang C-Y, Olieric V, Howe N, Warshamanage R, Weinert T, Panepucci E, et al.
    In situ serial crystallography for rapid de novo membrane protein structure determination.
    Communications Biology. 2018; 1: 124 (8 pp.). https://doi.org/10.1038/S42003-018-0123-6
    DORA PSI
  • Jiang X, Maier T
    KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists
    Chemistry: A European Journal. 2018; 24(49): 13049-13057. https://doi.org/10.1002/chem.201802599
    DORA PSI
  • Jiang K, Faltova L, Hua S, Capitani G, Prota AE, Landgraf C, et al.
    Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex
    Structure. 2018; 26(3): 375-382. https://doi.org/10.1016/j.str.2017.12.017
    DORA PSI
  • Jørgensen MM, Ekundayo B, Zaratiegui M, Skriver K, Thon G, Schalch T
    Structure of the replication regulator Sap1 reveals functionally important interfaces
    Scientific Reports. 2018; 8(1): 10930. https://doi.org/10.1038/s41598-018-29198-9
    DORA PSI
  • Knoll KR, Eustermann S, Niebauer V, Oberbeckmann E, Stoehr G, Schall K, et al.
    The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling
    Nature Structural and Molecular Biology. 2018; 25(9): 823-832. https://doi.org/10.1038/s41594-018-0115-8
    DORA PSI
  • Knorr S, Sinn M, Galetskiy D, Williams RM, Wang C, Müller N, et al.
    Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate
    Nature Communications. 2018; 9(1): 5071 (10 pp.). https://doi.org/10.1038/s41467-018-07563-6
    DORA PSI
  • Krausze J, Hercher TW, Zwerschke D, Kirk ML, Blankenfeldt W, Mendel RR, et al.
    The functional principle of eukaryotic molybdenum insertases
    Biochemical Journal. 2018; 475(10): 1739-1753. https://doi.org/10.1042/BCJ20170935
    DORA PSI
  • Kropp HM, Dürr SL, Peter C, Diederichs K, Marx A
    Snapshots of a modified nucleotide moving through the confines of a DNA polymerase
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(40): 9992-9997. https://doi.org/10.1073/pnas.1811518115
    DORA PSI
  • Leonarski F, Redford S, Mozzanica A, Lopez-Cuenca C, Panepucci E, Nass K, et al.
    Fast and accurate data collection for macromolecular crystallography using the JUNGFRAU detector
    Nature Methods. 2018; 15(10): 799-804. https://doi.org/10.1038/s41592-018-0143-7
    DORA PSI
  • Lundgren CAK, Sjöstrand D, Biner O, Bennett M, Rudling A, Johansson A-L, et al.
    Scavenging of superoxide by a membrane-bound superoxide oxidase
    Nature Chemical Biology. 2018; 14(8): 788-793. https://doi.org/10.1038/s41589-018-0072-x
    DORA PSI
  • Lässig C, Lammens K, López JLG, Michalski S, Fettscher O, Hopfner K-P
    Unified mechanisms for self-RNA recognition by RIG-I singleton-merten syndrome variants
    eLife. 2018; 7: e38958. https://doi.org/10.7554/eLife.38958
    DORA PSI
  • Mader SL, Bräuer A, Groll M, Kaila VRI
    Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ
    Nature Communications. 2018; 9(1): 1168 (8 pp.). https://doi.org/10.1038/s41467-018-03442-2
    DORA PSI
  • Masuyer G, Zhang S, Barkho S, Shen Y, Henriksson L, Košenina S, et al.
    Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity
    Scientific Reports. 2018; 8(1): 4518 (10 pp.). https://doi.org/10.1038/s41598-018-22842-4
    DORA PSI
  • Matsuki M, Hoshi T, Yamamoto Y, Ikemori-Kawada M, Minoshima Y, Funahashi Y, et al.
    Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models
    Cancer Medicine. 2018; 7(6): 2641-2653. https://doi.org/10.1002/cam4.1517
    DORA PSI
  • Merceron R, Lucas S
    Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells
    Science. 2018; 362(6417): 952. https://doi.org/10.1126/science.aau2909
    DORA PSI
  • Moustakim M, Christott T, Monteiro OP, Bennett J, Giroud C, Ward J, et al.
    Discovery of an MLLT1/3 YEATS Domain Chemical Probe
    Angewandte Chemie International Edition. 2018; 57(50): 16302-16307. https://doi.org/10.1002/anie.201810617
    DORA PSI
  • Musil D, Rak A
    Estimation of Drug-Target Residence Times by tau-Random Acceleration Molecular Dynamics Simulations
    Journal of Chemical Theory and Computation. 2018; 14(7): 3859-3869. https://doi.org/10.1021/acs.jctc.8b00230
    DORA PSI
  • Nagarathinam K, Nakada-Nakura Y, Parthier C, Terada T, Juge N, Jaenecke F, et al.
    Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism
    Nature Communications. 2018; 9(1): 4005 (9 pp.). https://doi.org/10.1038/s41467-018-06306-x
    DORA PSI
  • Napiórkowska M, Boilevin J, Darbre T, Reymond J-L, Locher KP
    Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide
    Scientific Reports. 2018; 8(1): 16297. https://doi.org/10.1038/s41598-018-34534-0
    DORA PSI
  • Nelp MT, Kates PA, Hunt JT, Newitt JA, Balog A, Maley D, et al.
    Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(13): 3249-3254. https://doi.org/10.1073/pnas.1719190115
    DORA PSI
  • Niquille DL, Hansen DA, Mori T, Fercher D, Kries H, Hilvert D
    Nonribosomal biosynthesis of backbone-modified peptides
    Nature Chemistry. 2018; 10(3): 282-287. https://doi.org/10.1038/nchem.2891
    DORA PSI
  • Parnell AE, Mordhorst S, Kemper F, Giurrandino M, Prince JP, Schwarzer NJ, et al.
    Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(13): 3350-3355. https://doi.org/10.1073/pnas.1710741115
    DORA PSI
  • Pflüger T, Hernández CF, Lewe P, Frank F, Mertens H, Svergun D, et al.
    Signaling ammonium across membranes through an ammonium sensor histidine kinase
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