Publications
X06SA PDB Structure Gallery from BioSync
PXI Publications
Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA
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Berger B-T, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, et al.
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Cell Chemical Biology. 2021. https://doi.org/10.1016/j.chembiol.2021.01.003
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Delfosse V, Huet T, Harrus D, Granell M, Bourguet M, Gardia-Parège C, et al.
Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2021; 118(1): e2020551118 (10 pp.). https://doi.org/10.1073/PNAS.2020551118
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Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, et al.
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism
Science Advances. 2021; 7(5): eabe5504 (15 pp.). https://doi.org/10.1126/sciadv.abe5504
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Dimovasili C, Fadouloglou VE, Kefala A, Providaki M, Kotsifaki D, Kanavouras K, et al.
Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology
Journal of Neurochemistry. 2021. https://doi.org/10.1111/jnc.15296
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Focht D, Neumann C, Lyons J, Eguskiza Bilbao A, Blunck R, Malinauskaite L, et al.
A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition
EMBO Journal. 2021; 40(1): e105164 (13 pp.). https://doi.org/10.15252/embj.2020105164
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Ostertag E, Zheng L, Broger K, Stehle T, Li S-M, Zocher G
Reprogramming substrate and catalytic promiscuity of tryptophan prenyltransferases
Journal of Molecular Biology. 2021; 433(2): 166726 (14 pp.). https://doi.org/10.1016/j.jmb.2020.11.025
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Peter MF, Gebhardt C, Glaenzer J, Schneberger N, de Boer M, Thomas GH, et al.
Triggering closure of a sialic acid TRAP transporter substrate binding protein through binding of natural or artificial substrates
Journal of Molecular Biology. 2021; 433(3): 166756 (15 pp.). https://doi.org/10.1016/j.jmb.2020.166756
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Shen Y, Kalograiaki I, Prunotto A, Dunne M, Boulos S, Taylor NMI, et al.
Structural basis for recognition of bacterial cell wall teichoic acid by pseudo-symmetric SH3b-like repeats of a viral peptidoglycan hydrolase
Chemical Science. 2021; 12(2): 576-589. https://doi.org/10.1039/d0sc04394j
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Tomašič T, Rabbani S, Jakob RP, Reisner A, Jakopin Ž, Maier T, et al.
Does targeting Arg98 of FimH lead to high affinity antagonists?
European Journal of Medicinal Chemistry. 2021; 211: 113093 (16 pp.). https://doi.org/10.1016/j.ejmech.2020.113093
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Zhang L, Bill E, Kroneck PMH, Einsle O
A [3Cu:2S] cluster provides insight into the assembly and function of the CuZ site of nitrous oxide reductase
Chemical Science. 2021. https://doi.org/10.1039/D0SC05204C
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Zhang L, Bill E, Kroneck PMH, Einsle O
Histidine-gated proton-coupled electron transfer to the CuA site of nitrous oxide reductase
Journal of the American Chemical Society. 2021; 143(2): 830-838. https://doi.org/10.1021/jacs.0c10057
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Arnold FM, Weber MS, Gonda I, Gallenito MJ, Adenau S, Egloff P, et al.
The ABC exporter IrtAB imports and reduces mycobacterial siderophores
Nature. 2020; 580(7803): 413-417. https://doi.org/10.1038/s41586-020-2136-9
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Badmann T, Groll M
Structures in tetrahydrofolate methylation in desulfitobacterial glycine betaine metabolism at atomic resolution
ChemBioChem. 2020; 21(6): 776-779. https://doi.org/10.1002/cbic.201900515
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Bao C, Bajrami B, Marcotte DJ, Chodaparambil JV, Kerns HM, Henderson J, et al.
Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms
Cellular and Molecular Neurobiology. 2020. https://doi.org/10.1007/s10571-020-00875-6
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Bauer MR, Krämer A, Settanni G, Jones RN, Ni X, Khan Tareque R, et al.
Targeting cavity-creating p53 cancer mutations with small-molecule stabilizers: the Y220X paradigm
ACS Chemical Biology. 2020; 15(3): 657-668. https://doi.org/10.1021/acschembio.9b00748
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Bracco P, Wijma HJ, Nicolai B, Rodriguez Buitrago JA, Klünemann T, Vila A, et al.
CYP154C5 regioselectivity in steroid hydroxylation explored by substrate modifications and protein engineering
ChemBioChem. 2020. https://doi.org/10.1002/cbic.202000735
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Brunner JD, Jakob RP, Schulze T, Neldner Y, Moroni A, Thiel G, et al.
Structural basis for ion selectivity in TMEM175 K+ channels
eLife. 2020; 9: e53683 (24 pp.). https://doi.org/10.7554/eLife.53683
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Bräuer A, Zhou Q, Grammbitter GLC, Schmalhofer M, Rühl M, Kaila VRI, et al.
Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis
Nature Chemistry. 2020; 12(8): 755-763. https://doi.org/10.1038/s41557-020-0491-7
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Buonfiglio R, Prati F, Bischetti M, Cavarischia C, Furlotti G, Ombrato R
Discovery of novel imidazopyridine GSK-3β inhibitors supported by cmputational approaches
Molecules. 2020; 25(9): 2163 (29 pp.). https://doi.org/10.3390/molecules25092163
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Caldwell SJ, Haydon IC, Piperidou N, Huang P-S, Bick MJ, Sjöström HS, et al.
Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(48): 30362-30369. https://doi.org/10.1073/pnas.2008535117
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Chaikuad A, Pollinger J, Rühl M, Ni X, Kilu W, Heering J, et al.
Comprehensive set of tertiary complex structures and palmitic acid binding provide molecular insights into ligand design for RXR isoforms
International Journal of Molecular Sciences. 2020; 21(22): 1-13. https://doi.org/10.3390/ijms21228457
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Colarusso S, De Simone D, Frattarelli T, Andreini M, Cerretani M, Missineo A, et al.
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction
Bioorganic and Medicinal Chemistry. 2020; 28(21): 115738 (12 pp.). https://doi.org/10.1016/j.bmc.2020.115738
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Collie GW, Michaelides IN, Embrey K, Stubbs CJ, Börjesson U, Dale IL, et al.
Structural basis for targeting the folded P-loop conformation of c-MET
ACS Medicinal Chemistry Letters. 2020. https://doi.org/10.1021/acsmedchemlett.0c00392
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Crack JC, Amara P, Volbeda A, Mouesca J-M, Rohac R, Pellicer Martinez MT, et al.
Electron and proton transfers modulate DNA binding by the transcription regulator RsrR
Journal of the American Chemical Society. 2020; 142(11): 5104-5116. https://doi.org/10.1021/jacs.9b12250
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Dolbois A, Batiste L, Wiedmer L, Dong J, Brütsch M, Huang D, et al.
Hitting a moving target: simulation and crystallography study of ATAD2 bromodomain blockers
ACS Medicinal Chemistry Letters. 2020; 11(8): 1573-1580. https://doi.org/10.1021/acsmedchemlett.0c00080
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Draxler SW, Bauer M, Eickmeier C, Nadal S, Nar H, Rangel Rojas D, et al.
Hybrid screening approach for very small fragments: X-ray and computational screening on FKBP51
Journal of Medicinal Chemistry. 2020; 63(11): 5856-5864. https://doi.org/10.1021/acs.jmedchem.0c00120
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Du D, Katsuyama Y, Horiuchi M, Fushinobu S, Chen A, Davis TD, et al.
Structural basis for selectivity in a highly reducing type II polyketide synthase
Nature Chemical Biology. 2020; 16: 776-782. https://doi.org/10.1038/s41589-020-0530-0
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Ernst S, Ecker F, Kaspers MS, Ochtrop P, Hedberg C, Groll M, et al.
Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination
Science Advances. 2020; 6(20): eaaz8041 (14 pp.). https://doi.org/10.1126/sciadv.aaz8041
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Ernst P, Zosel F, Reichen C, Nettels D, Schuler B, Plückthun A
Structure-guided design of a peptide lock for modular peptide binders
ACS Chemical Biology. 2020; 15(2): 457-468. https://doi.org/10.1021/acschembio.9b00928
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Exner TE, Becker S, Becker S, Boniface-Guiraud A, Delepelaire P, Diederichs K, et al.
Binding of HasA by its transmembrane receptor HasR follows a conformational funnel mechanism
European Biophysics Journal. 2020; 49(1): 39-57. https://doi.org/10.1007/s00249-019-01411-1
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Fairhurst RA, Knoepfel T, Buschmann N, Leblanc C, Mah R, Todorov M, et al.
Discovery of roblitinib (FGF401) as a reversible-covalent inhibitor of the kinase activity of fibroblast growth factor receptor 4
Journal of Medicinal Chemistry. 2020; 63(21): 12542-12573. https://doi.org/10.1021/acs.jmedchem.0c01019
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Ferri E, Le Thomas A, Ackerly Wallweber H, Day ES, Walters BT, Kaufman SE, et al.
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
Nature Communications. 2020; 11(1): 6387 (15 pp.). https://doi.org/10.1038/s41467-020-19974-5
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Gandini R, Reichenbach T, Spadiut O, Tan T-C, Kalyani DC, Divne C
A transmembrane crenarchaeal mannosyltransferase is involved in N-glycan biosynthesis and displays an unexpected minimal cellulose-synthase-like fold
Journal of Molecular Biology. 2020; 432(16): 4658-4672. https://doi.org/10.1016/j.jmb.2020.06.016
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Gao L, Meiring JCM, Kraus Y, Wranik M, Weinert T, Pritzl SD, et al.
A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton
Cell Chemical Biology. 2020. https://doi.org/10.1016/j.chembiol.2020.11.007
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Ge P, Scholl D, Prokhorov NS, Avaylon J, Shneider MM, Browning C, et al.
Action of a minimal contractile bactericidal nanomachine
Nature. 2020; 580(7805): 658-662. https://doi.org/10.1038/s41586-020-2186-z
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Gebel J, Tuppi M, Chaikuad A, Hötte K, Schröder M, Schulz L, et al.
p63 uses a switch-like mechanism to set the threshold for induction of apoptosis
Nature Chemical Biology. 2020; 16: 1078-1086. https://doi.org/10.1038/s41589-020-0600-3
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Gellrich L, Heitel P, Heering J, Kilu W, Pollinger J, Goebel T, et al.
L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ
Journal of Medicinal Chemistry. 2020; 63(13): 6727-6740. https://doi.org/10.1021/acs.jmedchem.9b02150
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Gotfryd K, Boesen T, Mortensen JS, Khelashvili G, Quick M, Terry DS, et al.
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Nature Communications. 2020; 11(1): 1005 (14 pp.). https://doi.org/10.1038/s41467-020-14735-w
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Grob P, Huber M, Walla B, Hermann J, Janowski R, Niessing D, et al.
Crystal contact engineering enables efficient capture and purification of an oxidoreductase by technical crystallization
Biotechnology Journal. 2020; 15(11): 2000010 (8 pp.). https://doi.org/10.1002/biot.202000010
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Grāve K, Griese JJ, Berggren G, Bennett MD, Högbom M
The Bacillus anthracis class Ib ribonucleotide reductase subunit NrdF intrinsically selects manganese over iron
Journal of Biological Inorganic Chemistry. 2020; 25: 571-582. https://doi.org/10.1007/s00775-020-01782-3
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Görlich S, Samuel AJ, Best RJ, Seidel R, Vacelet J, Leonarski FK, et al.
Natural hybrid silica/protein superstructure at atomic resolution
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(49): 31088-31093. https://doi.org/10.1073/pnas.2019140117
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Hanke T, Cheung S-Y, Kilu W, Heering J, Ni X, Planz V, et al.
A selective modulator of peroxisome proliferator-activated receptor γ with an unprecedented binding mode
Journal of Medicinal Chemistry. 2020; 63(9): 4555-4561. https://doi.org/10.1021/acs.jmedchem.9b01786
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Hepp S, Trauth J, Hasenjäger S, Bezold F, Essen L-O, Taxis C
An optogenetic tool for induced protein stabilization based on the Phaeodactylum tricornutum aureochrome 1a light-oxygen-voltage domain
Journal of Molecular Biology. 2020; 432(7): 1880-1900. https://doi.org/10.1016/j.jmb.2020.02.019
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Himmelstoß M, Erharter K, Renard E, Ennifar E, Kreutz C, Micura R
2′-O-trifluoromethylated RNA - a powerful modification for RNA chemistry and NMR spectroscopy
Chemical Science. 2020; 11(41): 11322-11330. https://doi.org/10.1039/d0sc04520a
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Hofmann MH, Mani R, Engelhardt H, Impagnatiello MA, Carotta S, Kerenyi M, et al.
Selective and potent CDK8/19 inhibitors enhance NK-cell activity and promote tumor surveillance
Molecular Cancer Therapeutics. 2020; 19(4): 1018-1030. https://doi.org/10.1158/1535-7163.MCT-19-0789
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Hortschansky P, Misslinger M, Mörl J, Gsaller F, Bromley MJ, Brakhage AA, et al.
Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus
Life Science Alliance. 2020; 3(7): e202000729 (12 pp.). https://doi.org/10.26508/lsa.202000729
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Huang C-Y, Olieric V, Caffrey M, Wang M
In meso in situ serial X-Ray crystallography (IMISX): a protocol for membrane protein structure determination at the Swiss Light Source
In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:293-319. https://doi.org/10.1007/978-1-0716-0373-4_20
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Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, et al.
An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5
Autophagy. 2020; 16(2): 256-270. https://doi.org/10.1080/15548627.2019.1606637
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Hügle M, Regenass P, Warstat R, Hau M, Schmidtkunz K, Lucas X, et al.
4-acyl pyrroles as dual BET-BRD7/9 bromodomain inhibitors address BETi insensitive human cancer cell lines
Journal of Medicinal Chemistry. 2020. https://doi.org/10.1021/acs.jmedchem.0c00478
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Iacovino LG, Savino S, Borg AJE, Binda C, Nidetzky B, Mattevi A
Crystallographic snapshots of UDP-glucuronic acid 4-epimerase ligand binding, rotation, and reduction
Journal of Biological Chemistry. 2020; 295(35): 12461-12473. https://doi.org/10.1074/jbc.ra120.014692
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Jespers W, Verdon G, Azuaje J, Majellaro M, Keränen H, García-Mera X, et al.
X-Ray crystallography and free energy calculations reveal the binding mechanism of A2A adenosine receptor antagonists
Angewandte Chemie International Edition. 2020; 59(38): 16536-16543. https://doi.org/10.1002/anie.202003788
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Kaiser M, Wurm JP, Märtens B, Bläsi U, Pogoryelov D, Wöhnert J
Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus
FEBS Open Bio. 2020; 10(2): 221-228. https://doi.org/10.1002/2211-5463.12772
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Karpik A, Martiel I, Kristiansen PM, Padeste C
Fabrication of ultrathin suspended polymer membranes as supports for serial protein crystallography
Micro and Nano Engineering. 2020; 7: 100053 (6 pp.). https://doi.org/10.1016/j.mne.2020.100053
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Kessler D, Bergner A, Böttcher J, Fischer G, Döbel S, Hinkel M, et al.
Drugging all RAS isoforms with one pocket
Future Medicinal Chemistry. 2020; 12(21): 1911-1923. https://doi.org/10.4155/fmc-2020-0221
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Kessler D, Gollner A, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, et al.
Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(7): 3365-3367. https://doi.org/10.1073/pnas.1921236117
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Kisgeropoulos EC, Griese JJ, Smith ZR, Branca RMM, Schneider CR, Högbom M, et al.
Key structural motifs balance metal binding and oxidative reactivity in a heterobimetallic Mn/Fe protein
ACS Applied Materials and Interfaces. 2020; 142(11): 5338-5354. https://doi.org/10.1021/jacs.0c00333
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Klatt F, Leitner A, Kim IV, Ho-Xuan H, Schneider EV, Langhammer F, et al.
A precisely positioned MED12 activation helix stimulates CDK8 kinase activity
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(6): 2894-2905. https://doi.org/10.1073/pnas.1917635117
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Knez D, Colettis N, Iacovino LG, Sova M, Pišlar A, Konc J, et al.
Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and B
Journal of Medicinal Chemistry. 2020; 63(3): 1361-1387. https://doi.org/10.1021/acs.jmedchem.9b01886
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Kries H, Bloch JS, Bunzel HA, Pinkas DM, Hilvert D
Contribution of oxyanion stabilization to kemp eliminase efficiency
ACS Catalysis. 2020; 10(8): 4460-4464. https://doi.org/10.1021/acscatal.0c00575
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Leger PR, Hu DX, Biannic B, Bui M, Han X, Karbarz E, et al.
Discovery of potent, selective, and orally bioavailable inhibitors of USP7 with in vivo antitumor activity
Journal of Medicinal Chemistry. 2020; 63(10): 5398-5420. https://doi.org/10.1021/acs.jmedchem.0c00245
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Leonarski F, Mozzanica A, Brückner M, Lopez-Cuenca C, Redford S, Sala L, et al.
JUNGFRAU detector for brighter x-ray sources: solutions for IT and data science challenges in macromolecular crystallography
Structural Dynamics. 2020; 7(1): 014305 (13 pp.). https://doi.org/10.1063/1.5143480
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Ma B, Bohnert T, Otipoby KL, Tien E, Arefayene M, Bai J, et al.
Discovery of BIIB068: a selective, potent, reversible Bruton's tyrosine kinase inhibitor as an orally efficacious agent for autoimmune diseases
Journal of Medicinal Chemistry. 2020; 63(21): 12526-12541. https://doi.org/10.1021/acs.jmedchem.0c00702
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Macdonald DS, Garrabou X, Klaus C, Verez R, Mori T, Hilvert D
Engineered artificial carboligases facilitate regioselective preparation of enantioenriched aldol adducts
Journal of the American Chemical Society. 2020; 142(23): 10250-10254. https://doi.org/10.1021/jacs.0c02351
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Magiera‐Mularz K, Kuska K, Skalniak L, Grudnik P, Musielak B, Plewka J, et al.
Macrocyclic peptide inhibitor of PD‐1/PD‐L1 immune checkpoint
Advanced Therapeutics. 2020. https://doi.org/10.1002/adtp.202000195
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Maliar N, Kovalev K, Baeken C, Balandin T, Astashkin R, Rulev M, et al.
Crystal structure of the N112A mutant of the light-driven sodium pump KR2
Crystals. 2020; 10(6): 496 (15 pp.). https://doi.org/10.3390/cryst10060496
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Malik IT, Pereira R, Vielberg M-T, Mayer C, Straetener J, Thomy D, et al.
Functional characterisation of ClpP mutations conferring resistance to acyldepsipeptide antibiotics in firmicutes
ChemBioChem. 2020; 21(14): 1997-2012. https://doi.org/10.1002/cbic.201900787
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Martiel I, Huang C-Y, Villanueva-Perez P, Panepucci E, Basu S, Caffrey M, et al.
Low-dose in situ prelocation of protein microcrystals by 2D X-ray phase-contrast imaging for serial crystallography
IUCrJ. 2020; 7(6): 1131-1141. https://doi.org/10.1107/S2052252520013238
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Martiel I, Buntschu D, Meier N, Gobbo A, Panepucci E, Schneider R, et al.
The TELL automatic sample changer for macromolecular crystallography
Journal of Synchrotron Radiation. 2020; 27: 860-863. https://doi.org/10.1107/S1600577520002416
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Martiel I, Mozzanica A, Opara NL, Panepucci E, Leonarski F, Redford S, et al.
X-ray fluorescence detection for serial macromolecular crystallography using a JUNGFRAU pixel detector
Journal of Synchrotron Radiation. 2020; 27: 329-339. https://doi.org/10.1107/S1600577519016758
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Matthews A, Saleem-Batcha R, Sanders JN, Stull F, Houk KN, Teufel R
Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases
Nature Chemical Biology. 2020; 16(5): 556-563. https://doi.org/10.1038/s41589-020-0476-2
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Medits I, Vaney M-C, Rouvinski A, Rey M, Chamot-Rooke J, Rey FA, et al.
Extensive flavivirus E trimer breathing accompanies stem zippering of the post-fusion hairpin
EMBO Reports. 2020; 21: e50069 (17 pp.). https://doi.org/10.15252/embr.202050069
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Methot JL, Achab A, Christopher M, Zhou H, McGowan MA, Trotter BW, et al.
Optimization of versatile oxindoles as selective PI3Kδ inhibitors
ACS Medicinal Chemistry Letters. 2020; 11(12): 2461-2469. https://doi.org/10.1021/acsmedchemlett.0c00441
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Metje-Sprink J, Groffmann J, Neumann P, Barg-Kues B, Ficner R, Kühnel K, et al.
Crystal structure of the Rab33B/Atg16L1 effector complex
Scientific Reports. 2020; 10(1): 12956 (13 pp.). https://doi.org/10.1038/s41598-020-69637-0
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Metrick CM, Peterson EA, Santoro JC, Enyedy IJ, Murugan P, Chen TY, et al.
Human PLD structures enable drug design and characterization of isoenzyme selectivity
Nature Chemical Biology. 2020; 16: 391-399. https://doi.org/10.1038/s41589-019-0458-4
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Moosmann P, Ecker F, Leopold-Messer S, Cahn JKB, Dieterich CL, Groll M, et al.
A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds
Nature Chemistry. 2020; 12(10): 968-972. https://doi.org/10.1038/s41557-020-0515-3
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Munzel L, Neumann P, Otto FB, Krick R, Metje-Sprink J, Kroppen B, et al.
Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore
Autophagy. 2020. https://doi.org/10.1080/15548627.2020.1766332
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Nakamura R, Hikita M, Ogawa S, Takahashi Y, Fujishiro T
Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes
FEBS Journal. 2020; 287(6): 1138-1154. https://doi.org/10.1111/febs.15081
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Ni X, Knapp S, Chaikuad A
Comparative structural analyses and nucleotide-binding characterization of the four KH domains of FUBP1
Scientific Reports. 2020; 10: 13459 (10 pp.). https://doi.org/10.1038/s41598-020-69832-z
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Nicoll CR, Bailleul G, Fiorentini F, Mascotti ML, Fraaije MW, Mattevi A
Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs
Nature Structural and Molecular Biology. 2020; 27(1): 14-24. https://doi.org/10.1038/s41594-019-0347-2
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Olatunji S, Yu X, Bailey J, Huang C-Y, Zapotoczna M, Bowen K, et al.
Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
Nature Communications. 2020; 11(1): 140 (11 pp.). https://doi.org/10.1038/s41467-019-13724-y
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Ontoria JM, Biancofiore I, Fezzardi P, Ferrigno F, Torrente E, Colarusso S, et al.
Combined peptide and small-molecule approach toward nonacidic THIQ inhibitors of the KEAP1/NRF2 interaction
ACS Medicinal Chemistry Letters. 2020; 11(5): 740-746. https://doi.org/10.1021/acsmedchemlett.9b00594
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Ost GS, Wirth C, Bogdanović X, Kao W-C, Schorch B, Aktories PJK, et al.
Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins
Science Advances. 2020; 6(11): eaaz2094 (12 pp.). https://doi.org/10.1126/sciadv.aaz2094
DORA PSI -
Pan BS, Perera SA, Piesvaux JA, Presland JP, Schroeder GK, Cumming JN, et al.
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