Publications

PDB structures measured at X06SA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Alen J, Schade M, Wagener M, Christian F, Nordhoff S, Merla B, et al.
    Fragment-based discovery of novel potent sepiapterin reductase inhibitors
    Journal of Medicinal Chemistry. 2019; 62(13): 6391-6397. https://doi.org/10.1021/acs.jmedchem.9b00218
    DORA PSI
  • Antoshvili M, Caspy I, Hippler M, Nelson N
    Structure and function of photosystem I in Cyanidioschyzon merolae
    Photosynthesis Research. 2019; 139(1-3): 499-508. https://doi.org/10.1007/s11120-018-0501-4
    DORA PSI
  • Apel A-K, Cheng RKY, Tautermann CS, Brauchle M, Huang C-Y, Pautsch A, et al.
    Crystal structure of CC chemokine receptor 2A in complex with an orthosteric antagonist provides insights for the design of selective antagonists
    Structure. 2019; 27(3): 427-438.e5. https://doi.org/10.1016/j.str.2018.10.027
    DORA PSI
  • Basu S, Kaminski JW, Panepucci E, Huang C-Y, Warshamanage R, Wang M, et al.
    Automated data collection and real-time data analysis suite for serial synchrotron crystallography
    Journal of Synchrotron Radiation. 2019; 26(1): 244-252. https://doi.org/10.1107/S1600577518016570
    DORA PSI
  • Battistutta R, Lolli G
    Inhibitory properties of ATP-competitive coumestrol and boldine are correlated to different modulations of CK2 flexibility
    Journal of Natural Products. 2019; 82(4): 1014-1018. https://doi.org/10.1021/acs.jnatprod.8b00889
    DORA PSI
  • Blech M, Hörer S, Kuhn AB, Kube S, Göddeke H, Kiefer H, et al.
    Structure of a therapeutic full-length anti-NPRA IgG4 antibody: dissecting conformational diversity
    Biophysical Journal. 2019; 116(9): 1637-1649. https://doi.org/10.1016/j.bpj.2019.03.036
    DORA PSI
  • Bogdanovic X, Schneider S, Levanova N, Wirth C, Trillhaase C, Steinemann M, et al.
    A cysteine protease-like domain enhances the cytotoxic effects of the Photorhabdus asymbiotica toxin PaTox
    Journal of Biological Chemistry. 2019; 294(3): 1035-1044. https://doi.org/10.1074/jbc.RA118.005043
    DORA PSI
  • Buchstaller H-P, Anlauf U, Dorsch D, Kuhn D, Lehmann M, Leuthner B, et al.
    Discovery and optimization of 2-Arylquinazolin-4-ones into a potent and selective tankyrase inhibitor modulating Wnt pathway activity
    Journal of Medicinal Chemistry. 2019; 62(17): 7897-7909. https://doi.org/10.1021/acs.jmedchem.9b00656
    DORA PSI
  • Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, et al.
    Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)
    Biochemical Journal. 2019; 476(5): 875-887. https://doi.org/10.1042/BCJ20190038
    DORA PSI
  • Colombano G, Caldwell JJ, Matthews TP, Bhatia C, Joshi A, McHardy T, et al.
    Binding to an unusual inactive kinase conformation by highly selective inhibitors of inositol-requiring enzyme 1α kinase-endoribonuclease
    Journal of Medicinal Chemistry. 2019; 62(5): 2447-2465. https://doi.org/10.1021/acs.jmedchem.8b01721
    DORA PSI
  • Damm-Ganamet KL, Arora N, Becart S, Edwards JP, Lebsack AD, McAllister HM, et al.
    Accelerating lead identification by high throughput virtual screening: prospective case studies from the pharmaceutical industry
    Journal of Chemical Information and Modeling. 2019; 59(5): 2046-2062. https://doi.org/10.1021/acs.jcim.8b00941
    DORA PSI
  • Ejby M, Guskov A, Pichler MJ, Zanten GC, Schoof E, Saburi W, et al.
    Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β-mannan possess distinct manno-oligosaccharide-binding profiles
    Molecular Microbiology. 2019; 112(1): 114-130. https://doi.org/10.1111/mmi.14257
    DORA PSI
  • Falchetto M, Ciossani G, Scolari F, Di Cosimo A, Nenci S, Field LM, et al.
    Structural and biochemical evaluation of Ceratitis capitata odorant-binding protein 22 affinity for odorants involved in intersex communication
    Insect Molecular Biology. 2019; 28(3): 431-443. https://doi.org/10.1111/imb.12559
    DORA PSI
  • Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, et al.
    BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
    Nature Chemical Biology. 2019; 15(7): 672-680. https://doi.org/10.1038/s41589-019-0294-6
    DORA PSI
  • Fradera X, Methot JL, Achab A, Christopher M, Altman MD, Zhou H, et al.
    Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow
    Bioorganic and Medicinal Chemistry Letters. 2019; 29(18): 2575-2580. https://doi.org/10.1016/j.bmcl.2019.08.004
    DORA PSI
  • Gall FM, Hohl D, Frasson D, Wermelinger T, Mittl PRE, Sievers M, et al.
    Drug design inspired by nature: crystallographic detection of an auto-tailored protease inhibitor template
    Angewandte Chemie International Edition. 2019; 58(12): 4051-4055. https://doi.org/10.1002/anie.201812348
    DORA PSI
  • Gollner A, Weinstabl H, Fuchs JE, Rudolph D, Garavel G, Hofbauer KS, et al.
    Targeted synthesis of complex spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by intramolecular cyclization of azomethine ylides: highly potent MDM2-p53 inhibitors
    ChemMedChem. 2019; 14(1): 88-93. https://doi.org/10.1002/cmdc.201800617
    DORA PSI
  • Grammbitter GLC, Schmalhofer M, Karimi K, Shi Y-M, Schöner TA, Tobias NJ, et al.
    An uncommon type II PKS catalyzes biosynthesis of aryl polyene pigments
    Journal of the American Chemical Society. 2019; 141(42): 16615-16623. https://doi.org/10.1021/jacs.8b10776
    DORA PSI
  • Griese JJ, Kositzki R, Haumann M, Högbom M
    Assembly of a heterodinuclear Mn/Fe cofactor is coupled to tyrosine-valine ether cross-link formation in the R2-like ligand-binding oxidase
    Journal of Biological Inorganic Chemistry. 2019; 24(2): 211-221. https://doi.org/10.1007/s00775-019-01639-4
    DORA PSI
  • Grāve K, Bennett MD, Högbom M
    Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis
    Communications Biology. 2019; 2(1): 175 (11 pp.). https://doi.org/10.1038/s42003-019-0427-1
    DORA PSI
  • Guerrero-Ferreira RC, Hupfeld M, Nazarov S, Taylor NMI, Shneider MM, Obbineni JM, et al.
    Structure and transformation of bacteriophage A511 baseplate and tail upon infection of Listeria cells
    EMBO Journal. 2019; 38(3): e99455 (20 pp.). https://doi.org/10.15252/embj.201899455
    DORA PSI
  • Heber S, Gáspár I, Tants J-N, Günther J, Moya SMF, Janowski R, et al.
    Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains
    Nature Communications. 2019; 10(1): 1659 (16 pp.). https://doi.org/10.1038/s41467-019-09655-3
    DORA PSI
  • Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, et al.
    An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5
    Autophagy. 2019. https://doi.org/10.1080/15548627.2019.1606637
    DORA PSI
  • Hutter CAJ, Timachi MH, Hürlimann LM, Zimmermann I, Egloff P, Göddeke H, et al.
    The extracellular gate shapes the energy profile of an ABC exporter
    Nature Communications. 2019; 10(1): 2260 (13 pp.). https://doi.org/10.1038/s41467-019-09892-6
    DORA PSI
  • Jaeger K, Bruenle S, Weinert T, Guba W, Muehle J, Miyazaki T, et al.
    Structural basis for allosteric ligand recognition in the human CC chemokine receptor 7
    Cell. 2019; 178(5): 1222-1230. https://doi.org/10.1016/j.cell.2019.07.028
    DORA PSI
  • Kaur H, Hartmann J-B, Jakob RP, Zahn M, Zimmermann I, Maier T, et al.
    Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach
    Journal of Biomolecular NMR. 2019; 73(6-7): 375-384. https://doi.org/10.1007/s10858-019-00250-8
    DORA PSI
  • Kropp HM, Diederichs K, Marx A
    The structure of an archaeal B-family DNA polymerase in complex with a chemically modified nucleotide
    Angewandte Chemie International Edition. 2019; 58(16): 5457-5461. https://doi.org/10.1002/anie.201900315
    DORA PSI
  • Lach M, Künzle M, Beck T
    Proteins as sustainable building blocks for the next generation of bioinorganic nanomaterials
    Biochemistry. 2019; 58(3): 140-141. https://doi.org/10.1021/acs.biochem.8b00966
    DORA PSI
  • Lee AW, Deruaz M, Lynch C, Davies G, Singh K, Alenazi Y, et al.
    A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins
    Journal of Biological Chemistry. 2019; 294(29): 11199-11212. https://doi.org/10.1074/jbc.RA119.008817
    DORA PSI
  • Li M, Müller C, Fröhlich K, Gorka O, Zhang L, Groß O, et al.
    Detection and characterization of a mycobacterial L-arabinofuranose ABC transporter identified with a rapid lipoproteomics protocol
    Cell Chemical Biology. 2019; 26(6): 852-862.e6. https://doi.org/10.1016/j.chembiol.2019.03.002
    DORA PSI
  • Mallagaray A, Creutznacher R, Dülfer J, Mayer PHO, Grimm LL, Orduña JM, et al.
    A post-translational modification of human norovirus capsid protein attenuates glycan binding
    Nature Communications. 2019; 10(1): 1320 (14 pp.). https://doi.org/10.1038/s41467-019-09251-5
    DORA PSI
  • Nakamura R, Hikita M, Ogawa S, Takahashi Y, Fujishiro T
    Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes
    FEBS Journal. 2019. https://doi.org/10.1111/febs.15081
    DORA PSI
  • Nguyen D, Lemos C, Wortmann L, Eis K, Holton SJ, Boemer U, et al.
    Discovery and characterization of the potent and highly selective (piperidin-4-yl)pyrido[3,2-d]pyrimidine based in vitro probe BAY-885 for the kinase ERK5.
    Journal of Medicinal Chemistry. 2019; 62(2): 928-940. https://doi.org/10.1021/acs.jmedchem.8b01606
    DORA PSI
  • Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier J-M, et al.
    Protein crystallization promotes type 2 immunity and is reversible by antibody treatment
    Science. 2019; 364(6442): eaaw4295 (17 pp.). https://doi.org/10.1126/science.aaw4295
    DORA PSI
  • Pichlo C, Juetten L, Wojtalla F, Schacherl M, Diaz D, Baumann U
    Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1
    Journal of Biological Chemistry. 2019; 294(30): 11525-11535. https://doi.org/10.1074/jbc.RA119.009029
    DORA PSI
  • Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, et al.
    Structural basis of BRCC36 function in DNA repair and immune regulation
    Molecular Cell. 2019; 75(3): 483-497.e9. https://doi.org/10.1016/j.molcel.2019.06.002
    DORA PSI
  • Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, et al.
    Leveraging compound promiscuity to identify targetable cysteines within the kinome
    Cell Chemical Biology. 2019; 26(6): 818-829.e9. https://doi.org/10.1016/j.chembiol.2019.02.021
    DORA PSI
  • Robinson GC, Kaufmann M, Roux C, Martinez-Font J, Hothorn M, Thore S, et al.
    Crystal structure of the pseudoenzyme PDX1.2 in complex with its cognate enzyme PDX1.3: a total eclipse
    Acta Crystallographica Section D: Structural Biology. 2019; 75(4): 400-415. https://doi.org/10.1107/S2059798319002912
    DORA PSI
  • Rozov A, Khusainov I, El Omari K, Duman R, Mykhaylyk V, Yusupov M, et al.
    Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction
    Nature Communications. 2019; 10(1): 2519 (12 pp.). https://doi.org/10.1038/s41467-019-10409-4
    DORA PSI
  • Sauer MM, Jakob RP, Luber T, Canonica F, Navarra G, Ernst B, et al.
    Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets
    Journal of the American Chemical Society. 2019; 141(2): 936-944. https://doi.org/10.1021/jacs.8b10736
    DORA PSI
  • Schneider T, Hung L-H, Aziz M, Wilmen A, Thaum S, Wagner J, et al.
    Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3
    Nature Communications. 2019; 10(1): 2266 (18 pp.). https://doi.org/10.1038/s41467-019-09769-8
    DORA PSI
  • Schopf FH, Huber EM, Dodt C, Lopez A, Biebl MM, Rutz DA, et al.
    The co-chaperone Cns1 and the recruiter protein Hgh1 link Hsp90 to translation elongation via chaperoning elongation factor 2
    Molecular Cell. 2019; 74(1): 73-87.e8. https://doi.org/10.1016/j.molcel.2019.02.011
    DORA PSI
  • Schuetz DA, Bernetti M, Bertazzo M, Musil D, Eggenweiler H-M, Recanatini M, et al.
    Predicting residence time and drug unbinding pathway through scaled molecular dynamics
    Journal of Chemical Information and Modeling. 2019; 59(1): 535-549. https://doi.org/10.1021/acs.jcim.8b00614
    DORA PSI
  • Schulte M, Frick K, Gnandt E, Jurkovic S, Burschel S, Labatzke R, et al.
    A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I
    Nature Communications. 2019; 10(1): 2551 (9 pp.). https://doi.org/10.1038/s41467-019-10429-0
    DORA PSI
  • Schönemann W, Cramer J, Mühlethaler T, Fiege B, Silbermann M, Rabbani S, et al.
    Improvement of aglycone π-stacking yields nanomolar to sub-nanomolar FimH antagonists
    ChemMedChem. 2019; 14(7): 749-757. https://doi.org/10.1002/cmdc.201900051
    DORA PSI
  • Schöppe J, Ehrenmann J, Klenk C, Rucktooa P, Schütz M, Doré AS, et al.
    Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
    Nature Communications. 2019; 10(1): 17 (11 pp.). https://doi.org/10.1038/s41467-018-07939-8
    DORA PSI
  • Sitsel A, De Raeymaecker J, Düring Drachmann N, Derua R, Smaardijk S, Lauwring Andersen J, et al.
    Structures of the heart specific SERCA2a Ca2+-ATPase
    EMBO Journal. 2019; 38(5): e100020 (17 pp.). https://doi.org/10.15252/embj.2018100020
    DORA PSI
  • Stampfli AR, Goncharenko KV, Meury M, Dubey BN, Schirmer T, Seebeck FP
    An alternative active site architecture for O2 activation in the ergothioneine biosynthetic EgtB from Chloracidobacterium thermophilum
    Journal of the American Chemical Society. 2019; 141(13): 5275-5285. https://doi.org/10.1021/jacs.8b13023
    DORA PSI
  • Subramanian G, Johnson PD, Zachary T, Roush N, Zhu Y, Bowen SJ, et al.
    Deciphering the allosteric binding mechanism of the human tropomyosin receptor kinase A (hTrkA) inhibitors
    ACS Chemical Biology. 2019; 14(6): 1205-1216. https://doi.org/10.1021/acschembio.9b00126
    DORA PSI
  • Tanina A, Wohlkönig A, Soror SH, Flipo M, Villemagne B, Prevet H, et al.
    A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR
    Biochimica et Biophysica Acta: Proteins and Proteomics. 2019; 1867(3): 248-258. https://doi.org/10.1016/j.bbapap.2018.12.003
    DORA PSI
  • Tomizaki T, Shinoda A, Tsujino S
    Single crystal time-lapse measurement using ultrasonic acoustic levitation
    In: Gwo S, Huang D-J, Wei D-H, eds. Proceedings of the 13th international conference on synchrotron radiation instrumentation – SRI2018. Vol. 2054. AIP conference proceedings. Melville, New York: AIP Publishing; 2019. https://doi.org/10.1063/1.5084703
    DORA PSI
  • Tsai C-J, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, et al.
    Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
    eLife. 2019; 8: e46041 (19 pp.). https://doi.org/10.7554/eLife.46041
    DORA PSI
  • Tsujino S, Shinoda A, Tomizaki T
    On-demand droplet loading of ultrasonic acoustic levitator and its application for protein crystallography experiments
    Applied Physics Letters. 2019; 114(21): 213702 (5 pp.). https://doi.org/10.1063/1.5095574
    DORA PSI
  • Tsujino S, Sato Y, Takeda Y, Tomizaki T
    Oscillation resonances and anisotropic damping of the motion of acoustically levitated droplets in single-axis acoustic levitators
    Applied Physics Letters. 2019; 115: 053702 (5 pp.). https://doi.org/10.1063/1.5112109
    DORA PSI
  • Varma N, Mutt E, Mühle J, Panneels V, Terakita A, Deupi X, et al.
    Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(29): 14574-14556. https://doi.org/10.1073/pnas.1902192116
    DORA PSI
  • Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, et al.
    Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle
    Nature. 2019; 568(7753): 571-575. https://doi.org/10.1038/s41586-019-1095-5
    DORA PSI
  • Vlieg HC, Huizinga EG, Janssen BJC
    Structure and flexibility of the extracellular region of the PirB receptor
    Journal of Biological Chemistry. 2019; 294(12): 4634-4643. https://doi.org/10.1074/jbc.RA118.004396
    DORA PSI
  • Wachter S, Jung J, Shafiq S, Basquin J, Fort C, Bastin P, et al.
    Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly
    EMBO Journal. 2019; 38(9): e101251 (18 pp.). https://doi.org/10.15252/embj.2018101251
    DORA PSI
  • Watts E, Heidenreich D, Tucker E, Raab M, Strebhardt K, Chesler L, et al.
    Designing dual inhibitors of anaplastic lymphoma kinase (ALK) and bromodomain-4 (BRD4) by tuning kinase selectivity
    Journal of Medicinal Chemistry. 2019; 62(5): 2618-2637. https://doi.org/10.1021/acs.jmedchem.8b01947
    DORA PSI
  • Weinert T, Skopintsev P, James D, Dworkowski F, Panepucci E, Kekilli D, et al.
    Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography
    Science. 2019; 365(6448): 61-65. https://doi.org/10.1126/science.aaw8634
    DORA PSI
  • Weinstabl H, Treu M, Rinnenthal J, Zahn SK, Ettmayer P, Bader G, et al.
    Intracellular trapping of the selective phosphoglycerate dehydrogenase (PHGDH) inhibitor BI-4924 disrupts serine biosynthesis
    Journal of Medicinal Chemistry. 2019; 62(17): 7976-7997. https://doi.org/10.1021/acs.jmedchem.9b00718
    DORA PSI
  • Wiedmer L, Schärer C, Spiliotopoulos D, Hürzeler M, Śledź P, Caflisch A
    Ligand retargeting by binding site analogy
    European Journal of Medicinal Chemistry. 2019; 175: 107-113. https://doi.org/10.1016/j.ejmech.2019.04.037
    DORA PSI
  • Xin B-T, Huber EM, de Bruin G, Heinemeyer W, Maurits E, Espinal C, et al.
    Structure-based design of inhibitors selective for human proteasome β2c or β2i subunits
    Journal of Medicinal Chemistry. 2019; 62(3): 1626-1642. https://doi.org/10.1021/acs.jmedchem.8b01884
    DORA PSI
  • Zhang AT, Montgomery MG, Leslie AGW, Cook GM, Walker JE
    The structure of the catalytic domain of the ATP synthase from Mycobacterium smegmatis is a target for developing antitubercular drugs
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2019; 116(10): 4206-4211. https://doi.org/10.1073/pnas.1817615116
    DORA PSI
  • Zhou Q, Bräuer A, Adihou H, Schmalhofer M, Saura P, Grammbitter GLC, et al.
    Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens
    Chemical Science. 2019; 10(25): 6341-6349. https://doi.org/10.1039/c9sc00749k
    DORA PSI
  • Andersen JL, Gesser B, Funder ED, Nielsen CJF, Gotfred-Rasmussen H, Rasmussen MK, et al.
    Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
    Nature Communications. 2018; 9(1): 4344 (8 pp.). https://doi.org/10.1038/s41467-018-06787-w
    DORA PSI
  • Apetri A, Crespo R, Juraszek J, Pascual G, Janson R, Zhu X, et al.
    A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities
    Acta Neuropathologica. 2018; 6: 43 (17 pp.). https://doi.org/10.1186/s40478-018-0543-z
    DORA PSI
  • Argy N, Le Gal S, Coppée R, Song Z, Vindrios W, Massias L, et al.
    Pneumocystis cytochrome B mutants associated with atovaquone prophylaxis failure as the cause of pneumocystis infection outbreak among heart transplant recipients
    Clinical Infectious Diseases. 2018; 67(6): 913-919. https://doi.org/10.1093/cid/ciy154
    DORA PSI
  • Batiste L, Unzue A, Dolbois A, Hassler F, Wang X, Deerain N, et al.
    Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple)
    ACS Central Science. 2018; 4(2): 180-188. https://doi.org/10.1021/acscentsci.7b00401
    DORA PSI
  • Bauer D, Meinhold S, Jakob RP, Stigler J, Merkel U, Maier T, et al.
    A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2018; 115(18): 4666-4671. https://doi.org/10.1073/pnas.1716899115
    DORA PSI
  • Bhatia S, Krieger V, Groll M, Osko JD, Reßing N, Ahlert H, et al.
    Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor
    Journal of Medicinal Chemistry. 2018; 61(22): 10299-10309. https://doi.org/10.1021/acs.jmedchem.8b01487
    DORA PSI
  • Bräuning B, Groll M
    Structural and mechanistic features of ClyA-like α-pore-forming toxins
    Toxins. 2018; 10(9): 343. https://doi.org/10.3390/toxins10090343
    DORA PSI
  • Bräuning B, Bertosin E, Praetorius F, Ihling C, Schatt A, Adler A, et al.
    Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB
    Nature Communications. 2018; 9(1): 1806 (14 pp.). https://doi.org/10.1038/s41467-018-04139-2
    DORA PSI
  • Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-SanJuan A, et al.
    High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design
    Scientific Reports. 2018; 8(1): 4242 (17 pp.). https://doi.org/10.1038/s41598-018-22382-x
    DORA PSI
  • Buth SA, Shneider MM, Scholl D, Leiman PG
    Structure and analysis of R1 and R2 pyocin receptor-binding fibers
    Viruses. 2018; 10(8): 427 (22 pp.). https://doi.org/10.3390/v10080427
    DORA PSI
  • Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, et al.
    Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
    Nature Communications. 2018; 9(1): 4500 (10 pp.). https://doi.org/10.1038/s41467-018-06955-y
    DORA PSI
  • Caldwell R, Liu-Bujalski L, Qiu H, Mochalkin I, Jones R, Neagu C, et al.
    Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk
    Bioorganic and Medicinal Chemistry Letters. 2018; 28(21): 3419-3424. https://doi.org/10.1016/j.bmcl.2018.09.033
    DORA PSI
  • Crawford JJ, Johnson AR, Misner DL, Belmont LD, Castanedo G, Choy R, et al.
    Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development
    Journal of Medicinal Chemistry. 2018; 61(6): 2227-2245. https://doi.org/10.1021/acs.jmedchem.7b01712
    DORA PSI
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