Publications

PDB structures measured at X06SA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Busch MR, Rajendran C, Sterner R
    Structural and functional characterization of the ureidoacrylate amidohydrolase RutB from Escherichia coli
    Biochemistry. 2023; 62(3): 863-872. https://doi.org/10.1021/acs.biochem.2c00640
    DORA PSI
  • Cucuzza S, Michel E, Mittl PRE, Zerbe O, Plückthun A
    Improved repeat protein stability by combined consensus and computational protein design
    Biochemistry. 2023; 62(2): 318-329. https://doi.org/10.1021/acs.biochem.2c00083
    DORA PSI
  • Davis-Gilbert ZW, Krämer A, Dunford JE, Howell S, Senbabaoglu F, Wells CI, et al.
    Discovery of a potent and selective naphthyridine-based chemical probe for casein kinase 2
    ACS Medicinal Chemistry Letters. 2023. https://doi.org/10.1021/acsmedchemlett.2c00530
    DORA PSI
  • Imai Y, Wakasugi D, Suzuki R, Kato S, Sugisaki M, Mima M, et al.
    Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor
    Bioorganic and Medicinal Chemistry Letters. 2023; 79: 129050 (6 pp.). https://doi.org/10.1016/j.bmcl.2022.129050
    DORA PSI
  • Leonarski F, Brückner M, Lopez-Cuenca C, Mozzanica A, Stadler H-C, Matěj Z, et al.
    Jungfraujoch: hardware-accelerated data-acquisition system for kilohertz pixel-array X-ray detectors
    Journal of Synchrotron Radiation. 2023; 30: 227-234. https://doi.org/10.1107/S1600577522010268
    DORA PSI
  • Mauxion F, Basquin J, Ozgur S, Rame M, Albrecht J, Schäfer I, et al.
    The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
    Cell Reports. 2023; 42(1): 111902 (18 pp.). https://doi.org/10.1016/j.celrep.2022.111902
    DORA PSI
  • Shishiuchi R, Kang H, Tagami T, Ueda Y, Lang W, Kimura A, et al.
    Discovery of α-L-glucosidase raises the possibility of α-L-glucosides in nature
    ACS Omega. 2023; 7(50): 47411-47423. https://doi.org/10.1021/acsomega.2c06991
    DORA PSI
  • Tang S, Garzon Sanz M, Smith O, Krämer A, Egbase D, Caton PW, et al.
    Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators
    Acta Pharmaceutica Sinica B. 2023; 13(2): 709-721. https://doi.org/10.1016/j.apsb.2022.07.016
    DORA PSI
  • Warstat R, Pervaiz M, Regenass P, Amann M, Schmidtkunz K, Einsle O, et al.
    A novel pan-selective bromodomain inhibitor for epigenetic drug design
    European Journal of Medicinal Chemistry. 2023; 249: 115139 (12 pp.). https://doi.org/10.1016/j.ejmech.2023.115139
    DORA PSI
  • Wranik M, Weinert T, Slavov C, Masini T, Furrer A, Gaillard N, et al.
    Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
    Nature Communications. 2023; 14(1): 903 (12 pp.). https://doi.org/10.1038/s41467-023-36481-5
    DORA PSI
  • Zhang L, Toplak M, Saleem-Batcha R, Höing L, Jakob R, Jehmlich N, et al.
    Bacterial dehydrogenases facilitate oxidative inactivation and bioremediation of chloramphenicol
    ChemBioChem. 2023; 24: 2-e202200632 (5 pp.). https://doi.org/10.1002/cbic.202200632
    DORA PSI
  • Albert L, Nagpal J, Steinchen W, Zhang L, Werel L, Djokovic N, et al.
    Bistable photoswitch allows in vivo control of hematopoiesis
    ACS Central Science. 2022; 8(1): 57-66. https://doi.org/10.1021/acscentsci.1c00434
    DORA PSI
  • Astro V, Ramirez-Calderon G, Pennucci R, Caroli J, Saera-Vila A, Cardona-Londoño K, et al.
    Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
    iScience. 2022; 25(7): 104665 (32 pp.). https://doi.org/10.1016/j.isci.2022.104665
    DORA PSI
  • Auman D, Ecker F, Mader SL, Dorst KM, Bräuer A, Widmalm G, et al.
    Peroxy intermediate drives carbon bond activation in the dioxygenase AsqJ
    Journal of the American Chemical Society. 2022; 144(34): 15622-15632. https://doi.org/10.1021/jacs.2c05650
    DORA PSI
  • Baudrexl M, Fida T, Berk B, Schwarz WH, Zverlov VV, Groll M, et al.
    Biochemical and structural characterization of thermostable GH159 glycoside hydrolases exhibiting α-L-arabinofuranosidase activity
    Frontiers in Molecular Biosciences. 2022; 9: 907439 (15 pp.). https://doi.org/10.3389/fmolb.2022.907439
    DORA PSI
  • Beaumet M, Dose A, Bräuer A, Mahy JP, Ghattas W, Groll M, et al.
    An artificial metalloprotein with metal-adaptive coordination sites and Ni-dependent quercetinase activity
    Journal of Inorganic Biochemistry. 2022; 235: 111914 (5 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111914
    DORA PSI
  • Begnini F, Geschwindner S, Johansson P, Wissler L, Lewis RJ, Danelius E, et al.
    Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction
    Journal of Medicinal Chemistry. 2022; 65(4): 3473-3517. https://doi.org/10.1021/acs.jmedchem.1c01975
    DORA PSI
  • Bloch JS, Sequeira JM, Ramírez AS, Quadros EV, Locher KP
    Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route
    FASEB Journal. 2022; 36(4): e22222 (11 pp.). https://doi.org/10.1096/fj.202101376RR
    DORA PSI
  • Bonagas N, Gustafsson NMS, Henriksson M, Marttila P, Gustafsson R, Wiita E, et al.
    Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
    Nature Cancer. 2022; 3(2): 156-172. https://doi.org/10.1038/s43018-022-00331-y
    DORA PSI
  • Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, et al.
    Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRASG12C inhibitor
    Journal of Medicinal Chemistry. 2022; 65(21): 14614-14629. https://doi.org/10.1021/acs.jmedchem.2c01120
    DORA PSI
  • Bärland N, Rueff A-S, Cebrero G, Hutter CAJ, Seeger MA, Veening JW, et al.
    Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification
    Science Advances. 2022; 8(9): eabm1122 (14 pp.). https://doi.org/10.1126/sciadv.abm1122
    DORA PSI
  • Cansfield AD, Ator MA, Banerjee J, Bestwick M, Bortolato A, Brown GA, et al.
    Novel macrocyclic antagonists of the calcitonin gene-related peptide receptor: design, realization, and structural characterization of protein-ligand complexes
    ACS Chemical Neuroscience. 2022; 13(6): 751-765. https://doi.org/10.1021/acschemneuro.1c00696
    DORA PSI
  • Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, et al.
    Chemoproteomics-enabled identification of 4-Oxo-β-lactams as inhibitors of dipeptidyl peptidases 8 and 9
    Angewandte Chemie International Edition. 2022; 61(47): e202210498 (10 pp.). https://doi.org/10.1002/anie.202210498
    DORA PSI
  • Cellini A, Shankar MK, Wahlgren WY, Nimmrich A, Furrer A, James D, et al.
    Structural basis of the radical pair state in photolyases and cryptochromes
    Chemical Communications. 2022; 58(31): 4889-4892. https://doi.org/10.1039/D2CC00376G
    DORA PSI
  • Chaikuad A, Zhubi R, Tredup C, Knapp S
    Comparative structural analyses of the NHL domains from the human E3 ligase TRIM-NHL family
    IUCrJ. 2022; 9(6): 720-727. https://doi.org/10.1107/S2052252522008582
    DORA PSI
  • Chen Y, Tso K, Heckrodt TJ, Li H, Yen R, Lin N, et al.
    Bicyclic pyrimidine compounds as potent IRAK4 inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2022; 73: 128900 (5 pp.). https://doi.org/10.1016/j.bmcl.2022.128900
    DORA PSI
  • Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, et al.
    N-heterocyclic 3-pyridyl carboxamide inhibitors of DHODH for the treatment of acute myelogenous leukemia
    Journal of Medicinal Chemistry. 2022; 65(16): 11241-11256. https://doi.org/10.1021/acs.jmedchem.2c00788
    DORA PSI
  • Cullati SN, Chaikuad A, Chen J-S, Gebel J, Tesmer L, Zhubi R, et al.
    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
    Molecular Cell. 2022; 82(11): 2006-2020.e8. https://doi.org/10.1016/j.molcel.2022.03.005
    DORA PSI
  • Daniels MH, Malojcic G, Clugston SL, Williams B, Coeffet-Le Gal M, Pan-Zhou X-R, et al.
    Discovery and optimization of highly selective inhibitors of CDK5
    Journal of Medicinal Chemistry. 2022; 65(4): 3575-3596. https://doi.org/10.1021/acs.jmedchem.1c02069
    DORA PSI
  • Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, et al.
    Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition
    Nature Communications. 2022; 13(1): 382 (13 pp.). https://doi.org/10.1038/s41467-021-27911-3
    DORA PSI
  • Diamanti R, Srinivas V, Johansson AI, Nordström A, Griese JJ, Lebrette H, et al.
    Comparative structural analysis provides new insights into the function of R2-like ligand-binding oxidase
    FEBS Letters. 2022; 569(12): 1600-1610. https://doi.org/10.1002/1873-3468.14319
    DORA PSI
  • Dileep KV, Ihara K, Mishima-Tsumagari C, Kukimoto-Niino M, Yonemochi M, Hanada K, et al.
    Crystal structure of human acetylcholinesterase in complex with tacrine: implications for drug discovery
    International Journal of Biological Macromolecules. 2022; 210: 172-181. https://doi.org/10.1016/j.ijbiomac.2022.05.009
    DORA PSI
  • Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, et al.
    Identification of pyrimidine-based lead compounds for understudied kinases implicated in driving neurodegeneration
    Journal of Medicinal Chemistry. 2022; 65(2): 1313-1328. https://doi.org/10.1021/acs.jmedchem.1c00440
    DORA PSI
  • Funck D, Sinn M, Fleming JR, Stanoppi M, Dietrich J, López-Igual R, et al.
    Discovery of a Ni2+-dependent guanidine hydrolase in bacteria
    Nature. 2022; 603(7901): 515-521. https://doi.org/10.1038/s41586-022-04490-x
    DORA PSI
  • Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, et al.
    In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M
    Journal of the American Chemical Society. 2022; 144(12): 5614-5628. https://doi.org/10.1021/jacs.2c01020
    DORA PSI
  • Ghosh P, Kropp HM, Betz K, Ludmann S, Diederichs K, Marx A, et al.
    Microenvironment-sensitive fluorescent nucleotide probes from benzofuran, benzothiophene, and selenophene as substrates for DNA polymerases
    Journal of the American Chemical Society. 2022; 144(23): 10556-10569. https://doi.org/10.1021/jacs.2c03454
    DORA PSI
  • Gilzer D, Schreiner M, Niemann HH
    Direct interaction of a chaperone-bound type III secretion substrate with the export gate
    Nature Communications. 2022; 13(1): 2858 (13 pp.). https://doi.org/10.1038/s41467-022-30487-1
    DORA PSI
  • Gude F, Molloy EM, Horch T, Dell M, Dunbar KL, Krabbe J, et al.
    A specialized polythioamide-binding protein confers antibiotic self-resistance in anaerobic bacteria
    Angewandte Chemie International Edition. 2022; 61(37): e202206168 (9 pp.). https://doi.org/10.1002/anie.202206168
    DORA PSI
  • Guo Y, Alvigini L, Trajkovic M, Alonso-Cotchico L, Monza E, Savino S, et al.
    Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound
    Nature Communications. 2022; 13(1): 7195 (12 pp.). https://doi.org/10.1038/s41467-022-34912-3
    DORA PSI
  • Heinrich T, Peterson C, Schneider R, Garg S, Schwarz D, Gunera J, et al.
    Optimization of TEAD P-site binding fragment hit into in vivo active lead MSC-4106
    Journal of Medicinal Chemistry. 2022; 65(13): 9206-9229. https://doi.org/10.1021/acs.jmedchem.2c00403
    DORA PSI
  • Hu S, El Sahili A, Kishore S, Wong YH, Hemu X, Goh BC, et al.
    Structural basis for proenzyme maturation, substrate recognition, and ligation by a hyperactive peptide asparaginyl ligase
    Plant Cell. 2022; 34(12): 4936-4949. https://doi.org/10.1093/plcell/koac281
    DORA PSI
  • Huang C-Y, Aumonier S, Engilberge S, Eris D, Smith KML, Leonarski F, et al.
    Probing ligand binding of endothiapepsin by 'temperature-resolved' macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 964-974. https://doi.org/10.1107/S205979832200612X
    DORA PSI
  • Huber EM, Hortschansky P, Scheven MT, Misslinger M, Haas H, Brakhage AA, et al.
    Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX
    Structure. 2022; 30(7): 934-946.e4. https://doi.org/10.1016/j.str.2022.04.001
    DORA PSI
  • Jia S, Sato Y, Tsujino S
    Size and shape dependent rotation characteristics of thin film ultrasonic rotors
    Applied Physics Letters. 2022; 121(25): 254102 (6 pp.). https://doi.org/10.1063/5.0126000
    DORA PSI
  • Kaminski JW, Vera L, Stegmann DP, Vering J, Eris D, Smith KML, et al.
    Fast fragment- and compound-screening pipeline at the Swiss Light Source
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 328-336. https://doi.org/10.1107/S2059798322000705
    DORA PSI
  • Kaplan E, Greene NP, Jepson AE, Koronakis V
    Structural basis of lipoprotein recognition by the bacterial Lol trafficking chaperone LolA
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2022; 119(36): e2208662119 (9 pp.). https://doi.org/10.1073/pnas.2208662119
    DORA PSI
  • Kepa MW, Tomizaki T, Sato Y, Ozerov D, Sekiguchi H, Yasuda N, et al.
    Acoustic levitation and rotation of thin films and their application for room temperature protein crystallography
    Scientific Reports. 2022; 12: 5349 (14 pp.). https://doi.org/10.1038/s41598-022-09167-z
    DORA PSI
  • Kiss C, Gall FM, Dreier B, Adams M, Riedl R, Plückthun A, et al.
    Structure of a hydrophobic leucinostatin derivative determined by host lattice display
    Acta Crystallographica Section D: Structural Biology. 2022; 78(12): 1439-1450. https://doi.org/10.1107/S2059798322010762
    DORA PSI
  • Kroef V, Ruegenberg S, Horn M, Allmeroth K, Ebert L, Bozkus S, et al.
    GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway
    eLife. 2022; 11: e69223 (29 pp.). https://doi.org/10.7554/eLife.69223
    DORA PSI
  • Kurz CG, Preuss F, Tjaden A, Cusack M, Amrhein JA, Chatterjee D, et al.
    Illuminating the dark: highly selective inhibition of serine/threonine kinase 17A with pyrazolo[1,5-a]pyrimidine-Based macrocycles
    Journal of Medicinal Chemistry. 2022; 65(11): 7799-7817. https://doi.org/10.1021/acs.jmedchem.2c00173
    DORA PSI
  • Leit S, Greenwood JR, Mondal S, Carriero S, Dahlgren M, Harriman GC, et al.
    Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
    Bioorganic and Medicinal Chemistry Letters. 2022; 73: 128891 (10 pp.). https://doi.org/10.1016/j.bmcl.2022.128891
    DORA PSI
  • Li P, Nayeri N, Górecki K, Becares ER, Wang K, Mahato DR, et al.
    PcoB is a defense outer membrane protein that facilitates cellular uptake of copper
    Protein Science. 2022; 31(7): e4364 (16 pp.). https://doi.org/10.1002/pro.4364
    DORA PSI
  • Li Y, Bedi RK, Nai F, von Roten V, Dolbois A, Zálešák F, et al.
    Structure-based design of ligands of the m6A-RNA reader YTHDC1
    European Journal of Medicinal Chemistry Reports. 2022; 5: 100057 (11 pp.). https://doi.org/10.1016/j.ejmcr.2022.100057
    DORA PSI
  • Maire AL, Rey M, Vivat V, Guée L, Blanc P, Malosse C, et al.
    Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids
    Journal of Molecular Endocrinology. 2022; 69(3): 377-390. https://doi.org/10.1530/JME-22-0021
    DORA PSI
  • Mehta V, Khanppnavar B, Schuster D, Kantarci I, Vercellino I, Kosturanova A, et al.
    Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
    eLife. 2022; 11: e77032 (21 pp.). https://doi.org/10.7554/ELIFE.77032
    DORA PSI
  • Metzner FJ, Huber E, Hopfner K-P, Lammens K
    Structural and biochemical characterization of human Schlafen 5
    Nucleic Acids Research. 2022; 50(2): 1147-1161. https://doi.org/10.1093/nar/gkab1278
    DORA PSI
  • Molina R, Garcia-Martin R, López-Méndez B, Grøn Jensen A L, Ciges-Tomas J R, Marchena-Hurtado J, et al.
    Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases
    Nucleic Acids Research. 2022; 50(19): 11199-11213. https://doi.org/10.1093/nar/gkac923
    DORA PSI
  • Mous S, Gotthard G, Ehrenberg D, Sen S, Weinert T, Johnson PJM, et al.
    Dynamics and mechanism of a light-driven chloride pump
    Science. 2022; 375(6583): 845-851. https://doi.org/10.1126/science.abj6663
    DORA PSI
  • Muckenfuss LM, Migenda Herranz AC, Boneberg FM, Clerici M, Jinek M
    Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis
    eLife. 2022; 11: e80332 (29 pp.). https://doi.org/10.7554/eLife.80332
    DORA PSI
  • Nass KJ, Ilie IM, Saller MJ, Driessen AJM, Caflisch A, Kammerer RA, et al.
    The role of the N-terminal amphipathic helix in bacterial YidC: insights from functional studies, the crystal structure and molecular dynamics simulations
    Biochimica et Biophysica Acta: Biomembranes. 2022; 1864(3): 183825 (9 pp.). https://doi.org/10.1016/j.bbamem.2021.183825
    DORA PSI
  • Ng S, Brueckner AC, Bahmanjah S, Deng Q, Johnston JM, Ge L, et al.
    Discovery and structure-based design of macrocyclic peptides targeting STUB1
    Journal of Medicinal Chemistry. 2022; 65(14): 9789-9801. https://doi.org/10.1021/acs.jmedchem.2c00406
    DORA PSI
  • Nozal V, Martínez-González L, Gomez-Almeria M, Gonzalo-Consuegra C, Santana P, Chaikuad A, et al.
    TDP-43 Modulation by Tau-Tubulin kinase 1 inhibitors: a new avenue for future amyotrophic lateral sclerosis therapy
    Journal of Medicinal Chemistry. 2022; 65(2): 1585-1607. https://doi.org/10.1021/acs.jmedchem.1c01942
    DORA PSI
  • Pacesa M, Lin C-H, Cléry A, Saha A, Arantes PR, Bargsten K, et al.
    Structural basis for Cas9 off-target activity
    Cell. 2022; 185(22): 4067-4081.e21. https://doi.org/10.1016/j.cell.2022.09.026
    DORA PSI
  • Pallesen JS, Munier CC, Bosica F, Andrei SA, Edman K, Gunnarsson A, et al.
    Designing selective drug-like molecular glues for the glucocorticoid receptor/14-3-3 protein-protein interaction
    Journal of Medicinal Chemistry. 2022; 65(24): 16818-16828. https://doi.org/10.1021/acs.jmedchem.2c01635
    DORA PSI
  • Priyanka A, Tisi D, Sixma TK
    Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain
    Journal of Structural Biology. 2022; 214(3): 107862 (9 pp.). https://doi.org/10.1016/j.jsb.2022.107862
    DORA PSI
  • Ramanadane K, Straub MS, Dutzler R, Manatschal C
    Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family
    eLife. 2022; 11: e74589 (29 pp.). https://doi.org/10.7554/eLife.74589
    DORA PSI
  • Rohac R, Crack JC, de Rosny E, Gigarel O, Le Brun NE, Fontecilla-Camps JC, et al.
    Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors
    Communications Biology. 2022; 5(1): 769 (11 pp.). https://doi.org/10.1038/s42003-022-03745-7
    DORA PSI
  • Rossetti GG, Ossorio MA, Rempel S, Kratzel A, Dionellis VS, Barriot S, et al.
    Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits
    Scientific Reports. 2022; 12(1): 2505 (9 pp.). https://doi.org/10.1038/s41598-022-06306-4
    DORA PSI
  • Salustros N, Grønberg C, Abeyrathna NS, Lyu P, Orädd F, Wang K, et al.
    Structural basis of ion uptake in copper-transporting P1B-type ATPases
    Nature Communications. 2022; 13(1): 5121 (11 pp.). https://doi.org/10.1038/s41467-022-32751-w
    DORA PSI
  • Shi Y-M, Hirschmann M, Shi Y-N, Ahmed S, Abebew D, Tobias NJ, et al.
    Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria
    Nature Chemistry. 2022; 14(6): 701-712. https://doi.org/10.1038/s41557-022-00923-2
    DORA PSI
  • Stauffer M, Jeckelmann J-M, Ilgü H, Ucurum Z, Boggavarapu R, Fotiadis D
    Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor
    Communications Chemistry. 2022; 5(1): 23 (10 pp.). https://doi.org/10.1038/s42004-022-00636-0
    DORA PSI
  • Stephenson Clarke JR, Douglas LR, Duriez PJ, Balourdas D-I, Joerger AC, Khadiullina R, et al.
    Discovery of nanomolar-affinity pharmacological chaperones stabilizing the oncogenic p53 mutant Y220C
    ACS Pharmacology & Translational Science. 2022; 5(11): 1169-1180. https://doi.org/10.1021/acsptsci.2c00164
    DORA PSI
  • Strubel A, Münick P, Chaikuad A, Dreier B, Schaefer J, Gebel J, et al.
    Designed ankyrin repeat proteins as a tool box for analyzing p63
    Cell Death and Differentiation. 2022; 29: 2445-2458. https://doi.org/10.1038/s41418-022-01030-y
    DORA PSI
  • Takeuchi K, Ikeda Y, Senda M, Harada A, Okuwaki K, Fukuzawa K, et al.
    The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity
    Structure. 2022; 30(6): 886-899.e4. https://doi.org/10.1016/j.str.2022.04.004
    DORA PSI
  • Tao H, Lauterbach L, Bian G, Chen R, Hou A, Mori T, et al.
    Discovery of non-squalene triterpenes
    Nature. 2022; 606(7913): 414-419. https://doi.org/10.1038/s41586-022-04773-3
    DORA PSI
  • Trottmann F, Ishida K, Ishida-Ito M, Kries H, Groll M, Hertweck C
    Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead
    Nature Chemistry. 2022; 14(8): 884-890. https://doi.org/10.1038/s41557-022-01005-z
    DORA PSI
  • Tsugita A, Uehara S, Matsui T, Yokoyama T, Ostash I, Deneka M, et al.
    The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK
    FEBS Journal. 2022; 289(19): 6038-6057. https://doi.org/10.1111/febs.16460
    DORA PSI
  • Vollheyde K, Kühnel K, Lambrecht F, Kawelke S, Herrfurth C, Feussner I
    Crystal structure of the bifunctional wax synthase 1 from Acinetobacter baylyi suggests a conformational change upon substrate binding and formation of additional substrate binding sites
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