Publications

PDB structures measured at X06SA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Bauer MR, Krämer A, Settanni G, Jones RN, Ni X, Khan Tareque R, et al.
    Targeting cavity-creating p53 cancer mutations with small-molecule stabilizers: the Y220X paradigm
    ACS Chemical Biology. 2020. https://doi.org/10.1021/acschembio.9b00748
    DORA PSI
  • Crack JC, Amara P, Volbeda A, Mouesca J-M, Rohac R, Pellicer Martinez MT, et al.
    Electron and proton transfers modulate DNA binding by the transcription regulator RsrR
    Journal of the American Chemical Society. 2020. https://doi.org/10.1021/jacs.9b12250
    DORA PSI
  • Ernst P, Zosel F, Reichen C, Nettels D, Schuler B, Plückthun A
    Structure-guided design of a peptide lock for modular peptide binders
    ACS Chemical Biology. 2020; 15(2): 457-468. https://doi.org/10.1021/acschembio.9b00928
    DORA PSI
  • Huang C-Y, Olieric V, Caffrey M, Wang M
    In meso in situ serial X-Ray crystallography (IMISX): a protocol for membrane protein structure determination at the Swiss Light Source
    In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020. https://doi.org/10.1007/978-1-0716-0373-4_20
    DORA PSI
  • Kaiser M, Wurm JP, Märtens B, Bläsi U, Pogoryelov D, Wöhnert J
    Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus
    FEBS Open Bio. 2020; 10(2): 221-228. https://doi.org/10.1002/2211-5463.12772
    DORA PSI
  • Klatt F, Leitner A, Kim IV, Ho-Xuan H, Schneider EV, Langhammer F, et al.
    A precisely positioned MED12 activation helix stimulates CDK8 kinase activity
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(6): 2894-2905. https://doi.org/10.1073/pnas.1917635117
    DORA PSI
  • Knez D, Colettis N, Iacovino LG, Sova M, Pišlar A, Konc J, et al.
    Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and B
    Journal of Medicinal Chemistry. 2020. https://doi.org/10.1021/acs.jmedchem.9b01886
    DORA PSI
  • Leonarski F, Mozzanica A, Brückner M, Lopez-Cuenca C, Redford S, Sala L, et al.
    JUNGFRAU detector for brighter x-ray sources: solutions for IT and data science challenges in macromolecular crystallography
    Structural Dynamics. 2020; 7(1): 014305 (13 pp.). https://doi.org/10.1063/1.5143480
    DORA PSI
  • Metrick CM, Peterson EA, Santoro JC, Enyedy IJ, Murugan P, Chen TY, et al.
    Human PLD structures enable drug design and characterization of isoenzyme selectivity
    Nature Chemical Biology. 2020. https://doi.org/10.1038/s41589-019-0458-4
    DORA PSI
  • Nicoll CR, Bailleul G, Fiorentini F, Mascotti ML, Fraaije MW, Mattevi A
    Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs
    Nature Structural and Molecular Biology. 2020; 27(1): 14-24. https://doi.org/10.1038/s41594-019-0347-2
    DORA PSI
  • Olatunji S, Yu X, Bailey J, Huang C-Y, Zapotoczna M, Bowen K, et al.
    Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
    Nature Communications. 2020; 11(1): 140 (11 pp.). https://doi.org/10.1038/s41467-019-13724-y
    DORA PSI
  • Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, et al.
    Comparison of orexin 1 and orexin 2 ligand binding modes using X-ray crystallography and computational analysis
    Journal of Medicinal Chemistry. 2020. https://doi.org/10.1021/acs.jmedchem.9b01787
    DORA PSI
  • Welte H, Zhou T, Mihajlenko X, Mayans O, Kovermann M
    What does fluorine do to a protein? Thermodynamic, and highly-resolved structural insights into fluorine-labelled variants of the cold shock protein
    Scientific Reports. 2020; 10(1): 2640 (12 pp.). https://doi.org/10.1038/s41598-020-59446-w
    DORA PSI
  • Wiseman B, Högbom M
    Conformational changes in apolipoprotein N-acyltransferase (Lnt)
    Scientific Reports. 2020; 10(1): 639 (11 pp.). https://doi.org/10.1038/s41598-020-57419-7
    DORA PSI
  • Zhou H, McGowan MA, Lipford K, Christopher M, Fradera X, Witter D, et al.
    Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors
    Bioorganic and Medicinal Chemistry Letters. 2020; 30(1): 126715 (8 pp.). https://doi.org/10.1016/j.bmcl.2019.126715
    DORA PSI
  • Alen J, Schade M, Wagener M, Christian F, Nordhoff S, Merla B, et al.
    Fragment-based discovery of novel potent sepiapterin reductase inhibitors
    Journal of Medicinal Chemistry. 2019; 62(13): 6391-6397. https://doi.org/10.1021/acs.jmedchem.9b00218
    DORA PSI
  • Antoshvili M, Caspy I, Hippler M, Nelson N
    Structure and function of photosystem I in Cyanidioschyzon merolae
    Photosynthesis Research. 2019; 139(1-3): 499-508. https://doi.org/10.1007/s11120-018-0501-4
    DORA PSI
  • Apel A-K, Cheng RKY, Tautermann CS, Brauchle M, Huang C-Y, Pautsch A, et al.
    Crystal structure of CC chemokine receptor 2A in complex with an orthosteric antagonist provides insights for the design of selective antagonists
    Structure. 2019; 27(3): 427-438.e5. https://doi.org/10.1016/j.str.2018.10.027
    DORA PSI
  • Bach J, Eastwood P, González J, Gómez E, Alonso JA, Fonquerna S, et al.
    Identification of 2-imidazopyridine and 2-aminopyridone purinones as potent pan-Janus kinase (JAK) inhibitors for the inhaled treatment of respiratory diseases
    Journal of Medicinal Chemistry. 2019; 62(20): 9045-9060. https://doi.org/10.1021/acs.jmedchem.9b00533
    DORA PSI
  • Badmann T, Groll M
    Structures in tetrahydrofolate methylation in desulfitobacterial glycine betaine metabolism at atomic resolution
    ChemBioChem. 2019. https://doi.org/10.1002/cbic.201900515
    DORA PSI
  • Basu S, Kaminski JW, Panepucci E, Huang C-Y, Warshamanage R, Wang M, et al.
    Automated data collection and real-time data analysis suite for serial synchrotron crystallography
    Journal of Synchrotron Radiation. 2019; 26(1): 244-252. https://doi.org/10.1107/S1600577518016570
    DORA PSI
  • Battistutta R, Lolli G
    Inhibitory properties of ATP-competitive coumestrol and boldine are correlated to different modulations of CK2 flexibility
    Journal of Natural Products. 2019; 82(4): 1014-1018. https://doi.org/10.1021/acs.jnatprod.8b00889
    DORA PSI
  • Blech M, Hörer S, Kuhn AB, Kube S, Göddeke H, Kiefer H, et al.
    Structure of a therapeutic full-length anti-NPRA IgG4 antibody: dissecting conformational diversity
    Biophysical Journal. 2019; 116(9): 1637-1649. https://doi.org/10.1016/j.bpj.2019.03.036
    DORA PSI
  • Bogdanovic X, Schneider S, Levanova N, Wirth C, Trillhaase C, Steinemann M, et al.
    A cysteine protease-like domain enhances the cytotoxic effects of the Photorhabdus asymbiotica toxin PaTox
    Journal of Biological Chemistry. 2019; 294(3): 1035-1044. https://doi.org/10.1074/jbc.RA118.005043
    DORA PSI
  • Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis D
    Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
    Nature Communications. 2019; 10(1): 2649 (11 pp.). https://doi.org/10.1038/s41467-019-10566-6
    DORA PSI
  • Buchstaller H-P, Anlauf U, Dorsch D, Kuhn D, Lehmann M, Leuthner B, et al.
    Discovery and optimization of 2-Arylquinazolin-4-ones into a potent and selective tankyrase inhibitor modulating Wnt pathway activity
    Journal of Medicinal Chemistry. 2019; 62(17): 7897-7909. https://doi.org/10.1021/acs.jmedchem.9b00656
    DORA PSI
  • Böttcher J, Dilworth D, Reiser U, Neumüller RA, Schleicher M, Petronczki M, et al.
    Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
    Nature Chemical Biology. 2019; 15(8): 822-829. https://doi.org/10.1038/s41589-019-0310-x
    DORA PSI
  • Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, et al.
    Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)
    Biochemical Journal. 2019; 476(5): 875-887. https://doi.org/10.1042/BCJ20190038
    DORA PSI
  • Colombano G, Caldwell JJ, Matthews TP, Bhatia C, Joshi A, McHardy T, et al.
    Binding to an unusual inactive kinase conformation by highly selective inhibitors of inositol-requiring enzyme 1α kinase-endoribonuclease
    Journal of Medicinal Chemistry. 2019; 62(5): 2447-2465. https://doi.org/10.1021/acs.jmedchem.8b01721
    DORA PSI
  • Cury NM, Mühlethaler T, Laranjeira ABA, Canevarolo RR, Zenatti PP, Lucena-Agell D, et al.
    Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemia
    iScience. 2019; 21: 95-109. https://doi.org/10.1016/j.isci.2019.10.003
    DORA PSI
  • Damm-Ganamet KL, Arora N, Becart S, Edwards JP, Lebsack AD, McAllister HM, et al.
    Accelerating lead identification by high throughput virtual screening: prospective case studies from the pharmaceutical industry
    Journal of Chemical Information and Modeling. 2019; 59(5): 2046-2062. https://doi.org/10.1021/acs.jcim.8b00941
    DORA PSI
  • Dunne M, Rupf B, Tala M, Qabrati X, Ernst P, Shen Y, et al.
    Reprogramming bacteriophage host range through structure-guided design of chimeric receptor binding proteins
    Cell Reports. 2019; 29(5): 1336-1350.e4. https://doi.org/10.1016/j.celrep.2019.09.062
    DORA PSI
  • Ejby M, Guskov A, Pichler MJ, Zanten GC, Schoof E, Saburi W, et al.
    Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β-mannan possess distinct manno-oligosaccharide-binding profiles
    Molecular Microbiology. 2019; 112(1): 114-130. https://doi.org/10.1111/mmi.14257
    DORA PSI
  • Engelhardt H, Böse D, Petronczki M, Scharn D, Bader G, Baum A, et al.
    Start selective and rigidify: the discovery path toward a next generation of EGFR tyrosine kinase inhibitors
    Journal of Medicinal Chemistry. 2019; 62(22): 10272-10293. https://doi.org/10.1021/acs.jmedchem.9b01169
    DORA PSI
  • Ernst P, Honegger A, van der Valk F, Ewald C, Mittl PRE, Plückthun A
    Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts
    Scientific Reports. 2019; 9(1): 16162 (10 pp.). https://doi.org/10.1038/s41598-019-52121-9
    DORA PSI
  • Ernst P, Plückthun A, Mittl PRE
    Structural analysis of biological targets by host:guest crystal lattice engineering
    Scientific Reports. 2019; 9(1): 15199 (11 pp.). https://doi.org/10.1038/s41598-019-51017-y
    DORA PSI
  • Falchetto M, Ciossani G, Scolari F, Di Cosimo A, Nenci S, Field LM, et al.
    Structural and biochemical evaluation of Ceratitis capitata odorant-binding protein 22 affinity for odorants involved in intersex communication
    Insect Molecular Biology. 2019; 28(3): 431-443. https://doi.org/10.1111/imb.12559
    DORA PSI
  • Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, et al.
    BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
    Nature Chemical Biology. 2019; 15(7): 672-680. https://doi.org/10.1038/s41589-019-0294-6
    DORA PSI
  • Fradera X, Methot JL, Achab A, Christopher M, Altman MD, Zhou H, et al.
    Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow
    Bioorganic and Medicinal Chemistry Letters. 2019; 29(18): 2575-2580. https://doi.org/10.1016/j.bmcl.2019.08.004
    DORA PSI
  • Gall FM, Hohl D, Frasson D, Wermelinger T, Mittl PRE, Sievers M, et al.
    Drug design inspired by nature: crystallographic detection of an auto-tailored protease inhibitor template
    Angewandte Chemie International Edition. 2019; 58(12): 4051-4055. https://doi.org/10.1002/anie.201812348
    DORA PSI
  • Gollner A, Weinstabl H, Fuchs JE, Rudolph D, Garavel G, Hofbauer KS, et al.
    Targeted synthesis of complex spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by intramolecular cyclization of azomethine ylides: highly potent MDM2-p53 inhibitors
    ChemMedChem. 2019; 14(1): 88-93. https://doi.org/10.1002/cmdc.201800617
    DORA PSI
  • Grammbitter GLC, Schmalhofer M, Karimi K, Shi Y-M, Schöner TA, Tobias NJ, et al.
    An uncommon type II PKS catalyzes biosynthesis of aryl polyene pigments
    Journal of the American Chemical Society. 2019; 141(42): 16615-16623. https://doi.org/10.1021/jacs.8b10776
    DORA PSI
  • Griese JJ, Kositzki R, Haumann M, Högbom M
    Assembly of a heterodinuclear Mn/Fe cofactor is coupled to tyrosine-valine ether cross-link formation in the R2-like ligand-binding oxidase
    Journal of Biological Inorganic Chemistry. 2019; 24(2): 211-221. https://doi.org/10.1007/s00775-019-01639-4
    DORA PSI
  • Grädler U, Schwarz D, Blaesse M, Leuthner B, Johnson TL, Bernard F, et al.
    Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies
    Bioorganic and Medicinal Chemistry Letters. 2019; 29(23): 126717 (8 pp.). https://doi.org/10.1016/j.bmcl.2019.126717
    DORA PSI
  • Grāve K, Bennett MD, Högbom M
    Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis
    Communications Biology. 2019; 2(1): 175 (11 pp.). https://doi.org/10.1038/s42003-019-0427-1
    DORA PSI
  • Guerrero-Ferreira RC, Hupfeld M, Nazarov S, Taylor NMI, Shneider MM, Obbineni JM, et al.
    Structure and transformation of bacteriophage A511 baseplate and tail upon infection of Listeria cells
    EMBO Journal. 2019; 38(3): e99455 (20 pp.). https://doi.org/10.15252/embj.201899455
    DORA PSI
  • Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, et al.
    Structural basis of species-selective antagonist binding to the succinate receptor
    Nature. 2019; 574(7779): 581-585. https://doi.org/10.1038/s41586-019-1663-8
    DORA PSI
  • Heber S, Gáspár I, Tants J-N, Günther J, Moya SMF, Janowski R, et al.
    Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains
    Nature Communications. 2019; 10(1): 1659 (16 pp.). https://doi.org/10.1038/s41467-019-09655-3
    DORA PSI
  • Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, et al.
    An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5
    Autophagy. 2019. https://doi.org/10.1080/15548627.2019.1606637
    DORA PSI
  • Hutter CAJ, Timachi MH, Hürlimann LM, Zimmermann I, Egloff P, Göddeke H, et al.
    The extracellular gate shapes the energy profile of an ABC exporter
    Nature Communications. 2019; 10(1): 2260 (13 pp.). https://doi.org/10.1038/s41467-019-09892-6
    DORA PSI
  • Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, et al.
    A lipid site shapes the agonist response of a pentameric ligand-gated ion channel
    Nature Chemical Biology. 2019; 15(12): 1156-1164. https://doi.org/10.1038/s41589-019-0369-4
    DORA PSI
  • Jaeger K, Bruenle S, Weinert T, Guba W, Muehle J, Miyazaki T, et al.
    Structural basis for allosteric ligand recognition in the human CC chemokine receptor 7
    Cell. 2019; 178(5): 1222-1230. https://doi.org/10.1016/j.cell.2019.07.028
    DORA PSI
  • Kaur H, Hartmann J-B, Jakob RP, Zahn M, Zimmermann I, Maier T, et al.
    Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach
    Journal of Biomolecular NMR. 2019; 73(6-7): 375-384. https://doi.org/10.1007/s10858-019-00250-8
    DORA PSI
  • Kropp HM, Diederichs K, Marx A
    The structure of an archaeal B-family DNA polymerase in complex with a chemically modified nucleotide
    Angewandte Chemie International Edition. 2019; 58(16): 5457-5461. https://doi.org/10.1002/anie.201900315
    DORA PSI
  • Kutin Y, Kositzki R, Branca RMM, Srinivas V, Lundin D, Haumann M, et al.
    Chemical flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins
    Journal of Biological Chemistry. 2019; 294(48): 18372-18386. https://doi.org/10.1074/jbc.RA119.010570
    DORA PSI
  • Lach M, Künzle M, Beck T
    Proteins as sustainable building blocks for the next generation of bioinorganic nanomaterials
    Biochemistry. 2019; 58(3): 140-141. https://doi.org/10.1021/acs.biochem.8b00966
    DORA PSI
  • Ladi E, Everett C, Stivala CE, Daniels BE, Durk MR, Harris SF, et al.
    Design and evaluation of highly selective human immunoproteasome inhibitors reveal a compensatory process that preserves immune cell viability
    Journal of Medicinal Chemistry. 2019; 62(15): 7032-7041. https://doi.org/10.1021/acs.jmedchem.9b00509
    DORA PSI
  • Lee AW, Deruaz M, Lynch C, Davies G, Singh K, Alenazi Y, et al.
    A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins
    Journal of Biological Chemistry. 2019; 294(29): 11199-11212. https://doi.org/10.1074/jbc.RA119.008817
    DORA PSI
  • Li M, Müller C, Fröhlich K, Gorka O, Zhang L, Groß O, et al.
    Detection and characterization of a mycobacterial L-arabinofuranose ABC transporter identified with a rapid lipoproteomics protocol
    Cell Chemical Biology. 2019; 26(6): 852-862.e6. https://doi.org/10.1016/j.chembiol.2019.03.002
    DORA PSI
  • Mallagaray A, Creutznacher R, Dülfer J, Mayer PHO, Grimm LL, Orduña JM, et al.
    A post-translational modification of human norovirus capsid protein attenuates glycan binding
    Nature Communications. 2019; 10(1): 1320 (14 pp.). https://doi.org/10.1038/s41467-019-09251-5
    DORA PSI
  • Manatschal C, Pujol-Giménez J, Poirier M, Reymond J-L, Hediger MA, Dutzler R
    Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds
    eLife. 2019; 8: e51913 (36 pp.). https://doi.org/10.7554/eLife.51913
    DORA PSI
  • Molina R, Stella S, Feng M, Sofos N, Jauniskis V, Pozdnyakova I, et al.
    Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
    Nature Communications. 2019; 10(1): 4302 (14 pp.). https://doi.org/10.1038/s41467-019-12244-z
    DORA PSI
  • Müller AU, Leibundgut M, Ban N, Weber-Ban E
    Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC
    Nature Communications. 2019; 10(1): 4653 (14 pp.). https://doi.org/10.1038/s41467-019-12567-x
    DORA PSI
  • Nakamura R, Hikita M, Ogawa S, Takahashi Y, Fujishiro T
    Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes
    FEBS Journal. 2019. https://doi.org/10.1111/febs.15081
    DORA PSI
  • Nguyen D, Lemos C, Wortmann L, Eis K, Holton SJ, Boemer U, et al.
    Discovery and characterization of the potent and highly selective (piperidin-4-yl)pyrido[3,2-d]pyrimidine based in vitro probe BAY-885 for the kinase ERK5.
    Journal of Medicinal Chemistry. 2019; 62(2): 928-940. https://doi.org/10.1021/acs.jmedchem.8b01606
    DORA PSI
  • Ni X, Heidenreich D, Christott T, Bennett J, Moustakim M, Brennan PE, et al.
    Structural insights into interaction mechanisms of alternative piperazine-urea YEATS domain binders in MLLT1
    ACS Medicinal Chemistry Letters. 2019; 10(12): 1661-1666. https://doi.org/10.1021/acsmedchemlett.9b00460
    DORA PSI
  • Nida S, Tsibizov A, Ziemann T, Woerle J, Moesch A, Schulze-Briese C, et al.
    Silicon carbide X-ray beam position monitors for synchrotron applications
    Journal of Synchrotron Radiation. 2019; 26(1): 28-35. https://doi.org/10.1107/S1600577518014248
    DORA PSI
  • Oehlrich D, Peschiulli A, Tresadern G, Van Gool M, Vega JA, De Lucas AI, et al.
    Evaluation of a series of β-secretase 1 inhibitors containing novel heteroaryl-fused-piperazine amidine warheads
    ACS Medicinal Chemistry Letters. 2019; 10(8): 1159-1165. https://doi.org/10.1021/acsmedchemlett.9b00181
    DORA PSI
  • Pabis M, Corsini L, Vincendeau M, Tripsianes K, Gibson TJ, Brack-Werner R, et al.
    Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors
    Nucleic Acids Research. 2019; 47(9): 4859-4871. https://doi.org/10.1093/nar/gkz185
    DORA PSI
  • Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier J-M, et al.
    Protein crystallization promotes type 2 immunity and is reversible by antibody treatment
    Science. 2019; 364(6442): eaaw4295 (17 pp.). https://doi.org/10.1126/science.aaw4295
    DORA PSI
  • Pichlo C, Juetten L, Wojtalla F, Schacherl M, Diaz D, Baumann U
    Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1
    Journal of Biological Chemistry. 2019; 294(30): 11525-11535. https://doi.org/10.1074/jbc.RA119.009029
    DORA PSI
  • Plattner M, Shneider MM, Arbatsky NP, Shashkov AS, Chizhov AO, Nazarov S, et al.
    Structure and function of the branched receptor-binding complex of bacteriophage CBA120
    Journal of Molecular Biology. 2019; 431(19): 3718-3739. https://doi.org/10.1016/j.jmb.2019.07.022
    DORA PSI
  • Pollinger J, Schierle S, Gellrich L, Ohrndorf J, Kaiser A, Heitel P, et al.
    A novel biphenyl-based chemotype of retinoid X receptor ligands enables subtype and heterodimer preferences
    ACS Medicinal Chemistry Letters. 2019; 10(9): 1346-1352. https://doi.org/10.1021/acsmedchemlett.9b00306
    DORA PSI
  • Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, et al.
    Structural basis of BRCC36 function in DNA repair and immune regulation
    Molecular Cell. 2019; 75(3): 483-497.e9. https://doi.org/10.1016/j.molcel.2019.06.002
    DORA PSI
  • Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, et al.
    Leveraging compound promiscuity to identify targetable cysteines within the kinome
    Cell Chemical Biology. 2019; 26(6): 818-829.e9. https://doi.org/10.1016/j.chembiol.2019.02.021
    DORA PSI
  • Robinson GC, Kaufmann M, Roux C, Martinez-Font J, Hothorn M, Thore S, et al.
    Crystal structure of the pseudoenzyme PDX1.2 in complex with its cognate enzyme PDX1.3: a total eclipse
    Acta Crystallographica Section D: Structural Biology. 2019; 75(4): 400-415. https://doi.org/10.1107/S2059798319002912
    DORA PSI
  • Rozov A, Khusainov I, El Omari K, Duman R, Mykhaylyk V, Yusupov M, et al.
    Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction
    Nature Communications. 2019; 10(1): 2519 (12 pp.). https://doi.org/10.1038/s41467-019-10409-4
    DORA PSI
  • Sauer MM, Jakob RP, Luber T, Canonica F, Navarra G, Ernst B, et al.
    Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets
    Journal of the American Chemical Society. 2019; 141(2): 936-944. https://doi.org/10.1021/jacs.8b10736
    DORA PSI
  • Schneider T, Hung L-H, Aziz M, Wilmen A, Thaum S, Wagner J, et al.
    Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3
    Nature Communications. 2019; 10(1): 2266 (18 pp.). https://doi.org/10.1038/s41467-019-09769-8
    DORA PSI
  • Schopf FH, Huber EM, Dodt C, Lopez A, Biebl MM, Rutz DA, et al.
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