Publications

Amann M, Warstat R, Rechten KK, Theuer P, Schustereder M, Clavey S, et al.
A Novel inhibitor against the Bromodomain protein 1 of the malaria pathogen Plasmodium Falciparum
ChemMedChem. 2025; 20(11): e202500024 (5 pp.). https://doi.org/10.1002/cmdc.202500024
DORA PSI

Berardi A, Kaestner CL, Ghitti M, Quilici G, Cocomazzi P, Li J, et al.
The C-terminal PHD_VC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma
Nucleic Acids Research. 2025; 53(1): gkae1121 (20 pp.). https://doi.org/10.1093/nar/gkae1121
DORA PSI

Bobadilla Ugarte P, Halter S, Mutte SK, Heijstek C, Niault T, Terenin I, et al.
Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA
Molecular Cell. 2025; 85(10): 1920-1937.e10. https://doi.org/10.1016/j.molcel.2025.03.025
DORA PSI

Bosman R, Ortolani G, Ghosh S, James D, Norder P, Hammarin G, et al.
Structural basis for the prolonged photocycle of sensory rhodopsin II revealed by serial synchrotron crystallography
Nature Communications. 2025; 16(1): 3460 (12 pp.). https://doi.org/10.1038/s41467-025-58263-x
DORA PSI

Bruno P, Pala D, Micoli A, Corsi M, Accetta A, Carzaniga L, et al.
Discovery of CHF-6523, an inhaled selective PI3Kδ inhibitor for the treatment of chronic obstructive pulmonary disease
Journal of Medicinal Chemistry. 2025; 68: 2444-2465. https://doi.org/10.1021/acs.jmedchem.4c02062
DORA PSI

Chancellor A, Constantin D, Berloffa G, Yang Q, Nosi V, Loureiro JP, et al.
The carbonyl nucleobase adduct M₃Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells
Immunity. 2025; 58(2): 431-447. https://doi.org/10.1016/j.immuni.2024.11.019
DORA PSI

De Marco M, Rai SR, Scietti L, Mattoteia D, Liberi S, Moroni E, et al.
Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1
Nature Communications. 2025; 16(1): 3624 (17 pp.). https://doi.org/10.1038/s41467-025-59017-5
DORA PSI

Guerriere TB, Fraaije MW, Mattevi A
Biochemical and structural insights into pinoresinol hydroxylase from Pseudomonas sp
Archives of Biochemistry and Biophysics. 2025; 764: 110247 (8 pp.). https://doi.org/10.1016/j.abb.2024.110247
DORA PSI

Guerriere TB, Vancheri A, Ricotti I, Serapian SA, Eggerichs D, Tischler D, et al.
Dehydrogenase versus oxidase function: the interplay between substrate binding and flavin microenvironment
ACS Catalysis. 2025; 15(2): 1046-1060. https://doi.org/10.1021/acscatal.4c05944
DORA PSI

Hermanns T, Kolek S, Uthoff M, de Heiden RA, Mulder MPC, Baumann U, et al.
A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode
Molecular Cell. 2025; 85(6): 1202-1215.e5. https://doi.org/10.1016/j.molcel.2025.02.002
DORA PSI

Hofmeister A, Jahn-Hofmann K, Brunner B, Helms M, Metz-Weidmann C, Poeverlein C, et al.
Trivalent siRNA-conjugates with guanosine as ASGPR-binder show potent knock-down in vivo
Journal of Medicinal Chemistry. 2025; 68(6): 6193-6209. https://doi.org/10.1021/acs.jmedchem.4c02275
DORA PSI

Klaubert TJ, Gellner J, Bernard C, Effert J, Lombard C, Kaila VRI, et al.
Molecular basis for azetidine-2-carboxylic acid biosynthesis
Nature Communications. 2025; 16(1): 48 (12 pp.). https://doi.org/10.1038/s41467-025-56610-6
DORA PSI

Klett T, Stahlecker J, Schwer M, Jaag SJ, Masberg B, Knappe C, et al.
S_NAr reactive pyrazine derivatives as p53-Y220C cleft binders with diverse binding modes
Drug Design, Development and Therapy. 2025; 19: 4727-4753. https://doi.org/10.2147/DDDT.S513792
DORA PSI

Kolosova O, Zgadzay Y, Stetsenko A, Sukhinina AP, Atamas A, Validov S, et al.
Mechanism of read-through enhancement by aminoglycosides and mefloquine
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2025; 122(17): (12 pp.). https://doi.org/10.1073/pnas.2420261122
DORA PSI

Lotz R, Osterburg C, Chaikuad A, Weber S, Akutsu M, Machel AC, et al.
Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
Cell Death and Disease. 2025; 16(1): 4 (11 pp.). https://doi.org/10.1038/s41419-024-07320-2
DORA PSI

Lucignano R, Bologna A, Gramazio S, Wang PH, Taxis C, Essen LO, et al.
Unravelling the amyloid aggregation mechanism of the sweet protein Monellin: Insights from circular permutated mutants
International Journal of Biological Macromolecules. 2025; 308: 142239 (11 pp.). https://doi.org/10.1016/j.ijbiomac.2025.142239
DORA PSI

Moyano PM, Kubina T, Paruch ŠO, Jarošková A, Novotný J, Skočková V, et al.
Thieno[3,2-b]pyridine: attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode
Angewandte Chemie International Edition. 2025; 64(1): e202412786 (11 pp.). https://doi.org/10.1002/anie.202412786
DORA PSI

Mühle J, Alenfelder J, Rodrigues MJ, Jürgenliemke L, Guixà-González R, Grätz L, et al.
Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2025; 122(19): e2418398122 (12 pp.). https://doi.org/10.1073/pnas.2418398122
DORA PSI

Münick P, Strubel A, Balourdas DI, Funk JS, Mernberger M, Osterburg C, et al.
DARPin-induced reactivation of p53 in HPV-positive cells
Nature Structural and Molecular Biology. 2025: 1842 (823 pp.). https://doi.org/10.1038/s41594-024-01456-7
DORA PSI

Pagliarini RA, Henderson JA, Milgram BC, Borrelli DR, Brooijmans N, Hilbert BJ, et al.
STX-721, a covalent EGFR/HER2 Exon 20 inhibitor, utilizes exon 20–mutant dynamic protein states and achieves unique mutant selectivity across human cancer models
Clinical Cancer Research. 2025. https://doi.org/10.1158/1078-0432.CCR-24-3833
DORA PSI

Schulte T, Magdaong NCM, Di Valentin M, Agostini A, Tait CE, Niedzwiedzki DM, et al.
Structural and spectroscopic characterization of the peridinin-chlorophyll a-protein (PCP) complex from Heterocapsa pygmaea (HPPCP)
Biochimica et Biophysica Acta: Bioenergetics. 2025; 1866(1): 149510 (17 pp.). https://doi.org/10.1016/j.bbabio.2024.149510
DORA PSI

Su L, Schmalhofer M, Grammbitter GLC, Paczia N, Glatter T, Groll M, et al.
The isopropylstilbene precursor cinnamic acid inhibits anthraquinone pigment production by targeting AntI
Journal of the American Chemical Society. 2025; 147(24): 20246-20250. https://doi.org/10.1021/jacs.5c07388
DORA PSI

Terrosu S, Nurullina L, Supantanapong N, Pak BS, Nguyen S, Holm M, et al.
Synthesis of differentially halogenated lissoclimide analogues to probe ribosome e-site binding
ACS Chemical Biology. 2025; 20(4): 858-869. https://doi.org/10.1021/acschembio.4c00825
DORA PSI

Träger LK, Degen M, Pereira J, Durairaj J, Teixeira RD, Hiller S, et al.
Structural basis for cooperative ssDNA binding by bacteriophage protein filament P12
Nucleic Acids Research. 2025; 53(5): gkaf132 (15 pp.). https://doi.org/10.1093/nar/gkaf132
DORA PSI

Tröster V, Wong RP, Börgel A, Cakilkaya B, Renz C, Möckel MM, et al.
Custom affinity probes reveal DNA-damage-induced, ssDNA-independent chromatin SUMOylation in budding yeast
Cell Reports. 2025; 44(3): 115353 (22 pp.). https://doi.org/10.1016/j.celrep.2025.115353
DORA PSI

Walker ME, Zhu W, Peterson JH, Wang H, Patteson J, Soriano A, et al.
Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition
Nature Communications. 2025; 16(1): 3395 (20 pp.). https://doi.org/10.1038/s41467-025-58086-w
DORA PSI

Walla B, Maslakova A, Bischoff D, Janowski R, Niessing D, Weuster-Botz D
Rational introduction of electrostatic interactions at crystal contacts to enhance protein crystallization of an ene reductase
Biomolecules. 2025; 15(4): 467 (18 pp.). https://doi.org/10.3390/biom15040467
DORA PSI

Wang G, Seidler NJ, Röhm S, Pan Y, Liang XJ, Haarer L, et al.
Probing the protein kinases′ cysteinome by covalent fragments
Angewandte Chemie International Edition. 2025; 64(8): e202419736 (12 pp.). https://doi.org/10.1002/anie.202419736
DORA PSI

Wang PH, Hosokawa Y, C Soares J, Emmerich HJ, Fuchs V, Caramello N, et al.
Redox-state-dependent structural changes within a prokaryotic 6-4 photolyase
Journal of the American Chemical Society. 2025; 147(19): 16084-16098. https://doi.org/10.1021/jacs.4c18116
DORA PSI

Waterbury AL, Caroli J, Zhang O, Tuttle PR, Liu C, Li J, et al.
Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance
Nature Communications. 2025; 16(1): 3156 (14 pp.). https://doi.org/10.1038/s41467-025-57477-3
DORA PSI

Yamasaki T, Kohda D
An uncharacterized gene from the Actinobacillus genus encodes a glucosyltransferase with successive transfer activity and unique substrate specificity
Journal of Biological Chemistry. 2025; 301(6): 108567 (13 pp.). https://doi.org/10.1016/j.jbc.2025.108567
DORA PSI

Yudenko A, Bukhdruker S, Shishkin P, Rodin S, Burtseva A, Petrov A, et al.
Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers
Structure. 2025; 33(1): 171-180.e5. https://doi.org/10.1016/j.str.2024.10.028
DORA PSI

Zeides P, Bellmann-Sickert K, Zhang R, Seel CJ, Most V, Schoeder CT, et al.
Unraveling the molecular basis of substrate specificity and halogen activation in vanadium-dependent haloperoxidases
Nature Communications. 2025; 16(1): 2083 (13 pp.). https://doi.org/10.1038/s41467-025-57023-1
DORA PSI

Amrhein JA, Berger LM, Balourdas DI, Joerger AC, Menge A, Krämer A, et al.
Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
Journal of Medicinal Chemistry. 2024; 67(1): 674-690. https://doi.org/10.1021/acs.jmedchem.3c01980
DORA PSI

Balourdas DI, Markl AM, Krämer A, Settanni G, Joerger AC
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
Cell Death and Disease. 2024; 15(6): 408 (10 pp.). https://doi.org/10.1038/s41419-024-06739-x
DORA PSI

Basile L, Santema LL, Binda C, Fraaije MW
Discovery and structural characterization of a thermostable bacterial monoamine oxidase
FEBS Journal. 2024; 291: 849-864. https://doi.org/10.1111/febs.16973
DORA PSI

Bauer N, Balourdas DI, Schneider JR, Zhang X, Berger LM, Berger BT, et al.
Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
ACS Chemical Biology. 2024; 19(2): 266-279. https://doi.org/10.1021/acschembio.3c00427
DORA PSI

Beier A, Platzer G, Höfurthner T, Ptaszek AL, Lichtenecker RJ, Geist L, et al.
Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups
Journal of Medicinal Chemistry. 2024; 67(15): 13187-13196. https://doi.org/10.1021/acs.jmedchem.4c01128
DORA PSI

Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, et al.
PROTACs targeting BRM (SMARCA2) afford selective In vivo degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models
Journal of Medicinal Chemistry. 2024; 67: 1262-1313. https://doi.org/10.1021/acs.jmedchem.3c01781
DORA PSI

Bolduc PN, Pfaffenbach M, Evans R, Xin Z, Henry KL, Gao F, et al.
A tiny pocket packs a punch: leveraging pyridones for the discovery of CNS-penetrant aza-indazole IRAK4 inhibitors
ACS Medicinal Chemistry Letters. 2024; 15(5): 714-721. https://doi.org/10.1021/acsmedchemlett.4c00102
DORA PSI

Bozhüyük KAJ, Präve L, Kegler C, Schenk L, Kaiser S, Schelhas C, et al.
Evolution-inspired engineering of nonribosomal peptide synthetases
Science. 2024; 383(6689): eadg4320 (11 pp.). https://doi.org/10.1126/science.adg4320
DORA PSI

Brescia FF, Korf L, Essen L-O, Zorn H, Ruehl M
A novel O- and S-methyltransferase from Pleurotus sapidus is involved in flavor formation
Journal of Agricultural and Food Chemistry. 2024; 72(12): 6471-6480. https://doi.org/10.1021/acs.jafc.3c08849
DORA PSI

Bruno P, Micoli A, Corsi M, Pala D, Guariento S, Fiorelli C, et al.
Discovery and optimization of pyridazinones as PI3Kδ selective inhibitors for administration by inhalation
Journal of Medicinal Chemistry. 2024; 67: 11103-11124. https://doi.org/10.1021/acs.jmedchem.4c00610
DORA PSI

Buffa V, Meyners C, Sugiarto WO, Bauder M, Gaali S, Hausch F
1,4-pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile
ChemMedChem. 2024; 19(17): e202400264 (23 pp.). https://doi.org/10.1002/cmdc.202400264
DORA PSI

Böttcher J, Fuchs JE, Mayer M, Kahmann J, Zak KM, Wunberg T, et al.
Ligandability assessment of the C-terminal Rel-homology domain of NFAT1
Archiv der Pharmazie. 2024; 357(6): 2300649 (7 pp.). https://doi.org/10.1002/ardp.202300649
DORA PSI

Cadoux C, Maslać N, Bolte P, Murken F, Gu W, Milton RD, et al.
Structural comparison of (hyper-)thermophilic nitrogenase reductases from three marine Methanococcales
FEBS Journal. 2024; 291(15): 3454-3480. https://doi.org/10.1111/febs.17148
DORA PSI

Carswell E, Heinrich T, Petersson C, Gunera J, Garg S, Schwarz D, et al.
Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold
Bioorganic and Medicinal Chemistry Letters. 2024; 114: 129981 (8 pp.). https://doi.org/10.1016/j.bmcl.2024.129981
DORA PSI

Champiré A, Berabez R, Braka A, Cosson A, Corret J, Girardin C, et al.
Tetrahydropyridine LIMK inhibitors: structure activity studies and biological characterization
European Journal of Medicinal Chemistry. 2024; 271: 116391 (27 pp.). https://doi.org/10.1016/j.ejmech.2024.116391
DORA PSI

Chen D, Zhang X, Vorobieva AA, Tachibana R, Stein A, Jakob RP, et al.
An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway
Nature Chemistry. 2024. https://doi.org/10.1038/s41557-024-01562-5
DORA PSI

Chikunova A, Manley MP, Heijjer CN, Drenth CS, Cramer‐Blok AJ, Ahmad MUD, et al.
Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC
Protein Science. 2024; 33(4). https://doi.org/10.1002/pro.4972
DORA PSI

DeRatt LG, Zhang Z, Pietsch C, Cisar JS, Zhang X, Wang W, et al.
Discovery of JNJ-74856665: a novel isoquinolinone DHODH inhibitor for the treatment of AML
Journal of Medicinal Chemistry. 2024; 67: 11254-11272. https://doi.org/10.1021/acs.jmedchem.4c00809
DORA PSI

DeRatt LG, Zhang Z, Pietsch EC, Cisar J, Wang A, Wang C yuan, et al.
Identification of isoquinolinone DHODH inhibitor isosteres
Bioorganic and Medicinal Chemistry Letters. 2024; 113: 129965 (7 pp.). https://doi.org/10.1016/j.bmcl.2024.129965
DORA PSI

Dhamotharan K, Korn SM, Wacker A, Becker MA, Günther S, Schwalbe H, et al.
A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding
Nature Communications. 2024; 15(1): 10656 (16 pp.). https://doi.org/10.1038/s41467-024-55024-0
DORA PSI

Dötsch L, Davies C, Hennes E, Schönfeld J, Kumar A, Guita CDCL, et al.
Discovery of the sEH inhibitor epoxykynin as a potent kynurenine pathway modulator
Journal of Medicinal Chemistry. 2024; 67(6): 4691-4706. https://doi.org/10.1021/acs.jmedchem.3c02245
DORA PSI

Evans R, Bolduc PN, Pfaffenbach M, Gao F, May-Dracka T, Fang T, et al.
The discovery of 7-isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a potent, selective, and CNS-penetrant IRAK4 inhibitor for the treatment of ischemic stroke
Journal of Medicinal Chemistry. 2024; 67(6): 4676-4690. https://doi.org/10.1021/acs.jmedchem.3c02226
DORA PSI

Feuillard J, Couston J, Benito Y, Hodille E, Dumitrescu O, Blaise M
Biochemical and structural characterization of a class A β-lactamase from Nocardia cyriacigeorgica
Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2024; 80: 13-21. https://doi.org/10.1107/S2053230X23010671
DORA PSI

Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, et al.
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent EPHA2/GAK kinase inhibitors
Journal of Medicinal Chemistry. 2024; 67(1): 12534-12552. https://doi.org/10.1021/acs.jmedchem.4c00411
DORA PSI

Gerstberger T, Berger H, Büttner FH, Gmachl M, Kessler D, Koegl M, et al.
Chasing red herrings: Palladium metal salt impurities feigning KRAS activity in biochemical assays
Journal of Medicinal Chemistry. 2024; 67(14): 11701-11711. https://doi.org/10.1021/acs.jmedchem.3c02381
DORA PSI

Glover H, Saßmannshausen T, Bertrand Q, Trabuco M, Slavov C, Bacchin A, et al.
Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography
Nature Communications. 2024; 15(1): 10837 (13 pp.). https://doi.org/10.1038/s41467-024-55109-w
DORA PSI

Gollner A, Rudolph D, Weyer-Czernilofsky U, Baumgartinger R, Jung P, Weinstabl H, et al.
Discovery and characterization of brigimadlin, a novel and highly potent MDM2–p53 antagonist suitable for intermittent dose schedules
Molecular Cancer Therapeutics. 2024; 23(12): 1689-1702. https://doi.org/10.1158/1535-7163.MCT-23-0783
DORA PSI

Gotthard G, Mous S, Weinert T, Maia RNA, James D, Dworkowski F, et al.
Capturing the blue-light activated state of the Phot-LOV1 domain from Chlamydomonas reinhardtii using time-resolved serial synchrotron crystallography
IUCrJ. 2024; 11(5): (17 pp.). https://doi.org/10.1107/S2052252524005608
DORA PSI

Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, et al.
Computational design of soluble and functional membrane protein analogues
Nature. 2024; 631(8020): 449-458. https://doi.org/10.1038/s41586-024-07601-y
DORA PSI

Greco FA, Krämer A, Wahl L, Elson L, Ehret TAL, Gerninghaus J, et al.
Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting
European Journal of Medicinal Chemistry. 2024; 276: 116672 (22 pp.). https://doi.org/10.1016/j.ejmech.2024.116672
DORA PSI

Götz MG, Godwin K, Price R, Dorn R, Merrill-Steskal G, Klemmer W, et al.
Macrocyclic oxindole peptide epoxyketones - a comparative study of macrocyclic inhibitors of the 20S proteasome
ACS Medicinal Chemistry Letters. 2024; 15(4): 533-539. https://doi.org/10.1021/acsmedchemlett.4c00017
DORA PSI

Hazemann J, Kimmerlin T, Lange R, Sweeney AM, Bourquin G, Ritz D, et al.
Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for de novo drug design and computational chemistry approaches
RSC Medicinal Chemistry. 2024; 15(6): 2146-2159. https://doi.org/10.1039/d4md00106k
DORA PSI

Herhaus L, Gestal-Mato U, Eapen VV, Mačinković I, Bailey HJ, Prieto-Garcia C, et al.
IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion
Cell. 2024; 187(25): 7285-7302.e29. https://doi.org/10.1016/j.cell.2024.09.048
DORA PSI

Hermanns T, Uthoff M, Baumann U, Hofmann K
The structural basis for deubiquitination by the fingerless USP-type effector TssM
Life Science Alliance. 2024; 7(2): e202302422 (13 pp.). https://doi.org/10.26508/lsa.202302422
DORA PSI

Himmelbauer MK, Bajrami B, Basile R, Capacci A, Chen TY, Choi CK, et al.
Discovery and preclinical characterization of BIIB129, a covalent, selective, and brain-penetrant BTK inhibitor for the treatment of multiple sclerosis
Journal of Medicinal Chemistry. 2024; 67(10): 8122-8140. https://doi.org/10.1021/acs.jmedchem.4c00220
DORA PSI

Huang CY, Metz A, Lange R, Artico N, Potot C, Hazemann J, et al.
Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket
Acta Crystallographica Section D: Structural Biology. 2024; 80: 123-136. https://doi.org/10.1107/S2059798324000329
DORA PSI

Höing L, Sowa ST, Toplak M, Reinhardt JK, Jakob R, Maier T, et al.
Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products
Chemical Science. 2024; 15(20): 7749-7756. https://doi.org/10.1039/d4sc01715c
DORA PSI

Illigmann A, Vielberg MT, Lakemeyer M, Wolf F, Dema T, Stange P, et al.
Structure of Staphylococcus aureus ClpP bound to the covalent active-site inhibitor cystargolide A
Angewandte Chemie International Edition. 2024; 63(3): e202314028 (10 pp.). https://doi.org/10.1002/anie.202314028
DORA PSI

Inobe T, Sakaguchi R, Obita T, Mukaiyama A, Koike S, Yokoyama T, et al.
Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
FEBS Letters. 2024; 598: 2292-2305. https://doi.org/10.1002/1873-3468.14986
DORA PSI

Jungfer K, Sigg A, Jinek M
Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
Nucleic Acids Research. 2024; 52(1): 462-473. https://doi.org/10.1093/nar/gkad1102
DORA PSI

Kesteleyn B, Herschke F, Darville N, Stoops B, Jacobs T, Jacoby E, et al.
Spiro-azetidine oxindoles as long-acting injectables for pre-exposure prophylaxis against respiratory syncytial virus infections
Journal of Medicinal Chemistry. 2024; 67: 10986-11002. https://doi.org/10.1021/acs.jmedchem.4c00514
DORA PSI

Kielkopf CS, Shneider MM, Leiman PG, Taylor NMI
T6SS-associated Rhs toxin-encapsulating shells: structural and bioinformatical insights into bacterial weaponry and self-protection
Structure. 2024; 32(12): 2375-2389.e5. https://doi.org/10.1016/j.str.2024.10.008
DORA PSI

Kjeldsen T, Andersen AS, Hubálek F, Johansson E, Kreiner FF, Schluckebier G, et al.
Molecular engineering of insulin for recombinant expression in yeast
Trends in Biotechnology. 2024; 42(4): 464-478. https://doi.org/10.1016/j.tibtech.2023.09.012
DORA PSI

Klett T, Stahlecker J, Jaag S, Masberg B, Knappe C, Lämmerhofer M, et al.
Covalent fragments acting as tyrosine mimics for mutant p53-Y220C rescue by nucleophilic aromatic substitution
ACS Pharmacology & Translational Science. 2024; 7(12): 3984-3999. https://doi.org/10.1021/acsptsci.4c00414
DORA PSI

Koeppl LH, Popadić D, Saleem-Batcha R, Germer P, Andexer JN
Structure, function and substrate preferences of archaeal S-adenosyl-l-homocysteine hydrolases
Communications Biology. 2024; 7(1): 380 (15 pp.). https://doi.org/10.1038/s42003-024-06078-9
DORA PSI

Krawinski P, Smithers L, van Dalsen L, Boland C, Ostrovitsa N, Pérez J, et al.
7.10 MAG. A novel host monoacylglyceride for in meso (lipid cubic phase) crystallization of membrane proteins
Crystal Growth and Design. 2024; 24(7): 2985-3001. https://doi.org/10.1021/acs.cgd.4c00087
DORA PSI

Kuttenlochner W, Beller P, Kaysser L, Groll M
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Morita I, Faraone A, Salvisberg E, Zhang K, Jakob RP, Maier T, et al.
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Wohlwend D, Mérono L, Bucka S, Ritter K, Jessen HJ, Friedrich T
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Yagi S, Tagami S
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Yokoyama T, Takayama Y, Mizuguchi M, Nabeshima Y, Kusaka K
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Yu K, Zhang K, Jakob RP, Maier T, Ward TR
An artificial nickel chlorinase based on the biotin-streptavidin technology
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Boland C, Huang C-Y, Shanker Kaki S, Wang M, Olieric V, Caffrey M
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Brkic A, Leibundgut M, Jablonska J, Zanki V, Car Z, Petrovic Perokovic V, et al.
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Busch MR, Rajendran C, Sterner R
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Cao Y, Kümmel F, Logemann E, Gebauer JM, Lawson AW, Yu D, et al.
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Cucuzza S, Michel E, Mittl PRE, Zerbe O, Plückthun A
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