Publications
X06SA PDB Structure Gallery from BioSync
PXI Publications
Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA
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Amaral B, Capacci A, Anderson T, Tezer C, Bajrami B, Lulla M, et al.
Elucidation of the GSK3α structure informs the design of novel, paralog-selective inhibitors
ACS Chemical Neuroscience. 2023; 14(6): 1080-1094. https://doi.org/10.1021/acschemneuro.2c00476
DORA PSI -
Arifi S, Marschner JA, Pollinger J, Isigkeit L, Heitel P, Kaiser A, et al.
Targeting the alternative vitamin E metabolite binding site enables noncanonical PPARγ modulation
Journal of the American Chemical Society. 2023; 145(27): 14802-14810. https://doi.org/10.1021/jacs.3c03417
DORA PSI -
Balboa JR, Essig DJ, Ma S, Karer N, Clemmensen LS, Pedersen SW, et al.
Development of a potent cyclic peptide inhibitor of the nNOS/PSD-95 interaction
Journal of Medicinal Chemistry. 2023; 66(1): 976-990. https://doi.org/10.1021/acs.jmedchem.2c01803
DORA PSI -
Brkic A, Leibundgut M, Jablonska J, Zanki V, Car Z, Petrovic Perokovic V, et al.
Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
Nature Communications. 2023; 14(1): 5498 (12 pp.). https://doi.org/10.1038/s41467-023-41244-3
DORA PSI -
Buchstaller H-P, Sala-Hojman A, Leiendecker M, Albers J, Anlauf U, Berges N, et al.
Discovery of cycloalkyl[c]thiophenes as novel scaffolds for hypoxia-inducible factor-2α inhibitors
Journal of Medicinal Chemistry. 2023; 66(13): 8666-8686. https://doi.org/10.1021/acs.jmedchem.3c00332
DORA PSI -
Busch MR, Rajendran C, Sterner R
Structural and functional characterization of the ureidoacrylate amidohydrolase RutB from Escherichia coli
Biochemistry. 2023; 62(3): 863-872. https://doi.org/10.1021/acs.biochem.2c00640
DORA PSI -
Cao Y, Kümmel F, Logemann E, Gebauer JM, Lawson AW, Yu D, et al.
Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2023; 120(32): e2307604120 (11 pp.). https://doi.org/10.1073/pnas.2307604120
DORA PSI -
Cucuzza S, Michel E, Mittl PRE, Zerbe O, Plückthun A
Improved repeat protein stability by combined consensus and computational protein design
Biochemistry. 2023; 62(2): 318-329. https://doi.org/10.1021/acs.biochem.2c00083
DORA PSI -
Davis-Gilbert ZW, Krämer A, Dunford JE, Howell S, Senbabaoglu F, Wells CI, et al.
Discovery of a potent and selective naphthyridine-based chemical probe for casein kinase 2
ACS Medicinal Chemistry Letters. 2023. https://doi.org/10.1021/acsmedchemlett.2c00530
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Dienemann J-N, Chen S-Y, Hitzenberger M, Sievert ML, Hacker SM, Prigge ST, et al.
A chemical proteomic strategy reveals inhibitors of lipoate salvage in bacteria and parasites
Angewandte Chemie International Edition. 2023; 62(31): e202304533 (9 pp.). https://doi.org/10.1002/anie.202304533
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Ecker F, Vattekkatte A, Boland W, Groll M
Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors
Nature Chemistry. 2023; 15: 1188-1195. https://doi.org/10.1038/s41557-023-01235-9
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Fleming JR, Hauth F, Hartig JS, Mayans O
Crystal structure of a GCN5-related N-acetyltransferase from Lactobacillus curiae
Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2023; 79: 217-223. https://doi.org/10.1107/S2053230X2300571X
DORA PSI -
Fraley AE, Dell M, Schmalhofer M, Meoded RA, Bergande C, Groll M, et al.
Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation
Structure. 2023; 31(5): 565-572.e4. https://doi.org/10.1016/j.str.2023.02.010
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Glögl M, Friedrich N, Cerutti G, Lemmin T, Kwon YD, Gorman J, et al.
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization
Nature Structural and Molecular Biology. 2023; 30: 1323-1336. https://doi.org/10.1038/s41594-023-01062-z
DORA PSI -
Guler S, DiPoto MC, Crespo A, Caldwell R, Doerfel B, Grossmann N, et al.
Selective Wee1 inhibitors led to antitumor activity in vitro and correlated with myelosuppression
ACS Medicinal Chemistry Letters. 2023; 14(5): 566-576. https://doi.org/10.1021/acsmedchemlett.2c00481
DORA PSI -
Hashimoto K, Watanabe S, Akutsu M, Muraki N, Kamishina H, Furukawa Y, et al.
Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy–linked E40K mutation
Journal of Biological Chemistry. 2023; 299(6): 104798 (12 pp.). https://doi.org/10.1016/j.jbc.2023.104798
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Hu Z, Sitkoff D, Glunz PW, Zou Y, Wang C, Muckelbauer JK, et al.
Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors
Bioorganic and Medicinal Chemistry Letters. 2023; 88: 129304 (5 pp.). https://doi.org/10.1016/j.bmcl.2023.129304
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Huber EM, Kreling L, Heinrich AK, Dünnebacke M, Pöthig A, Bode HB, et al.
A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments
Structure. 2023; 31(5): 573-583.e5. https://doi.org/10.1016/j.str.2023.03.001
DORA PSI -
Imai Y, Wakasugi D, Suzuki R, Kato S, Sugisaki M, Mima M, et al.
Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor
Bioorganic and Medicinal Chemistry Letters. 2023; 79: 129050 (6 pp.). https://doi.org/10.1016/j.bmcl.2022.129050
DORA PSI -
Isaikina P, Petrovic I, Jakob RP, Sarma P, Ranjan A, Baruah M, et al.
A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes
Molecular Cell. 2023; 83(12): 2108-2121.e7. https://doi.org/10.1016/j.molcel.2023.05.002
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Kaenying W, Choengpanya K, Tagami T, Wattana-Amorn P, Lang W, Okuyama M, et al.
Crystal structure and identification of amino acid residues for catalysis and binding of GH3 AnBX β-xylosidase from Aspergillus niger
Applied Microbiology and Biotechnology. 2023; 107(7-8): 2335-2349. https://doi.org/10.1007/s00253-023-12445-z
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Kaspers MS, Pogenberg V, Pett C, Ernst S, Ecker F, Ochtrop P, et al.
Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b
Nature Communications. 2023; 14(1). https://doi.org/10.1038/s41467-023-37621-7
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Kim D, Herdeis L, Rudolph D, Zhao Y, Böttcher J, Vides A, et al.
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
Nature. 2023; 619(7968): 160-166. https://doi.org/10.1038/s41586-023-06123-3
DORA PSI -
Kuttruff CA, Fleck M, Carotta S, Arnhof H, Bretschneider T, Dahmann G, et al.
Discovery of BI 7446: a potent cyclic dinucleotide STING agonist with broad-spectrum variant activity for the treatment of cancer
Journal of Medicinal Chemistry. 2023; 66(14): 9376-9400. https://doi.org/10.1021/acs.jmedchem.3c00510
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Le K, Soth MJ, Cross JB, Liu G, Ray WJ, Ma J, et al.
Discovery of IACS-52825, a potent and selective DLK inhibitor for treatment of chemotherapy-induced peripheral neuropathy
Journal of Medicinal Chemistry. 2023; 66(14): 9954-9971. https://doi.org/10.1021/acs.jmedchem.3c00788
DORA PSI -
Lentink S, Salazar Marcano DE, Moussawi MA, Vandebroek L, Van Meervelt L, Parac-Vogt T N
Fine-tuning non-covalent interactions between hybrid metal-oxo clusters and proteins
Faraday Discussions. 2023; 244(21): 21-38. https://doi.org/10.1039/d2fd00161f
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Leonarski F, Brückner M, Lopez-Cuenca C, Mozzanica A, Stadler H-C, Matěj Z, et al.
Jungfraujoch: hardware-accelerated data-acquisition system for kilohertz pixel-array X-ray detectors
Journal of Synchrotron Radiation. 2023; 30: 227-234. https://doi.org/10.1107/S1600577522010268
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Manner C, Dias Teixeira R, Saha D, Kaczmarczyk A, Zemp R, Wyss F, et al.
A genetic switch controls Pseudomonas aeruginosa surface colonization
Nature Microbiology. 2023; 8: 1520-1533. https://doi.org/10.1038/s41564-023-01403-0
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Mattoteia D, Chiapparino A, Fumagalli M, De Marco M, De Giorgi F, Negro L, et al.
Identification of regulatory molecular "hot spots” for LH/PLOD collagen glycosyltransferase activity
International Journal of Molecular Sciences. 2023; 24(13): 11213 (22 pp.). https://doi.org/10.3390/ijms241311213
DORA PSI -
Mauxion F, Basquin J, Ozgur S, Rame M, Albrecht J, Schäfer I, et al.
The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
Cell Reports. 2023; 42(1): 111902 (18 pp.). https://doi.org/10.1016/j.celrep.2022.111902
DORA PSI -
Mazzucato R, Roberti M, Capelli AM, Rancati F, Biagetti M, Fiorelli C, et al.
Application of an “inhalation by design” approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors
European Journal of Medicinal Chemistry. 2023; 254: 115331 (15 pp.). https://doi.org/10.1016/j.ejmech.2023.115331
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Mizuguchi M, Yokoyama T, Okada T, Nakagawa Y, Fujii K, Nabeshima Y, et al.
Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis
Bioorganic and Medicinal Chemistry. 2023; 90: 117370 (12 pp.). https://doi.org/10.1016/j.bmc.2023.117370
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Mohr MKF, Saleem-Batcha R, Cornelissen NV, Andexer JN
Enzymatic synthesis of l-Methionine analogues and application in a methyltransferase catalysed alkylation cascade**
Chemistry: A European Journal. 2023; 29(46): e202301503 (6 pp.). https://doi.org/10.1002/chem.202301503
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Mordhorst S, Badmann T, Bösch NM, Morinaka BI, Rauch H, Piel J, et al.
Structural and biochemical insights into post-translational arginine-to-ornithine peptide modifications by an atypical arginase
ACS Chemical Biology. 2023; 18(3): 528-536. https://doi.org/10.1021/acschembio.2c00879
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Němec V, Khirsariya P, Janovská P, Moyano PM, Maier L, Procházková P, et al.
Discovery of potent and exquisitely selective inhibitors of kinase CK1 with tunable isoform selectivity
Angewandte Chemie International Edition. 2023; 62(11): e202217532 (7 pp.). https://doi.org/10.1002/anie.202217532
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Otake K, Ubukata M, Nagahashi N, Ogawa N, Hantani Y, Hantani R, et al.
Methyl and fluorine effects in novel orally bioavailable Keap1-Nrf2 PPI inhibitor
ACS Medicinal Chemistry Letters. 2023; 14(5): 658-665. https://doi.org/10.1021/acsmedchemlett.3c00067
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Owen RL, de Sanctis D, Pearson AR, Beale JH
A standard descriptor for fixed-target serial crystallography
Acta Crystallographica Section D: Structural Biology. 2023; 79(8): 668-672. https://doi.org/10.1107/S2059798323005429
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Rak M, Tesch R, Berger LM, Shevchenko E, Raab M, Tjaden A, et al.
Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily
European Journal of Medicinal Chemistry. 2023; 254: 115347. https://doi.org/10.1016/j.ejmech.2023.115347
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Rodriguez Buitrago JA, Leitis G, Kaņepe-Lapsa I, Rudnickiha A, Parisini E, Jirgensons A
Synthesis and evaluation of an agrocin 84 toxic moiety (TM84) analogue as a malarial threonyl tRNA synthetase inhibitor
Organic and Biomolecular Chemistry. 2023; 21(26): 5433-5439. https://doi.org/10.1039/D3OB00670K
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Shishiuchi R, Kang H, Tagami T, Ueda Y, Lang W, Kimura A, et al.
Discovery of α-L-glucosidase raises the possibility of α-L-glucosides in nature
ACS Omega. 2023; 7(50): 47411-47423. https://doi.org/10.1021/acsomega.2c06991
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Smith KML, Panepucci E, Kaminski JW, Aumonier S, Huang C-Y, Eris D, et al.
SDU - software for high-throughput automated data collection at the Swiss Light Source
Journal of Synchrotron Radiation. 2023; 30: 538-545. https://doi.org/10.1107/S1600577523002631
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Smithers L, Degtjarik O, Weichert D, Huang C-Y, Boland C, Bowen K, et al.
Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N-acyltransferase
Science Advances. 2023; 9(26): eadf5799 (17 pp.). https://doi.org/10.1126/sciadv.adf5799
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Subbiah V, Sahai V, Maglic D, Bruderek K, Touré BB, Zhao S, et al.
RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
Cancer Discovery. 2023; 13(9): 2012-2031. https://doi.org/10.1158/2159-8290.CD-23-0475
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Tang S, Garzon Sanz M, Smith O, Krämer A, Egbase D, Caton PW, et al.
Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators
Acta Pharmaceutica Sinica B. 2023; 13(2): 709-721. https://doi.org/10.1016/j.apsb.2022.07.016
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Taylor G, Cui H, Leodolter J, Giese C, Weber-Ban E
ClpC2 protects mycobacteria against a natural antibiotic targeting ClpC1-dependent protein degradation
Communications Biology. 2023; 6(1): 301 (13 pp.). https://doi.org/10.1038/s42003-023-04658-9
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Vaas S, Zimmermann MO, Schollmeyer D, Stahlecker J, Engelhardt MU, Rheinganz J, et al.
Principles and applications of CF2X moieties as unconventional halogen bond donors in medicinal chemistry, chemical biology, and drug discovery
Journal of Medicinal Chemistry. 2023; 66(15): 10202-10225. https://doi.org/10.1021/acs.jmedchem.3c00634
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Warstat R, Pervaiz M, Regenass P, Amann M, Schmidtkunz K, Einsle O, et al.
A novel pan-selective bromodomain inhibitor for epigenetic drug design
European Journal of Medicinal Chemistry. 2023; 249: 115139 (12 pp.). https://doi.org/10.1016/j.ejmech.2023.115139
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Werel L, Farmani N, Krol E, Serrania J, Essen L-O, Becker A
Structural basis of dual specificity of Sinorhizobium meliloti Clr, a cAMP and cGMP receptor protein
mBio. 2023; 14(2): (19 pp.). https://doi.org/10.1128/mbio.03028-22
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Werner A-D, Schauflinger M, Norris MJ, Klüver M, Trodler A, Herwig A, et al.
The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
Structure. 2023; 31(9): 1038-1051.e7. https://doi.org/10.1016/j.str.2023.06.004
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Wranik M, Weinert T, Slavov C, Masini T, Furrer A, Gaillard N, et al.
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Nature Communications. 2023; 14(1): 903 (12 pp.). https://doi.org/10.1038/s41467-023-36481-5
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Wurm JP
Structural basis for RNA-duplex unwinding by the DEAD-box helicase DbpA
RNA. 2023; 29(9): 1339-1354. https://doi.org/10.1261/rna.079582.123
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Zhang L, Toplak M, Saleem-Batcha R, Höing L, Jakob R, Jehmlich N, et al.
Bacterial dehydrogenases facilitate oxidative inactivation and bioremediation of chloramphenicol
ChemBioChem. 2023; 24: 2-e202200632 (5 pp.). https://doi.org/10.1002/cbic.202200632
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Zhang J, Lair C, Roubert C, Amaning K, Barrio MB, Benedetti Y, et al.
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents
Cell. 2023; 186(5): 1013-1025.e24. https://doi.org/10.1016/j.cell.2023.01.043
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Zhang S, Zhang L, Greule A, Tailhades J, Marschall E, Prasongpholchai P, et al.
P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate
Acta Pharmaceutica Sinica B. 2023; 13(8): 3561-3574. https://doi.org/10.1016/j.apsb.2023.03.021
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Albert L, Nagpal J, Steinchen W, Zhang L, Werel L, Djokovic N, et al.
Bistable photoswitch allows in vivo control of hematopoiesis
ACS Central Science. 2022; 8(1): 57-66. https://doi.org/10.1021/acscentsci.1c00434
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Astro V, Ramirez-Calderon G, Pennucci R, Caroli J, Saera-Vila A, Cardona-Londoño K, et al.
Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
iScience. 2022; 25(7): 104665 (32 pp.). https://doi.org/10.1016/j.isci.2022.104665
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Auman D, Ecker F, Mader SL, Dorst KM, Bräuer A, Widmalm G, et al.
Peroxy intermediate drives carbon bond activation in the dioxygenase AsqJ
Journal of the American Chemical Society. 2022; 144(34): 15622-15632. https://doi.org/10.1021/jacs.2c05650
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Balo T, Sapi A, Kiss A, Raimbaud E, Paysant J, Cattin M-E, et al.
Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors
Monatshefte für Chemie. 2022. https://doi.org/10.1007/s00706-021-02889-2
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Baudrexl M, Fida T, Berk B, Schwarz WH, Zverlov VV, Groll M, et al.
Biochemical and structural characterization of thermostable GH159 glycoside hydrolases exhibiting α-L-arabinofuranosidase activity
Frontiers in Molecular Biosciences. 2022; 9: 907439 (15 pp.). https://doi.org/10.3389/fmolb.2022.907439
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Beaumet M, Dose A, Bräuer A, Mahy JP, Ghattas W, Groll M, et al.
An artificial metalloprotein with metal-adaptive coordination sites and Ni-dependent quercetinase activity
Journal of Inorganic Biochemistry. 2022; 235: 111914 (5 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111914
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Begnini F, Geschwindner S, Johansson P, Wissler L, Lewis RJ, Danelius E, et al.
Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction
Journal of Medicinal Chemistry. 2022; 65(4): 3473-3517. https://doi.org/10.1021/acs.jmedchem.1c01975
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Bloch JS, Sequeira JM, Ramírez AS, Quadros EV, Locher KP
Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route
FASEB Journal. 2022; 36(4): e22222 (11 pp.). https://doi.org/10.1096/fj.202101376RR
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Bonagas N, Gustafsson NMS, Henriksson M, Marttila P, Gustafsson R, Wiita E, et al.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Nature Cancer. 2022; 3(2): 156-172. https://doi.org/10.1038/s43018-022-00331-y
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Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, et al.
Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRASG12C inhibitor
Journal of Medicinal Chemistry. 2022; 65(21): 14614-14629. https://doi.org/10.1021/acs.jmedchem.2c01120
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Bärland N, Rueff A-S, Cebrero G, Hutter CAJ, Seeger MA, Veening JW, et al.
Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification
Science Advances. 2022; 8(9): eabm1122 (14 pp.). https://doi.org/10.1126/sciadv.abm1122
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Cansfield AD, Ator MA, Banerjee J, Bestwick M, Bortolato A, Brown GA, et al.
Novel macrocyclic antagonists of the calcitonin gene-related peptide receptor: design, realization, and structural characterization of protein-ligand complexes
ACS Chemical Neuroscience. 2022; 13(6): 751-765. https://doi.org/10.1021/acschemneuro.1c00696
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Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, et al.
Chemoproteomics-enabled identification of 4-Oxo-β-lactams as inhibitors of dipeptidyl peptidases 8 and 9
Angewandte Chemie International Edition. 2022; 61(47): e202210498 (10 pp.). https://doi.org/10.1002/anie.202210498
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Cellini A, Shankar MK, Wahlgren WY, Nimmrich A, Furrer A, James D, et al.
Structural basis of the radical pair state in photolyases and cryptochromes
Chemical Communications. 2022; 58(31): 4889-4892. https://doi.org/10.1039/D2CC00376G
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Chaikuad A, Zhubi R, Tredup C, Knapp S
Comparative structural analyses of the NHL domains from the human E3 ligase TRIM-NHL family
IUCrJ. 2022; 9(6): 720-727. https://doi.org/10.1107/S2052252522008582
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Chen Y, Tso K, Heckrodt TJ, Li H, Yen R, Lin N, et al.
Bicyclic pyrimidine compounds as potent IRAK4 inhibitors
Bioorganic and Medicinal Chemistry Letters. 2022; 73: 128900 (5 pp.). https://doi.org/10.1016/j.bmcl.2022.128900
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Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, et al.
N-heterocyclic 3-pyridyl carboxamide inhibitors of DHODH for the treatment of acute myelogenous leukemia
Journal of Medicinal Chemistry. 2022; 65(16): 11241-11256. https://doi.org/10.1021/acs.jmedchem.2c00788
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Cullati SN, Chaikuad A, Chen J-S, Gebel J, Tesmer L, Zhubi R, et al.
Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
Molecular Cell. 2022; 82(11): 2006-2020.e8. https://doi.org/10.1016/j.molcel.2022.03.005
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Daniels MH, Malojcic G, Clugston SL, Williams B, Coeffet-Le Gal M, Pan-Zhou X-R, et al.
Discovery and optimization of highly selective inhibitors of CDK5
Journal of Medicinal Chemistry. 2022; 65(4): 3575-3596. https://doi.org/10.1021/acs.jmedchem.1c02069
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Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, et al.
Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition
Nature Communications. 2022; 13(1): 382 (13 pp.). https://doi.org/10.1038/s41467-021-27911-3
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Diamanti R, Srinivas V, Johansson AI, Nordström A, Griese JJ, Lebrette H, et al.
Comparative structural analysis provides new insights into the function of R2-like ligand-binding oxidase
FEBS Letters. 2022; 569(12): 1600-1610. https://doi.org/10.1002/1873-3468.14319
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Dileep KV, Ihara K, Mishima-Tsumagari C, Kukimoto-Niino M, Yonemochi M, Hanada K, et al.
Crystal structure of human acetylcholinesterase in complex with tacrine: implications for drug discovery
International Journal of Biological Macromolecules. 2022; 210: 172-181. https://doi.org/10.1016/j.ijbiomac.2022.05.009
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Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, et al.
Identification of pyrimidine-based lead compounds for understudied kinases implicated in driving neurodegeneration
Journal of Medicinal Chemistry. 2022; 65(2): 1313-1328. https://doi.org/10.1021/acs.jmedchem.1c00440
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Funck D, Sinn M, Fleming JR, Stanoppi M, Dietrich J, López-Igual R, et al.
Discovery of a Ni2+-dependent guanidine hydrolase in bacteria
Nature. 2022; 603(7901): 515-521. https://doi.org/10.1038/s41586-022-04490-x
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Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, et al.
In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M
Journal of the American Chemical Society. 2022; 144(12): 5614-5628. https://doi.org/10.1021/jacs.2c01020
DORA PSI -
Ghosh P, Kropp HM, Betz K, Ludmann S, Diederichs K, Marx A, et al.
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