Publications

PDB structures measured at X06SA

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Berardi A, Kaestner CL, Ghitti M, Quilici G, Cocomazzi P, Li J, et al.
    The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma
    Nucleic Acids Research. 2025; 53(1): gkae1121 (20 pp.). https://doi.org/10.1093/nar/gkae1121
    DORA PSI
  • Bobadilla Ugarte P, Halter S, Mutte SK, Heijstek C, Niault T, Terenin I, et al.
    Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA
    Molecular Cell. 2025; 85(10): 1920-1937.e10. https://doi.org/10.1016/j.molcel.2025.03.025
    DORA PSI
  • Bosman R, Ortolani G, Ghosh S, James D, Norder P, Hammarin G, et al.
    Structural basis for the prolonged photocycle of sensory rhodopsin II revealed by serial synchrotron crystallography
    Nature Communications. 2025; 16(1): 3460 (12 pp.). https://doi.org/10.1038/s41467-025-58263-x
    DORA PSI
  • Bruno P, Pala D, Micoli A, Corsi M, Accetta A, Carzaniga L, et al.
    Discovery of CHF-6523, an inhaled selective PI3Kδ inhibitor for the treatment of chronic obstructive pulmonary disease
    Journal of Medicinal Chemistry. 2025; 68: 2444-2465. https://doi.org/10.1021/acs.jmedchem.4c02062
    DORA PSI
  • Chancellor A, Constantin D, Berloffa G, Yang Q, Nosi V, Loureiro JP, et al.
    The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells
    Immunity. 2025; 58(2): 431-447. https://doi.org/10.1016/j.immuni.2024.11.019
    DORA PSI
  • De Marco M, Rai SR, Scietti L, Mattoteia D, Liberi S, Moroni E, et al.
    Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1
    Nature Communications. 2025; 16(1): 3624 (17 pp.). https://doi.org/10.1038/s41467-025-59017-5
    DORA PSI
  • Guerriere TB, Fraaije MW, Mattevi A
    Biochemical and structural insights into pinoresinol hydroxylase from Pseudomonas sp
    Archives of Biochemistry and Biophysics. 2025; 764: 110247 (8 pp.). https://doi.org/10.1016/j.abb.2024.110247
    DORA PSI
  • Guerriere TB, Vancheri A, Ricotti I, Serapian SA, Eggerichs D, Tischler D, et al.
    Dehydrogenase versus oxidase function: the interplay between substrate binding and flavin microenvironment
    ACS Catalysis. 2025; 15(2): 1046-1060. https://doi.org/10.1021/acscatal.4c05944
    DORA PSI
  • Hermanns T, Kolek S, Uthoff M, de Heiden RA, Mulder MPC, Baumann U, et al.
    A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode
    Molecular Cell. 2025; 85(6): 1202-1215.e5. https://doi.org/10.1016/j.molcel.2025.02.002
    DORA PSI
  • Hofmeister A, Jahn-Hofmann K, Brunner B, Helms M, Metz-Weidmann C, Poeverlein C, et al.
    Trivalent siRNA-conjugates with guanosine as ASGPR-binder show potent knock-down in vivo
    Journal of Medicinal Chemistry. 2025; 68(6): 6193-6209. https://doi.org/10.1021/acs.jmedchem.4c02275
    DORA PSI
  • Klaubert TJ, Gellner J, Bernard C, Effert J, Lombard C, Kaila VRI, et al.
    Molecular basis for azetidine-2-carboxylic acid biosynthesis
    Nature Communications. 2025; 16(1): 48 (12 pp.). https://doi.org/10.1038/s41467-025-56610-6
    DORA PSI
  • Kolosova O, Zgadzay Y, Stetsenko A, Sukhinina AP, Atamas A, Validov S, et al.
    Mechanism of read-through enhancement by aminoglycosides and mefloquine
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2025; 122(17): (12 pp.). https://doi.org/10.1073/pnas.2420261122
    DORA PSI
  • Lotz R, Osterburg C, Chaikuad A, Weber S, Akutsu M, Machel AC, et al.
    Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
    Cell Death and Disease. 2025; 16(1): 4 (11 pp.). https://doi.org/10.1038/s41419-024-07320-2
    DORA PSI
  • Lucignano R, Bologna A, Gramazio S, Wang PH, Taxis C, Essen LO, et al.
    Unravelling the amyloid aggregation mechanism of the sweet protein Monellin: Insights from circular permutated mutants
    International Journal of Biological Macromolecules. 2025; 308: 142239 (11 pp.). https://doi.org/10.1016/j.ijbiomac.2025.142239
    DORA PSI
  • Moyano PM, Kubina T, Paruch ŠO, Jarošková A, Novotný J, Skočková V, et al.
    Thieno[3,2-b]pyridine: attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode
    Angewandte Chemie International Edition. 2025; 64(1): e202412786 (11 pp.). https://doi.org/10.1002/anie.202412786
    DORA PSI
  • Schulte T, Magdaong NCM, Di Valentin M, Agostini A, Tait CE, Niedzwiedzki DM, et al.
    Structural and spectroscopic characterization of the peridinin-chlorophyll a-protein (PCP) complex from Heterocapsa pygmaea (HPPCP)
    Biochimica et Biophysica Acta: Bioenergetics. 2025; 1866(1): 149510 (17 pp.). https://doi.org/10.1016/j.bbabio.2024.149510
    DORA PSI
  • Terrosu S, Nurullina L, Supantanapong N, Pak BS, Nguyen S, Holm M, et al.
    Synthesis of differentially halogenated lissoclimide analogues to probe ribosome e-site binding
    ACS Chemical Biology. 2025; 20(4): 858-869. https://doi.org/10.1021/acschembio.4c00825
    DORA PSI
  • Träger LK, Degen M, Pereira J, Durairaj J, Teixeira RD, Hiller S, et al.
    Structural basis for cooperative ssDNA binding by bacteriophage protein filament P12
    Nucleic Acids Research. 2025; 53(5): gkaf132 (15 pp.). https://doi.org/10.1093/nar/gkaf132
    DORA PSI
  • Tröster V, Wong RP, Börgel A, Cakilkaya B, Renz C, Möckel MM, et al.
    Custom affinity probes reveal DNA-damage-induced, ssDNA-independent chromatin SUMOylation in budding yeast
    Cell Reports. 2025; 44(3): 115353 (22 pp.). https://doi.org/10.1016/j.celrep.2025.115353
    DORA PSI
  • Walker ME, Zhu W, Peterson JH, Wang H, Patteson J, Soriano A, et al.
    Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition
    Nature Communications. 2025; 16(1): 3395 (20 pp.). https://doi.org/10.1038/s41467-025-58086-w
    DORA PSI
  • Walla B, Maslakova A, Bischoff D, Janowski R, Niessing D, Weuster-Botz D
    Rational introduction of electrostatic interactions at crystal contacts to enhance protein crystallization of an ene reductase
    Biomolecules. 2025; 15(4): 467 (18 pp.). https://doi.org/10.3390/biom15040467
    DORA PSI
  • Wang G, Seidler NJ, Röhm S, Pan Y, Liang XJ, Haarer L, et al.
    Probing the protein kinases′ cysteinome by covalent fragments
    Angewandte Chemie International Edition. 2025; 64(8): e202419736 (12 pp.). https://doi.org/10.1002/anie.202419736
    DORA PSI
  • Yudenko A, Bukhdruker S, Shishkin P, Rodin S, Burtseva A, Petrov A, et al.
    Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers
    Structure. 2025; 33(1): 171-180.e5. https://doi.org/10.1016/j.str.2024.10.028
    DORA PSI
  • Zeides P, Bellmann-Sickert K, Zhang R, Seel CJ, Most V, Schoeder CT, et al.
    Unraveling the molecular basis of substrate specificity and halogen activation in vanadium-dependent haloperoxidases
    Nature Communications. 2025; 16(1): 2083 (13 pp.). https://doi.org/10.1038/s41467-025-57023-1
    DORA PSI
  • Amrhein JA, Berger LM, Balourdas DI, Joerger AC, Menge A, Krämer A, et al.
    Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
    Journal of Medicinal Chemistry. 2024; 67(1): 674-690. https://doi.org/10.1021/acs.jmedchem.3c01980
    DORA PSI
  • Balourdas DI, Markl AM, Krämer A, Settanni G, Joerger AC
    Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
    Cell Death & Disease. 2024; 15(6): 408 (10 pp.). https://doi.org/10.1038/s41419-024-06739-x
    DORA PSI
  • Basile L, Santema LL, Binda C, Fraaije MW
    Discovery and structural characterization of a thermostable bacterial monoamine oxidase
    FEBS Journal. 2024; 291: 849-864. https://doi.org/10.1111/febs.16973
    DORA PSI
  • Bauer N, Balourdas DI, Schneider JR, Zhang X, Berger LM, Berger BT, et al.
    Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
    ACS Chemical Biology. 2024; 19(2): 266-279. https://doi.org/10.1021/acschembio.3c00427
    DORA PSI
  • Beier A, Platzer G, Höfurthner T, Ptaszek AL, Lichtenecker RJ, Geist L, et al.
    Probing protein-ligand methyl−π interaction geometries through chemical shift measurements of selectively labeled methyl groups
    Journal of Medicinal Chemistry. 2024; 67(15): 13187-13196. https://doi.org/10.1021/acs.jmedchem.4c01128
    DORA PSI
  • Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, et al.
    PROTACs targeting BRM (SMARCA2) afford selective In vivo degradation over BRG1 (SMARCA4) and are active in BRG1 mutant xenograft tumor models
    Journal of Medicinal Chemistry. 2024; 67: 1262-1313. https://doi.org/10.1021/acs.jmedchem.3c01781
    DORA PSI
  • Bolduc PN, Pfaffenbach M, Evans R, Xin Z, Henry KL, Gao F, et al.
    A tiny pocket packs a punch: leveraging pyridones for the discovery of CNS-penetrant aza-indazole IRAK4 inhibitors
    ACS Medicinal Chemistry Letters. 2024; 15(5): 714-721. https://doi.org/10.1021/acsmedchemlett.4c00102
    DORA PSI
  • Bozhüyük KAJ, Präve L, Kegler C, Schenk L, Kaiser S, Schelhas C, et al.
    Evolution-inspired engineering of nonribosomal peptide synthetases
    Science. 2024; 383(6689): eadg4320 (11 pp.). https://doi.org/10.1126/science.adg4320
    DORA PSI
  • Brescia FF, Korf L, Essen L-O, Zorn H, Ruehl M
    A novel O- and S-methyltransferase from Pleurotus sapidus is involved in flavor formation
    Journal of Agricultural and Food Chemistry. 2024; 72(12): 6471-6480. https://doi.org/10.1021/acs.jafc.3c08849
    DORA PSI
  • Bruno P, Micoli A, Corsi M, Pala D, Guariento S, Fiorelli C, et al.
    Discovery and optimization of pyridazinones as PI3Kδ selective inhibitors for administration by inhalation
    Journal of Medicinal Chemistry. 2024; 67: 11103-11124. https://doi.org/10.1021/acs.jmedchem.4c00610
    DORA PSI
  • Buffa V, Meyners C, Sugiarto WO, Bauder M, Gaali S, Hausch F
    1,4-pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile
    ChemMedChem. 2024; 19(17): e202400264 (23 pp.). https://doi.org/10.1002/cmdc.202400264
    DORA PSI
  • Böttcher J, Fuchs JE, Mayer M, Kahmann J, Zak KM, Wunberg T, et al.
    Ligandability assessment of the C-terminal Rel-homology domain of NFAT1
    Archiv der Pharmazie. 2024; 357(6): 2300649 (7 pp.). https://doi.org/10.1002/ardp.202300649
    DORA PSI
  • Cadoux C, Maslać N, Bolte P, Murken F, Gu W, Milton RD, et al.
    Structural comparison of (hyper-)thermophilic nitrogenase reductases from three marine Methanococcales
    FEBS Journal. 2024; 291(15): 3454-3480. https://doi.org/10.1111/febs.17148
    DORA PSI
  • Carswell E, Heinrich T, Petersson C, Gunera J, Garg S, Schwarz D, et al.
    Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold
    Bioorganic and Medicinal Chemistry Letters. 2024; 114: 129981 (8 pp.). https://doi.org/10.1016/j.bmcl.2024.129981
    DORA PSI
  • Champiré A, Berabez R, Braka A, Cosson A, Corret J, Girardin C, et al.
    Tetrahydropyridine LIMK inhibitors: structure activity studies and biological characterization
    European Journal of Medicinal Chemistry. 2024; 271: 116391 (27 pp.). https://doi.org/10.1016/j.ejmech.2024.116391
    DORA PSI
  • Chen D, Zhang X, Vorobieva AA, Tachibana R, Stein A, Jakob RP, et al.
    An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway
    Nature Chemistry. 2024. https://doi.org/10.1038/s41557-024-01562-5
    DORA PSI
  • Chikunova A, Manley MP, Heijjer CN, Drenth CS, Cramer‐Blok AJ, Ahmad MUD, et al.
    Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC
    Protein Science. 2024; 33(4). https://doi.org/10.1002/pro.4972
    DORA PSI
  • DeRatt LG, Zhang Z, Pietsch C, Cisar JS, Zhang X, Wang W, et al.
    Discovery of JNJ-74856665: a novel isoquinolinone DHODH inhibitor for the treatment of AML
    Journal of Medicinal Chemistry. 2024; 67: 11254-11272. https://doi.org/10.1021/acs.jmedchem.4c00809
    DORA PSI
  • DeRatt LG, Zhang Z, Pietsch EC, Cisar J, Wang A, Wang C yuan, et al.
    Identification of isoquinolinone DHODH inhibitor isosteres
    Bioorganic and Medicinal Chemistry Letters. 2024; 113: 129965 (7 pp.). https://doi.org/10.1016/j.bmcl.2024.129965
    DORA PSI
  • Dhamotharan K, Korn SM, Wacker A, Becker MA, Günther S, Schwalbe H, et al.
    A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding
    Nature Communications. 2024; 15(1): 10656 (16 pp.). https://doi.org/10.1038/s41467-024-55024-0
    DORA PSI
  • Dötsch L, Davies C, Hennes E, Schönfeld J, Kumar A, Guita CDCL, et al.
    Discovery of the sEH inhibitor epoxykynin as a potent kynurenine pathway modulator
    Journal of Medicinal Chemistry. 2024; 67(6): 4691-4706. https://doi.org/10.1021/acs.jmedchem.3c02245
    DORA PSI
  • Evans R, Bolduc PN, Pfaffenbach M, Gao F, May-Dracka T, Fang T, et al.
    The discovery of 7-isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a potent, selective, and CNS-penetrant IRAK4 inhibitor for the treatment of ischemic stroke
    Journal of Medicinal Chemistry. 2024; 67(6): 4676-4690. https://doi.org/10.1021/acs.jmedchem.3c02226
    DORA PSI
  • Feuillard J, Couston J, Benito Y, Hodille E, Dumitrescu O, Blaise M
    Biochemical and structural characterization of a class A β-lactamase from Nocardia cyriacigeorgica
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2024; 80: 13-21. https://doi.org/10.1107/S2053230X23010671
    DORA PSI
  • Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, et al.
    Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent EPHA2/GAK kinase inhibitors
    Journal of Medicinal Chemistry. 2024; 67(1): 12534-12552. https://doi.org/10.1021/acs.jmedchem.4c00411
    DORA PSI
  • Gerstberger T, Berger H, Büttner FH, Gmachl M, Kessler D, Koegl M, et al.
    Chasing red herrings: Palladium metal salt impurities feigning KRAS activity in biochemical assays
    Journal of Medicinal Chemistry. 2024; 67(14): 11701-11711. https://doi.org/10.1021/acs.jmedchem.3c02381
    DORA PSI
  • Glover H, Saßmannshausen T, Bertrand Q, Trabuco M, Slavov C, Bacchin A, et al.
    Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography
    Nature Communications. 2024; 15(1): 10837 (13 pp.). https://doi.org/10.1038/s41467-024-55109-w
    DORA PSI
  • Gollner A, Rudolph D, Weyer-Czernilofsky U, Baumgartinger R, Jung P, Weinstabl H, et al.
    Discovery and characterization of brigimadlin, a novel and highly potent MDM2–p53 antagonist suitable for intermittent dose schedules
    Molecular Cancer Therapeutics. 2024; 23(12): 1689-1702. https://doi.org/10.1158/1535-7163.MCT-23-0783
    DORA PSI
  • Gotthard G, Mous S, Weinert T, Maia RNA, James D, Dworkowski F, et al.
    Capturing the blue-light activated state of the Phot-LOV1 domain from Chlamydomonas reinhardtii using time-resolved serial synchrotron crystallography
    IUCrJ. 2024; 11(5): (17 pp.). https://doi.org/10.1107/S2052252524005608
    DORA PSI
  • Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, et al.
    Computational design of soluble and functional membrane protein analogues
    Nature. 2024; 631(8020): 449-458. https://doi.org/10.1038/s41586-024-07601-y
    DORA PSI
  • Greco FA, Krämer A, Wahl L, Elson L, Ehret TAL, Gerninghaus J, et al.
    Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting
    European Journal of Medicinal Chemistry. 2024; 276: 116672 (22 pp.). https://doi.org/10.1016/j.ejmech.2024.116672
    DORA PSI
  • Götz MG, Godwin K, Price R, Dorn R, Merrill-Steskal G, Klemmer W, et al.
    Macrocyclic oxindole peptide epoxyketones - a comparative study of macrocyclic inhibitors of the 20S proteasome
    ACS Medicinal Chemistry Letters. 2024; 15(4): 533-539. https://doi.org/10.1021/acsmedchemlett.4c00017
    DORA PSI
  • Hazemann J, Kimmerlin T, Lange R, Sweeney AM, Bourquin G, Ritz D, et al.
    Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for de novo drug design and computational chemistry approaches
    RSC Medicinal Chemistry. 2024; 15(6): 2146-2159. https://doi.org/10.1039/d4md00106k
    DORA PSI
  • Herhaus L, Gestal-Mato U, Eapen VV, Mačinković I, Bailey HJ, Prieto-Garcia C, et al.
    IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion
    Cell. 2024; 187(25): 7285-7302.e29. https://doi.org/10.1016/j.cell.2024.09.048
    DORA PSI
  • Hermanns T, Uthoff M, Baumann U, Hofmann K
    The structural basis for deubiquitination by the fingerless USP-type effector TssM
    Life Science Alliance. 2024; 7(2): e202302422 (13 pp.). https://doi.org/10.26508/lsa.202302422
    DORA PSI
  • Himmelbauer MK, Bajrami B, Basile R, Capacci A, Chen TY, Choi CK, et al.
    Discovery and preclinical characterization of BIIB129, a covalent, selective, and brain-penetrant BTK inhibitor for the treatment of multiple sclerosis
    Journal of Medicinal Chemistry. 2024; 67(10): 8122-8140. https://doi.org/10.1021/acs.jmedchem.4c00220
    DORA PSI
  • Huang CY, Metz A, Lange R, Artico N, Potot C, Hazemann J, et al.
    Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket
    Acta Crystallographica Section D: Structural Biology. 2024; 80: 123-136. https://doi.org/10.1107/S2059798324000329
    DORA PSI
  • Höing L, Sowa ST, Toplak M, Reinhardt JK, Jakob R, Maier T, et al.
    Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products
    Chemical Science. 2024; 15(20): 7749-7756. https://doi.org/10.1039/d4sc01715c
    DORA PSI
  • Illigmann A, Vielberg MT, Lakemeyer M, Wolf F, Dema T, Stange P, et al.
    Structure of Staphylococcus aureus ClpP bound to the covalent active-site inhibitor cystargolide A
    Angewandte Chemie International Edition. 2024; 63(3): e202314028 (10 pp.). https://doi.org/10.1002/anie.202314028
    DORA PSI
  • Inobe T, Sakaguchi R, Obita T, Mukaiyama A, Koike S, Yokoyama T, et al.
    Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
    FEBS Letters. 2024; 598: 2292-2305. https://doi.org/10.1002/1873-3468.14986
    DORA PSI
  • Jungfer K, Sigg A, Jinek M
    Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
    Nucleic Acids Research. 2024; 52(1): 462-473. https://doi.org/10.1093/nar/gkad1102
    DORA PSI
  • Kesteleyn B, Herschke F, Darville N, Stoops B, Jacobs T, Jacoby E, et al.
    Spiro-azetidine oxindoles as long-acting injectables for pre-exposure prophylaxis against respiratory syncytial virus infections
    Journal of Medicinal Chemistry. 2024; 67: 10986-11002. https://doi.org/10.1021/acs.jmedchem.4c00514
    DORA PSI
  • Kielkopf CS, Shneider MM, Leiman PG, Taylor NMI
    T6SS-associated Rhs toxin-encapsulating shells: structural and bioinformatical insights into bacterial weaponry and self-protection
    Structure. 2024; 32(12): 2375-2389.e5. https://doi.org/10.1016/j.str.2024.10.008
    DORA PSI
  • Kjeldsen T, Andersen AS, Hubálek F, Johansson E, Kreiner FF, Schluckebier G, et al.
    Molecular engineering of insulin for recombinant expression in yeast
    Trends in Biotechnology. 2024; 42(4): 464-478. https://doi.org/10.1016/j.tibtech.2023.09.012
    DORA PSI
  • Klett T, Stahlecker J, Jaag S, Masberg B, Knappe C, Lämmerhofer M, et al.
    Covalent fragments acting as tyrosine mimics for mutant p53-Y220C rescue by nucleophilic aromatic substitution
    ACS Pharmacology & Translational Science. 2024; 7(12): 3984-3999. https://doi.org/10.1021/acsptsci.4c00414
    DORA PSI
  • Koeppl LH, Popadić D, Saleem-Batcha R, Germer P, Andexer JN
    Structure, function and substrate preferences of archaeal S-adenosyl-l-homocysteine hydrolases
    Communications Biology. 2024; 7(1): 380 (15 pp.). https://doi.org/10.1038/s42003-024-06078-9
    DORA PSI
  • Krawinski P, Smithers L, van Dalsen L, Boland C, Ostrovitsa N, Pérez J, et al.
    7.10 MAG. A novel host monoacylglyceride for in meso (lipid cubic phase) crystallization of membrane proteins
    Crystal Growth and Design. 2024; 24(7): 2985-3001. https://doi.org/10.1021/acs.cgd.4c00087
    DORA PSI
  • Kuttenlochner W, Beller P, Kaysser L, Groll M
    Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: a structure–activity relationship study
    Journal of Biological Chemistry. 2024; 300(9): 107646 (8 pp.). https://doi.org/10.1016/j.jbc.2024.107646
    DORA PSI
  • Legare S, Heide F, Gabir H, Rafiei F, Meier M, Padilla-Meier GP, et al.
    Identifying the molecular basis of Laminin N-terminal domain Ca2+ binding using a hybrid approach
    Biophysical Journal. 2024; 123(16): 2422-2430. https://doi.org/10.1016/j.bpj.2024.06.005
    DORA PSI
  • Li F, Zhu WF, Empel C, Datsenko O, Kumar A, Xu Y, et al.
    Photosensitization enables Pauson-Khand-type reactions with nitrenes
    Science. 2024; 383(6682): 498-503. https://doi.org/10.1126/science.adm8095
    DORA PSI
  • Metz A, Stegmann DP, Panepucci EH, Buehlmann S, Huang CY, McAuley KE, et al.
    HEIDI: an experiment-management platform enabling high-throughput fragment and compound screening
    Acta Crystallographica Section D: Structural Biology. 2024; 80: 328-335. https://doi.org/10.1107/S2059798324002833
    DORA PSI
  • Mitrovic S-A, Demalgiriya-Gamage C, Winter L-M, Kiechle T, Ebenhoch R, Neubauer H, et al.
    GPR180 is a new member of the Golgi-dynamics domain seven-transmembrane helix protein family
    Communications Biology. 2024; 7(1): 1588 (14 pp.). https://doi.org/10.1038/s42003-024-07260-9
    DORA PSI
  • Mizuguchi M, Nakagawa Y, Yokoyama T, Okada T, Fujii K, Takahashi K, et al.
    Development of benziodarone analogues with enhanced potency for selective binding to transthyretin in human plasma
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