Publications
X06SA PDB Structure Gallery from BioSync
PXI Publications
Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA
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Busch MR, Rajendran C, Sterner R
Structural and functional characterization of the ureidoacrylate amidohydrolase RutB from Escherichia coli
Biochemistry. 2023; 62(3): 863-872. https://doi.org/10.1021/acs.biochem.2c00640
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Cucuzza S, Michel E, Mittl PRE, Zerbe O, Plückthun A
Improved repeat protein stability by combined consensus and computational protein design
Biochemistry. 2023; 62(2): 318-329. https://doi.org/10.1021/acs.biochem.2c00083
DORA PSI -
Imai Y, Wakasugi D, Suzuki R, Kato S, Sugisaki M, Mima M, et al.
Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor
Bioorganic and Medicinal Chemistry Letters. 2023; 79: 129050 (6 pp.). https://doi.org/10.1016/j.bmcl.2022.129050
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Leonarski F, Brückner M, Lopez-Cuenca C, Mozzanica A, Stadler H-C, Matěj Z, et al.
Jungfraujoch: hardware-accelerated data-acquisition system for kilohertz pixel-array X-ray detectors
Journal of Synchrotron Radiation. 2023; 30: 227-234. https://doi.org/10.1107/S1600577522010268
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Mauxion F, Basquin J, Ozgur S, Rame M, Albrecht J, Schäfer I, et al.
The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
Cell Reports. 2023; 42(1): 111902 (18 pp.). https://doi.org/10.1016/j.celrep.2022.111902
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Shishiuchi R, Kang H, Tagami T, Ueda Y, Lang W, Kimura A, et al.
Discovery of α-L-glucosidase raises the possibility of α-L-glucosides in nature
ACS Omega. 2023; 7(50): 47411-47423. https://doi.org/10.1021/acsomega.2c06991
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Warstat R, Pervaiz M, Regenass P, Amann M, Schmidtkunz K, Einsle O, et al.
A novel pan-selective bromodomain inhibitor for epigenetic drug design
European Journal of Medicinal Chemistry. 2023; 249: 115139 (12 pp.). https://doi.org/10.1016/j.ejmech.2023.115139
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Wranik M, Weinert T, Slavov C, Masini T, Furrer A, Gaillard N, et al.
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
Nature Communications. 2023; 14(1): 903 (12 pp.). https://doi.org/10.1038/s41467-023-36481-5
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Zhang L, Toplak M, Saleem-Batcha R, Höing L, Jakob R, Jehmlich N, et al.
Bacterial dehydrogenases facilitate oxidative inactivation and bioremediation of chloramphenicol
ChemBioChem. 2023; 24: 2-e202200632 (5 pp.). https://doi.org/10.1002/cbic.202200632
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Albert L, Nagpal J, Steinchen W, Zhang L, Werel L, Djokovic N, et al.
Bistable photoswitch allows in vivo control of hematopoiesis
ACS Central Science. 2022; 8(1): 57-66. https://doi.org/10.1021/acscentsci.1c00434
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Astro V, Ramirez-Calderon G, Pennucci R, Caroli J, Saera-Vila A, Cardona-Londoño K, et al.
Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
iScience. 2022; 25(7): 104665 (32 pp.). https://doi.org/10.1016/j.isci.2022.104665
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Auman D, Ecker F, Mader SL, Dorst KM, Bräuer A, Widmalm G, et al.
Peroxy intermediate drives carbon bond activation in the dioxygenase AsqJ
Journal of the American Chemical Society. 2022; 144(34): 15622-15632. https://doi.org/10.1021/jacs.2c05650
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Baudrexl M, Fida T, Berk B, Schwarz WH, Zverlov VV, Groll M, et al.
Biochemical and structural characterization of thermostable GH159 glycoside hydrolases exhibiting α-L-arabinofuranosidase activity
Frontiers in Molecular Biosciences. 2022; 9: 907439 (15 pp.). https://doi.org/10.3389/fmolb.2022.907439
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Beaumet M, Dose A, Bräuer A, Mahy JP, Ghattas W, Groll M, et al.
An artificial metalloprotein with metal-adaptive coordination sites and Ni-dependent quercetinase activity
Journal of Inorganic Biochemistry. 2022; 235: 111914 (5 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111914
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Begnini F, Geschwindner S, Johansson P, Wissler L, Lewis RJ, Danelius E, et al.
Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1-Nrf2 protein-protein interaction
Journal of Medicinal Chemistry. 2022; 65(4): 3473-3517. https://doi.org/10.1021/acs.jmedchem.1c01975
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Bloch JS, Sequeira JM, Ramírez AS, Quadros EV, Locher KP
Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route
FASEB Journal. 2022; 36(4): e22222 (11 pp.). https://doi.org/10.1096/fj.202101376RR
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Bonagas N, Gustafsson NMS, Henriksson M, Marttila P, Gustafsson R, Wiita E, et al.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Nature Cancer. 2022; 3(2): 156-172. https://doi.org/10.1038/s43018-022-00331-y
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Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, et al.
Fragment optimization of reversible binding to the switch II pocket on KRAS leads to a potent, in vivo active KRASG12C inhibitor
Journal of Medicinal Chemistry. 2022; 65(21): 14614-14629. https://doi.org/10.1021/acs.jmedchem.2c01120
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Bärland N, Rueff A-S, Cebrero G, Hutter CAJ, Seeger MA, Veening JW, et al.
Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification
Science Advances. 2022; 8(9): eabm1122 (14 pp.). https://doi.org/10.1126/sciadv.abm1122
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Cansfield AD, Ator MA, Banerjee J, Bestwick M, Bortolato A, Brown GA, et al.
Novel macrocyclic antagonists of the calcitonin gene-related peptide receptor: design, realization, and structural characterization of protein-ligand complexes
ACS Chemical Neuroscience. 2022; 13(6): 751-765. https://doi.org/10.1021/acschemneuro.1c00696
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Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, et al.
Chemoproteomics-enabled identification of 4-Oxo-β-lactams as inhibitors of dipeptidyl peptidases 8 and 9
Angewandte Chemie International Edition. 2022; 61(47): e202210498 (10 pp.). https://doi.org/10.1002/anie.202210498
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Cellini A, Shankar MK, Wahlgren WY, Nimmrich A, Furrer A, James D, et al.
Structural basis of the radical pair state in photolyases and cryptochromes
Chemical Communications. 2022; 58(31): 4889-4892. https://doi.org/10.1039/D2CC00376G
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Chaikuad A, Zhubi R, Tredup C, Knapp S
Comparative structural analyses of the NHL domains from the human E3 ligase TRIM-NHL family
IUCrJ. 2022; 9(6): 720-727. https://doi.org/10.1107/S2052252522008582
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Chen Y, Tso K, Heckrodt TJ, Li H, Yen R, Lin N, et al.
Bicyclic pyrimidine compounds as potent IRAK4 inhibitors
Bioorganic and Medicinal Chemistry Letters. 2022; 73: 128900 (5 pp.). https://doi.org/10.1016/j.bmcl.2022.128900
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Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, et al.
N-heterocyclic 3-pyridyl carboxamide inhibitors of DHODH for the treatment of acute myelogenous leukemia
Journal of Medicinal Chemistry. 2022; 65(16): 11241-11256. https://doi.org/10.1021/acs.jmedchem.2c00788
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Cullati SN, Chaikuad A, Chen J-S, Gebel J, Tesmer L, Zhubi R, et al.
Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
Molecular Cell. 2022; 82(11): 2006-2020.e8. https://doi.org/10.1016/j.molcel.2022.03.005
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Daniels MH, Malojcic G, Clugston SL, Williams B, Coeffet-Le Gal M, Pan-Zhou X-R, et al.
Discovery and optimization of highly selective inhibitors of CDK5
Journal of Medicinal Chemistry. 2022; 65(4): 3575-3596. https://doi.org/10.1021/acs.jmedchem.1c02069
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Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, et al.
Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition
Nature Communications. 2022; 13(1): 382 (13 pp.). https://doi.org/10.1038/s41467-021-27911-3
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Diamanti R, Srinivas V, Johansson AI, Nordström A, Griese JJ, Lebrette H, et al.
Comparative structural analysis provides new insights into the function of R2-like ligand-binding oxidase
FEBS Letters. 2022; 569(12): 1600-1610. https://doi.org/10.1002/1873-3468.14319
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Dileep KV, Ihara K, Mishima-Tsumagari C, Kukimoto-Niino M, Yonemochi M, Hanada K, et al.
Crystal structure of human acetylcholinesterase in complex with tacrine: implications for drug discovery
International Journal of Biological Macromolecules. 2022; 210: 172-181. https://doi.org/10.1016/j.ijbiomac.2022.05.009
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Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, et al.
Identification of pyrimidine-based lead compounds for understudied kinases implicated in driving neurodegeneration
Journal of Medicinal Chemistry. 2022; 65(2): 1313-1328. https://doi.org/10.1021/acs.jmedchem.1c00440
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Funck D, Sinn M, Fleming JR, Stanoppi M, Dietrich J, López-Igual R, et al.
Discovery of a Ni2+-dependent guanidine hydrolase in bacteria
Nature. 2022; 603(7901): 515-521. https://doi.org/10.1038/s41586-022-04490-x
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Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, et al.
In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M
Journal of the American Chemical Society. 2022; 144(12): 5614-5628. https://doi.org/10.1021/jacs.2c01020
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Ghosh P, Kropp HM, Betz K, Ludmann S, Diederichs K, Marx A, et al.
Microenvironment-sensitive fluorescent nucleotide probes from benzofuran, benzothiophene, and selenophene as substrates for DNA polymerases
Journal of the American Chemical Society. 2022; 144(23): 10556-10569. https://doi.org/10.1021/jacs.2c03454
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Gilzer D, Schreiner M, Niemann HH
Direct interaction of a chaperone-bound type III secretion substrate with the export gate
Nature Communications. 2022; 13(1): 2858 (13 pp.). https://doi.org/10.1038/s41467-022-30487-1
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Gude F, Molloy EM, Horch T, Dell M, Dunbar KL, Krabbe J, et al.
A specialized polythioamide-binding protein confers antibiotic self-resistance in anaerobic bacteria
Angewandte Chemie International Edition. 2022; 61(37): e202206168 (9 pp.). https://doi.org/10.1002/anie.202206168
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Guo Y, Alvigini L, Trajkovic M, Alonso-Cotchico L, Monza E, Savino S, et al.
Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound
Nature Communications. 2022; 13(1): 7195 (12 pp.). https://doi.org/10.1038/s41467-022-34912-3
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Heinrich T, Peterson C, Schneider R, Garg S, Schwarz D, Gunera J, et al.
Optimization of TEAD P-site binding fragment hit into in vivo active lead MSC-4106
Journal of Medicinal Chemistry. 2022; 65(13): 9206-9229. https://doi.org/10.1021/acs.jmedchem.2c00403
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Hu S, El Sahili A, Kishore S, Wong YH, Hemu X, Goh BC, et al.
Structural basis for proenzyme maturation, substrate recognition, and ligation by a hyperactive peptide asparaginyl ligase
Plant Cell. 2022; 34(12): 4936-4949. https://doi.org/10.1093/plcell/koac281
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Huang C-Y, Aumonier S, Engilberge S, Eris D, Smith KML, Leonarski F, et al.
Probing ligand binding of endothiapepsin by 'temperature-resolved' macromolecular crystallography
Acta Crystallographica Section D: Structural Biology. 2022; 78: 964-974. https://doi.org/10.1107/S205979832200612X
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Huber EM, Hortschansky P, Scheven MT, Misslinger M, Haas H, Brakhage AA, et al.
Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX
Structure. 2022; 30(7): 934-946.e4. https://doi.org/10.1016/j.str.2022.04.001
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Jia S, Sato Y, Tsujino S
Size and shape dependent rotation characteristics of thin film ultrasonic rotors
Applied Physics Letters. 2022; 121(25): 254102 (6 pp.). https://doi.org/10.1063/5.0126000
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Kaminski JW, Vera L, Stegmann DP, Vering J, Eris D, Smith KML, et al.
Fast fragment- and compound-screening pipeline at the Swiss Light Source
Acta Crystallographica Section D: Structural Biology. 2022; 78: 328-336. https://doi.org/10.1107/S2059798322000705
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Kaplan E, Greene NP, Jepson AE, Koronakis V
Structural basis of lipoprotein recognition by the bacterial Lol trafficking chaperone LolA
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2022; 119(36): e2208662119 (9 pp.). https://doi.org/10.1073/pnas.2208662119
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Kepa MW, Tomizaki T, Sato Y, Ozerov D, Sekiguchi H, Yasuda N, et al.
Acoustic levitation and rotation of thin films and their application for room temperature protein crystallography
Scientific Reports. 2022; 12: 5349 (14 pp.). https://doi.org/10.1038/s41598-022-09167-z
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Kiss C, Gall FM, Dreier B, Adams M, Riedl R, Plückthun A, et al.
Structure of a hydrophobic leucinostatin derivative determined by host lattice display
Acta Crystallographica Section D: Structural Biology. 2022; 78(12): 1439-1450. https://doi.org/10.1107/S2059798322010762
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Kroef V, Ruegenberg S, Horn M, Allmeroth K, Ebert L, Bozkus S, et al.
GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway
eLife. 2022; 11: e69223 (29 pp.). https://doi.org/10.7554/eLife.69223
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Kurz CG, Preuss F, Tjaden A, Cusack M, Amrhein JA, Chatterjee D, et al.
Illuminating the dark: highly selective inhibition of serine/threonine kinase 17A with pyrazolo[1,5-a]pyrimidine-Based macrocycles
Journal of Medicinal Chemistry. 2022; 65(11): 7799-7817. https://doi.org/10.1021/acs.jmedchem.2c00173
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Leit S, Greenwood JR, Mondal S, Carriero S, Dahlgren M, Harriman GC, et al.
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
Bioorganic and Medicinal Chemistry Letters. 2022; 73: 128891 (10 pp.). https://doi.org/10.1016/j.bmcl.2022.128891
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Li P, Nayeri N, Górecki K, Becares ER, Wang K, Mahato DR, et al.
PcoB is a defense outer membrane protein that facilitates cellular uptake of copper
Protein Science. 2022; 31(7): e4364 (16 pp.). https://doi.org/10.1002/pro.4364
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Li Y, Bedi RK, Nai F, von Roten V, Dolbois A, Zálešák F, et al.
Structure-based design of ligands of the m6A-RNA reader YTHDC1
European Journal of Medicinal Chemistry Reports. 2022; 5: 100057 (11 pp.). https://doi.org/10.1016/j.ejmcr.2022.100057
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Maire AL, Rey M, Vivat V, Guée L, Blanc P, Malosse C, et al.
Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids
Journal of Molecular Endocrinology. 2022; 69(3): 377-390. https://doi.org/10.1530/JME-22-0021
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Mehta V, Khanppnavar B, Schuster D, Kantarci I, Vercellino I, Kosturanova A, et al.
Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
eLife. 2022; 11: e77032 (21 pp.). https://doi.org/10.7554/ELIFE.77032
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Metzner FJ, Huber E, Hopfner K-P, Lammens K
Structural and biochemical characterization of human Schlafen 5
Nucleic Acids Research. 2022; 50(2): 1147-1161. https://doi.org/10.1093/nar/gkab1278
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Molina R, Garcia-Martin R, López-Méndez B, Grøn Jensen A L, Ciges-Tomas J R, Marchena-Hurtado J, et al.
Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases
Nucleic Acids Research. 2022; 50(19): 11199-11213. https://doi.org/10.1093/nar/gkac923
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Mous S, Gotthard G, Ehrenberg D, Sen S, Weinert T, Johnson PJM, et al.
Dynamics and mechanism of a light-driven chloride pump
Science. 2022; 375(6583): 845-851. https://doi.org/10.1126/science.abj6663
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Muckenfuss LM, Migenda Herranz AC, Boneberg FM, Clerici M, Jinek M
Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis
eLife. 2022; 11: e80332 (29 pp.). https://doi.org/10.7554/eLife.80332
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Nass KJ, Ilie IM, Saller MJ, Driessen AJM, Caflisch A, Kammerer RA, et al.
The role of the N-terminal amphipathic helix in bacterial YidC: insights from functional studies, the crystal structure and molecular dynamics simulations
Biochimica et Biophysica Acta: Biomembranes. 2022; 1864(3): 183825 (9 pp.). https://doi.org/10.1016/j.bbamem.2021.183825
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Ng S, Brueckner AC, Bahmanjah S, Deng Q, Johnston JM, Ge L, et al.
Discovery and structure-based design of macrocyclic peptides targeting STUB1
Journal of Medicinal Chemistry. 2022; 65(14): 9789-9801. https://doi.org/10.1021/acs.jmedchem.2c00406
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Nozal V, Martínez-González L, Gomez-Almeria M, Gonzalo-Consuegra C, Santana P, Chaikuad A, et al.
TDP-43 Modulation by Tau-Tubulin kinase 1 inhibitors: a new avenue for future amyotrophic lateral sclerosis therapy
Journal of Medicinal Chemistry. 2022; 65(2): 1585-1607. https://doi.org/10.1021/acs.jmedchem.1c01942
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Pacesa M, Lin C-H, Cléry A, Saha A, Arantes PR, Bargsten K, et al.
Structural basis for Cas9 off-target activity
Cell. 2022; 185(22): 4067-4081.e21. https://doi.org/10.1016/j.cell.2022.09.026
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Pallesen JS, Munier CC, Bosica F, Andrei SA, Edman K, Gunnarsson A, et al.
Designing selective drug-like molecular glues for the glucocorticoid receptor/14-3-3 protein-protein interaction
Journal of Medicinal Chemistry. 2022; 65(24): 16818-16828. https://doi.org/10.1021/acs.jmedchem.2c01635
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Priyanka A, Tisi D, Sixma TK
Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain
Journal of Structural Biology. 2022; 214(3): 107862 (9 pp.). https://doi.org/10.1016/j.jsb.2022.107862
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Ramanadane K, Straub MS, Dutzler R, Manatschal C
Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family
eLife. 2022; 11: e74589 (29 pp.). https://doi.org/10.7554/eLife.74589
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Rohac R, Crack JC, de Rosny E, Gigarel O, Le Brun NE, Fontecilla-Camps JC, et al.
Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors
Communications Biology. 2022; 5(1): 769 (11 pp.). https://doi.org/10.1038/s42003-022-03745-7
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Rossetti GG, Ossorio MA, Rempel S, Kratzel A, Dionellis VS, Barriot S, et al.
Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits
Scientific Reports. 2022; 12(1): 2505 (9 pp.). https://doi.org/10.1038/s41598-022-06306-4
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Salustros N, Grønberg C, Abeyrathna NS, Lyu P, Orädd F, Wang K, et al.
Structural basis of ion uptake in copper-transporting P1B-type ATPases
Nature Communications. 2022; 13(1): 5121 (11 pp.). https://doi.org/10.1038/s41467-022-32751-w
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Shi Y-M, Hirschmann M, Shi Y-N, Ahmed S, Abebew D, Tobias NJ, et al.
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria
Nature Chemistry. 2022; 14(6): 701-712. https://doi.org/10.1038/s41557-022-00923-2
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Stauffer M, Jeckelmann J-M, Ilgü H, Ucurum Z, Boggavarapu R, Fotiadis D
Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor
Communications Chemistry. 2022; 5(1): 23 (10 pp.). https://doi.org/10.1038/s42004-022-00636-0
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Stephenson Clarke JR, Douglas LR, Duriez PJ, Balourdas D-I, Joerger AC, Khadiullina R, et al.
Discovery of nanomolar-affinity pharmacological chaperones stabilizing the oncogenic p53 mutant Y220C
ACS Pharmacology & Translational Science. 2022; 5(11): 1169-1180. https://doi.org/10.1021/acsptsci.2c00164
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Strubel A, Münick P, Chaikuad A, Dreier B, Schaefer J, Gebel J, et al.
Designed ankyrin repeat proteins as a tool box for analyzing p63
Cell Death and Differentiation. 2022; 29: 2445-2458. https://doi.org/10.1038/s41418-022-01030-y
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Takeuchi K, Ikeda Y, Senda M, Harada A, Okuwaki K, Fukuzawa K, et al.
The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity
Structure. 2022; 30(6): 886-899.e4. https://doi.org/10.1016/j.str.2022.04.004
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Tao H, Lauterbach L, Bian G, Chen R, Hou A, Mori T, et al.
Discovery of non-squalene triterpenes
Nature. 2022; 606(7913): 414-419. https://doi.org/10.1038/s41586-022-04773-3
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Trottmann F, Ishida K, Ishida-Ito M, Kries H, Groll M, Hertweck C
Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead
Nature Chemistry. 2022; 14(8): 884-890. https://doi.org/10.1038/s41557-022-01005-z
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Tsugita A, Uehara S, Matsui T, Yokoyama T, Ostash I, Deneka M, et al.
The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK
FEBS Journal. 2022; 289(19): 6038-6057. https://doi.org/10.1111/febs.16460
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Vollheyde K, Kühnel K, Lambrecht F, Kawelke S, Herrfurth C, Feussner I
Crystal structure of the bifunctional wax synthase 1 from Acinetobacter baylyi suggests a conformational change upon substrate binding and formation of additional substrate binding sites
ACS Catalysis. 2022; 12(15): 9753-9765. https://doi.org/10.1021/acscatal.2c01712
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Voss M, Hüppi S, Schaub D, Hayashi T, Ligibel M, Sager E, et al.
Enzyme engineering enables inversion of substrate stereopreference of the halogenase WelO5*
ChemCatChem. 2022; 14(24): e202201115 (7 pp.). https://doi.org/10.1002/cctc.202201115
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Wiuf A, Steffen JH, Becares ER, Grønberg C, Mahato DR, Rasmussen SGF, et al.
The two-domain elevator-type mechanism of zinc-transporting ZIP proteins
Science Advances. 2022; 8(28): eabn4331 (14 pp.). https://doi.org/10.1126/sciadv.abn4331
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Zhang Q, Balourdas D-I, Baron B, Senitzki A, Haran TE, Wiman KG, et al.
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
Cell Death & Disease. 2022; 13(3): 214 (11 pp.). https://doi.org/10.1038/s41419-022-04653-8
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Akaki T, Bessho Y, Ito T, Fujioka S, Ubukata M, Mori G, et al.
Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases
Bioorganic and Medicinal Chemistry. 2021; 44: 116283 (15 pp.). https://doi.org/10.1016/j.bmc.2021.116283
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Akram M, Dietl A, Müller M, Barends TRM
Purification of the key enzyme complexes of the anammox pathway from DEMON sludge
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