EMBO Workshop on Nuclear Mechano-Genomics
in collaboration with Marco Foiani (IFOM - The FIRC Institute of Molecular Oncology, IT) and Caroline Uhler ( Massachusetts Institute of Technology, US), G.V. Shivashankar is organizing the 2024 EMBO workshop on Nuclear Mechanogenomics, taking place in from April 16 to April 19 in Sardinia, Italy.
This EMBO Workshop on Nuclear Mechano-Genomics will focus on developing an in-depth understanding of the coupling between mechanical micro-environment of cells and the 3D genome organization to regulate cell behavior. While our understanding of the epigenetic biochemical factors, kinases, transcription factors and chromatin remodeling enzymes has rapidly progressed, the mechano-chemical basis of such regulatory programs is only beginning to be understood. For example, the activation of transcription factors by cell mechanics, active cytoplasmic to nuclear localization of regulatory molecules, the coupling between cytoskeletal filaments with nuclear mechanical architecture, the spatio-temporal dynamics of chromatin modulated by active physical forces, mechanics of genome regulation and its maintenance, and how alterations in this mechanical architecture of the nucleus correlates with disease pathologies are all areas of intense research in recent years. This EMBO Workshop will enhance the discussions in this area by taking advantage of highly interdisciplinary approaches and building new connections to the single-cell genomics community as well as extending more into disease implications. It will bring together physicists, engineers, computer scientists and biologists to understand the coupling between nuclear mechanics and genome regulation and its impact on diseases.
This EMBO Workshop is also an outcome of the ongoing successful “Mechano-Genomics Seminar Series” that was started during the pandemic.
For more information and registration please visit https://meetings.embo.org/event/24-mechano-genomics