Skip to main content
  • Paul Scherrer Institut PSI
  • PSI Research, Labs & User Services

Digital User Office

  • Digital User Office
  • DE
  • EN
  • FR
Paul Scherrer Institut (PSI)
Search
Paul Scherrer Institut (PSI)

Hauptnavigation

  • Our ResearchOpen mainmenu item
    • Current topics from our research
    • Future Technologies
    • Energy and Climate
    • Health Innovation
    • Fundamentals of Nature
    • Large Research Facilities
    • Brochures
    • 5232 — The magazine of the Paul Scherrer Institute
    • Research Divisions & Labs (only english)
  • IndustryOpen mainmenu item
    • Overview
    • Technology Transfer
    • Expertise
    • Spin-off Companies
    • Park Innovaare
  • Proton TherapyOpen mainmenu item
    • Overview
    • For patients and family members
    • For physicians, referrers and researchers
  • CareerOpen mainmenu item
    • Overview
    • Job Opportunities
    • Working at PSI
    • Personnel Policy
    • Equal Opportunities, Diversity & Inclusion
    • Training and Further Education
    • Vocational Training
    • PSI Education Centre
    • Career Center
    • Support Program "PSI Career Return Program"
    • PSI-FELLOW/COFUND
  • Visit to PSIOpen mainmenu item
    • Overview
    • Visitor Centre psi forum
    • Schülerlabor iLab
    • Public Events
    • How to find us
  • About PSIOpen mainmenu item
    • PSI in brief
    • Strategy
    • Guiding principles
    • Facts and figures
    • Organisational structure
    • For the media
    • Suppliers and customers
    • Customers E-Billing
  • DE
  • EN
  • FR

Digital User Office (mobile)

  • Digital User Office

You are here:

  1. PSI Home
  2. Education and Jobs
  3. PSI-FELLOW
  4. Ultrafast structural changes direct the first molecular events of vision

Secondary navigation

PSI-FELLOW

  • About PSI-FELLOW
    • Timeline
    • Application Concept
    • Scientific Fields
  • Our partners from science and industry
  • Advisory Board Members
  • Fellows Profile
  • Education Programme
  • Call for Applications
    • Eligibility Criteria
    • Guidelines & Templates for Applicants
    • List of Principle Investigators and Themes
    • Selection Process
    • Redress Procedure
  • Publications PSI-FELLOW-III
  • Publications PSI-FELLOW-II
  • Publications PSI-FELLOW-I
  • Highlights
  • Contact
  • FAQ
25 April 2023

Ultrafast structural changes direct the first molecular events of vision

Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs)1. A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which isomerizes within 200 femtoseconds to the all-trans conformation2, thereby initiating the cellular signal transduction processes that ultimately lead to vision. However, the intramolecular mechanism by which the photoactivated retinal induces the activation events inside rhodopsin remains experimentally unclear. Here we use ultrafast time-resolved crystallography at room temperature3 to determine how an isomerized twisted all-trans retinal stores the photon energy that is required to initiate the protein conformational changes associated with the formation of the G protein-binding signalling state. The distorted retinal at a 1-ps time delay after photoactivation has pulled away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Notably, the very early structural motions in the protein side chains of rhodopsin appear in regions that are involved in later stages of the conserved class A GPCR activation mechanism. Our study sheds light on the earliest stages of vision in vertebrates and points to fundamental aspects of the molecular mechanisms of agonist-mediated GPCR activation.

Contact

Dr. Saumik Sen
Paul Scherrer Institute

Condensed Matter Theory Group
Forschungsstrasse 111
5232 Villigen PSI
Switzerland

Telefon: +41 56 310 36 65

E-Mail: saumik.sen@psi.ch

Original publication (DOI)

https://www.nature.com/articles/s41586-023-05863-6

Sidebar

EU Logo

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 884104.

top

Footer

Paul Scherrer Institut

Forschungsstrasse 111
5232 Villigen PSI
Switzerland

Telephone: +41 56 310 21 11
Telefax: +41 56 310 21 99

How to find us
Contact

Visitor Centre psi forum
School Lab iLab (in German)
Center for Proton Therapy
PSI Education Centre
PSI Guest House
PSI Gastronomie (in German)
psi forum shop

Service & Support

  • Phone Book
  • User Office
  • Accelerator Status
  • PSI Publications
  • Suppliers
  • E-Billing
  • Computing
  • Safety (in German)

Career

  • Working at PSI
  • Job Opportunities
  • Training and further education
  • Career Center
  • Vocational Training (in German)
  • PSI Education Center

For the media

  • PSI in brief
  • Facts and Figures
  • Media corner
  • Media Releases
  • Social Media

Follow us: Twitter (in English) LinkedIn Youtube Facebook Instagram Issuu RSS

Footer legal

  • Imprint
  • Terms and Conditions
  • Editors' login