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Macromolecular Crystallography Group

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  • PX I (X06SA)
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15 May 2020

First MX results of the priority COVID-19 call

Beamline X06SA-PXI

Scientists from the Goethe University in Frankfurt am Main, Germany have published results on the papain-like protease (PLpro), an essential enzyme of SARS-CoV-2. The structural biology work was performed at the macromolecular crystallography beamline X06SA-PXI at SLS following the opening of the "PRIORITY COVID-19 Call”. The paper was submitted within one month after answering the proposal call. The crystallographic data collection happened on the 9th of April after the planned Easter shutdown of the SLS was cancelled for this specific experiment.

The protease PLpro is required for the processing of viral polypeptides and the assembly of new viral particles within human cells. In addition, SARS-CoV-2 uses this enzyme to dampen the anti-viral immune response, helping the virus to modulate the host’s immune system to its own benefit. By this, the virus can easily multiply and spread further. The team has demonstrated that pharmaceutical targeting of PLpro by a non-covalent inhibitor (GRL-0617) blocks virus spread and increases anti-viral immunity in human epithelial cells, the prime site of pathogen entry.

The respective results were made publicly available on a preprint server. The PDB 6YVA was released on the 13th of May.

Structural analysis of SARS-CoV-2 PLpro in complex with full length ISG15
Structural analysis of SARS-CoV-2 PLpro in complex with full length ISG15
Contact

Dr. Vincent Olieric, Swiss Light Source
Paul Scherrer Institut, 5232 Villigen PSI, Switzerland
Phone: +41 56 310 5233, e-mail: vincent.olieric@psi.ch

Dr. Meitian Wang, Swiss Light Source
Paul Scherrer Institut, 5232 Villigen PSI, Switzerland
Phone: +41 56 310 4175, e-mail: meitian.wang@psi.ch

Media release

https://www.biochem2.com/newsentry/2020-05-05
 

Publications

Inhibition of papain-like protease PLpro blocks SARS-CoV-2 spread and promotes anti-viral immunity
Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, Denisa Bojkova, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, Marek Widera, Ahmad Reza Mehdipour, Georg Tascher, Paul P. Geurink, Gerbrand J. van der Heden van Noort, Huib Ovaa, Klaus- Peter Knobeloch, Krishnaraj Rajalingam, Brenda A. Schulman, Jindrich Cinatl, Gerhard Hummer, Sandra Ciesek, Ivan Dikic
http://doi.org/10.21203/rs.3.rs-27134/v1

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Associated Beamlines

  • PX I (X06SA)
  • PX II (X10SA)
  • PX III (X06DA)

Contact

Head of MX
and Group Leader (i.p.) MX Applications
Dr. Meitian Wang
Telephone:
+41 56 310 4175
E-mail:
meitian.wang@psi.ch


Group Leader MX Instrumentation
Wayne Glettig
Telephone:
+41 56 310 5823
E-mail:
wayne.glettig@psi.ch


Group Leader MX Samples
Dr. May Sharpe née Marsh
Telephone:
+41 56 310 5437
E-mail:
may.sharpe@psi.ch


Group Leader MX Data
Dr. Justyna Aleksandra Wojdyla
Telephone:
+41 56 310 5428
E-mail:
justyna.wojdyla@psi.ch

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