Dr. Jinghui Luo

Scientist

Paul Scherrer Institute
Forschungsstrasse 111
5232 Villigen PSI
Switzerland

Telephone

Research interests

1. Structural and biophysical characterization of amyloid proteins

2. Single-channel electrical and optical studies of ion channel, amyloid and other membrane proteins in the lipid bilayer

Short CV

2017.07-now: Principal Investigator, Paul Scherrer Institute, Switzerland

2014.12-2017.06: Research Fellow, Oxford University, UK

2014.06: PhD, Leiden University, the Netherlands

2009.06-2009.12: Traineeship, EMBL, Germany

2009.06: MSc, Uppsala University, Sweden

Publications

2019

Nuclear Pore Membrane Proteins Self-Assemble into Nanopores Panatala R, Barbato S, Kozai T, Luo J, Kapinos Larisa E, Lim Roderick YH
BIOCHEMISTRY 58, 484 (2019).
DOI: 10.1021/acs.biochem.8b01179

2018

Membrane-mimetic systems for biophysical studies of the amyloid-? peptide Österlund N, Luo J, Wärmländer Sebastian KTS, Gräslund A
BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS AND PROTEOMICS , S1570963918302036 (2018).
DOI: 10.1016/j.bbapap.2018.11.005
The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-? (A?) Peptide at the Oligomeric Stage Wallin C, Hiruma Y, Wärmländer SKTS, Huvent I, Jarvet J, Abrahams J, Gräslund A, Lippens G, Luo J
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140, 8138 (2018).
DOI: 10.1021/jacs.7b13623

2017

Alzheimer?s disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-? peptide aggregation Wallin C, Sholts Sabrina B, Österlund N, Luo J, Jarvet J, Roos Per M, Ilag L, Gräslund A, Wärmländer Sebastian KTS
Scientific Reports 7, 14423 (2017).
DOI: 10.1038/s41598-017-13759-5
Maleimido-proxyl as an EPR spin label for the evaluation of conformational changes of albumin Pavicevic A, Luo J, Popovic-Bijelic A, Mojovic M
European Biophysics Journal 46, 773 (2017).
DOI: 10.1007/s00249-017-1257-z

2016

Characterization of Mn(II) ion binding to the amyloid-? peptide in Alzheimer?s disease Wallin C, Kulkarni Yashraj S, Abelein A, Jarvet J, Liao Q, Strodel B, Olsson L, Luo J, Abrahams J, Sholts Sabrina B, Roos Per M, Kamerlin Shina CL, Gräslund A, Wärmländer Sebastian KTS
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY , (2016).
DOI: 10.1016/j.jtemb.2016.03.009
Coupled commensurate charge density wave and lattice distortion in Na2Ti2Pn2O(Pn=As,Sb) determined by x-ray diffraction and angle-resolved photoemission spectroscopy Davies NR, Johnson RD, Princep AJ, Gannon LA, Ma JZ, Qian T, Richard P, Li H, Shi M, Nowell H, Baker PJ, Shi YG, Ding H, Luo J, Guo YF, Boothroyd AT
PHYSICAL REVIEW B 94, 104515 (2016).
DOI: 10.1103/PhysRevB.94.104515
Cross-interactions between the Alzheimer Disease Amyloid-? Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
JOURNAL OF BIOLOGICAL CHEMISTRY 291, 16485 (2016).
DOI: 10.1074/jbc.R116.714576
Non-covalent S?O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation Peacock H, Luo J, Yamashita T, Luccarelli J, Thompson S, Hamilton Andrew D
CHEMICAL SCIENCE 7, 6435 (2016).
DOI: 10.1039/C6SC00756B
Reciprocal Molecular Interactions between the A? Peptide Linked to Alzheimer?s Disease and Insulin Linked to Diabetes Mellitus Type II Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
ACS Chemical Neuroscience 7, 269 (2016).
DOI: 10.1021/acschemneuro.5b00325
Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species Tiiman A, Luo J, Wallin C, Olsson L, Lindgren J, Jarvet J, Per R, Sholts Sabrina B, Rahimipour S, Abrahams J, Karlström A, Gräslund A, Wärmländer Sebastian KTS
Journal of Alzheimer's Disease 54, 971 (2016).
DOI: 10.3233/JAD-160427
The Amyloid-? Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions Wallin C, Luo J, Jarvet J, Wärmländer Sebastian KTS, Gräslund A
ISRAEL JOURNAL OF CHEMISTRY 57, 674 (2016).
DOI: 10.1002/ijch.201600105

2014

Alzheimer Peptides Aggregate into Transient Nanoglobules That Nucleate Fibrils Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
BIOCHEMISTRY 53, 6302 (2014).
DOI: 10.1021/bi5003579
ChemInform Abstract: Cyclic Peptides as Inhibitors of Amyloid Fibrillation Luo J, Abrahams J
ChemInform 45, no (2014).
DOI: 10.1002/chin.201422265
Cyclic Peptides as Inhibitors of Amyloid Fibrillation Luo J, Abrahams J
CHEMISTRY - A EUROPEAN JOURNAL 20, 2410 (2014).
DOI: 10.1002/chem.201304253
Endogenous Polyamines Reduce the Toxicity of Soluble A? Peptide Aggregates Associated with Alzheimer?s Disease Luo J, Mohammed I, Wärmländer Sebastian KTS, Hiruma Y, Gräslund A, Abrahams J
BIOMACROMOLECULES 15, 1985 (2014).
DOI: 10.1021/bm401874j
Non-chaperone Proteins Can Inhibit Aggregation and Cytotoxicity of Alzheimer Amyloid ? Peptide Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
JOURNAL OF BIOLOGICAL CHEMISTRY 289, 27766 (2014).
DOI: 10.1074/jbc.M114.574947
The A- peptide forms non-amyloid fibrils in the presence of carbon nanotubes Luo J, Waermlaender Sebastian KTS, Yu C, Muhammad K, Graeslund A, Abrahams JP
NANOSCALE 6, 6720 (2014).
DOI: 10.1039/c4nr00291a
The hairpin conformation of the amyloid ? peptide is an important structural motif along the aggregation pathway Abelein A, Abrahams J, Danielsson J, Gräslund A, Jarvet J, Luo J, Tiiman A, Wärmländer Sebastian KTS
JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19, 623 (2014).
DOI: 10.1007/s00775-014-1131-8

2013

An efficient nanolitre-volume multi-channel device for highly viscous materials used in membrane protein crystallization Luo J, Zwier R, Abrahams J
JOURNAL OF APPLIED CRYSTALLOGRAPHY 46, 829 (2013).
DOI: 10.1107/S0021889813006742
Biophysical Studies of the Amyloid ?-Peptide: Interactions with Metal Ions and Small Molecules Wärmländer S, Tiiman A, Abelein A, Luo J, Jarvet J, Söderberg Kajsa L, Danielsson J, Gräslund A
CHEMBIOCHEM 14, 1692 (2013).
DOI: 10.1002/cbic.201300262
Cellular Polyamines Promote Amyloid-Beta (A?) Peptide Fibrillation and Modulate the Aggregation Pathways Luo J, Yu C, Yu H, Borstnar R, Kamerlin Shina CL, Gräslund A, Abrahams J, Wärmländer Sebastian KTS
ACS Chemical Neuroscience 4, 454 (2013).
DOI: 10.1021/cn300170x
Exploiting preQ 1 Riboswitches To Regulate Ribosomal Frameshifting Yu C, Luo J, Iwata-Reuyl D, Olsthoorn RCL
ACS CHEMICAL BIOLOGY 8, 733 (2013).
DOI: 10.1021/cb300629b
Human lysozyme inhibits the in vitro aggregation of A? peptides, which in vivo are associated with Alzheimer's disease Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J
CHEMICAL COMMUNICATIONS 49, 6507 (2013).
DOI: 10.1039/c3cc42325e
Inhibiting and Reversing Amyloid-? Peptide (1-40) Fibril Formation with Gramicidin S and Engineered Analogues Luo J, Otero José M, Yu C, Wärmländer Sebastian KTS, Gräslund A, Overhand M, Abrahams J
CHEMISTRY - A EUROPEAN JOURNAL 19, 17338 (2013).
DOI: 10.1002/chem.201301535

2012

Catalytic promiscuity in Pseudomonas aeruginosa arylsulfatase as an example of chemistry-driven protein evolution Luo J, van Loo B, Kamerlin Shina CL
FEBS LETTERS 586, 1622 (2012).
DOI: 10.1016/j.febslet.2012.04.012
Conformation Effects of CpG Methylation on Single-Stranded DNA Oligonucleotides: Analysis of the Opioid Peptide Dynorphin-Coding Sequences Taqi M, Wärmländer Sebastian KTS, Yamskova O, Madani F, Bazov I, Luo J, Zubarev R, Verbeek D, Gräslund A, Bakalkin G
PLOS ONE 7, e39605 (2012).
DOI: 10.1371/journal.pone.0039605
Examining the promiscuous phosphatase activity of Pseudomonas aeruginosa arylsulfatase: A comparison to analogous phosphatases Luo J, van Loo B, Kamerlin SCL
PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS 80, 1211 (2012).
DOI: 10.1002/prot.24020

2011

A Straightforward and Robust Method for Introducing Human Hair as a Nucleant into High Throughput Crystallization Trials Nederlof I, Hosseini R, Georgieva D, Luo J, Li D, Abrahams J
CRYSTAL GROWTH & DESIGN 11, 1170 (2011).
DOI: 10.1021/cg101374r
Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2 Öhrström M, Popovic-Bijelic A, Luo J, Stenmark P, Högbom M, Gräslund A
JOURNAL OF PEPTIDE SCIENCE 17, 756 (2011).
DOI: 10.1002/psc.1399
Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): A combined experimental and theoretical study Popovic-Bijelic A, Kowol CR, Lind Maria ES, Luo J, Himo F, Enyedy EA, Arion VB, Graeslund A
JOURNAL OF INORGANIC BIOCHEMISTRY 105, 1422 (2011).
DOI: 10.1016/j.jinorgbio.2011.07.003
Ribonucleotide reductase inhibition by p-alkoxyphenols studied by molecular docking and molecular dynamics simulations Luo J, Gräslund A
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 516, 29 (2011).
DOI: 10.1016/j.abb.2011.09.003

2010

In Silico Analysis of the Apolipoprotein E and the Amyloid ? Peptide Interaction: Misfolding Induced by Frustration of the Salt Bridge Network Luo J, Maréchal J, Wärmländer S, Gräslund A, Perálvarez-Marín A
PLOS COMPUTATIONAL BIOLOGY 6, e1000663 (2010).
DOI: 10.1371/journal.pcbi.1000663