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Laboratory of Nanoscale Biology

  • About LNB
  • Research and Technology Innovation Expanded submenu item
    • Electron diffraction of biological specimens
    • EM&D Group, Electron Microscopy Facility
    • Cellular structural biology and imaging
    • Structural Neurobiology
    • Mechano-Genomics
    • Cellular Engineering and Microscopy
    • Biointerfaces: Enabling Technology for Bio-Research
    • Ultrasound Mechanobiology
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Mechano-Genomics

Laboratory of Nanoscale Biology:
Mechano-Genomics group

MGG_Teaser_image

Our research group is focused on understanding the role of mechano-chemical signals on 3D chromatin organization and function that regulate cell-state transitions. We study this during cellular ageing and rejuvenation. Furthermore, we explore if alterations in chromatin organization could provide robust biomarkers for ageing related disease diagnostics, including fibrosis, cancer and neurodegeneration. In these studies, we use bio-imaging combined with bio-interfaces, functional genomics and machine learning methods. On the computational side, we collaborate closely with Caroline Uhler’s group at MIT. Furthermore, we develop technologies to create artificial microenvironments for cell-based experiments as well as novel methods for microscopy and micromanipulation of cells.

>>> Mechano-Genomics Group website 

Group Leader and Head of LNB: G.V. Shivashankar

Associated scientists

  • Philipp Berger (Cellular engineering and microscopy)
  • Celestino Padeste (Biointerfaces, supports for protein crystallography)
  • Soichiro Tsujino (Ultrasound mechanobiology)

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Contact

G.V. Shivashankar
Professor of Mechano-Genomics
Department of Health Sciences and Technology, ETH Zurich
& Paul Scherrer Institute, Switzerland

Head of the Laboratory
of Nanoscale Biology

Paul Scherrer Institute
Laboratory of Nanoscale Biology
OFLC/107
Forschungsstrasse 111
CH-5232 Villigen PSI
Switzerland

gshivasha@ethz.ch
gv.shivashankar@psi.ch


Secretariat

Anita Strittmatter
Secretary

Paul Scherrer Institut
Division of Biology and Chemistry
OFLC/108
Forschungsstrasse 111
CH-5232 Villigen PSI
Switzerland

Phone: +41 56 310 20 35
Fax: +41 56 310 21 99
anita.strittmatter@psi.ch

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Paul Scherrer Institut

Forschungsstrasse 111
5232 Villigen PSI
Switzerland

Telephone: +41 56 310 21 11
Telefax: +41 56 310 21 99

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