Scientific Highlights

6 May 2021
Teaser Tubulin

Cell cytoskeleton as target for new active agents

Media Releases Research Using Synchrotron Light Biology Human Health

Using a combination of computer simulations and laboratory experiments, PSI researchers have identified new binding sites for active agents on the vital protein tubulin.

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20 May 2020
Petr Skopintsev (links), Jörg Standfuss (Mitte) und Christopher Milne (rechts) an der Experimentierstation Alvra am Freie-Elektronen-Röntgenlaser SwissFEL

Elucidating the mechanism of a light-driven sodium pump

Media Releases SwissFEL Biology

Researchers at the Paul Scherrer Institute PSI have succeeded for the first time in recording a light-driven sodium pump from bacterial cells in action. The findings promise progress in developing new methods in neurobiology. The researchers used the new X-ray free-electron laser SwissFEL for their investigations.

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22 August 2019
Teaser Chemokin-Rezeptor

Preventing tumour metastasis

Media Releases Biology Human Health Medical Science Research Using Synchrotron Light

Researchers at the Paul Scherrer Institute PSI, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step towards the development of an active substance against the metastasis of certain cancers. Using the Swiss Light Source SLS, they deciphered the structure of a receptor that plays a crucial role in the migration of cancer cells.

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4 July 2019
Teaser Molekulare Energiemaschine als Filmstar

Molecular energy machine as a movie star

Media Releases Biology SwissFEL Large Research Facilities Research Using Synchrotron Light

Using the Swiss Light Source SLS, PSI researchers have recorded a molecular energy machine in action and thus revealed how energy production at cell membranes works. For this purpose, they developed a new investigative method that could make the analysis of cellular processes significantly more effective than before.

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24 June 2019
Teaser Choi Steinmetz

Molecular scissors stabilise the cell's cytoskeleton

Media Releases Biology Human Health Medical Science

Researchers at the Paul Scherrer Institute PSI have an important part of the regulatory cycle that is involved in the formation and degradation of the cytoskeleton. Among other things, they have watched molecular scissors at work.

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26 April 2019
teaser adenylate cyclase

Bringing information into the cell

Media Releases Biology Human Health Medical Science

Researchers at the Paul Scherrer Institute PSI have elucidated an important part of a siganalling pathway that transmits information through the cell membrane into the interior of a cell. This exists in all mammals and plays an important role, among other things, in the regulation of the heartbeat. The new findings could lead to new therapies.

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22 August 2018

A biotechnological revolution

Biology Medical Science Human Health Radiopharmacy

Gebhard Schertler is head of the research division Biology and Chemistry at the Paul Scherrer Institute PSI and professor for Structural Biology at ETH Zurich. In this interview he talks about biological research at PSI and the future of drug development.

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14 June 2018
teaser picture

Biological light sensor filmed in action

Media Releases Biology SwissFEL

Using X-ray laser technology, a team led by researchers of the Paul Scherrer Institute PSI has recorded one of the fastest processes in biology. In doing so, they produced a molecular movie that reveals how the light sensor retinal is activated in a protein molecule. Such reactions occur in numerous organisms. The movie shows for the first time how a protein efficiently controls the reaction of the embedded light sensor.

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