Biography
Hector Dejea is a PhD student in the X-ray Tomography Group at Paul Scherrer Institut and ETH Zürich since 2017. Before that, he received his Degree in Biomedical Engineering from Universitat Pompeu Fabra (Barcelona, Spain) in 2015 and his MSc in Biomedical Engineering - Bioimaging from ETH Zürich in 2017.
Scientific Research
Hector’s research focuses on the application of synchrotron radiation imaging for the study of cardiovascular diseases, including the design of X-ray imaging setups and protocols as well as image processing tools for the quantification of cardiac structure. This includes the study of human cardiac biopsies and transmural pieces, as well as ex-vivo and in-vitro rodent models of cardiovascular disease.
Hector's PhD is carried out in collaboration with the UniversitätSpital Zürich (Zürich, Switzerland) and the University Hospital Centre Zagreb (Zagreb, Croatia), and he is also actively involved in several projects together with IDIBAPS (Barcelona, Spain), Universitat Pompeu Fabra (Barcelona, Spain), University College London (London, United Kingdom), and the Computer Vision Lab in ETH Zürich (Zürich, Switzerland).
Publications
A complete list of publication can be found in ORCID.
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Bernardino G, Calvet-Mirabent À, Dejea H, Guasch E, Bonnin A, Garcia-Canadilla P
The use of ethanol as contrast enhancer in synchrotron X-ray phase-contrast imaging leads to heterogeneous myocardial tissue shrinkage: a case report
Journal of Synchrotron Radiation. 2025; 32(1): 200-209. https://doi.org/10.1107/S1600577524010221
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Silva Barreto I, Liebi M, Le Cann S, Ahmed S, Nielsen LC, Grünewald TA, et al.
Lack of embryonic skeletal muscle in mice leads to abnormal mineral deposition and growth
Journal of Structural Biology. 2025; 217(1): 108178 (12 pp.). https://doi.org/10.1016/j.jsb.2025.108178
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Skreb N, Loncaric F, Li KYC, Bonnin A, Dejea H, Garcia-Canadilla P, et al.
Synchrotron-based X-ray 3D phase contrast imaging and analysis of transmural myocardial tissue from heart failure patients
Scientific Reports. 2025; 15: 25867 (11 pp.). https://doi.org/10.1038/s41598-025-04012-5
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Dejea H, Pierantoni M, Orozco GA, B. Wrammerfors ET, Gstöhl SJ, Schlepütz CM, et al.
In situ loading and time-resolved synchrotron-based phase contrast tomography for the mechanical investigation of connective knee tissues: a proof-of-concept study
Advanced Science. 2024; 11(21): 2308811 (14 pp.). https://doi.org/10.1002/advs.202308811
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Jönsson V, Orozco GA, Pierantoni M, Dejea H, Gustafsson A, Grassi L, et al.
Influence of articular cartilage sample geometry on mechanical response and properties using finite element simulation
Journal of Biomechanics. 2024; 176: 112323 (8 pp.). https://doi.org/10.1016/j.jbiomech.2024.112323
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Li KYC, Syrris P, Bonnin A, Treibel TA, Budhram-Mahadeo V, Dejea H, et al.
Cryo-X-ray phase contrast imaging enables combined 3D structural quantification and nucleic acid analysis of myocardial biopsies
Advanced Science. 2024; 11(48): 2409163 (9 pp.). https://doi.org/10.1002/advs.202409163
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Li KYC, Syrris P, Bonnin A, Treibel TA, Budhram-Mahadeo V, Dejea H, et al.
Cryo-X-ray phase contrast imaging for 3D structural and molecular analysis of frozen biopsy samples
Nature Reviews Cardiology. 2024; 21: 845 (29 pp.). https://doi.org/10.1038/s41569-024-01084-0
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Sharma K, Silva Barreto I, Dejea H, Hammerman M, Appel C, Geraki K, et al.
Elemental and structural characterization of heterotopic ossification during Achilles tendon healing provides new insights on the formation process
ACS Biomaterials Science & Engineering. 2024; 10(8): 4938-4946. https://doi.org/10.1021/acsbiomaterials.4c00935
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Dejea H, Raina DB, Silva Barreto I, Sharma K, Liu Y, Ferreira Sanchez D, et al.
Multi-scale characterization of the spatio-temporal interplay between elemental composition, mineral deposition and remodelling in bone fracture healing
Acta Biomaterialia. 2023; 167: 135-146. https://doi.org/10.1016/j.actbio.2023.06.031
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Li KYC, Dejea H, De Winne K, Bonnin A, D’Onofrio V, Cox JA, et al.
Feasibility and safety of synchrotron-based X-ray phase contrast imaging as a technique complementary to histopathology analysis
Histochemistry and Cell Biology. 2023; 160: 377-389. https://doi.org/10.1007/s00418-023-02220-6
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Planinc I, Ilic I, Dejea H, Garcia-Canadilla P, Gasparovic H, Jurin H, et al.
A novel three-dimensional approach towards evaluating endomyocardial biopsies for follow-up after heart transplantation: X-ray phase contrast imaging and its agreement with classical histopathology
Transplant International. 2023; 36: 11046 (8 pp.). https://doi.org/10.3389/ti.2023.11046
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Dejea H, Schlepütz CM, Méndez-Carmona N, Arnold M, Garcia-Canadilla P, Longnus SL, et al.
A tomographic microscopy-compatible Langendorff system for the dynamic structural characterization of the cardiac cycle
Frontiers in Cardiovascular Medicine. 2022; 9: 1023483 (13 pp.). https://doi.org/10.3389/fcvm.2022.1023483
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Loncaric F, Garcia-Canadilla P, Garcia-Alvarez A, Sanchis L, Prat S, Doltra A, et al.
Etiology-discriminative multimodal imaging of left ventricular hypertrophy and synchrotron-based assessment of microstructural tissue remodeling
Frontiers in Cardiovascular Medicine. 2021; 8: 670734 (13 pp.). https://doi.org/10.3389/fcvm.2021.670734
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Planinc I, Garcia-Canadilla P, Dejea H, Ilic I, Guasch E, Zamora M, et al.
Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging
Scientific Reports. 2021; 11(1): 14020 (13 pp.). https://doi.org/10.1038/s41598-021-93054-6
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Vila-Comamala J, Romano L, Jefimovs K, Dejea H, Bonnin A, Cook AC, et al.
High sensitivity X-ray phase contrast imaging by laboratory grating-based interferometry at high Talbot order geometry
Optics Express. 2021; 29(2): 2049-2064. https://doi.org/10.1364/OE.414174
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Dejea H, Bonnin A, Cook AC, Garcia-Canadilla P
Cardiac multi-scale investigation of the right and left ventricle ex vivo: a review
Cardiovascular Diagnosis & Therapy. 2020; 10(5): 1701-1717. https://doi.org/10.21037/cdt-20-269
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Soveral I, Crispi F, Walter C, Guirado L, García-Cañadilla P, Cook A, et al.
Early cardiac remodeling in aortic coarctation: insights from fetal and neonatal functional and structural assessment
Ultrasound in Obstetrics and Gynecology. 2020; 56: 837-849. https://doi.org/10.1002/uog.21970
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Dejea H, Garcia-Canadilla P, Cook AC, Guasch E, Zamora M, Crispi F, et al.
Comprehensive analysis of animal models of cardiovascular disease using multiscale X-ray phase contrast tomography
Scientific Reports. 2019; 9(1): 6996 (12 pp.). https://doi.org/10.1038/s41598-019-43407-z
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Dejea H, Tanner C, Achanta R, Stampanoni M, Perez-Cruz F, Konukoglu E, et al.
Synchrotron X-ray phase contrast imaging and deep neural networks for cardiac collagen quantification in hypertensive rat model
In: Coudière Y, Ozenne V, Vigmond E, Zemzemi N, eds. Funtcional imgaing and modeling of the heart. 10th international conference, FIMH 2019, Bordeaux, France, June 6-8, 2019, Proceedings. Vol. 11504. Lecture notes in computer science. Cham: Springer; 2019:187-195. https://doi.org/10.1007/978-3-030-21949-9_21
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Garcia-Canadilla P, Dejea H, Bonnin A, Balicevic V, Loncaric S, Zhang C, et al.
Complex congenital heart disease associated with disordered myocardial architecture in a midtrimester human fetus
Circulation: Cardiovascular Imaging. 2018; 11(10): e007753 (10 pp.). https://doi.org/10.1161/CIRCIMAGING.118.007753
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Dejea H, Garcia-Canadilla P, Stampanoni M, Zamora M, Crispi F, Bijnens B, et al.
Microstructural analysis of cardiac endomyocardial biopsies with synchrotron radiation-based X-ray phase contrast imaging
In: Pop M, Wright GA, eds. Functional imaging and modelling of the heart. Vol. 10263. Lecture notes in computer science. Cham, Switzerland: Springer; 2017:23-31. https://doi.org/10.1007/978-3-319-59448-4_3
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