Dr. Christian Matthias Schlepütz

Short description
Beamline Scientist
photo of Christian Schlepütz
Telephone
Paul Scherrer Institute PSI
Forschungsstrasse 111
5232 Villigen PSI
Switzerland

My entire scientific career has been revolving around synchrotron-based structural investigations. Both my diploma in experimental physics and my doctoral thesis were carried out at the Materials Science beamline of the Swiss light source, investigating the atomic structure of thin films and crystal surfaces using Surface X-ray Diffraction, for which I obtained my PhD in experimental physics from the University of Zürich (Switzerland) in 2009. This lead to a postdoctoral research position at the University of Michigan (Ann Arbor, USA), continuing studies using X-ray diffraction and becoming a regular user of the diffraction beamlines at the Advanced Photon Source (APS). In 2011, I became a beamline scientist in the Surface Scattering and Microdiffraction group, Sector 33, of the Advanced Photon Source (APS) at Argonne National Laboratory (Chicago, USA), being involved in the user-operation of two beamlines and developing advanced methods for reciprocal space imaging using area detectors. In 2015, the focus of my research shifted from reciprocal space back to real space, when I returned to Switzerland to rejoin the Swiss Light Source as a new member of the TOMCAT group, devoting my time to exploring the wonders of the 3-dimensional microscopic world in motion.

Resolving dynamic phenomena at the microscale in space and time - that is, in a nutshell, what my current research is all about. The world around us is in constant motion, and most of the macroscopic phenomena we experience are governed by dynamic processes happening at the microscale. To reveal and understand those complex mechanisms, I develop and use the unique tools and capabilities of the TOMCAT beamline that allow us to collect X-ray tomographic microscopy datasets at unprecedented temporal resolutions to create 4-dimensional microscopic movies. Applications range from geoscience via food-processing, materials testing and complex multi-phase flows all the way to biomechanical investigations. The latest speed record at TOMCAT was set at 1000 tomographic scans per second (Garcia-Moreno, 2021), while sub-second time-resolutions of up to 20 tomographies per second are routinely available to our user community. Currently, I focus on expanding the range of available sample environments to make these capabilities accessible for an even larger range of applications. In parallel, we are working on implementing real-time reconstruction algorithms to establish a true feedback loop of experiments that are controlled and driven by the observed microscopic response of the sample. Last but not least, the SLS 2.0 upgrade provides exciting opportunities for the future, and our team is working hard to make the next generation imaging beamlines at the SLS a reality, allowing to push the current capabilities even farther.

For an extensive overview of all PSI-related publications, we kindly refer you to our online publication repository DORA.

Complete publication list

An up-to-date and complete list of all of my publications can be found on my ResearcherID profile (http://www.researcherid.com/rid/C-4696-2008) or in my ORCID record (http://orcid.org/0000-0002-0485-2708).

All of my PSI-related publications can be found via a DORA search.

List of PSI-related publications (last five years)

  • Achuo Dze S, Phillips T, Najafi-Silab R, Perez S, Bultreys T, Novak V, et al.
    Analysis and comparison of natural shear and induced tensile fractures for caprock leakage assessment
    Transport in Porous Media. 2026; 153(2): 29 (26 pp.). https://doi.org/10.1007/s11242-025-02283-0
    DORA PSI
  • Amiri H, Dialeismas V, Freitas D, Rizzo R, Chogani A, Schlepütz CM, et al.
    Transient porosity during fluid-mineral interaction. Part 1: in situ 4D tomography
    Journal of Geophysical Research: Solid Earth. 2026; 131(6): 2025JB032881 (25 pp.). https://doi.org/10.1029/2025JB032881
    DORA PSI
  • B. Wrammerfors ET, Pierantoni M, Dejea H, Sjögren A, Orozco GA, Das Gupta S, et al.
    Synchrotron phase-contrast microtomography reveals the impact of degeneration on the 3D structure of human articular cartilage
    Osteoarthritis and Cartilage. 2026. https://doi.org/10.1016/j.joca.2026.04.001
    DORA PSI
  • Bauland J, Roux SG, Gstöhl S, Schlepütz CM, Haist M, Divoux T
    Visualizing shear-induced structures in carbon black gels by tomo-rheoscopy
    Rheologica Acta. 2026. https://doi.org/10.1007/s00397-026-01583-6
    DORA PSI
  • Colombier M, Cáceres F, Birnbaum J, deGraffenried R, Lavallée Y, Kendrick JE, et al.
    Inherent duality of vesiculation kinematics revealed through 4D imaging
    Journal of Volcanology and Geothermal Research. 2026; 470: 108505 (13 pp.). https://doi.org/10.1016/j.jvolgeores.2025.108505
    DORA PSI
  • Ivarsson N, Hall S, Toft N, Pettersson S, Hallberg H, Schlepütz CM, et al.
    In-situ peel test analysis via synchrotron tomography and DVC
    Tomography of Materials and Structures. 2026; 11: 100084 (18 pp.). https://doi.org/10.1016/j.tmater.2026.100084
    DORA PSI
  • Jönsson V, Grassi L, Gustafsson A, Pierantoni M, Dejea H, Sjögren A, et al.
    Degeneration dependent changes in human knee cartilage mechanical properties revealed by synchrotron tomography based finite element modeling
    Osteoarthritis and Cartilage Open. 2026; 8(3): 100825 (10 pp.). https://doi.org/10.1016/j.ocarto.2026.100825
    DORA PSI
  • Pande A, Rose L, England SJ, Rahman IA, Pérez-de la Fuente R, Bodey AJ, et al.
    Hunting ecology predicts eye arrangements in the modular visual system of spiders
    Current Biology. 2026. https://doi.org/10.1016/j.cub.2026.06.019
    DORA PSI
  • Rodgers G, Lotto C, Li C, Schmeltz M, Ivanovic A, Schlepütz CM, et al.
    Dynamic microtomography of human tympanic membrane motions
    Hearing Research. 2026; 470: 109508 (13 pp.). https://doi.org/10.1016/j.heares.2025.109508
    DORA PSI
  • Adam I, Zai AT, Stepien AE, Yamahachi H, Schlepütz CM, Hahnloser RHR, et al.
    A synchrotron X-ray CT-based 3D atlas of the songbird syrinx with single muscle fibre resolution implies fine motor control of syringeal vocal folds
    Philosophical Transactions of the Royal Society B: Biological Sciences. 2025; 380(1920): 20230430 (10 pp.). https://doi.org/10.1098/rstb.2023.0430
    DORA PSI
  • Ivanovic A, Cheng JT, Schmeltz M, Wimmer W, Schlepuetz CM, Remenschneider AK, et al.
    Dynamic X-ray microtomography vs. laser-doppler vibrometry: a comparative study
    Journal of the Association for Research in Otolaryngology (JARO). 2025; 26: 63-75. https://doi.org/10.1007/s10162-024-00971-0
    DORA PSI
  • Kamm PH, Börner S, Neu TR, Schlepütz CM, Dittrich D, Banhart J, et al.
    Operando X-ray tomoscopy of laser beam welding
    Advanced Science. 2025; 12(9): 2413108 (8 pp.). https://doi.org/10.1002/advs.202413108
    DORA PSI
  • Maiditsch IP, Schulz-Mirbach T, Heß M, Ladich F, Stampanoni M, Schlepütz CM
    A standing wave tube-like setup designed for tomographic imaging of the sound-induced motion patterns in fish hearing structures
    BMC Biology. 2025; 23(1): 277 (13 pp.). https://doi.org/10.1186/s12915-025-02388-4
    DORA PSI
  • Olbinado MP, Novak V, Gruenzweig C, Bonnin A, Marone F, Schlepuetz CM, et al.
    ANAXAM @ TOMCAT 2.0: easy access to cutting-edge tomographic microscopy for industry
    In: 14th conference on industrial computed tomography (ICT 2025). Vol. 30. E-journal of nondestructive testing. Mayen: Nondestructive Testing (NDT); 2025:(8 pp.). https://doi.org/10.58286/30750
    DORA PSI
  • Qu Q, Maiditsch IP, Heß M, Schulz-Mirbach T, Stampanoni M, Schlepütz CM
    Measurement of sub-micron motion of fish hearing structures in 4D synchrotron CT
    Measurement. 2025; 253: 117654 (10 pp.). https://doi.org/10.1016/j.measurement.2025.117654
    DORA PSI
  • Ringel BM, Semeraro F, Ferguson JC, Barnard HS, Dias B, Schlepütz CM, et al.
    Carbon fiber oxidation in 4D
    Advanced Materials. 2025; 37(42): 2502007 (10 pp.). https://doi.org/10.1002/adma.202502007
    DORA PSI
  • Schmeltz M, Ivanovic A, Schlepütz CM, Wimmer W, Bonnin A, Anschuetz L
    Comparison of Thiel-fixed and fresh-frozen temporal bon biomechanics with dynamic synchrotron-based X-ray imaging
    Clinical Biomechanics. 2025; 125: 106522 (9 pp.). https://doi.org/10.1016/j.clinbiomech.2025.106522
    DORA PSI
  • Schott F, Dollet B, Santucci S, Schlepütz CM, Claudet C, Gstöhl S, et al.
    Multiscale stress dynamics in sheared liquid foams revealed by tomo-rheoscopy
    Nature Communications. 2025; 16(1): 9210 (11 pp.). https://doi.org/10.1038/s41467-025-64412-z
    DORA PSI
  • Wang H, Hadjiivanov A, Blazquez E, Schlepütz CM, Stampanoni M, Lovric G
    Event-guided temporally super-resolved synchrotron X-ray imaging
    Communications Physics. 2025; 8(1): 222 (11 pp.). https://doi.org/10.1038/s42005-025-02142-w
    DORA PSI
  • Bonnin A, Lovric G, Marone F, Olbinado M, Schlepütz CM, Stampanoni M
    Multiscale synchrotron propagation-based phase-contrast X-ray tomographic microscopy at the TOMCAT beamline: latest achievements and future plans
    Synchrotron Radiation News. 2024; 37(5): 4-6. https://doi.org/10.1080/08940886.2024.2414713
    DORA PSI
  • Buffry AD, Currea JP, Franke-Gerth FA, Palavalli-Nettimi R, Bodey AJ, Rau C, et al.
    Evolution of compound eye morphology underlies differences in vision between closely related Drosophila species
    BMC Biology. 2024; 22(1): 67 (15 pp.). https://doi.org/10.1186/s12915-024-01864-7
    DORA PSI
  • Bultreys T, Ellman S, Schlepütz CM, Boone MN, Pakkaner GK, Wang S, et al.
    4D microvelocimetry reveals multiphase flow field perturbations in porous media
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2024; 121(12): 2316723121 (8 pp.). https://doi.org/10.1073/pnas.2316723121
    DORA PSI
  • Celiker E, Woodrow C, Guadayol Ò, Davranoglou LR, Schlepütz CM, Mortimer B, et al.
    Mechanical network equivalence between the katydid and mammalian inner ears
    PLoS Computational Biology. 2024; 20(12): e1012641 (17 pp.). https://doi.org/10.1371/journal.pcbi.1012641
    DORA PSI
  • Dejea H, Pierantoni M, Orozco GA, B. Wrammerfors ET, Gstöhl SJ, Schlepütz CM, et al.
    In situ loading and time-resolved synchrotron-based phase contrast tomography for the mechanical investigation of connective knee tissues: a proof-of-concept study
    Advanced Science. 2024; 11(21): 2308811 (14 pp.). https://doi.org/10.1002/advs.202308811
    DORA PSI
  • Freitas D, Butler IB, Elphick SC, Gilgannon J, Rizzo RE, Plümper O, et al.
    Heitt Mjölnir: a heated miniature triaxial apparatus for 4D synchrotron microtomography
    Journal of Synchrotron Radiation. 2024; 31(1): 150-161. https://doi.org/10.1107/S1600577523009876
    DORA PSI
  • Gilgannon J, Freitas D, Rizzo RE, Wheeler J, Butler IB, Seth S, et al.
    Elastic stresses can form metamorphic fabrics
    Geology. 2024; 52(3): 166-170. https://doi.org/10.1130/G51612.1
    DORA PSI
  • Phillips T, Bultreys T, Van Stappen J, Singh K, Achuo Dze S, Van Offenwert S, et al.
    Influence of local aperture heterogeneity on invading fluid connectivity during rough fracture drainage
    Transport in Porous Media. 2024; 151: 2387-2403. https://doi.org/10.1007/s11242-024-02117-5
    DORA PSI
  • Schmeltz M, Ivanovic A, Schlepütz CM, Wimmer W, Anschuetz L, Bonnin A
    High-resolution dynamic synchrotron-based x-ray microtomography of the human middle ear
    In: Müller B, Wang G, eds. Developments in X-ray tomography XV. Vol. 13152. Proceedings of SPIE. Bellingham: SPIE; 2024:1315203 (11 pp.). https://doi.org/10.1117/12.3029408
    DORA PSI
  • Schmeltz M, Ivanovic A, Schlepütz CM, Wimmer W, Remenschneider AK, Caversaccio M, et al.
    The human middle ear in motion: 3D visualization and quantification using dynamic synchrotron-based X-ray imaging
    Communications Biology. 2024; 7(1): 157 (12 pp.). https://doi.org/10.1038/s42003-023-05738-6
    DORA PSI
  • Waldner S, Wendelspiess E, Detampel P, Schlepütz CM, Huwyler J, Puchkov M
    Advanced analysis of disintegrating pharmaceutical compacts using deep learning-based segmentation of time-resolved micro-tomography images
    Heliyon. 2024; 10(4): e26025 (17 pp.). https://doi.org/10.1016/j.heliyon.2024.e26025
    DORA PSI
  • Blaskovic S, Anagnostopoulou P, Borisova E, Schittny D, Donati Y, Haberthür D, et al.
    Airspace diameter map - a quantitative measurement of all pulmonary airspaces to characterize structural lung diseases
    Cells. 2023; 12(19): 2375 (22 pp.). https://doi.org/10.3390/cells12192375
    DORA PSI
  • Fusseis F, Allsop C, Gilgannon J, Schrank C, Harley S, Schlepütz CM
    Strain shadow "megapores" in mid-crustal ultramylonites
    Geology. 2023; 51(8): 748-752. https://doi.org/10.1130/G51128.1
    DORA PSI
  • Guo R, Stubbe J, Zhang Y, Schlepütz CM, Rojas Gomez C, Mehdikhani M, et al.
    Deep-learning image enhancement and fibre segmentation from time-resolved computed tomography of fibre-reinforced composites
    Composites Science and Technology. 2023; 244: 110278 (10 pp.). https://doi.org/10.1016/j.compscitech.2023.110278
    DORA PSI
  • Kamm PH, Yin K, Neu TR, Schlepütz CM, García-Moreno F, Wegst UGK
    X-ray tomoscopy reveals the dynamics of ice templating
    Advanced Functional Materials. 2023; 33(48): 2304738 (11 pp.). https://doi.org/10.1002/adfm.202304738
    DORA PSI
  • Link J, Strybny B, Divoux T, Sowoidnich T, Coenen M, Gstöhl S, et al.
    Mechanisms of thixotropy in cement suspensions considering influences from shear history and hydration
    In: Ludwig H-M, Lieboldt M, Baron T, eds. 21st ibausil - international conference on building material. Vol. 6. ce/papers - proceedings in civil engineering. Berlin: Ernst & Sohn GmbH; 2023:698-704. https://doi.org/10.1002/cepa.2810
    DORA PSI
  • Makowska MG, Verga F, Pfeiffer S, Marone F, Chang CST, Florio K, et al.
    Operando tomographic microscopy during laser-based powder bed fusion of alumina
    Communications Materials. 2023; 4: 73 (15 pp.). https://doi.org/10.1038/s43246-023-00401-3
    DORA PSI
  • Blaskovic S, Donati Y, Ruchonnet-Metrailler I, Avila Y, Schittny D, Schlepütz CM, et al.
    Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema
    Respiratory Research. 2022; 23(1): 44 (18 pp.). https://doi.org/10.1186/s12931-022-01956-4
    DORA PSI
  • Dahms SO, Schnapp G, Winter M, Büttner FH, Schlepütz M, Gnamm C, et al.
    Dichlorophenylpyridine-based molecules inhibit furin through an induced-fit mechanism
    ACS Chemical Biology. 2022; 17(4): 816-821. https://doi.org/10.1021/acschembio.2c00103
    DORA PSI
  • Davranoglou L-R, Malenovsky I, Soh ZWW, Schlepütz CM, Wilson MR
    Redescription of the planthopper Bursinia genei (Dufour, 1849), with a new record from Greece (Hemiptera: Fulgoromorpha: Dictyopharidae)
    Zoological Studies. 2022; 61: 51 (15 pp.). https://doi.org/10.6620/ZS.2022.61-51
    DORA PSI
  • Dejea H, Schlepütz CM, Méndez-Carmona N, Arnold M, Garcia-Canadilla P, Longnus SL, et al.
    A tomographic microscopy-compatible Langendorff system for the dynamic structural characterization of the cardiac cycle
    Frontiers in Cardiovascular Medicine. 2022; 9: 1023483 (13 pp.). https://doi.org/10.3389/fcvm.2022.1023483
    DORA PSI
  • Fischer R, Schlepütz CM, Zhao J, Boillat P, Hegemann D, Rossi RM, et al.
    Wicking dynamics in yarns
    Journal of Colloid and Interface Science. 2022; 625: 1-11. https://doi.org/10.1016/j.jcis.2022.04.060
    DORA PSI
  • Fischer R, Schlepütz CM, Rossi RM, Derome D, Carmeliet J
    Wicking through complex interfaces at interlacing yarns
    Journal of Colloid and Interface Science. 2022; 626: 416-425. https://doi.org/10.1016/j.jcis.2022.06.103
    DORA PSI
  • Maiditsch IP, Ladich F, Heß M, Schlepütz CM, Schulz-Mirbach T
    Revealing sound-induced motion patterns in fish hearing structures in 4D: a standing wave tube-like setup designed for high-resolution time-resolved tomography
    Journal of Experimental Biology. 2022; 225(1): jeb243614 (7 pp.). https://doi.org/10.1242/JEB.243614
    DORA PSI
  • Migga A, Schulz G, Rodgers G, Osterwalder M, Tanner C, Blank H, et al.
    Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve
    Journal of Medical Imaging. 2022; 9(3): 031507 (26 pp.). https://doi.org/10.1117/1.JMI.9.3.031507
    DORA PSI
  • Novák V, Blažek M, Schlepütz CM, Kočí P, Stampanoni M
    Drying of water from porous structures investigated by time-resolved X-ray tomography
    Drying Technology. 2022; 40(16): 3675-3693. https://doi.org/10.1080/07373937.2022.2076239
    DORA PSI
  • Phillips T, Bultreys T, Van Stappen J, Van Offenwert S, Callow B, Borji M, et al.
    Fluid invasion characteristics in a natural geological fracture: implications for subsurface fracture leakage
    In: Sixth international conference on fault and top seals 2022. Conference proceedings. sine loco: EAGE; 2022:1-4. https://doi.org/10.3997/2214-4609.202243022
    DORA PSI
  • Shi Z, Josell D, Jefimovs K, Romano L, Moffat TP, Stampanoni M, et al.
    Fabrication of a fractal pattern device for focus characterizations of X-ray imaging systems by Si deep reactive ion etching and bottom-up Au electroplating
    Applied Optics. 2022; 61(13): 3850-3854. https://doi.org/10.1364/AO.456427
    DORA PSI