Biography
My entire scientific career has been revolving around synchrotron-based structural investigations. Both my diploma in experimental physics and my doctoral thesis were carried out at the Materials Science beamline of the Swiss light source, investigating the atomic structure of thin films and crystal surfaces using Surface X-ray Diffraction, for which I obtained my PhD in experimental physics from the University of Zürich (Switzerland) in 2009. This lead to a postdoctoral research position at the University of Michigan (Ann Arbor, USA), continuing studies using X-ray diffraction and becoming a regular user of the diffraction beamlines at the Advanced Photon Source (APS). In 2011, I became a beamline scientist in the Surface Scattering and Microdiffraction group, Sector 33, of the Advanced Photon Source (APS) at Argonne National Laboratory (Chicago, USA), being involved in the user-operation of two beamlines and developing advanced methods for reciprocal space imaging using area detectors. In 2015, the focus of my research shifted from reciprocal space back to real space, when I returned to Switzerland to rejoin the Swiss Light Source as a new member of the TOMCAT group, devoting my time to exploring the wonders of the 3-dimensional microscopic world in motion.
Research
Resolving dynamic phenomena at the microscale in space and time - that is, in a nutshell, what my current research is all about. The world around us is in constant motion, and most of the macroscopic phenomena we experience are governed by dynamic processes happening at the microscale. To reveal and understand those complex mechanisms, I develop and use the unique tools and capabilities of the TOMCAT beamline that allow us to collect X-ray tomographic microscopy datasets at unprecedented temporal resolutions to create 4-dimensional microscopic movies. Applications range from geoscience via food-processing, materials testing and complex multi-phase flows all the way to biomechanical investigations. The latest speed record at TOMCAT was set at 1000 tomographic scans per second (Garcia-Moreno, 2021), while sub-second time-resolutions of up to 20 tomographies per second are routinely available to our user community. Currently, I focus on expanding the range of available sample environments to make these capabilities accessible for an even larger range of applications. In parallel, we are working on implementing real-time reconstruction algorithms to establish a true feedback loop of experiments that are controlled and driven by the observed microscopic response of the sample. Last but not least, the SLS 2.0 upgrade provides exciting opportunities for the future, and our team is working hard to make the next generation imaging beamlines at the SLS a reality, allowing to push the current capabilities even farther.
Publications
For an extensive overview of all PSI-related publications, we kindly refer you to our online publication repository DORA.
Complete publication list
An up-to-date and complete list of all of my publications can be found on my ResearcherID profile (http://www.researcherid.com/rid/C-4696-2008) or in my ORCID record (http://orcid.org/0000-0002-0485-2708).
All of my PSI-related publications can be found via a DORA search.
List of PSI-related publications (last five years)
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Achuo Dze S, Phillips T, Najafi-Silab R, Perez S, Bultreys T, Novak V, et al.
Analysis and comparison of natural shear and induced tensile fractures for caprock leakage assessment
Transport in Porous Media. 2026; 153(2): 29 (26 pp.). https://doi.org/10.1007/s11242-025-02283-0
DORA PSI -
Amiri H, Dialeismas V, Freitas D, Rizzo R, Chogani A, Schlepütz CM, et al.
Transient porosity during fluid-mineral interaction. Part 1: in situ 4D tomography
Journal of Geophysical Research: Solid Earth. 2026; 131(6): 2025JB032881 (25 pp.). https://doi.org/10.1029/2025JB032881
DORA PSI -
B. Wrammerfors ET, Pierantoni M, Dejea H, Sjögren A, Orozco GA, Das Gupta S, et al.
Synchrotron phase-contrast microtomography reveals the impact of degeneration on the 3D structure of human articular cartilage
Osteoarthritis and Cartilage. 2026. https://doi.org/10.1016/j.joca.2026.04.001
DORA PSI -
Bauland J, Roux SG, Gstöhl S, Schlepütz CM, Haist M, Divoux T
Visualizing shear-induced structures in carbon black gels by tomo-rheoscopy
Rheologica Acta. 2026. https://doi.org/10.1007/s00397-026-01583-6
DORA PSI -
Colombier M, Cáceres F, Birnbaum J, deGraffenried R, Lavallée Y, Kendrick JE, et al.
Inherent duality of vesiculation kinematics revealed through 4D imaging
Journal of Volcanology and Geothermal Research. 2026; 470: 108505 (13 pp.). https://doi.org/10.1016/j.jvolgeores.2025.108505
DORA PSI -
Ivarsson N, Hall S, Toft N, Pettersson S, Hallberg H, Schlepütz CM, et al.
In-situ peel test analysis via synchrotron tomography and DVC
Tomography of Materials and Structures. 2026; 11: 100084 (18 pp.). https://doi.org/10.1016/j.tmater.2026.100084
DORA PSI -
Jönsson V, Grassi L, Gustafsson A, Pierantoni M, Dejea H, Sjögren A, et al.
Degeneration dependent changes in human knee cartilage mechanical properties revealed by synchrotron tomography based finite element modeling
Osteoarthritis and Cartilage Open. 2026; 8(3): 100825 (10 pp.). https://doi.org/10.1016/j.ocarto.2026.100825
DORA PSI -
Pande A, Rose L, England SJ, Rahman IA, Pérez-de la Fuente R, Bodey AJ, et al.
Hunting ecology predicts eye arrangements in the modular visual system of spiders
Current Biology. 2026. https://doi.org/10.1016/j.cub.2026.06.019
DORA PSI -
Rodgers G, Lotto C, Li C, Schmeltz M, Ivanovic A, Schlepütz CM, et al.
Dynamic microtomography of human tympanic membrane motions
Hearing Research. 2026; 470: 109508 (13 pp.). https://doi.org/10.1016/j.heares.2025.109508
DORA PSI -
Adam I, Zai AT, Stepien AE, Yamahachi H, Schlepütz CM, Hahnloser RHR, et al.
A synchrotron X-ray CT-based 3D atlas of the songbird syrinx with single muscle fibre resolution implies fine motor control of syringeal vocal folds
Philosophical Transactions of the Royal Society B: Biological Sciences. 2025; 380(1920): 20230430 (10 pp.). https://doi.org/10.1098/rstb.2023.0430
DORA PSI -
Ivanovic A, Cheng JT, Schmeltz M, Wimmer W, Schlepuetz CM, Remenschneider AK, et al.
Dynamic X-ray microtomography vs. laser-doppler vibrometry: a comparative study
Journal of the Association for Research in Otolaryngology (JARO). 2025; 26: 63-75. https://doi.org/10.1007/s10162-024-00971-0
DORA PSI -
Kamm PH, Börner S, Neu TR, Schlepütz CM, Dittrich D, Banhart J, et al.
Operando X-ray tomoscopy of laser beam welding
Advanced Science. 2025; 12(9): 2413108 (8 pp.). https://doi.org/10.1002/advs.202413108
DORA PSI -
Maiditsch IP, Schulz-Mirbach T, Heß M, Ladich F, Stampanoni M, Schlepütz CM
A standing wave tube-like setup designed for tomographic imaging of the sound-induced motion patterns in fish hearing structures
BMC Biology. 2025; 23(1): 277 (13 pp.). https://doi.org/10.1186/s12915-025-02388-4
DORA PSI -
Olbinado MP, Novak V, Gruenzweig C, Bonnin A, Marone F, Schlepuetz CM, et al.
ANAXAM @ TOMCAT 2.0: easy access to cutting-edge tomographic microscopy for industry
In: 14th conference on industrial computed tomography (ICT 2025). Vol. 30. E-journal of nondestructive testing. Mayen: Nondestructive Testing (NDT); 2025:(8 pp.). https://doi.org/10.58286/30750
DORA PSI -
Qu Q, Maiditsch IP, Heß M, Schulz-Mirbach T, Stampanoni M, Schlepütz CM
Measurement of sub-micron motion of fish hearing structures in 4D synchrotron CT
Measurement. 2025; 253: 117654 (10 pp.). https://doi.org/10.1016/j.measurement.2025.117654
DORA PSI -
Ringel BM, Semeraro F, Ferguson JC, Barnard HS, Dias B, Schlepütz CM, et al.
Carbon fiber oxidation in 4D
Advanced Materials. 2025; 37(42): 2502007 (10 pp.). https://doi.org/10.1002/adma.202502007
DORA PSI -
Schmeltz M, Ivanovic A, Schlepütz CM, Wimmer W, Bonnin A, Anschuetz L
Comparison of Thiel-fixed and fresh-frozen temporal bon biomechanics with dynamic synchrotron-based X-ray imaging
Clinical Biomechanics. 2025; 125: 106522 (9 pp.). https://doi.org/10.1016/j.clinbiomech.2025.106522
DORA PSI -
Schott F, Dollet B, Santucci S, Schlepütz CM, Claudet C, Gstöhl S, et al.
Multiscale stress dynamics in sheared liquid foams revealed by tomo-rheoscopy
Nature Communications. 2025; 16(1): 9210 (11 pp.). https://doi.org/10.1038/s41467-025-64412-z
DORA PSI -
Wang H, Hadjiivanov A, Blazquez E, Schlepütz CM, Stampanoni M, Lovric G
Event-guided temporally super-resolved synchrotron X-ray imaging
Communications Physics. 2025; 8(1): 222 (11 pp.). https://doi.org/10.1038/s42005-025-02142-w
DORA PSI -
Bonnin A, Lovric G, Marone F, Olbinado M, Schlepütz CM, Stampanoni M
Multiscale synchrotron propagation-based phase-contrast X-ray tomographic microscopy at the TOMCAT beamline: latest achievements and future plans
Synchrotron Radiation News. 2024; 37(5): 4-6. https://doi.org/10.1080/08940886.2024.2414713
DORA PSI -
Buffry AD, Currea JP, Franke-Gerth FA, Palavalli-Nettimi R, Bodey AJ, Rau C, et al.
Evolution of compound eye morphology underlies differences in vision between closely related Drosophila species
BMC Biology. 2024; 22(1): 67 (15 pp.). https://doi.org/10.1186/s12915-024-01864-7
DORA PSI -
Bultreys T, Ellman S, Schlepütz CM, Boone MN, Pakkaner GK, Wang S, et al.
4D microvelocimetry reveals multiphase flow field perturbations in porous media
Proceedings of the National Academy of Sciences of the United States of America PNAS. 2024; 121(12): 2316723121 (8 pp.). https://doi.org/10.1073/pnas.2316723121
DORA PSI -
Celiker E, Woodrow C, Guadayol Ò, Davranoglou LR, Schlepütz CM, Mortimer B, et al.
Mechanical network equivalence between the katydid and mammalian inner ears
PLoS Computational Biology. 2024; 20(12): e1012641 (17 pp.). https://doi.org/10.1371/journal.pcbi.1012641
DORA PSI -
Dejea H, Pierantoni M, Orozco GA, B. Wrammerfors ET, Gstöhl SJ, Schlepütz CM, et al.
In situ loading and time-resolved synchrotron-based phase contrast tomography for the mechanical investigation of connective knee tissues: a proof-of-concept study
Advanced Science. 2024; 11(21): 2308811 (14 pp.). https://doi.org/10.1002/advs.202308811
DORA PSI -
Freitas D, Butler IB, Elphick SC, Gilgannon J, Rizzo RE, Plümper O, et al.
Heitt Mjölnir: a heated miniature triaxial apparatus for 4D synchrotron microtomography
Journal of Synchrotron Radiation. 2024; 31(1): 150-161. https://doi.org/10.1107/S1600577523009876
DORA PSI -
Gilgannon J, Freitas D, Rizzo RE, Wheeler J, Butler IB, Seth S, et al.
Elastic stresses can form metamorphic fabrics
Geology. 2024; 52(3): 166-170. https://doi.org/10.1130/G51612.1
DORA PSI -
Phillips T, Bultreys T, Van Stappen J, Singh K, Achuo Dze S, Van Offenwert S, et al.
Influence of local aperture heterogeneity on invading fluid connectivity during rough fracture drainage
Transport in Porous Media. 2024; 151: 2387-2403. https://doi.org/10.1007/s11242-024-02117-5
DORA PSI -
Schmeltz M, Ivanovic A, Schlepütz CM, Wimmer W, Anschuetz L, Bonnin A
High-resolution dynamic synchrotron-based x-ray microtomography of the human middle ear
In: Müller B, Wang G, eds. Developments in X-ray tomography XV. Vol. 13152. Proceedings of SPIE. Bellingham: SPIE; 2024:1315203 (11 pp.). https://doi.org/10.1117/12.3029408
DORA PSI -
Schmeltz M, Ivanovic A, Schlepütz CM, Wimmer W, Remenschneider AK, Caversaccio M, et al.
The human middle ear in motion: 3D visualization and quantification using dynamic synchrotron-based X-ray imaging
Communications Biology. 2024; 7(1): 157 (12 pp.). https://doi.org/10.1038/s42003-023-05738-6
DORA PSI -
Waldner S, Wendelspiess E, Detampel P, Schlepütz CM, Huwyler J, Puchkov M
Advanced analysis of disintegrating pharmaceutical compacts using deep learning-based segmentation of time-resolved micro-tomography images
Heliyon. 2024; 10(4): e26025 (17 pp.). https://doi.org/10.1016/j.heliyon.2024.e26025
DORA PSI -
Blaskovic S, Anagnostopoulou P, Borisova E, Schittny D, Donati Y, Haberthür D, et al.
Airspace diameter map - a quantitative measurement of all pulmonary airspaces to characterize structural lung diseases
Cells. 2023; 12(19): 2375 (22 pp.). https://doi.org/10.3390/cells12192375
DORA PSI -
Fusseis F, Allsop C, Gilgannon J, Schrank C, Harley S, Schlepütz CM
Strain shadow "megapores" in mid-crustal ultramylonites
Geology. 2023; 51(8): 748-752. https://doi.org/10.1130/G51128.1
DORA PSI -
Guo R, Stubbe J, Zhang Y, Schlepütz CM, Rojas Gomez C, Mehdikhani M, et al.
Deep-learning image enhancement and fibre segmentation from time-resolved computed tomography of fibre-reinforced composites
Composites Science and Technology. 2023; 244: 110278 (10 pp.). https://doi.org/10.1016/j.compscitech.2023.110278
DORA PSI -
Kamm PH, Yin K, Neu TR, Schlepütz CM, García-Moreno F, Wegst UGK
X-ray tomoscopy reveals the dynamics of ice templating
Advanced Functional Materials. 2023; 33(48): 2304738 (11 pp.). https://doi.org/10.1002/adfm.202304738
DORA PSI -
Link J, Strybny B, Divoux T, Sowoidnich T, Coenen M, Gstöhl S, et al.
Mechanisms of thixotropy in cement suspensions considering influences from shear history and hydration
In: Ludwig H-M, Lieboldt M, Baron T, eds. 21st ibausil - international conference on building material. Vol. 6. ce/papers - proceedings in civil engineering. Berlin: Ernst & Sohn GmbH; 2023:698-704. https://doi.org/10.1002/cepa.2810
DORA PSI -
Makowska MG, Verga F, Pfeiffer S, Marone F, Chang CST, Florio K, et al.
Operando tomographic microscopy during laser-based powder bed fusion of alumina
Communications Materials. 2023; 4: 73 (15 pp.). https://doi.org/10.1038/s43246-023-00401-3
DORA PSI -
Blaskovic S, Donati Y, Ruchonnet-Metrailler I, Avila Y, Schittny D, Schlepütz CM, et al.
Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema
Respiratory Research. 2022; 23(1): 44 (18 pp.). https://doi.org/10.1186/s12931-022-01956-4
DORA PSI -
Dahms SO, Schnapp G, Winter M, Büttner FH, Schlepütz M, Gnamm C, et al.
Dichlorophenylpyridine-based molecules inhibit furin through an induced-fit mechanism
ACS Chemical Biology. 2022; 17(4): 816-821. https://doi.org/10.1021/acschembio.2c00103
DORA PSI -
Davranoglou L-R, Malenovsky I, Soh ZWW, Schlepütz CM, Wilson MR
Redescription of the planthopper Bursinia genei (Dufour, 1849), with a new record from Greece (Hemiptera: Fulgoromorpha: Dictyopharidae)
Zoological Studies. 2022; 61: 51 (15 pp.). https://doi.org/10.6620/ZS.2022.61-51
DORA PSI -
Dejea H, Schlepütz CM, Méndez-Carmona N, Arnold M, Garcia-Canadilla P, Longnus SL, et al.
A tomographic microscopy-compatible Langendorff system for the dynamic structural characterization of the cardiac cycle
Frontiers in Cardiovascular Medicine. 2022; 9: 1023483 (13 pp.). https://doi.org/10.3389/fcvm.2022.1023483
DORA PSI -
Fischer R, Schlepütz CM, Zhao J, Boillat P, Hegemann D, Rossi RM, et al.
Wicking dynamics in yarns
Journal of Colloid and Interface Science. 2022; 625: 1-11. https://doi.org/10.1016/j.jcis.2022.04.060
DORA PSI -
Fischer R, Schlepütz CM, Rossi RM, Derome D, Carmeliet J
Wicking through complex interfaces at interlacing yarns
Journal of Colloid and Interface Science. 2022; 626: 416-425. https://doi.org/10.1016/j.jcis.2022.06.103
DORA PSI -
Maiditsch IP, Ladich F, Heß M, Schlepütz CM, Schulz-Mirbach T
Revealing sound-induced motion patterns in fish hearing structures in 4D: a standing wave tube-like setup designed for high-resolution time-resolved tomography
Journal of Experimental Biology. 2022; 225(1): jeb243614 (7 pp.). https://doi.org/10.1242/JEB.243614
DORA PSI -
Migga A, Schulz G, Rodgers G, Osterwalder M, Tanner C, Blank H, et al.
Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve
Journal of Medical Imaging. 2022; 9(3): 031507 (26 pp.). https://doi.org/10.1117/1.JMI.9.3.031507
DORA PSI -
Novák V, Blažek M, Schlepütz CM, Kočí P, Stampanoni M
Drying of water from porous structures investigated by time-resolved X-ray tomography
Drying Technology. 2022; 40(16): 3675-3693. https://doi.org/10.1080/07373937.2022.2076239
DORA PSI -
Phillips T, Bultreys T, Van Stappen J, Van Offenwert S, Callow B, Borji M, et al.
Fluid invasion characteristics in a natural geological fracture: implications for subsurface fracture leakage
In: Sixth international conference on fault and top seals 2022. Conference proceedings. sine loco: EAGE; 2022:1-4. https://doi.org/10.3997/2214-4609.202243022
DORA PSI -
Shi Z, Josell D, Jefimovs K, Romano L, Moffat TP, Stampanoni M, et al.
Fabrication of a fractal pattern device for focus characterizations of X-ray imaging systems by Si deep reactive ion etching and bottom-up Au electroplating
Applied Optics. 2022; 61(13): 3850-3854. https://doi.org/10.1364/AO.456427
DORA PSI