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Laboratory of Nanoscale Biology

  • About LNB
  • Research and Technology Innovation Expanded submenu item
    • Electron diffraction of biological specimens
    • EM&D Group, Electron Microscopy Facility
    • Cellular structural biology and imaging
    • Structural Neurobiology
    • Mechano-Genomics
    • Cellular Engineering and Microscopy
    • Biointerfaces: Enabling Technology for Bio-Research
    • Ultrasound Mechanobiology
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Laboratory of Nanoscale Biology: Research and Technology Innovation

Activities of LNB are organized in three major research themes, "Electron Microscopy and Diffraction", "Cellular Structural Biology & Multi-scale Bioimaging", and "Mechano-Genomics & Computational Biology". In addition, we provide expertise in technologies such as micro- and nanofabrication, biointerfaces, cellular engineering and light microscopy. 

Electron Microscopy & Diffraction

electron diffraction of single molecules

Electron diffraction of biological specimens

We are developing novel methods for visualizing life at atomic resolution using electron diffraction and coherent electron diffractive imaging.

nanodiffraction
Electron Microscopy

Electron microscopy, EM Facility

The Electron Microscopy and Diffraction group is running the electron microscopy facility of PSI. Method development and implementation are currently focussing on diffractive techniques.

Electron Microscopy and Diffraction

 

Cellular Structural Biology & Multi-scale Bioimaging

cellular structural biology

Cellular Structural Biology

Using core stengths in electron tomography and protein bioengineering the cellular structural biology  group focuses on analysis of 3D structures of biological macromolecules in the cell, in particular using cryo-electron tomography.

Cellular structural Biology
cryo-EM

Structural Neurobiology

In the context of research on neurodegenerative diseases, we investigate the structure and function of neurodegenerative amyloid proteins by integrative biophysical methods. Furthermore, we are developing methods for multi-scale imaging of the mouse brain connectome.
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Structural Neurobiology

 

Mechano-Genomics & Computational Biology

MGG

Mechano-Genomics

We are investigating mesoscale functional links between cell mechanics, genome organization and gene expression during cellular ageing, rejuvenation and tissue homeostasis.

Mechano-genomics group
computational biology

Computational Biology (in planning)

Recent developments in computational methods, including deep learning techniques, offer unique opportunities towards linking multi-domain and multi-scale biology-raleted data sets.

 

Technology support and related research

Building on expertise in micro- and nanofabrication, biointerfaces, cellular engineering and light microscopy we are running and supporting projects in different fields including mechano-genomics and protein crystallography.

Fluorescence Microscopy

Cellular Engineering and Microscopy

We are developing novel tools to monitor and quantify trafficking and signalling of receptor tyrosine kinases and G protein-coupled receptors (GPCRs).

Cellular Engineering and Microscopy
Grafted structure functionalized with Alexa-SAv

Biointerfaces

Surfaces for application in biomolecular research range from protein patterns on glass and polymers to micro- and nanostructures and templates for replication in biocompatible polymers.

Biointerfaces
acoustic levitation

Ultrasound Mechanobiology

We are developing tools for bio-reated research, including acoustic tweezers for non-invasive  intracellular manipulation and an ultrasonic acoustic levitation diffractometer for protein crystallography.

Ultrasound Mechanobiology

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Contact

G.V. Shivashankar
Professor of Mechano-Genomics
Department of Health Sciences and Technology, ETH Zurich
& Paul Scherrer Institute, Switzerland

Head of the Laboratory
of Nanoscale Biology

Paul Scherrer Institute
Laboratory of Nanoscale Biology
OFLC/107
Forschungsstrasse 111
CH-5232 Villigen PSI
Switzerland

gshivasha@ethz.ch
gv.shivashankar@psi.ch


Secretariat

Anita Strittmatter
Secretary

Paul Scherrer Institut
Division of Biology and Chemistry
OFLC/108
Forschungsstrasse 111
CH-5232 Villigen PSI
Switzerland

Phone: +41 56 310 20 35
Fax: +41 56 310 21 99
anita.strittmatter@psi.ch

BIO Open positions

Current openings in the Division of Biology and Chemistry


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How to get to the Paul Scherrer Institute (description and map)

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Paul Scherrer Institut

Forschungsstrasse 111
5232 Villigen PSI
Switzerland

Telephone: +41 56 310 21 11
Telefax: +41 56 310 21 99

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