Events & Scientific Highlights
2018
November 2018: Marcel defended his PhD with "summa cum laude"
September 2018: Three-days retreat in the Duranna hut (Canton Graubünden)
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine-site of tubulin published in Nat. Comm.(2018)
Structure-function relationship of the Bik1-Bim1 complex published in Structure (2018)
2017
Paper published in Nature Comm. (2017) describing the deconvolution of Buparlisib's mechanism of action into specific PI3K and tubulin inhibitors for therapeutic intervention
September 2017: Two-days hike to Tannensee/Conterseralp (Canton Graubünden)
Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex published in Nature Cell Biol. (2017)
Paper published in Structure (2017) reporting a novel sequence motif targeting diverse proteins to growing microtubule ends
2016
Discovery that centriolar CPAP/SAS-4 imparts slow processive microtubule growth published in Dev. Cell (2016)
Discovery that Eribulin induces lattice defects that promote microtubule catastrophes published in Curr. Biol. (2016)
September 2016: Two-days hike to the Säntis (Canton Appenzell)
SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture; Nat. Cell Biol. (2016)
September 2015: Two-days hike 'Vier-Seen-Höhenwanderung' from Planplatten (Alpen Tower) to Engelberg (central Switzerland)
2014
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs published in Proc. Natl. Acad. Sci. USA (2014)
September 2014: Hike from Holderbank through Roggenschnarz to Egerkingen (Canton Solothurn)
2013
Structural basis of tubulin tyrosination by tubulin tyrosine ligase published in J. Cell Biol. (2013)
Science (2013) paper on the molecular mechanism of action of microtubule-stabilizing anticancer agents;
Error: (1) can't find MAS_1.png at AUTHOR_WWW/LBR.ImageBoardAugust 2013: Two-days hike to the Creux du Van (Val de Travers, Neuchâtel)
March 2013: Game and fun event
2011
Structural basis of the nine-fold symmetry of centrioles; Cell (2011)
2012: Hike along the river Aare
2010
Molecular basis of coiled-coil oligomerization published in Proc. Natl. Acad. Sci. USA (2010)
2009
Discovery of a microtubule tip localization signal published in Cell (2009)
2007
Establishing the structure-function relationship of CAP-Gly domains; Nat. Struct. Mol. Biol. (2007)
Molecular basis of the specific inhibition of protein kinase G from Mycobacterium tuberculosis published in Proc. Natl. Acad. Sci. USA (2007)
Molecular basis of coiled-coil formation published in Proc. Natl. Acad. Sci. USA (2007)
2006
Deciphering key interaction modes of dynamic +TIP networks; Mol. Cell (2006)
2005
Discovery of a trimerization motif that controls the topology of short coiled coils; published in Proc. Natl. Acad. Sci. USA (2005)
2004
Exploring amyloid formation by a de novo design; Proc. Natl. Acad. Sci. USA (2004)
