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Laboratory of Biomolecular Research

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Events & Scientific Highlights

2018

November 2018: Marcel defended his PhD with "summa cum laude"

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September 2018: Three-days retreat in the Duranna hut (Canton Graubünden)

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A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine-site of tubulin published in Nat. Comm.(2018)

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Structure-function relationship of the Bik1-Bim1 complex published in Structure (2018)

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2017

Paper published in Nature Comm. (2017) describing the deconvolution of Buparlisib's mechanism of action into specific PI3K and tubulin inhibitors for therapeutic intervention

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September 2017: Two-days hike to Tannensee/Conterseralp (Canton Graubünden)

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Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex published in Nature Cell Biol. (2017)

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Paper published in Structure (2017) reporting a novel sequence motif targeting diverse proteins to growing microtubule ends

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2016

Discovery that centriolar CPAP/SAS-4 imparts slow processive microtubule growth published in Dev. Cell (2016)

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Discovery that Eribulin induces lattice defects that promote microtubule catastrophes published in Curr. Biol. (2016)

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September 2016: Two-days hike to the Säntis (Canton Appenzell)

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SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture; Nat. Cell Biol. (2016)

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September 2015: Two-days hike 'Vier-Seen-Höhenwanderung' from Planplatten (Alpen Tower) to Engelberg (central Switzerland)

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2014

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs published in Proc. Natl. Acad. Sci. USA (2014)

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September 2014: Hike from Holderbank through Roggenschnarz to Egerkingen (Canton Solothurn)

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2013

Structural basis of tubulin tyrosination by tubulin tyrosine ligase published in J. Cell Biol. (2013)

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Science (2013) paper on the molecular mechanism of action of microtubule-stabilizing anticancer agents;

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August 2013: Two-days hike to the Creux du Van (Val de Travers, Neuchâtel)

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March 2013: Game and fun event

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2011

Structural basis of the nine-fold symmetry of centrioles; Cell (2011)

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2012: Hike along the river Aare

Aare-hike-2012.jpg

2010

Molecular basis of coiled-coil oligomerization published in Proc. Natl. Acad. Sci. USA (2010)

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2009

Discovery of a microtubule tip localization signal published in Cell (2009)

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2007

Establishing the structure-function relationship of CAP-Gly domains; Nat. Struct. Mol. Biol. (2007)

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Molecular basis of the specific inhibition of protein kinase G from Mycobacterium tuberculosis published in Proc. Natl. Acad. Sci. USA (2007)

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Molecular basis of coiled-coil formation published in Proc. Natl. Acad. Sci. USA (2007)

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2006

Deciphering key interaction modes of dynamic +TIP networks; Mol. Cell (2006)

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2005

Discovery of a trimerization motif that controls the topology of short coiled coils; published in Proc. Natl. Acad. Sci. USA (2005)

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2004

Exploring amyloid formation by a de novo design; Proc. Natl. Acad. Sci. USA (2004)

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Laboratory of Biomolecular Research

Secretariat

Anita Strittmatter
Secretary

Paul Scherrer Institut
Department of Biology and Chemistry
OFLC/108
Forschungsstrasse 111
CH-5232 Villigen PSI
Switzerland

Telephone: +41 56 310 20 35
Fax: +41 56 310 21 99
E-mail: anita.strittmatter@psi.ch

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Current openings in the Division of Biology and Chemistry


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Telephone: +41 56 310 21 11
Telefax: +41 56 310 21 99

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