Prof. Dr. Michel Steinmetz

Head Laboratory of Biomolecular Research
Forschungsstrasse 111
5232 Villigen PSI
Switzerland
Research
Regulation of microtubule structure and dynamics
Proteins and their interaction networks are at the heart of life. Understanding how diverse proteins come together spatially and temporally and how their specific complexes translate into cellular functions is important to understand health and disease but represents a major challenge. Microtubules are filamentous structures fundamentally involved in diverse cellular processes ranging from cell division, motility and polarity to signaling and intracellular transport. They are also key to form centrioles of centrosomes and axonemes of cilia and flagella. Because of their important role for cell survival, the malfunctioning of the microtubule cytoskeleton is associated with several severe human pathologies including cancer and various forms of ciliopathies as well as cardiovascular, infectious and brain diseases. We use X-ray crystallography in combination with biochemical and biophysical methods to investigate how proteins and drugs regulate the structure, function and dynamics of the microtubule cytoskeleton.
Control of microtubule organization and dynamics: the two ends in the limelight.
Akhmanova, A., Steinmetz, M.O.
Nat. Rev. Mol. Cell Biol., 16, 711-726 (2015).
Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Prota, A.E., Bargsten, K., Zurwerra, D., Field, J.J., Díaz, J.F. Altmann, K.-H., Steinmetz, M.O.
Science, 339, 587-590 (2013).
Structural basis of the nine-fold symmetry of centrioles.
Kitagawa, D., Vakonakis, I., Olieric, N., Hilbert, M., Keller, D., Olieric, V., Bortfeld, M., Erat, M.C., Flückiger, I., Gönczy, P., Steinmetz, M.O.
Cell 144, 1-12 (2011).
An EB1-binding motif acts as a microtubule tip localization signal.
Honnappa, S., Montenegro Gouveia, S., Weisbrich, A., Damberger, F.F., Bhavesh, N.S., Jawhari, H., Grigoriev, I., van Rijssel, F.J.A., Buey, R.M., Lawera, A., Jelesarov, I., Winkler, F.K., Wüthrich, K., Akhmanova, A. and Steinmetz, M.O.
Cell 138, 366-376 (2009).
Members
Head Laboratory of Biomolecular Research
Ph.D. student
Ph.D. student
Ph.D. student
Master Student
Events and Scientific Highlights
Sung and Natacha published a paper “Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex” in Nat Struct Mol Biol. (2019)
June 2019: Three-days retreat in the Teamlodge in Lenk im Simmenthal (Canton Bern)
May 2019: Andrea was awarded the Horizon 2020 MSCA-ITN EJD Grant TubInTrain (www.tubintrain.eu).
The TubInTrain network has participants from six European countries and encompasses ten academic groups and ten companies committed to creating an outstanding training program for thirteen early stage researchers (ESRs) to elucidate the mechanisms of neurodegeneration associated to microtubules structure and dynamics.
January 2018: Natacha and Ashwani were awarded a FreeNovation grant (www.novartis.ch)
Development of lead molecules against apicomplex parasites
Apicomplexa are single-celled parasites responsible for diseases such as malaria, toxoplasmosis and cryptosporidiosis. Based on structural information on a protein, which plays an important role in the cell division of the Apicomplexa, lead molecules for this protein should be identified in this project. The results obtained will provide a basis for the development of novel drugs for the control of multidrug-resistant parasites.
Publications since 2002
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Akhmanova A, Steinmetz MO
Microtubule minus-end regulation at a glance
Journal of Cell Science. 2019; 132(11): jcs227850 (7 pp.). https://doi.org/10.1242/jcs.227850
DORA PSI -
Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, et al.
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
European Journal of Medicinal Chemistry. 2019; 162: 290-320. https://doi.org/10.1016/j.ejmech.2018.11.004
DORA PSI -
Chen X, Widmer LA, Stangier MM, Steinmetz MO, Stelling J, Barral Y
Remote control of microtubule plus-end dynamics and function from the minus-end
eLife. 2019; 8: e48627 (32 pp.). https://doi.org/10.7554/eLife.48627
DORA PSI -
Dohle W, Prota AE, Menchon G, Hamel E, Steinmetz MO, Potter BVL
Tetrahydroisoquinoline sulfamates as potent microtubule disruptors: synthesis, antiproliferative and antitubulin activity of dichlorobenzyl-based derivatives, and a Tubulin cocrystal structure.
ACS Omega. 2019; 4: 755-764. https://doi.org/10.1021/acsomega.8b02879
DORA PSI -
Dolenc J, van Gunsteren WF, Prota AE, Steinmetz MO, Missimer JH
Conformational properties of the chemotherapeutic drug analogue Epothilone A: how to model a flexible protein ligand using scarcely available experimental data
Journal of Chemical Information and Modeling. 2019; 59(5): 2218-2230. https://doi.org/10.1021/acs.jcim.9b00171
DORA PSI -
Faltova L, Jiang K, Frey D, Wu Y, Capitani G, Prota AE, et al.
Crystal structure of a heterotetrameric katanin p60:p80 complex
Structure. 2019; 27(9): 1375-1383.e3. https://doi.org/10.1016/j.str.2019.07.002
DORA PSI -
Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes G-J, Peeters CAE, Katrukha EA, et al.
MAP7 family proteins regulate kinesin-1 recruitment and activation
Journal of Cell Biology. 2019; 218(4): 1298-1318. https://doi.org/10.1083/jcb.201808065
DORA PSI -
Kashyap AS, Fernandez-Rodriguez L, Zhao Y, Monaco G, Trefny MP, Yoshida N, et al.
GEF-H1 signaling upon microtubule destabilization is required for dendritic cell activation and specific anti-tumor responses
Cell Reports. 2019; 28(13): 3367-3380.e1. https://doi.org/10.1016/j.celrep.2019.08.057
DORA PSI -
Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, et al.
VISAGE reveals a targetable mitotic spindle vulnerability in cancer cells
Cell Systems. 2019; 9(1): 74-92.e8. https://doi.org/10.1016/j.cels.2019.05.009
DORA PSI -
Wang N, Bosc C, Ryul Choi S, Boulan B, Peris L, Olieric N, et al.
Structural basis of tubulin detyrosination by the vasohibin–SVBP enzyme complex
Nature Structural and Molecular Biology. 2019; 26(7): 571-582. https://doi.org/10.1038/s41594-019-0241-y
DORA PSI -
de Asís Balaguer F, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián J, Risinger AL, et al.
Crystal structure of the cyclostreptin-tubulin adduct: implications for tubulin activation by taxane-site ligands
International Journal of Molecular Sciences. 2019; 20(6): 1392 (17 pp.). https://doi.org/10.3390/ijms20061392
DORA PSI
- CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain.
DEVELOPMENTAL CELL 46, 40 (2018).
- Cep120 promotes microtubule formation through a unique tubulin binding C2 domain
JOURNAL OF STRUCTURAL BIOLOGY -, S1047847718300248 (2018).DOI: 10.1016/j.jsb.2018.01.009
- Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton
TRENDS IN CELL BIOLOGY 28, 776 (2018).DOI: 10.1016/j.tcb.2018.05.001
- Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure
JOURNAL OF MEDICINAL CHEMISTRY , acs.jmedchem.7b01474 (2018).DOI: 10.1021/acs.jmedchem.7b01474
- Resolution extension by image summing in serial femtosecond crystallography of two-dimensional membrane-protein crystals
IUCRJ 5, 103 (2018).DOI: 10.1107/S2052252517017043
- Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex
STRUCTURE -, S0969212617304422 (2018).DOI: 10.1016/j.str.2017.12.017
- Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 162, 290 (2018).
- Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site
Scientific Reports 8, 10617 (2018).DOI: 10.1038/s41598-018-28880-2
- A structural model for microtubule minus-end recognition and protection by CAMSAP proteins
NATURE STRUCTURAL & MOLECULAR BIOLOGY 24, 931 (2017).DOI: 10.1038/nsmb.3483
- Antivascular and antitumor properties of the tubulin-binding chalcone TUB091
ONCOTARGET 8, 14325 (2017).DOI: 10.18632/oncotarget.9527
- Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.
MOLECULAR CELL Oct 5;68(1), 210 (2017).DOI: 10.1016/j.molcel.2017.09.012
- Deconvolution of Buparlisib?s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention
NATURE COMMUNICATIONS 8, 14683 (2017).DOI: 10.1038/ncomms14683
- Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis
CURRENT BIOLOGY 27, 2486 (2017).DOI: 10.1016/j.cub.2017.07.011
- Kinesin-4 KIF21B is a potent microtubule pausing factor
ELIFE 6, - (2017).DOI: 10.7554/eLife.24746
- Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.
NATURE CELL BIOLOGY 19, 480 (2017).DOI: 10.1038/NCB3511
- Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18, 1336 (2017).DOI: 10.3390/ijms18071336
- Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier.
Scientific Reports 7, 4970 (2017).DOI: 10.1038/S41598-017-05148-9
- Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons
NATURE COMMUNICATIONS 8, 542 (2017).DOI: 10.1038/s41467-017-00630-4
- Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends.
STRUCTURE 25, 924 (2017).DOI: 10.1016/J.STR.2017.04.010
- Structural Basis of Microtubule Stabilization by Discodermolide
CHEMBIOCHEM , (2017).DOI: 10.1002/cbic.201600696
- Structural Basis of cis- and trans-Combretastatin Binding to Tubulin
Chem 2, 102 (2017).DOI: 10.1016/j.chempr.2016.12.005
- Structural basis of katanin p60:p80 complex formation
Scientific Reports 7, 14893 (2017).DOI: 10.1038/s41598-017-14194-2
- Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A.
STRUCTURE 25, 341 (2017).DOI: 10.1016/J.STR.2016.12.012
- Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.
CELL CHEMICAL BIOLOGY 24, 737 (2017).DOI: 10.1016/J.CHEMBIOL.2017.05.016
- Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites.
JOURNAL OF NATURAL PRODUCTS , (2017).DOI: 10.1021/acs.jnatprod.7b00704
- Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network.
JOURNAL OF BIOLOGICAL CHEMISTRY 291, 18496 (2016).DOI: 10.1074/JBC.M116.739771
- Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth
DEVELOPMENTAL CELL 37, 362-376 (2016).DOI: 10.1016/j.devcel.2016.04.024
- Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies
JOURNAL OF BIOLOGICAL CHEMISTRY 291, 16292-16306 (2016).DOI: 10.1074/jbc.M116.726547
- Data-collection strategy for challenging native SAD phasing
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY 72, 421 (2016).DOI: 10.1107/S2059798315024110
- EB1 interacts with outwardly curved and straight regions of the microtubule lattice
NATURE CELL BIOLOGY 18, 1102 (2016).DOI: 10.1038/ncb3412
- Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity
CURRENT BIOLOGY 26, 849 (2016).DOI: 10.1016/j.cub.2016.01.048
- Molecular basis of Kar9-Bim1 complex function during mating and spindle positioning
MOLECULAR BIOLOGY OF THE CELL 27, 3729 (2016).DOI: 10.1091/mbc.E16-07-0552
- Pironetin Binds Covalently to alpha Cys316 and Perturbs a Major Loop and Helix of alpha-Tubulin to Inhibit Microtubule Formation.
JOURNAL OF MOLECULAR BIOLOGY 428, 2981 (2016).DOI: 10.1016/J.JMB.2016.06.023
- SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture
NATURE CELL BIOLOGY 18, 393-+ (2016).DOI: 10.1038/ncb3329
- Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics
PLOS ONE 11, e0160890 (2016).DOI: 10.1371/journal.pone.0160890
- Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells
ACS Omega 1, 1192 (2016).DOI: 10.1021/acsomega.6b00317
- Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations
Scientific Reports 6, 30668 (2016).DOI: 10.1038/srep30668
- Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes
CURRENT BIOLOGY 26, 1713-1721 (2016).DOI: 10.1016/j.cub.2016.04.053
- The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding
STRUCTURE 24, 1358 (2016).DOI: 10.1016/j.str.2016.06.011
- The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity
SCIENCE TRANSLATIONAL MEDICINE 8, 365ra159 (2016).DOI: 10.1126/scitranslmed.aag1093
- Control of microtubule organization and dynamics: two ends in the limelight
NATURE REVIEWS MOLECULAR CELL BIOLOGY 16, 711 (2015).DOI: 10.1038/nrm4084
- Fast native-SAD phasing for routine macromolecular structure determination
NATURE METHODS 12, 131-U163 (2015).DOI: 10.1038/nmeth.3211
- Optochemistry to control the microtubule cytoskeleton
The EMBO Journal 34, 2114 (2015).DOI: 10.15252/embj.201592415
- The use of ene adducts to study and engineer enoyl-thioester reductases.
NATURE CHEMICAL BIOLOGY 11, 398 (2015).DOI: 10.1038/NCHEMBIO.1794
- A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family
HUMAN MOLECULAR GENETICS 23, 5940 (2014).DOI: 10.1093/hmg/ddu318
- A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111, 13817-13821 (2014).DOI: 10.1073/pnas.1408124111
- Actin?microtubule coordination at growing microtubule ends
NATURE COMMUNICATIONS 5, 4778 (2014).DOI: 10.1038/ncomms5778
- Localizing Chemical Groups while Imaging Single Native Proteins by High-Resolution Atomic Force Microscopy
NANO LETTERS 14, 2957-2964 (2014).DOI: 10.1021/nl5012905
- Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein
NATURE CELL BIOLOGY 16, 804 (2014).DOI: 10.1038/ncb2999
- Reconstitution of a hierarchical plus TIP interaction network controlling microtubule end tracking of dynein
NATURE CELL BIOLOGY 16, 804-U314 (2014).DOI: 10.1038/ncb2999
- Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53, 1621-1625 (2014).DOI: 10.1002/anie.201307749
- Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A
NATURE 505, 108-+ (2014).DOI: 10.1038/nature12732
- The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization
JOURNAL OF MOLECULAR BIOLOGY 426, 1848-1860 (2014).DOI: 10.1016/j.jmb.2014.02.005
- Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, 11373 (2013).DOI: 10.1073/pnas.1302721110
- End Binding Proteins Are Obligatory Dimers
PLOS ONE 8, e74448 (2013).DOI: 10.1371/journal.pone.0074448
- End-binding proteins sensitize microtubules to the action of microtubule-targeting agents
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, 8900-8905 (2013).DOI: 10.1073/pnas.1300395110
- Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
SCIENCE 339, 587-590 (2013).DOI: 10.1126/science.1230582
- Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry
CURRENT BIOLOGY 23, 1620 (2013).DOI: 10.1016/j.cub.2013.06.061
- Structural Basis for Universal Corrinoid Recognition by the Cobalamin Transport Protein Haptocorrin
JOURNAL OF BIOLOGICAL CHEMISTRY 288, 25466 (2013).
- Structural Basis for the Oligomerization-State Switch from a Dimer to a Trimer of an Engineered Cortexillin-1 Coiled-Coil Variant
PLOS ONE 8, e63370 (2013).DOI: 10.1371/journal.pone.0063370
- Structural basis of tubulin tyrosination by tubulin tyrosine ligase
JOURNAL OF CELL BIOLOGY 200, 259-270 (2013).DOI: 10.1083/jcb.201211017
- A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins
CURRENT BIOLOGY 22, 1800 (2012).DOI: 10.1016/j.cub.2012.07.047
- Cooperative Stabilization of Microtubule Dynamics by EB1 and CLIP-170 Involves Displacement of Stably Bound P i at Microtubule Ends
BIOCHEMISTRY 51, 3021 (2012).DOI: 10.1021/bi300038t
- Influence of 63Ser Phosphorylation and Dephosphorylation on the Structure of the Stathmin Helical Nucleation Sequence: A Molecular Dynamics Study
BIOCHEMISTRY 51, 8455-8463 (2012).DOI: 10.1021/bi300885y
- Probing the Structure and Dynamics of Proteins by Combining Molecular Dynamics Simulations and Experimental NMR Data
JOURNAL OF CHEMICAL THEORY AND COMPUTATION 8, 3430 (2012).DOI: 10.1021/ct300393b
- Sequence Determinants of a Microtubule Tip Localization Signal (MtLS)
JOURNAL OF BIOLOGICAL CHEMISTRY 287, 28227 (2012).DOI: 10.1074/jbc.M112.373928
- Tyrosine-dependent capture of CAP-Gly domain-containing proteins in complex mixture by EB1 C-terminal peptidic probes
Journal of Proteomics 75, 3605 (2012).DOI: 10.1016/j.jprot.2012.04.006
- ELM--the database of eukaryotic linear motifs
NUCLEIC ACIDS RESEARCH 40, D242 (2011).DOI: 10.1093/nar/gkr1064
- Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice
MOLECULAR BIOLOGY OF THE CELL 22, 2912 (2011).DOI: 10.1091/mbc.E11-01-0017
- Automated seamless DNA co-transformation cloning with direct expression vectors applying positive or negative insert selection
BMC BIOTECHNOLOGY 10, 56 (2010).DOI: 10.1186/1472-6750-10-56
- Drosophila Stathmins Bind Tubulin Heterodimers with High and Variable Stoichiometries
JOURNAL OF BIOLOGICAL CHEMISTRY 285, 11667 (2010).DOI: 10.1074/jbc.M109.096727
- In Vitro Reconstitution of the Functional Interplay between MCAK and EB3 at Microtubule Plus Ends
CURRENT BIOLOGY 20, 1717 (2010).DOI: 10.1016/j.cub.2010.08.020
- Methods of NMR structure refinement: molecular dynamics simulations improve the agreement with measured NMR data of a C-terminal peptide of GCN4-p1
JOURNAL OF BIOMOLECULAR NMR 47, 221 (2010).DOI: 10.1007/s10858-010-9425-9
- Molecular Insights into Mammalian End-binding Protein Heterodimerization
JOURNAL OF BIOLOGICAL CHEMISTRY 285, 5802 (2010).DOI: 10.1074/jbc.M109.068130
- An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal
CELL 138, 366 (2009).DOI: 10.1016/j.cell.2009.04.065
- Automated unrestricted multigene recombineering for multiprotein complex production
NATURE METHODS 6, 447 (2009).DOI: 10.1038/nmeth.1326
- Mammalian end binding proteins control persistent microtubule growth
JOURNAL OF CELL BIOLOGY 184, 691 (2009).DOI: 10.1083/jcb.200807179
- Mutational studies of Pa-AGOG DNA glycosylase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum
DNA REPAIR 8, 857 (2009).DOI: 10.1016/j.dnarep.2009.03.009
- Solid-State NMR Spectroscopy Reveals that E. coli Inclusion Bodies of HET-s(218 - 289) are Amyloids
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48, 4858 (2009).DOI: 10.1002/anie.200806100
- The second level trigger system of FAST
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 609, 235 (2009).DOI: 10.1016/j.nima.2009.07.097
- Capturing protein tails by CAP-Gly domains
TRENDS IN BIOCHEMICAL SCIENCES 33, 535 (2008).DOI: 10.1016/j.tibs.2008.08.006
- Exploring the Conserved Water Site and Hydration of a Coiled-Coil Trimerisation Motif: A MD Simulation Study
CHEMBIOCHEM 9, 1749 (2008).DOI: 10.1002/cbic.200800096
- High-level Expression and Purification of a Designed Angiopoietin-1 Chimeric Protein, COMP-Ang1, Produced in Chinese Hamster Ovary Cells
THE PROTEIN JOURNAL 27, 319 (2008).DOI: 10.1007/s10930-008-9140-5
- Polymorphism in an Amyloid-Like Fibril-Forming Model Peptide
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 47, 5842 (2008).DOI: 10.1002/anie.200800021
- Suppression of Microtubule Dynamic Instability by the +TIP Protein EB1 and Its Modulation by the CAP-Gly Domain of p150 Glued ?
BIOCHEMISTRY 47, 779 (2008).DOI: 10.1021/bi701912g
- Suppression of microtubule dynamic instability by the plus TIP protein EB1 and its modulation by the CAP-Gly domain of p150(Glued)
BIOCHEMISTRY 47, 779-786 (2008).DOI: 10.1021/bi701912g
- Tracking the ends: a dynamic protein network controls the fate of microtubule tips
NATURE REVIEWS MOLECULAR CELL BIOLOGY 9, 309 (2008).DOI: 10.1038/nrm2369
- Configurational entropy elucidates the role of salt-bridge networks in protein thermostability
PROTEIN SCIENCE 16, 1349 (2007).DOI: 10.1110/ps.062542907
- Molecular basis of coiled-coil formation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104, 7062 (2007).DOI: 10.1073/pnas.0700321104
- Motor Neuron Disease-Associated Mutant Vesicle-Associated Membrane Protein-Associated Protein (VAP) B Recruits Wild-Type VAPs into Endoplasmic Reticulum-Derived Tubular Aggregates
JOURNAL OF NEUROSCIENCE 27, 9801 (2007).DOI: 10.1523/jneurosci.2661-07.2007
- Production of in vitro amplified DNA pseudolibraries and high-throughput cDNA target amplification
BMC BIOTECHNOLOGY 7, 31 (2007).DOI: 10.1186/1472-6750-7-31
- Structure and thermodynamics of the tubulin?stathmin interaction
JOURNAL OF STRUCTURAL BIOLOGY 158, 137 (2007).DOI: 10.1016/j.jsb.2006.07.018
- The Caenorhabditis elegans septin complex is nonpolar
The EMBO Journal 26, 3296 (2007).DOI: 10.1038/sj.emboj.7601775
- 13C, 15N Resonance Assignment of Parts of the HET-s Prion Protein in its Amyloid Form
JOURNAL OF BIOMOLECULAR NMR 34, 75 (2006).DOI: 10.1007/s10858-005-5582-7
- C-13, N-15 resonance assignment of parts of the HET-s prion protein in its amyloid form
JOURNAL OF BIOMOLECULAR NMR 34, 75-87 (2006).DOI: 10.1007/s10858-005-5582-7
- Control of Intrinsically Disordered Stathmin by Multisite Phosphorylation
JOURNAL OF BIOLOGICAL CHEMISTRY 281, 16078 (2006).DOI: 10.1074/jbc.M513524200
- De novo design of a two-stranded coiled-coil switch peptide
JOURNAL OF STRUCTURAL BIOLOGY 155, 146 (2006).DOI: 10.1016/j.jsb.2006.01.017
- Structure of the Extracellular Domain of Tie Receptor Tyrosine Kinases and Localization of the Angiopoietin-binding Epitope
JOURNAL OF BIOLOGICAL CHEMISTRY 281, 28408 (2006).DOI: 10.1074/jbc.M605219200
- A conserved trimerization motif controls the topology of short coiled coils
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102, 13891-13896 (2005).DOI: 10.1073/pnas.0502390102
- Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules
MOLECULAR BIOLOGY OF THE CELL 16, 2786-2798 (2005).
- Design of a coiled-coil-based model peptide system to explore the fundamentals of amyloid fibril formation
International Journal of Peptide Research and Therapeutics 11, 43-52 (2005).DOI: 10.1007/s10989-004-1720-4
- Molecular-dynamics simulations of C- and N-terminal peptide derivatives of GCN4-p1 in aqueous solution
Chemistry & Biodiversity 2, 1086-1104 (2005).
- Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2
JOURNAL OF BIOLOGICAL CHEMISTRY 280, 20126-20131 (2005).DOI: 10.1074/jbc.M500292200
- Structural and functional analysis of coronin 1
FEBS JOURNAL 272, 320-321 (2005).
- Structural basis for the regulation of tubulin by vinblastine
NATURE 435, 519-522 (2005).DOI: 10.1038/nature03566
- Structural insights into the EB1-APC interaction (vol 24, pg 261, 2005)
EMBO JOURNAL 24, 872-872 (2005).DOI: 10.1038/sj.emboj.7600590
- A Molecular Dynamics Study of Reovirus Attachment Protein ?1 Reveals Conformational Changes in ?1 Structure
BIOPHYSICAL JOURNAL 86, 3423 (2004).DOI: 10.1529/biophysj.103.030825
- COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101, 5547-5552 (2004).DOI: 10.1073/pnas.0307574101
- Exploring amyloid formation by a de novo design
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101, 4435-4440 (2004).DOI: 10.1073/pnas.0306786101
- Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100, 5366 (2003).DOI: 10.1073/pnas.0937718100
- Thermodynamics of the Op18/stathmin-tubulin interaction
JOURNAL OF BIOLOGICAL CHEMISTRY 278, 38926-38934 (2003).DOI: 10.1074/jbc.M305546200
- The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99, 10641 (2002).DOI: 10.1073/pnas.162360499
Former Members
Bargsten,Katja
Technician
Bianchi,Sarah Dr.
Ph.D. Student
E-mail: sarah.bianchi88@gmail.com
Bjelic,Sasa Dr.
Postdoc
Brunner, Janine Postdoc
Bortfeld,Miriam
Technician
De Groot,Christian
Ph.D. Student
Hilbert,Manuel Dr.
Postdoc
Honnappa,Srinivas Dr.
Postdoc
Jawhari,Hatim Dr.
Postdoc
John,Corinne
Ph.D. Student
Kambach,Christian Dr.
Senior scientist
Kraatz,Sebastian
Ph.D. Student
E-mail: SebKraatz@aol.com
Kumar, Anil
Postdoc
Manatschal,Cristina
Ph.D. Student
Martinez,Ruben
Postdoc
Menchon,Grégory
Postdoc
Rezabkova,Lenka
Postdoc
E-mail: lenka.rezabkova@chem.ethz.ch
Sejwal, Kushal
Postdoc
Sen,Indrani
Ph.D. Student
Stangier, Marcel
Ph.D student
Steiner-Degen,Miriam
Postdoc
Vakonakis, John
Postdoc
Weisbrich, Anke
Ph.D student