Prof. Dr. Michel Steinmetz

Curriculum Vitae

Regulation of microtubule structure and dynamics

Proteins and their interaction networks are at the heart of life. Understanding how diverse proteins come together spatially and temporally and how their specific complexes translate into cellular functions is important to understand health and disease but represents a major challenge. Microtubules are filamentous structures fundamentally involved in diverse cellular processes ranging from cell division, motility and polarity to signaling and intracellular transport. They are also key to form centrioles of centrosomes and axonemes of cilia and flagella. Because of their important role for cell survival, the malfunctioning of the microtubule cytoskeleton is associated with several severe human pathologies including cancer and various forms of ciliopathies as well as cardiovascular, infectious and brain diseases. We use X-ray crystallography in combination with biochemical and biophysical methods to investigate how proteins and drugs regulate the structure, function and dynamics of the microtubule cytoskeleton.

Control of microtubule organization and dynamics: the two ends in the limelight.
Akhmanova, A., Steinmetz, M.O.
Nat. Rev. Mol. Cell Biol., 16, 711-726 (2015).

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Prota, A.E., Bargsten, K., Zurwerra, D., Field, J.J., Díaz, J.F. Altmann, K.-H., Steinmetz, M.O.
Science, 339, 587-590 (2013).

Structural basis of the nine-fold symmetry of centrioles.
Kitagawa, D., Vakonakis, I., Olieric, N., Hilbert, M., Keller, D., Olieric, V., Bortfeld, M., Erat, M.C., Flückiger, I., Gönczy, P., Steinmetz, M.O.
Cell 144, 1-12 (2011).

An EB1-binding motif acts as a microtubule tip localization signal.
Honnappa, S., Montenegro Gouveia, S., Weisbrich, A., Damberger, F.F., Bhavesh, N.S., Jawhari, H., Grigoriev, I., van Rijssel, F.J.A., Buey, R.M., Lawera, A., Jelesarov, I., Winkler, F.K., Wüthrich, K., Akhmanova, A. and Steinmetz, M.O.
Cell 138, 366-376 (2009).

September 2020: Two-day hike on the Creux_du_Van and visit to the asphalt mines of La Presta (Val-de-Travers NE)

Sung and Natacha published a paper “Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex” in Nat Struct Mol Biol. (2019)

June 2019: Three-days retreat in the Teamlodge in Lenk im Simmenthal (Canton Bern)

May 2019: Andrea was awarded the Horizon 2020 MSCA-ITN EJD Grant TubInTrain (www.tubintrain.eu).

The TubInTrain network has participants from six European countries and encompasses ten academic groups and ten companies committed to creating an outstanding training program for thirteen early stage researchers (ESRs) to elucidate the mechanisms of neurodegeneration associated to microtubules structure and dynamics.

January 2018: Natacha and Ashwani were awarded a FreeNovation grant (www.novartis.ch)

Development of lead molecules against apicomplex parasites

Apicomplexa are single-celled parasites responsible for diseases such as malaria, toxoplasmosis and cryptosporidiosis. Based on structural information on a protein, which plays an important role in the cell division of the Apicomplexa, lead molecules for this protein should be identified in this project. The results obtained will provide a basis for the development of novel drugs for the control of multidrug-resistant parasites.

Previous Events

• CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain. Aher A, Kok M, Sharma A, Rai A, Olieric N, Rodriguez-Garcia R, Katrukha EA, Weinert T, Olieric V, Kapitein LC, Steinmetz MO, Dogterom M, Akhmanova A
  DEVELOPMENTAL CELL 46, 40 (2018).
• Cep120 promotes microtubule formation through a unique tubulin binding C2 domain Sharma A, Gerard Samuel F, Olieric N, Steinmetz Michel O
  JOURNAL OF STRUCTURAL BIOLOGY -, S1047847718300248 (2018).
  DOI: 10.1016/j.jsb.2018.01.009
• Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton Steinmetz Michel O, Prota Andrea E
  TRENDS IN CELL BIOLOGY 28, 776 (2018).
  DOI: 10.1016/j.tcb.2018.05.001
• Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure Dohle W, Jourdan Fabrice L, Menchon G, Prota Andrea E, Foster Paul A, Mannion P, Hamel E, Thomas Mark P, Kasprzyk Philip G, Ferrandis E, Steinmetz Michel O, Leese Mathew P, Potter Barry VL
  JOURNAL OF MEDICINAL CHEMISTRY , acs.jmedchem.7b01474 (2018).
  DOI: 10.1021/acs.jmedchem.7b01474
• Resolution extension by image summing in serial femtosecond crystallography of two-dimensional membrane-protein crystals Casadei Cecilia M, Tsai C, Barty A, Hunter Mark S, Zatsepin Nadia A, Padeste C, Capitani G, Benner WHenry, Boutet S, Hau-Riege Stefan P, Kupitz C, Messerschmidt M, Ogren John I, Pardini T, Rothschild Kenneth J, Sala L, Segelke B, Williams Garth J, Evans James E, Li X, Coleman M, Pedrini B, Frank M
  IUCRJ 5, 103 (2018).
  DOI: 10.1107/S2052252517017043
• Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex Jiang K, Faltova L, Hua S, Capitani G, Prota Andrea E, Landgraf C, Volkmer R, Kammerer Richard A, Steinmetz Michel O, Akhmanova A
  STRUCTURE -, S0969212617304422 (2018).
  DOI: 10.1016/j.str.2017.12.017
• Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asis Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, Conte M, Lopresti L, Magnano S, Amet R, Kinsella P, Zisterer DM, Ibrahim O, OSullivan J, Morbidelli L, Spaccapelo R, Baldari C, Butini S, Novellino E, Campiani G, Altucci L, Steinmetz MO, Brogi S
  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 162, 290 (2018).
• Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site Smedley Christopher J, Stanley Paul A, Qazzaz Mohannad E, Prota Andrea E, Olieric N, Collins H, Eastman H, Barrow Andrew S, Lim K, Kam T, Smith Brian J, Duivenvoorden Hendrika M, Parker Belinda S, Bradshaw Tracey D, Steinmetz Michel O, Moses John E
  Scientific Reports 8, 10617 (2018).
  DOI: 10.1038/s41598-018-28880-2

• A structural model for microtubule minus-end recognition and protection by CAMSAP proteins Atherton J, Jiang K, Stangier M, Luo Y, Hua S, Houben K, van Hooff J, Joseph A, Scarabelli G, Grant B, Roberts A, Topf M, Steinmetz M, Baldus M, Moores C, Akhmanova A
  NATURE STRUCTURAL & MOLECULAR BIOLOGY 24, 931 (2017).
  DOI: 10.1038/nsmb.3483
• Antivascular and antitumor properties of the tubulin-binding chalcone TUB091 Canela M, Noppen S, Bueno O, Prota A, Bargsten K, Sáez-Calvo G, Jimeno M, Benkheil M, Ribatti D, Velázquez S, Camarasa M, Díaz JFernando, Steinmetz MO, Priego E, Pérez-Pérez M, Liekens S
  ONCOTARGET 8, 14325 (2017).
  DOI: 10.18632/oncotarget.9527
• Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS
  MOLECULAR CELL Oct 5;68(1), 210 (2017).
  DOI: 10.1016/j.molcel.2017.09.012
• Deconvolution of Buparlisib?s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention Bohnacker T, Prota AE, Beaufils F, Burke John E, Melone A, Inglis Alison J, Rageot D, Sele Alexander M, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JFernando, Fabbro D, Zvelebil M, Williams Roger L, Steinmetz MO, Wymann Matthias P
  NATURE COMMUNICATIONS 8, 14683 (2017).
  DOI: 10.1038/ncomms14683
• Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, Busso C, Olieric N, Sorzano Carlos Oscar S, Steinmetz Michel O, Guichard P, Gönczy P
  CURRENT BIOLOGY 27, 2486 (2017).
  DOI: 10.1016/j.cub.2017.07.011
• Kinesin-4 KIF21B is a potent microtubule pausing factor van Riel W, Rai A, Bianchi S, Katrukha E, Liu Q, Heck A, Hoogenraad C, Steinmetz M, Kapitein L, Akhmanova A
  ELIFE 6, - (2017).
  DOI: 10.7554/eLife.24746
• Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Maarten Altelaar AF, Heck AJR, Kammerer RA, Steinmetz MO, Akhmanova A
  NATURE CELL BIOLOGY 19, 480 (2017).
  DOI: 10.1038/NCB3511
• Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin Sharma A, Sáez-Calvo G, Olieric N, de Asís Balaguer F, Barasoain I, Lamberth C, Díaz J, Steinmetz M
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18, 1336 (2017).
  DOI: 10.3390/ijms18071336
• Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier. Aeschimann W, Staats S, Kammer S, Olieric N, Jeckelmann JM, Fotiadis D, Netscher T, Rimbach G, Cascella M, Stocker A
  Scientific Reports 7, 4970 (2017).
  DOI: 10.1038/S41598-017-05148-9
• Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons Weinert T, Olieric N, Cheng R, Brünle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Doré Andrew S, Geng T, Cooke Robert M, Liang M, Prota Andrea E, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz Michel O, Wang M, Standfuss J
  NATURE COMMUNICATIONS 8, 542 (2017).
  DOI: 10.1038/s41467-017-00630-4
• Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends. Kumar A, Manatschal C, Rai A, Grigoriev I, Degen MS, Jaussi R, Kretzschmar I, Prota AE, Volkmer R, Kammerer RA, Akhmanova A, Steinmetz MO
  STRUCTURE 25, 924 (2017).
  DOI: 10.1016/J.STR.2017.04.010
• Structural Basis of Microtubule Stabilization by Discodermolide Prota Andrea E, Bargsten K, Redondo M, Smith III Amos B, Yang ChiaPing H, McDaid Hayley M, Paterson I, Horwitz Susan B, Díaz J, Steinmetz Michel O
  CHEMBIOCHEM , (2017).
  DOI: 10.1002/cbic.201600696
• Structural Basis of cis- and trans-Combretastatin Binding to Tubulin Gaspari R, Prota Andrea E, Bargsten K, Cavalli A, Steinmetz Michel O
  Chem 2, 102 (2017).
  DOI: 10.1016/j.chempr.2016.12.005
• Structural basis of katanin p60:p80 complex formation Rezabkova L, Jiang K, Capitani G, Prota Andrea E, Akhmanova A, Steinmetz Michel O, Kammerer Richard A
  Scientific Reports 7, 14893 (2017).
  DOI: 10.1038/s41598-017-14194-2
• Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A. Markovic-Mueller S, Stuttfeld E, Asthana M, Weinert T, Bliven S, Goldie KN, Kisko K, Capitani G, Ballmer-Hofer K
  STRUCTURE 25, 341 (2017).
  DOI: 10.1016/J.STR.2016.12.012
• Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin. Saez-Calvo G, Sharma A, Balaguer FA, Barasoain I, Rodriguez-Salarichs J, Olieric N, Munoz-Hernandez H, Berbis MA, Wendeborn S, Penalva MA, Matesanz R, Canales A, Prota AE, Jimenez-Barbero J, Andreu JM, Lamberth C, Steinmetz MO, Diaz JF
  CELL CHEMICAL BIOLOGY 24, 737 (2017).
  DOI: 10.1016/J.CHEMBIOL.2017.05.016
• Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. Field JJ, Pera B, Gallego JE, Calvo E, Rodriguez-Salarichs J, Saez-Calvo G, Zuwerra D, Jordi M, Andreu JM, Prota AE, Menchon G, Miller JH, Altmann KH, Diaz JF
  JOURNAL OF NATURAL PRODUCTS , (2017).
  DOI: 10.1021/acs.jnatprod.7b00704

• Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network. Rezabkova L, Kraatz SH, Akhmanova A, Steinmetz MO, Kammerer RA
  JOURNAL OF BIOLOGICAL CHEMISTRY 291, 18496 (2016).
  DOI: 10.1074/JBC.M116.739771
• Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth Sharma Ashwani, Aher Amol, Dynes Nicola J, Frey Daniel, Katrukha Eugene A, Jaussi Rolf, Grigoriev Ilya, Croisier Marie, Kammerer Richard A, Akhmanova Anna, Gonczy Pierre, Steinmetz Michel O
  DEVELOPMENTAL CELL 37, 362-376 (2016).
  DOI: 10.1016/j.devcel.2016.04.024
• Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies Burger Dominique, Stihle Martine, Sharma Ashwani, Di Lello Paola, Benz Jorg, D'Arcy Brigitte, Debulpaep Maja, Fry David, Huber Walter, Kremer Thomas, Laeremans Toon, Matile Hugues, Ross Alfred, Rufer Arne C, Schoch Guillaume, Steinmetz Michel O, Steyaert Jan, Rudolph Markus G, Thoma Ralf, Ruf Armin
  JOURNAL OF BIOLOGICAL CHEMISTRY 291, 16292-16306 (2016).
  DOI: 10.1074/jbc.M116.726547
• Data-collection strategy for challenging native SAD phasing Olieric V, Weinert T, Finke Aaron D, Anders C, Li D, Olieric N, Borca Camelia N, Steinmetz Michel O, Caffrey M, Jinek M, Wang M
  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY 72, 421 (2016).
  DOI: 10.1107/S2059798315024110
• EB1 interacts with outwardly curved and straight regions of the microtubule lattice Guesdon A, Bazile F, Buey RM, Mohan R, Monier S, García R, Angevin M, Heichette C, Wieneke R, Tampé R, Duchesne L, Akhmanova A, Steinmetz MO, Chrétien D
  NATURE CELL BIOLOGY 18, 1102 (2016).
  DOI: 10.1038/ncb3412
• Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity Kevenaar Josta T, Bianchi S, van Spronsen M, Olieric N, Lipka J, Frias Cátia P, Mikhaylova M, Harterink M, Keijzer N, Wulf Phebe S, Hilbert M, Kapitein Lukas C, de Graaff E, Ahkmanova A, Steinmetz Michel O, Hoogenraad Casper C
  CURRENT BIOLOGY 26, 849 (2016).
  DOI: 10.1016/j.cub.2016.01.048
• Molecular basis of Kar9-Bim1 complex function during mating and spindle positioning Manatschal C, Farcas AM, Degen MS, Bayer M, Kumar A, Landgraf C, Volkmer R, Barral Y, Steinmetz MO
  MOLECULAR BIOLOGY OF THE CELL 27, 3729 (2016).
  DOI: 10.1091/mbc.E16-07-0552
• Pironetin Binds Covalently to alpha Cys316 and Perturbs a Major Loop and Helix of alpha-Tubulin to Inhibit Microtubule Formation. Prota AE, Setter J, Waight AB, Bargsten K, Murga J, Diaz JF, Steinmetz MO
  JOURNAL OF MOLECULAR BIOLOGY 428, 2981 (2016).
  DOI: 10.1016/J.JMB.2016.06.023
• SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture Hilbert Manuel, Noga Akira, Frey Daniel, Hamel Virginie, Guichard Paul, Kraatz Sebastian H W, Pfreundschuh Moritz, Hosner Sarah, Flueckiger Isabelle, Jaussi Rolf, Wieser Mara M, Thieltges Katherine M, Deupi Xavier, Mueller Daniel J, Kammerer Richard A, Goenczy Pierre, Hirono Masafumi, Steinmetz Michel O
  NATURE CELL BIOLOGY 18, 393-+ (2016).
  DOI: 10.1038/ncb3329
• Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics Waight AB, Bargsten K, Doronina S, Steinmetz MO, Sussman D, Prota AE
  PLOS ONE 11, e0160890 (2016).
  DOI: 10.1371/journal.pone.0160890
• Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells Trigili C, Barasoain I, Sánchez-Murcia Pedro A, Bargsten K, Redondo-Horcajo M, Nogales A, Gardner Nicola M, Meyer A, Naylor Guy J, Gómez-Rubio E, Gago F, Steinmetz Michel O, Paterson I, Prota Andrea E, Díaz JFernando
  ACS Omega 1, 1192 (2016).
  DOI: 10.1021/acsomega.6b00317
• Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations Bianchi S, van Riel Wilhelmina E, Kraatz Sebastian HW, Olieric N, Frey D, Katrukha Eugene A, Jaussi R, Missimer J, Grigoriev I, Olieric V, Benoit Roger M, Steinmetz Michel O, Akhmanova A, Kammerer Richard A
  Scientific Reports 6, 30668 (2016).
  DOI: 10.1038/srep30668
• Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes Doodhi Harinath, Prota Andrea E, Rodriguez-Garcia Ruddi, Xiao Hui, Custar Daniel W, Bargsten Katja, Katrukha Eugene A, Hilbert Manuel, Hua Shasha, Jiang Kai, Grigoriev Ilya, Yang ChiaPing H, Cox David, Horwitz Susan Band, Kapitein Lukas C, Akhmanova Anna, Steinmetz Michel O
  CURRENT BIOLOGY 26, 1713-1721 (2016).
  DOI: 10.1016/j.cub.2016.04.053
• The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding Kraatz S, Guichard P, Obbineni Jagan M, Olieric N, Hatzopoulos Georgios N, Hilbert M, Sen I, Missimer J, Gönczy P, Steinmetz Michel O
  STRUCTURE 24, 1358 (2016).
  DOI: 10.1016/j.str.2016.06.011
• The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity Wieczorek Michal, Tcherkezian Joseph, Bernier Cynthia, Prota AE, Chaaban Sami, Rolland Yanneve, Godbout Claude, Hancock Mark A, Arezzo Joseph C, Ocal Ozhan, Rocha Cecilia, Olieric N, Hall Anita, Ding Hui, Bramoulle Alexandre, Annis Matthew G, Zogopoulos George, Harran Patrick G, Wilkie Thomas M, Brekken Rolf A, Siegel Peter M, Steinmetz MO, Shore Gordon C, Brouhard Gary J, Roulston Anne
  SCIENCE TRANSLATIONAL MEDICINE 8, 365ra159 (2016).
  DOI: 10.1126/scitranslmed.aag1093

• Control of microtubule organization and dynamics: two ends in the limelight Akhmanova A, Steinmetz Michel O
  NATURE REVIEWS MOLECULAR CELL BIOLOGY 16, 711 (2015).
  DOI: 10.1038/nrm4084
• Fast native-SAD phasing for routine macromolecular structure determination Weinert Tobias, Olieric Vincent, Waltersperger Sandro, Panepucci Ezequiel, Chen Lirong, Zhang Hua, Zhou Dayong, Rose John, Ebihara Akio, Kuramitsu Seiki, Li Dianfan, Howe Nicole, Schnapp Gisela, Pautsch Alexander, Bargsten Katja, Prota Andrea E, Surana Parag, Kottur Jithesh, Nair Deepak T, Basilico Federica, Cecatiello Valentina, Pasqualato Sebastiano, Boland Andreas, Weichenrieder Oliver, Wang Bi-Cheng, Steinmetz Michel O, Caffrey Martin, Wang Meitian
  NATURE METHODS 12, 131-U163 (2015).
  DOI: 10.1038/nmeth.3211
• Optochemistry to control the microtubule cytoskeleton Janke C, Steinmetz MO
  The EMBO Journal 34, 2114 (2015).
  DOI: 10.15252/embj.201592415
• The use of ene adducts to study and engineer enoyl-thioester reductases. Rosenthal RG, Vogeli B, Quade N, Capitani G, Kiefer P, Vorholt JA, Ebert MO, Erb TJ
  NATURE CHEMICAL BIOLOGY 11, 398 (2015).
  DOI: 10.1038/NCHEMBIO.1794

• A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family Khan MA, Rupp VM, Orpinell M, Hussain MS, Altmuller J, Steinmetz MO, Enzinger C, Thiele H, Hohne W, Nurnberg G, Baig SM, Ansar M, Nurnberg P, Vincent JB, Speicher MR, Gonczy P, Windpassinger C
  HUMAN MOLECULAR GENETICS 23, 5940 (2014).
  DOI: 10.1093/hmg/ddu318
• A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs Prota Andrea E, Bargsten Katja, Fernando Diaz J, Marsh May, Cuevas Carmen, Liniger Marc, Neuhaus Christian, Andreu Jose M, Altmann Karl-Heinz, Steinmetz Michel O
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111, 13817-13821 (2014).
  DOI: 10.1073/pnas.1408124111
• Actin?microtubule coordination at growing microtubule ends López M, Huber F, Grigoriev I, Steinmetz Michel O, Akhmanova A, Koenderink Gijsje H, Dogterom M
  NATURE COMMUNICATIONS 5, 4778 (2014).
  DOI: 10.1038/ncomms5778
• Localizing Chemical Groups while Imaging Single Native Proteins by High-Resolution Atomic Force Microscopy Pfreundschuh Moritz, Alsteens David, Hilbert Manuel, Steinmetz Michel O, Mueller Daniel J
  NANO LETTERS 14, 2957-2964 (2014).
  DOI: 10.1021/nl5012905
• Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein Duellberg C, Trokter M, Jha R, Sen I, Steinmetz Michel O, Surrey T
  NATURE CELL BIOLOGY 16, 804 (2014).
  DOI: 10.1038/ncb2999
• Reconstitution of a hierarchical plus TIP interaction network controlling microtubule end tracking of dynein Duellberg Christian, Trokter Martina, Jha Rupam, Sen Indrani, Steinmetz Michel O, Surrey Thomas
  NATURE CELL BIOLOGY 16, 804-U314 (2014).
  DOI: 10.1038/ncb2999
• Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A Prota Andrea E, Bargsten Katja, Northcote Peter T, Marsh May, Altmann Karl-Heinz, Miller John H, Fernando Diaz Jose, Steinmetz Michel O
  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53, 1621-1625 (2014).
  DOI: 10.1002/anie.201307749
• Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A Benoit Roger M, Frey Daniel, Hilbert Manuel, Kevenaar Josta T, Wieser Mara M, Stirnimann Christian U, McMillan David, Ceska Tom, Lebon Florence, Jaussi Rolf, Steinmetz Michel O, Schertler Gebhard F X, Hoogenraad Casper C, Capitani Guido, Kammerer Richard A
  NATURE 505, 108-+ (2014).
  DOI: 10.1038/nature12732
• The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization Prota Andrea E, Danel Franck, Bachmann Felix, Bargsten Katja, Buey Ruben M, Pohlmann Jens, Reinelt Stefan, Lane Heidi, Steinmetz Michel O
  JOURNAL OF MOLECULAR BIOLOGY 426, 1848-1860 (2014).
  DOI: 10.1016/j.jmb.2014.02.005

• Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry Hilbert M, Erat MC, Hachet V, Guichard P, Blank ID, Fluckiger I, Slater L, Lowe ED, Hatzopoulos GN, Steinmetz MO, Gonczy P, Vakonakis I
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, 11373 (2013).
  DOI: 10.1073/pnas.1302721110
• End Binding Proteins Are Obligatory Dimers Wiche G, Sen I, Veprintsev D, Akhmanova A, Steinmetz Michel O
  PLOS ONE 8, e74448 (2013).
  DOI: 10.1371/journal.pone.0074448
• End-binding proteins sensitize microtubules to the action of microtubule-targeting agents Mohan Renu, Katrukha Eugene A, Doodhi Harinath, Smal Ihor, Meijering Erik, Kapitein Lukas C, Steinmetz Michel O, Akhmanova Anna
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, 8900-8905 (2013).
  DOI: 10.1073/pnas.1300395110
• Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents Prota Andrea E, Bargsten Katja, Zurwerra Didier, Field Jessica J, Fernando Diaz Jose, Altmann Karl-Heinz, Steinmetz Michel O
  SCIENCE 339, 587-590 (2013).
  DOI: 10.1126/science.1230582
• Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry Guichard P, Hachet V, Majubu N, Neves A, Demurtas D, Olieric N, Fluckiger I, Yamada A, Kihara K, Nishida Y, Moriya S, Steinmetz Michel O, Hongoh Y, Gönczy P
  CURRENT BIOLOGY 23, 1620 (2013).
  DOI: 10.1016/j.cub.2013.06.061
• Structural Basis for Universal Corrinoid Recognition by the Cobalamin Transport Protein Haptocorrin Furger E, Frei DC, Schibli R, Fischer E, Prota AE
  JOURNAL OF BIOLOGICAL CHEMISTRY 288, 25466 (2013).
• Structural Basis for the Oligomerization-State Switch from a Dimer to a Trimer of an Engineered Cortexillin-1 Coiled-Coil Variant Bjelic Sasa, Wieser Mara, Frey Daniel, Stirnimann Christian U, Chance Mark R, Jaussi Rolf, Steinmetz Michel O, Kammerer Richard A
  PLOS ONE 8, e63370 (2013).
  DOI: 10.1371/journal.pone.0063370
• Structural basis of tubulin tyrosination by tubulin tyrosine ligase Prota Andrea E, Magiera Maria M, Kuijpers Marijn, Bargsten Katja, Frey Daniel, Wieser Mara, Jaussi Rolf, Hoogenraad Casper C, Kammerer Richard A, Janke Carsten, Steinmetz Michel O
  JOURNAL OF CELL BIOLOGY 200, 259-270 (2013).
  DOI: 10.1083/jcb.201211017

• A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins Jiang K, Toedt G, Montenegro Gouveia S, Davey Norman E, Hua S, van der Vaart B, Grigoriev I, Larsen J, Pedersen Lotte B, Bezstarosti K, Lince-Faria M, Demmers J, Steinmetz Michel O, Gibson Toby J, Akhmanova A
  CURRENT BIOLOGY 22, 1800 (2012).
  DOI: 10.1016/j.cub.2012.07.047
• Cooperative Stabilization of Microtubule Dynamics by EB1 and CLIP-170 Involves Displacement of Stably Bound P i at Microtubule Ends Lopus M, Manatschal C, Buey Ruben M, Bjelic S, Miller Herbert P, Steinmetz Michel O, Wilson L
  BIOCHEMISTRY 51, 3021 (2012).
  DOI: 10.1021/bi300038t
• Influence of 63Ser Phosphorylation and Dephosphorylation on the Structure of the Stathmin Helical Nucleation Sequence: A Molecular Dynamics Study Missimer John H, Steinmetz Michel O, van Gunsteren Wilfred F, Dolenc Jozica
  BIOCHEMISTRY 51, 8455-8463 (2012).
  DOI: 10.1021/bi300885y
• Probing the Structure and Dynamics of Proteins by Combining Molecular Dynamics Simulations and Experimental NMR Data Allison Jane R, Hertig S, Missimer John H, Smith Lorna J, Steinmetz Michel O, Dolenc J
  JOURNAL OF CHEMICAL THEORY AND COMPUTATION 8, 3430 (2012).
  DOI: 10.1021/ct300393b
• Sequence Determinants of a Microtubule Tip Localization Signal (MtLS) Buey RM, Sen I, Kortt O, Mohan R, Gfeller D, Veprintsev D, Kretzschmar I, Scheuermann J, Neri D, Zoete V, Michielin O, de Pereda JM, Akhmanova A, Volkmer R, Steinmetz MO
  JOURNAL OF BIOLOGICAL CHEMISTRY 287, 28227 (2012).
  DOI: 10.1074/jbc.M112.373928
• Tyrosine-dependent capture of CAP-Gly domain-containing proteins in complex mixture by EB1 C-terminal peptidic probes Calligaris D, Manatschal C, Marcellin M, Villard C, Monsarrat B, Burlet-Schiltz O, Steinmetz Michel O, Braguer D, Lafitte D, Verdier-Pinard P
  Journal of Proteomics 75, 3605 (2012).
  DOI: 10.1016/j.jprot.2012.04.006

• ELM--the database of eukaryotic linear motifs Dinkel H, Michael S, Weatheritt RJ, Davey NE, Van Roey K, Altenberg B, Toedt G, Uyar B, Seiler M, Budd A, Jodicke L, Dammert MA, Schroeter C, Hammer M, Schmidt T, Jehl P, McGuigan C, Dymecka M, Chica C, Luck K, Via A, Chatr-aryamontri A, Haslam N, Grebnev G, Edwards RJ, Steinmetz MO, Meiselbach H, Diella F, Gibson TJ
  NUCLEIC ACIDS RESEARCH 40, D242 (2011).
  DOI: 10.1093/nar/gkr1064
• Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice Buey RM, Mohan R, Leslie K, Walzthoeni T, Missimer JH, Menzel A, Bjelic S, Bargsten K, Grigoriev I, Smal I, Meijering E, Aebersold R, Akhmanova A, Steinmetz MO
  MOLECULAR BIOLOGY OF THE CELL 22, 2912 (2011).
  DOI: 10.1091/mbc.E11-01-0017

• Automated seamless DNA co-transformation cloning with direct expression vectors applying positive or negative insert selection Olieric N, Kuchen M, Wagen S, Sauter M, Crone S, Edmondson S, Frey D, Ostermeier C, Steinmetz M, Jaussi R
  BMC BIOTECHNOLOGY 10, 56 (2010).
  DOI: 10.1186/1472-6750-10-56
• Drosophila Stathmins Bind Tubulin Heterodimers with High and Variable Stoichiometries Lachkar S, Lebois M, Steinmetz MO, Guichet A, Lal N, Curmi PA, Sobel A, Ozon S
  JOURNAL OF BIOLOGICAL CHEMISTRY 285, 11667 (2010).
  DOI: 10.1074/jbc.M109.096727
• In Vitro Reconstitution of the Functional Interplay between MCAK and EB3 at Microtubule Plus Ends Gouveia SM, Leslie K, Kapitein LC, Buey RM, Grigoriev I, Wagenbach M, Smal I, Meijering E, Hoogenraad CC, Wordeman L, Steinmetz MO, Akhmanova A
  CURRENT BIOLOGY 20, 1717 (2010).
  DOI: 10.1016/j.cub.2010.08.020
• Methods of NMR structure refinement: molecular dynamics simulations improve the agreement with measured NMR data of a C-terminal peptide of GCN4-p1 Dolenc J, Missimer John H, Steinmetz Michel O, van Gunsteren Wilfred F
  JOURNAL OF BIOMOLECULAR NMR 47, 221 (2010).
  DOI: 10.1007/s10858-010-9425-9
• Molecular Insights into Mammalian End-binding Protein Heterodimerization De Groot CO, Jelesarov I, Damberger FF, Bjelic S, Scharer MA, Bhavesh NS, Grigoriev I, Buey RM, Wuthrich K, Capitani G, Akhmanova A, Steinmetz MO
  JOURNAL OF BIOLOGICAL CHEMISTRY 285, 5802 (2010).
  DOI: 10.1074/jbc.M109.068130

• An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal Honnappa S, Gouveia SM, Weisbrich A, Damberger FF, Bhavesh NS, Jawhari H, Grigoriev I, van Rijssel FJA, Buey RM, Lawera A, Jelesarov I, Winkler FK, Wuthrich K, Akhmanova A, Steinmetz MO
  CELL 138, 366 (2009).
  DOI: 10.1016/j.cell.2009.04.065
• Automated unrestricted multigene recombineering for multiprotein complex production Bieniossek C, Nie Y, Frey D, Olieric N, Schaffitzel C, Collinson I, Romier C, Berger P, Richmond T, Steinmetz M, Berger I
  NATURE METHODS 6, 447 (2009).
  DOI: 10.1038/nmeth.1326
• Mammalian end binding proteins control persistent microtubule growth Komarova Y, De Groot CO, Grigoriev I, Gouveia SM, Munteanu EL, Schober JM, Honnappa S, Buey RM, Hoogenraad CC, Dogterom M, Borisy GG, Steinmetz MO, Akhmanova A
  JOURNAL OF CELL BIOLOGY 184, 691 (2009).
  DOI: 10.1083/jcb.200807179
• Mutational studies of Pa-AGOG DNA glycosylase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum Lingaraju Gondichatnahalli M, Prota AE, Winkler FK
  DNA REPAIR 8, 857 (2009).
  DOI: 10.1016/j.dnarep.2009.03.009
• Solid-State NMR Spectroscopy Reveals that E. coli Inclusion Bodies of HET-s(218 - 289) are Amyloids Wasmer C, Benkemoun L, Sabaté R, Steinmetz Michel O, Coulary-Salin B, Wang L, Riek R, Saupe Sven J, Meier Beat H
  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48, 4858 (2009).
  DOI: 10.1002/anie.200806100
• The second level trigger system of FAST Martinez G, Barcyzk A, Berdugo J, Casaus J, Casella C, De Laere S, Deiters K, Dick P, Kirkby J, Malgeri L, Mana C, Marin J, Pohl M, Petitjean C, Sanchez E, Willmott C
  NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 609, 235 (2009).
  DOI: 10.1016/j.nima.2009.07.097

• Capturing protein tails by CAP-Gly domains Steinmetz Michel O, Akhmanova A
  TRENDS IN BIOCHEMICAL SCIENCES 33, 535 (2008).
  DOI: 10.1016/j.tibs.2008.08.006
• Exploring the Conserved Water Site and Hydration of a Coiled-Coil Trimerisation Motif: A MD Simulation Study Dolenc J, Baron R, Missimer John H, Steinmetz Michel O, van Gunsteren Wilfred F
  CHEMBIOCHEM 9, 1749 (2008).
  DOI: 10.1002/cbic.200800096
• High-level Expression and Purification of a Designed Angiopoietin-1 Chimeric Protein, COMP-Ang1, Produced in Chinese Hamster Ovary Cells Hwang S, Kim S, Kim H, Steinmetz Michel O, Koh G, Lee G
  THE PROTEIN JOURNAL 27, 319 (2008).
  DOI: 10.1007/s10930-008-9140-5
• Polymorphism in an Amyloid-Like Fibril-Forming Model Peptide Verel R, Tomka Ivan T, Bertozzi C, Cadalbert R, Kammerer Richard A, Steinmetz MO, Meier Beat H
  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 47, 5842 (2008).
  DOI: 10.1002/anie.200800021
• Suppression of Microtubule Dynamic Instability by the +TIP Protein EB1 and Its Modulation by the CAP-Gly Domain of p150 Glued ? Manna T, Honnappa S, Steinmetz Michel O, Wilson L
  BIOCHEMISTRY 47, 779 (2008).
  DOI: 10.1021/bi701912g
• Suppression of microtubule dynamic instability by the plus TIP protein EB1 and its modulation by the CAP-Gly domain of p150(Glued) Manna Tapas, Honnappa Srinivas, Steinmetz Michel O, Wilson Leslie
  BIOCHEMISTRY 47, 779-786 (2008).
  DOI: 10.1021/bi701912g
• Tracking the ends: a dynamic protein network controls the fate of microtubule tips Akhmanova A, Steinmetz Michel O
  NATURE REVIEWS MOLECULAR CELL BIOLOGY 9, 309 (2008).
  DOI: 10.1038/nrm2369

• Configurational entropy elucidates the role of salt-bridge networks in protein thermostability Missimer JH, Steinmetz MO, Baron R, Winkler FK, Kammerer Richard A, Daura X, van Gunsteren Wilfred F
  PROTEIN SCIENCE 16, 1349 (2007).
  DOI: 10.1110/ps.062542907
• Molecular basis of coiled-coil formation Steinmetz MO, Jelesarov I, Matousek WM, Honnappa S, Jahnke W, Missimer JH, Frank S, Alexandrescu AT, Kammerer RA
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104, 7062 (2007).
  DOI: 10.1073/pnas.0700321104
• Motor Neuron Disease-Associated Mutant Vesicle-Associated Membrane Protein-Associated Protein (VAP) B Recruits Wild-Type VAPs into Endoplasmic Reticulum-Derived Tubular Aggregates Teuling E, Ahmed S, Haasdijk E, Demmers J, Steinmetz MO, Akhmanova A, Jaarsma D, Hoogenraad CC
  JOURNAL OF NEUROSCIENCE 27, 9801 (2007).
  DOI: 10.1523/jneurosci.2661-07.2007
• Production of in vitro amplified DNA pseudolibraries and high-throughput cDNA target amplification Frey D, Kambach C, Steinmetz M, Jaussi R
  BMC BIOTECHNOLOGY 7, 31 (2007).
  DOI: 10.1186/1472-6750-7-31
• Structure and thermodynamics of the tubulin?stathmin interaction Steinmetz Michel O
  JOURNAL OF STRUCTURAL BIOLOGY 158, 137 (2007).
  DOI: 10.1016/j.jsb.2006.07.018
• The Caenorhabditis elegans septin complex is nonpolar John C, Hite R, Weirich C, Fitzgerald D, Jawhari H, Faty M, Schläpfer D, Kroschewski R, Winkler F, Walz T, Barral Y, Steinmetz M
  The EMBO Journal 26, 3296 (2007).
  DOI: 10.1038/sj.emboj.7601775

• 13C, 15N Resonance Assignment of Parts of the HET-s Prion Protein in its Amyloid Form Siemer Ansgar B, Ritter C, Steinmetz Michel O, Ernst M, Riek R, Meier Beat H
  JOURNAL OF BIOMOLECULAR NMR 34, 75 (2006).
  DOI: 10.1007/s10858-005-5582-7
• C-13, N-15 resonance assignment of parts of the HET-s prion protein in its amyloid form Siemer AB, Ritter C, Steinmetz MO, Ernst M, Riek R, Meier BH
  JOURNAL OF BIOMOLECULAR NMR 34, 75-87 (2006).
  DOI: 10.1007/s10858-005-5582-7
• Control of Intrinsically Disordered Stathmin by Multisite Phosphorylation Honnappa S, Jahnke W, Seelig J, Steinmetz MO
  JOURNAL OF BIOLOGICAL CHEMISTRY 281, 16078 (2006).
  DOI: 10.1074/jbc.M513524200
• De novo design of a two-stranded coiled-coil switch peptide Kammerer Richard A, Steinmetz MO
  JOURNAL OF STRUCTURAL BIOLOGY 155, 146 (2006).
  DOI: 10.1016/j.jsb.2006.01.017
• Structure of the Extracellular Domain of Tie Receptor Tyrosine Kinases and Localization of the Angiopoietin-binding Epitope Macdonald PR, Progias P, Ciani B, Patel S, Mayer U, Steinmetz MO, Kammerer RA
  JOURNAL OF BIOLOGICAL CHEMISTRY 281, 28408 (2006).
  DOI: 10.1074/jbc.M605219200

• A conserved trimerization motif controls the topology of short coiled coils Kammerer RA, Kostrewa D, Progias P, Honnappa S, Avila D, Lustig A, Winkler FK, Pieters J, Steinmetz MO
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102, 13891-13896 (2005).
  DOI: 10.1073/pnas.0502390102
• Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules Gatfield J, Albrecht I, Zanolari B, Steinmetz MO, Pieters J
  MOLECULAR BIOLOGY OF THE CELL 16, 2786-2798 (2005).
• Design of a coiled-coil-based model peptide system to explore the fundamentals of amyloid fibril formation Steinmetz MO, Garcia-Echeverria C, Kammerer RA
  International Journal of Peptide Research and Therapeutics 11, 43-52 (2005).
  DOI: 10.1007/s10989-004-1720-4
• Molecular-dynamics simulations of C- and N-terminal peptide derivatives of GCN4-p1 in aqueous solution Missimer JH, Steinmetz MO, Jahnke W, Winkler FK, van Gunsteren WF, Daura X
  Chemistry & Biodiversity 2, 1086-1104 (2005).
• Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2 Kim KT, Choi HH, Steinmetz MO, Maco B, Kammerer RA, Ahn SY, Kim HZ, Lee GM, Koh GY
  JOURNAL OF BIOLOGICAL CHEMISTRY 280, 20126-20131 (2005).
  DOI: 10.1074/jbc.M500292200
• Structural and functional analysis of coronin 1 Albrecht I, Gatfield J, Zanolari B, Steinmetz MO, Pieters J
  FEBS JOURNAL 272, 320-321 (2005).
• Structural basis for the regulation of tubulin by vinblastine Gigant B, Wang CG, Ravelli RBG, Roussi F, Steinmetz MO, Curmi PA, Sobel A, Knossow M
  NATURE 435, 519-522 (2005).
  DOI: 10.1038/nature03566
• Structural insights into the EB1-APC interaction (vol 24, pg 261, 2005) Honnappa S, John CM, Kostrewa D, Winkler FK, Steinmetz MO
  EMBO JOURNAL 24, 872-872 (2005).
  DOI: 10.1038/sj.emboj.7600590

• A Molecular Dynamics Study of Reovirus Attachment Protein ?1 Reveals Conformational Changes in ?1 Structure Cavalli A, Prota AE, Stehle T, Dermody Terence S, Recanatini M, Folkers G, Scapozza L
  BIOPHYSICAL JOURNAL 86, 3423 (2004).
  DOI: 10.1529/biophysj.103.030825
• COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity Cho CH, Kammerer RA, Lee HJ, Steinmetz MO, Ryu YS, Lee SH, Yasunaga K, Kim KT, Kim I, Choi HH, Kim W, Kim SH, Park SK, Lee GM, Koh GY
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101, 5547-5552 (2004).
  DOI: 10.1073/pnas.0307574101
• Exploring amyloid formation by a de novo design Kammerer RA, Kostrewa D, Zurdo J, Detken A, Garcia-Echeverria C, Green JD, Muller SA, Meier BH, Winkler FK, Dobson CM, Steinmetz MO
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101, 4435-4440 (2004).
  DOI: 10.1073/pnas.0306786101

• Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, Aurrand-Lions M, Imhof BA, Dermody TS, Stehle T
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100, 5366 (2003).
  DOI: 10.1073/pnas.0937718100
• Thermodynamics of the Op18/stathmin-tubulin interaction Honnappa S, Cutting B, Jahnke W, Seelig J, Steinmetz MO
  JOURNAL OF BIOLOGICAL CHEMISTRY 278, 38926-38934 (2003).
  DOI: 10.1074/jbc.M305546200

• The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding Prota AE, Sage DR, Stehle T, Fingeroth JD
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99, 10641 (2002).
  DOI: 10.1073/pnas.162360499

Bargsten, Katja
Technician

Bianchi, Sarah
Ph.D. student

Bjelic, Sasa
Postdoc

Brunner, Janine

Postdoc

Bortfeld, Miriam
Technician

De Groot, Christian
Ph.D. student

Hilbert, Manuel
Postdoc

Honnappa, Srinivas
Ph.D. student, Postdoc

Jawhari, Hatim
Postdoc

John, Corinne
Ph.D. student

Kambach, Christian
Senior scientist

Kraatz, Sebastian
Ph.D. student

Kumar, Anil

Postdoc

Manatschal, Cristina
Ph.D. student

Martinez, Ruben
Postdoc

Menchon, Grégory
Postdoc

Rezabkova, Lenka
Postdoc

Sejwal, Kushal

Postdoc

Sen, Indrani
Ph.D. student

Stangier, Marcel

Ph.D student

Steiner-Degen, Miriam
Postdoc

Vakonakis, John
Postdoc

Weisbrich, Anke

Ph.D student