Dr. Marco Ranocchiari

Syncat Group Leader

Paul Scherrer Institute
Forschungsstrasse 111
5232 Villigen PSI
Switzerland

Research Bio

As the group leader of the Syncat group, I am actively working on the synthesis of single-site heterogeneous catalysts based on metal-organic frameworks (MOFs) defined at the molecular level. Their application in selective catalytic transformation such as asymmetric hydrogenation, olefin metathesis, olefin hydroformylation, and stereoselective organocatalysis is being explored. A full use of various characterization techniques - such as infra-red, UV-Visible, X-ray photoelectron emission, X-ray Absorption, and NMR spectroscopies as well as X-ray diffraction techniques and electron microscopy to understand structure-performance relations – is employed. Several studies aimed at proving that MOFs are unique heterogeneous molecular catalysts are conducted showing that one can tune active sites and the environment around them at the atomic level to get unique selectivity in catalytic reactions. I am also heavily involved in the low-temperature gas-phase direct oxidation of methane to methanol mediated by copper zeolites and published several publications on the topic.

Curriculum Vitae

2019 - current Lecturer of the course "Industrial Chemistry" at ETH Zurich, Switzerland
2017 - current Co-founder and scientific advisor of novoMOF
2016 - current Group Leader at Energy and Environment Division - Paul Scherrer Institute, Switzerland
2012 - 2018 Lecturer of the course "Catalysis" at ETH Zurich, Switzerland
2013 - 2015 Scientist in Department for Synchrotron Radiation and Nanotechnology, Paul Scherrer Institute, Switzerland
2010 - 2013 Postdoc in the van Bokhoven Group, Paul Scherrer Institute, Switzerland
2005 - 2009 Ph.D., ETH Zürich, Switzerland
2000 - 2005 B.Sc. and M.Sc., Università degli Studi di Milano, Italy

Publications

Tomkins, P., Mansouri, A., Sushkevich, V. L., van der Wal, L. I., Bozbag, S. E., Krumeich, F., Ranocchiari, M., & van Bokhoven, J. A. (2019). Increasing the activity of copper exchanged mordenite in the direct isothermal conversion of methane to methanol by Pt and Pd doping. Chemical Science, 10(1), 167-171. http://dx.doi.org/10.1039/c8sc02795a

Sushkevich, V. L., Palagin, D., Ranocchiari, M., & van Bokhoven, J. A. (2018). Response to Comment on "Selective anaerobic oxidation of methane enables direct synthesis of methanol". Science, 359(6377). http://dx.doi.org/10.1126/science.aar6868

Bozbag, S. E., Sot, P., Nachtegaal, M., Ranocchiari, M., van Bolchoven, J. A., & Mesters, C. (2018). Direct Stepwise Oxidation of Methane to Methanol over Cu-SiO2. Acs Catalysis, 8(7), 5721-5731. http://dx.doi.org/10.1021/acscatal.8b01021

Vilhanova, B., van Bokhoven, J. A., & Ranocchiari, M. (2017). Gold Particles Supported on Amino-Functionalized Silica Catalyze Transfer Hydrogenation of N-Heterocyclic Compounds. Adv Synth Catal, 359(4), 677-686. http://dx.doi.org/10.1002/adsc.201601147

Vilhanova, B., Vaclavik, J., Artiglia, L., Ranocchiari, M., Togni, A., & van Bokhoven, J. A. (2017). Subnanometer Gold Clusters on Amino-Functionalized Silica: An Efficient Catalyst for the Synthesis of 1,3-Diynes by Oxidative Alkyne Coupling. Acs Catalysis, 7(5), 3414-3418. http://dx.doi.org/10.1021/acscatal.7b00691

Tomkins, P., Ranocchiari, M., & van Bokhoven, J. A. (2017). Direct Conversion of Methane to Methanol under Mild Conditions over Cu-Zeolites and beyond. Acc. Chem. Res., 50(2), 418-425. http://dx.doi.org/10.1021/acs.accounts.6b00534

Taddei, M., Tiana, D., Casati, N., van Bokhoven, J. A., Smit, B., & Ranocchiari, M. (2017). Mixed-linker UiO-66: structure-property relationships revealed by a combination of high-resolution powder X-ray diffraction and density functional theory calculations. Phys Chem Chem Phys, 19(2), 1551-1559. http://dx.doi.org/10.1039/c6cp07801j

Taddei, M., Casati, N., Steitz, D. A., Dumbgen, K. C., van Bokhoven, J. A., & Ranocchiari, M. (2017). In situ high-resolution powder X-ray diffraction study of UiO-66 under synthesis conditions in a continuous-flow microwave reactor. Crystengcomm, 19(23), 3206-3214. http://dx.doi.org/10.1039/c7ce00867h

Sushkevich, V. L., Palagin, D., Ranocchiari, M., & van Bokhoven, J. A. (2017). Selective anaerobic oxidation of methane enables direct synthesis of methanol. Science, 356(6337), 523-+. http://dx.doi.org/10.1126/science.aam9035

Sushkevich, V. L., Palagin, D., Ranocchiari, M., & van Bokhoven, J. A. (2017). Response to Comment on "Selective anaerobic oxidation of methane enables direct synthesis of methanol". Science, 358(6360). http://dx.doi.org/10.1126/science.aan6083

Ravi, M., Ranocchiari, M., & van Bokhoven, J. A. (2017). The Direct Catalytic Oxidation of Methane to Methanol-A Critical Assessment. Angew Chem Int Edit, 56(52), 16464-16483. http://dx.doi.org/10.1002/anie.201702550

Park, M. B., Ahn, S. H., Mansouri, A., Ranocchiari, M., & van Bokhoven, J. A. (2017). Comparative Study of Diverse Copper Zeolites for the Conversion of Methane into Methanol. Chemcatchem, 9(19), 3705-3713. http://dx.doi.org/10.1002/cctc.201700768

Palagin, D., Knorpp, A. J., Pinar, A. B., Ranocchiari, M., & van Bokhoven, J. A. (2017). Assessing the relative stability of copper oxide clusters as active sites of a CuMOR zeolite for methane to methanol conversion: size matters? Nanoscale, 9(3), 1144-1153. http://dx.doi.org/10.1039/c6nr07723d

Palagin, D., Knorpp, A., Pinar, A., Ranocchiari, M., & van Bokhoven, J. (2017). Copper oxide clusters as active catalytic sites of CuMOR zeolite for methane to methanol conversion: Size matters? Abstr Pap Am Chem S, 253. 

Carraro, F., Chapman, K., Chen, Z. J., Dinca, M., Easun, T., Eddaoudi, M., Farha, O., Forgan, R., Gagliardi, L., Haase, F., Harris, D., Kitagawa, S., Knichal, J., Lamberti, C., Lee, J. S. M., Leus, K., Li, J., Lin, W. B., Lloyd, G., Long, J. R., Lu, C., Ma, S. Q., McHugh, L., Perez, J. P. H., Ranocchiari, M., Rosi, N., Rosseinsky, M., Ryder, M. R., Ting, V., van der Veen, M., Van Der Voort, P., Volkmer, D., Walsh, A., Woods, D., & Yaghi, O. M. (2017). Catalysis in MOFs: general discussion. Faraday Discuss, 201, 369-370. http://dx.doi.org/10.1039/c7fd90046e

Bauer, G., Ongari, D., Xu, X. Y., Tiana, D., Smit, B., & Ranocchiari, M. (2017). Metal-Organic Frameworks Invert Molecular Reactivity: Lewis Acidic Phosphonium Zwitterions Catalyze the Aldol-Tishchenko Reaction. Journal of the American Chemical Society, 139(50), 18166-18169. http://dx.doi.org/10.1021/jacs.7b10928

Banerjee, T., Bennett, T., Butler, K., Easun, T. L., Eddaoudi, M., Forgan, R., Gagliardi, L., Hendon, C., Jorge, M., Lamberti, C., Lee, J. S. M., Leus, K., Li, J., Lin, W. B., Ranocchiari, M., Rosi, N., Santaclara, J. G., Shevlin, S., Svane, K., Ting, V., van der Veen, M., Van der Voort, P., Walsh, A., Woods, D., Yaghi, O. M., & Zhu, G. S. (2017). Electronic, magnetic and photophysical properties of MOFs and COFs: general discussion. Faraday Discuss, 201, 87-99. http://dx.doi.org/10.1039/c7fd90043k

Addicoat, M., Butler, K., Farha, O., Gagliardi, L., Farmahini, A. H., Hendon, C., Jorge, M., Kitagawa, S., Lamberti, C., Lee, J. S. M., Li, J., Liu, X. W., Moggach, S., Ranocchiari, M., Sarkisov, L., Shevlin, S., Stassen, I., Svane, K., Volkmer, D., Walsh, A., Wilmer, C., & Yaghi, O. M. (2017). MOFs modeling and theory: general discussion. Faraday Discuss, 201, 233-245. http://dx.doi.org/10.1039/c7fd90045g

Addicoat, M., Bennett, T., Chapman, K., Denysenko, D., Dinca, M., Doan, H., Easun, T., Eddaoudi, M., Farha, O., Gagliardi, L., Haase, F., Farmahini, A. H., Hendon, C., Jorge, M., Kitagawa, S., Lamberti, C., Lee, J. S. M., Leus, K., Li, J., Lin, W. B., Liu, X. W., Lloyd, G., Lu, C., Ma, S. Q., Perez, J. P. H., Ranocchiari, M., Rosi, N., Stassen, I., Ting, V., van der Veen, M., Van Der Voort, P., Vande Velde, C. M. L., Volkmer, D., Vornholt, S., Walsh, A., & Yaghi, O. M. (2017). New directions in gas sorption and separation with MOFs: general discussion. Faraday Discuss, 201, 175-194. http://dx.doi.org/10.1039/c7fd90044a

Vilhanova, B., Ranocchiari, M., & van Bokhoven, J. A. (2016). Enantioselective Hydrogenation of Olefins Enhanced by Metal-Organic Framework Additives. Chemcatchem, 8(2), 308-312. http://dx.doi.org/10.1002/cctc.201500907

Tomkins, P., Mansouri, A., Bozbag, S. E., Krumeich, F., Park, M. B., Alayon, E. M. C., Ranocchiari, M., & van Bokhoven, J. A. (2016). Isothermal Cyclic Conversion of Methane into Methanol over Copper-Exchanged Zeolite at Low Temperature. Angew Chem Int Edit, 55(18), 5467-5471. http://dx.doi.org/10.1002/anie.201511065

Todaro, M., Buscarino, G., Sciortino, L., Alessi, A., Messina, F., Taddei, M., Ranocchiari, M., Cannas, M., & Gelardi, F. M. (2016). Decomposition Process of Carboxylate MOF HKUST-1 Unveiled at the Atomic Scale Level. J Phys Chem C, 120(23), 12879-12889. http://dx.doi.org/10.1021/acs.jpcc.6b03237

Taddei, M., Steitz, D. A., van Bokhoven, J. A., & Ranocchiari, M. (2016). Continuous-Flow Microwave Synthesis of Metal-Organic Frameworks: A Highly Efficient Method for Large-Scale Production. Chem-Eur J, 22(10), 3245-3249. http://dx.doi.org/10.1002/chem.201505139

Taddei, M., Dumbgen, K. C., van Bokhoven, J. A., & Ranocchiari, M. (2016). Aging of the reaction mixture as a tool to modulate the crystallite size of UiO-66 into the low nanometer range. Chemical Communications, 52(38), 6411-6414. http://dx.doi.org/10.1039/c6cc02517j

Redondo, A. B., Ranocchiari, M., & van Bokhoven, J. A. (2016). Synthesis of sub-nanometer gold particles on modified silica. Dalton T, 45(7), 2983-2988. http://dx.doi.org/10.1039/c5dt04957a

Meyer, K., Bashir, S., Llorca, J., Idriss, H., Ranocchiari, M., & van Bokhoven, J. A. (2016). Photocatalyzed Hydrogen Evolution from Water by a Composite Catalyst of NH2-MIL-125(Ti) and Surface Nickel(II) Species. Chem-Eur J, 22(39), 13894-13899. http://dx.doi.org/10.1002/chem.201601988

Bozbag, S. E., Alayon, E. M. C., Pechacek, J., Nachtegaal, M., Ranocchiari, M., & van Bokhoven, J. A. (2016). Methane to methanol over copper mordenite: yield improvement through multiple cycles and different synthesis techniques. Catalysis Science & Technology, 6(13), 5011-5022. http://dx.doi.org/10.1039/c6cy00041j

Taddei, M., Dau, P. V., Cohen, S. M., Ranocchiari, M., van Bokhoven, J. A., Costantino, F., Sabatini, S., & Vivani, R. (2015). Efficient microwave assisted synthesis of metal-organic framework UiO-66: optimization and scale up. Dalton T, 44(31), 14019-14026. http://dx.doi.org/10.1039/c5dt01838b

Schutrumpf, A., Kirpi, E., Bulut, A., Morel, F. L., Ranocchiari, M., Lork, E., Zorlu, Y., Grabowsky, S., Yucesan, G., & Beckmann, J. (2015). Tetrahedral Tetraphosphonic Acids. New Building Blocks in Supramolecular Chemistry. Cryst Growth Des, 15(10), 4925-4931. http://dx.doi.org/10.1021/acs.cgd.5b00811

Redondo, A. B., Morel, F. L., Ranocchiari, M., & van Bokhoven, J. A. (2015). Functionalized Ruthenium-Phosphine Metal-Organic Framework for Continuous Vapor-Phase Dehydrogenation of Formic Acid. Acs Catalysis, 5(12), 7099-7103. http://dx.doi.org/10.1021/acscatal.5b01987

Ranocchiari, M., Xu, X. Y., Morel, F. L., Redondo, A. B., & Van Bokhoven, J. (2015). Phosphine netal-organic frameworks: Versatile materials for heterogeneous metal-and organocatalysis. Abstr Pap Am Chem S, 250. 

Morel, F. L., Xu, X. Y., Ranocchiari, M., & van Bokhoven, J. A. (2015). Functional Metal-Organic Frameworks: Synthesis and Reactivity. Chemistry of Organo-Hybrids: Synthesis and Characterization of Functional Nano-Objects, 200-232. 

Morel, F. L., Pin, S., Huthwelker, T., Ranocchiari, M., & van Bokhoven, J. A. (2015). Phosphine and phosphine oxide groups in metal-organic frameworks detected by P K-edge XAS. Phys Chem Chem Phys, 17(5), 3326-3331. http://dx.doi.org/10.1039/c4cp05151c

Meyer, K., Ranocchiari, M., & van Bokhoven, J. A. (2015). Metal organic frameworks for photo-catalytic water splitting. Energ Environ Sci, 8(7), 1923-1937. http://dx.doi.org/10.1039/c5ee00161g

Alayon, E. M. C., Nachtegaal, M., Bodi, A., Ranocchiari, M., & van Bokhoven, J. A. (2015). Bis(mu-oxo) versus mono(mu-oxo)dicopper cores in a zeolite for converting methane to methanol: an in situ XAS and DFT investigation. Phys Chem Chem Phys, 17(12), 7681-7693. http://dx.doi.org/10.1039/c4cp03226h

Xu, X. Y., van Bokhoven, J. A., & Ranocchiari, M. (2014). Tuning Regioisomer Reactivity in Catalysis using Bifunctional Metal-Organic Frameworks with Mixed Linkers. Chemcatchem, 6(7), 1887-1891. http://dx.doi.org/10.1002/cctc.201402164

Xu, X. Y., Rummelt, S. M., Morel, F. L., Ranocchiari, M., & van Bokhoven, J. A. (2014). Selective Catalytic Behavior of a Phosphine-Tagged Metal-Organic Framework Organocatalyst. Chem-Eur J, 20(47), 15467-15472. http://dx.doi.org/10.1002/chem.201404498

van Bokhoven, J. A., Alayon, E. M., Nachtegaal, M., Boedi, A., & Ranocchiari, M. (2014). Methane to methanol over Cu/mordenite, from active site to methanol. Abstr Pap Am Chem S, 247. 

Morel, F. L., Ranocchiari, M., & van Bokhoven, J. A. (2014). Synthesis and Characterization of Phosphine-Functionalized Metal-Organic Frameworks Based on MOF-5 and MIL-101 Topologies. Industrial & Engineering Chemistry Research, 53(22), 9120-9127. http://dx.doi.org/10.1021/ie403549v

Vaclavik, J., Servalli, M., Lothschutz, C., Szlachetko, J., Ranocchiari, M., & van Bokhoven, J. A. (2013). AuI Catalysis on a Coordination Polymer: A Solid Porous Ligand with Free Phosphine Sites. Chemcatchem, 5(3), 692-696. http://dx.doi.org/10.1002/cctc.201200844

Tuci, G., Rossin, A., Xu, X. Y., Ranocchiari, M., Bokhoven, J. A., Luconi, L., Manet, I., Melucci, M., & Giambastiani, G. (2013). "Click" on MOFs: A Versatile Tool for the Multimodal Derivatization of N-3-Decorated Metal Organic Frameworks. Chem Mater, 25(11), 2297-2308. http://dx.doi.org/10.1021/cm400899a

Sa, J., Szlachetko, J., Kleymenov, E., Lothschutz, C., Nachtegaal, M., Ranocchiari, M., Safonova, O. V., Servalli, M., Smolentsev, G., & van Bokhoven, J. A. (2013). Fine tuning of gold electronic structure by IRMOF post-synthetic modification. Rsc Adv, 3(30), 12043-12048. http://dx.doi.org/10.1039/c3ra40970h

Ranocchiari, M., & van Bokhoven, J. A. (2013). Synthesis and Reactivity of Zn-Biphenyl Metal-Organic Frameworks, Introducing a Diphenylphosphino Functional Group. Chimia, 67(6), 397-402. http://dx.doi.org/10.2533/chimia.2013.397

Egloff, J., Ranocchiari, M., Schira, A., Schotes, C., & Mezzetti, A. (2013). Highly Enantioselective Ruthenium/PNNP-Catalyzed Imine Aziridination: Evidence of Carbene Transfer from a Diazoester Complex. Organometallics, 32(16), 4690-4701. http://dx.doi.org/10.1021/om400735P

Servalli, M., Ranocchiari, M., & Van Bokhoven, J. A. (2012). Fast and high yield post-synthetic modification of metal-organic frameworks by vapor diffusion. Chemical Communications, 48(13), 1904-1906. http://dx.doi.org/10.1039/c2cc17461h

Rummelt, S. M., Ranocchiari, M., & van Bokhoven, J. A. (2012). Synthesis of Water-Soluble Phosphine Oxides by Pd/C-Catalyzed P-C Coupling in Water. Organic Letters, 14(8), 2188-2190. http://dx.doi.org/10.1021/ol300582y

Ranocchiari, M., Lothschutz, C., Grolimund, D., & van Bokhoven, J. A. (2012). Single-atom active sites on metal-organic frameworks. P Roy Soc a-Math Phy, 468(2143), 1985-1999. http://dx.doi.org/10.1098/rspa.2012.0078

Alayon, E. M. C., Nachtegaal, M., Ranocchiari, M., & van Bokhoven, J. A. (2012). Catalytic Conversion of Methane to Methanol Using Cu-Zeolites. Chimia, 66(9), 668-674. http://dx.doi.org/10.2533/chimia.2012.668

Alayon, E. M., Nachtegaal, M., Ranocchiari, M., & van Bokhoven, J. A. (2012). Catalytic conversion of methane to methanol over Cu-mordenite. Chemical Communications, 48(3), 404-406. http://dx.doi.org/10.1039/c1cc15840f

Schotes, C., Ranocchiari, M., & Mezzetti, A. (2011). Aqua and Diethyl Ether PNNP Complexes of Ruthenium(II): Structure and Solution Behavior. Organometallics, 30(13), 3596-3602. http://dx.doi.org/10.1021/om200289x

Ranocchiari, M., & van Bokhoven, J. A. (2011). Catalysis by metal-organic frameworks: fundamentals and opportunities. Phys Chem Chem Phys, 13(14), 6388-6396. http://dx.doi.org/10.1039/c0cp02394a

Carlucci, L., Ciani, G., Maggini, S., Proserpio, D. M., Ragaini, F., Gallo, E., Ranocchiari, M., & Caselli, A. (2010). Synthesis and characterization of new tetra-substituted porphyrins with exo-donor carboxylic groups as building blocks for supramolecular architectures. Catalytic and structural studies of their metalated derivatives. J Porphyr Phthalocya, 14(9), 804-814. http://dx.doi.org/10.1142/S1088424610002641

Ranocchiari, M., & Mezzetti, A. (2009). PNNP Macrocycles: A New Class of Ligands for Asymmetric Catalysis. Organometallics, 28(5), 1286-1288. http://dx.doi.org/10.1021/om900028w

Ranocchiari, M., & Mezzetti, A. (2009). Ru/PNNP-Catalyzed Asymmetric Imine Aziridination by Diazo Ester Activation. Organometallics, 28(13), 3611-3613. http://dx.doi.org/10.1021/om900415g