Lab News & Scientific Highlights
Nanobodies against SARS-CoV-2
In a study published in EMBO Journal, researchers at the Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, developed nanobodies that efficiently block the coronavirus SARS-CoV-2 and its variants. The high resolution structural characterization was performed at the X10SA crystallography beamline at the Swiss Light Source.
Imaging strain with high resolution
Imaging strain in crystalline materials with high resolution can be a challenging task. Researchers demonstrate an original use of X-ray ptychography for this purpose: ptychographic topography.
How ethane-consuming archaea pick up their favorite dish
Scientists decode the structure of the enzyme responsible for the ethane fixation by – beside others – using the SLS.
PSI: stetig voran im Kampf gegen Corona
Kristallstrukturanalyse, Computermodelle, Zellkulturen – um Sars-CoV-2 zu erforschen, beschreitet das PSI viele Wege. Ein Überblick.
Stoneflies: Youth influences adulthood
Evolutionary biologists at the University of Bonn scan 219 species in different particle accelerators, beside others the Swiss Light Source SLS.
Wie Katalysatoren altern
Katalysatoren, die in der Industrie eingesetzt werden, verändern über die Jahre ihre Materialstruktur. Mit einer neuen Methode haben PSI-Forschende dies nun auf der Nano-Skala untersucht.
Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
In a study published in Nature Communications, researchers at the NHC Key Laboratory of Systems Biology of Pathogens in Beijing, China, in collaboration with the Paul Scherrer Institut characterize the interactions of SARS-CoV-2 orf9b and human TOM70 biochemically, and they determine the 2.2 Å crystal structure of the TOM70 cytosolic domain with a bound SARS-CoV-2 orf9b peptide.
Quantifying oriented myelin in mouse and human brain
Myelin 'insulates' our neurons enabling fast signal transduction in our brain. Myelin levels, integrity, and neuron orientations are important determinants of brain development and disease. Small-angle X-ray scattering tensor tomography (SAXS-TT) is a promising technique for non-destructive, stain-free imaging of brain samples, enabling quantitative studies of myelination and neuron orientations, i.e. of nano-scale properties imaged over centimeter-sized samples.
Wie Remdesivir gegen das Coronavirus wirkt
Forschende der Goethe-Universität Frankfurt haben in Kooperation mit dem PSI vermutlich einen weiteren, bislang unbekannten Wirkmechanismus des Virostatikums Remdesivir entdeckt.