Laboratory of Nanoscale Biology (LNB)

The Laboratory of Nanoscale Biology (LNB) investigates the molecular structure and dynamics of complex molecular machines and cascades within the context of the living cell. Technological developments at the PSI provide novel approaches for studying fundamental, molecular processes of life within their physiological context. Electron diffraction and cryo-electron microscopy of bio-molecular complexes form the technological basis of the LNB, together with electron tomography and X-ray diffractive imaging of larger, nanoscopic structures. We develop these technologies in studies of fundamental, molecular aspects of neuro-degeneration and cell motility, and investigate other fundamental processes of life in collaboration. Intellectual property on novel technologies developed at the LNB may lead to commercial spin-outs. As per January 1st, 2021, the Mechano-Genomics Group of Prof. G.V. Shivashankar has been integrated into the Lab. of Nanoscale Biology. 

Nanodiffraction

Novel technologies for visualising the atomic structures within the cell.

Cellular Structure Imaging

Cryo-EM and electron/X-ray tomography of cellular structure

Structural Biology of Neuronal Systems

Molecular neurobiology of fundamental responses to protein misfolding

Mechano-Genomics

Investigating mesoscale functional links between cell mechanics, genome organization and gene expression during cellular ageing, rejuvenation and tissue homeostasis.

Electron Microscopy and Diffraction