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Dieser Inhalt ist nicht auf Deutsch verfügbar.Laboratory of Nanoscale Biology (LNB)
In presence of TNFa, translocation of p65 from the cytolsol to the nucleus is observed.
(Fluorescence microscopy of immuno-stained cells)
The Laboratory of Nanoscale Biology (LNB) investigates the molecular structure and dynamics of complex molecular machines and cascades in the context of the living cell. Current strengths of LNB include technology innovation and the uncovering of structure-function relationships in specific biological contexts. Using our distinct expertise, we engage in the development and improvement of novel methods for electron microscopy and diffraction. In addition, we have unique capabilities in protein bioengineering, (bio-)microfabrication and correlative imaging methods. LNB’s scientific strengths are to link structural information to functional contexts at length scales ranging from proteins to single cells to tissue. Typical examples include it situ studies on eukaryotic cilia proteins in their natural context, studies of protein aggregation or chromatin structure in the context of cell function as well as computation of connectome maps of the brain based on bio-imaging data to reveal new insights into brain function.
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LNB News and Scientific Highlights
Imaging biomarkers for Alzheimer’s disease
Artificial intelligence pinpoints cells indicative of Alzheimer’s disease based on DNA packing in mouse brain images, shows study in Nature Communications
Automated synapse-level reconstruction of neural circuits in the larval zebrafish brain
Researchers from the Max Planck Institute for Biological Intelligence, Google Inc. and the Paul Scherrer Institute published a new method and data resource that makes connectomic analyses of the entire larval zebrafish brain possible.
Paul Scherrer Institut und Apollo Health Ventures gründen Focal Biosciences
Das neu gegründete Unternehmen Focal Biosciences wird sich darauf konzentrieren, führende Experten und wissenschaftliche Entdeckungen zusammenzubringen, um die Umprogrammierung von Zellen für den Kampf gegen weit verbreitete altersbedingte Krankheiten nutzbar zu machen.