Molecular, Ultrastructural and Functional Profiles of Neuronal Circuits in the Healthy and Diseased Brain
Our research aims to reveal the molecular, ultrastructural and functional profiles of neuronal circuits that underlie neuronal computations and cognition in the healthy and diseased brain. We address these fundamental questions using a dynamical proteo-connectomics approach that combines behavioral experiments, in vivo multiphoton calcium imaging, ultra-highplex proteomics, X-ray and volume electron microscopy with dense neuronal circuit reconstruction, computational modeling and network analysis. We are developing novel electron and X-ray microscopy techniques for dense, multiscale imaging of neuronal circuits from individual synapses in local circuits to single cell resolution projection patterns.
Our research is generously supported by
- a SERI-funded ERC Starting Grant
- the Swiss National Science Foundation
- the NIH BRAIN CONNECTS program
- a Young Investigator Grant from the Helmut Horten Foundation
- the SNI PhD School
- the PSI Fellow Program
Group Members
I completed my PhD at Delft University of Technology, the Netherlands. At PSI I am working on the implementation of a workflow for large-scale connectomics using a combination of broad-ion beam milling and multibeam scanning electron microscopy.
