Using light to switch drugs on and off
PSI researchers record a molecular film of a cancer drug fitted with a photoswitch. This opens new insights for drug developers.
A new spin on sample delivery for membrane proteins
Proteins hover in front of the X-ray beam at a Swiss Light Source beamline. Now, spinning thin films bring on board these trickiest of proteins.
How to get chloride ions into the cell
A molecular movie shot at PSI reveals the mechanism of a light-driven chloride pump
New, better coronavirus rapid test
The test identifies different virus variants and improves disease prognosis.
Cell cytoskeleton as target for new active agents
Using a combination of computer simulations and laboratory experiments, PSI researchers have identified new binding sites for active agents on the vital protein tubulin.
PSI Thesis Medal 2021 for pioneering Structural Biology at SwissFEL
Dr. Petr Skopintsev received PSI Thesis Medal 2021 for his work on the sodium pump KR2.
Elucidating the mechanism of a light-driven sodium pump
Researchers at the Paul Scherrer Institute PSI have succeeded for the first time in recording a light-driven sodium pump from bacterial cells in action. The findings promise progress in developing new methods in neurobiology. The researchers used the new X-ray free-electron laser SwissFEL for their investigations.
Preventing tumour metastasis
Researchers at the Paul Scherrer Institute PSI, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step towards the development of an active substance against the metastasis of certain cancers. Using the Swiss Light Source SLS, they deciphered the structure of a receptor that plays a crucial role in the migration of cancer cells.
Molecular energy machine as a movie star
Using the Swiss Light Source SLS, PSI researchers have recorded a molecular energy machine in action and thus revealed how energy production at cell membranes works. For this purpose, they developed a new investigative method that could make the analysis of cellular processes significantly more effective than before.