Publications

Recent publications are listed below. For an extensive overview we kindly refer you to our publication repository DORA

  • Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, et al.
    Ultrafast structural changes direct the first molecular events of vision
    Nature. 2023; 615: 939-944. https://doi.org/10.1038/s41586-023-05863-6
    DORA PSI
  • Nguyen HTV, Chen X, Parada C, Luo A-C, Shih O, Jeng U-S, et al.
    Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome
    Nature Communications. 2023; 14(1): 1903 (13 pp.). https://doi.org/10.1038/s41467-023-37543-4
    DORA PSI
  • Owen RL, de Sanctis D, Pearson AR, Beale JH
    A standard descriptor for fixed-target serial crystallography
    Acta Crystallographica Section D: Structural Biology. 2023; 79(8): 668-672. https://doi.org/10.1107/S2059798323005429
    DORA PSI
  • Qin B, Li Z, Tang K, Wang T, Xie Y, Aumonier S, et al.
    Identification of the SARS-unique domain of SARS-CoV-2 as an antiviral target
    Nature Communications. 2023; 14(1): 3999 (13 pp.). https://doi.org/10.1038/s41467-023-39709-6
    DORA PSI
  • Smith KML, Panepucci E, Kaminski JW, Aumonier S, Huang C-Y, Eris D, et al.
    SDU - software for high-throughput automated data collection at the Swiss Light Source
    Journal of Synchrotron Radiation. 2023; 30: 538-545. https://doi.org/10.1107/S1600577523002631
    DORA PSI
  • Smithers L, Degtjarik O, Weichert D, Huang C-Y, Boland C, Bowen K, et al.
    Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N-acyltransferase
    Science Advances. 2023; 9(26): eadf5799 (17 pp.). https://doi.org/10.1126/sciadv.adf5799
    DORA PSI
  • Stegmann DP, Steuber J, Fritz G, Wojdyla JA, Sharpe ME
    Fast fragment and compound screening pipeline at the Swiss Light Source
    In: Methods in enzymology. sine loco: Elsevier; 2023. https://doi.org/10.1016/bs.mie.2023.08.005
    DORA PSI
  • Wranik M, Weinert T, Slavov C, Masini T, Furrer A, Gaillard N, et al.
    Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
    Nature Communications. 2023; 14(1): 903 (12 pp.). https://doi.org/10.1038/s41467-023-36481-5
    DORA PSI
  • Abiko LA, Dias Teixeira R, Engilberge S, Grahl A, Mühlethaler T, Sharpe T, et al.
    Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol
    Nature Chemistry. 2022; 14: 1133-1141. https://doi.org/10.1038/s41557-022-01009-9
    DORA PSI
  • Alsarraf HMAB, Ung KL, Johansen MD, Dimon J, Olieric V, Kremer L, et al.
    Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N‐acetyltransferase
    FEBS Letters. 2022; 596(12): 1516-1532. https://doi.org/10.1002/1873-3468.14360
    DORA PSI
  • Aumonier S, Engilberge S, Caramello N, von Stetten D, Gotthard G, Leonard GA, et al.
    Slow protein dynamics probed by time-resolved oscillation crystallography at room temperature
    IUCrJ. 2022; 9(6): 756-767. https://doi.org/10.1107/S2052252522009150
    DORA PSI
  • Bleuler-Martinez S, Varrot A, Olieric V, Schubert M, Vogt E, Fetz C, et al.
    Structure–function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity
    Glycobiology. 2022; 32(7): 600-615. https://doi.org/10.1093/glycob/cwac020
    DORA PSI
  • Cellini A, Shankar MK, Wahlgren WY, Nimmrich A, Furrer A, James D, et al.
    Structural basis of the radical pair state in photolyases and cryptochromes
    Chemical Communications. 2022; 58(31): 4889-4892. https://doi.org/10.1039/D2CC00376G
    DORA PSI
  • Collu G, Bierig T, Krebs A-S, Engilberge S, Varma N, Guixà-González R, et al.
    Chimeric single α-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology
    Structure. 2022; 30(1): 95-106. https://doi.org/10.1016/j.str.2021.09.002
    DORA PSI
  • Huang C-Y, Aumonier S, Engilberge S, Eris D, Smith KML, Leonarski F, et al.
    Probing ligand binding of endothiapepsin by 'temperature-resolved' macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 964-974. https://doi.org/10.1107/S205979832200612X
    DORA PSI
  • Kaminski JW, Vera L, Stegmann DP, Vering J, Eris D, Smith KML, et al.
    Fast fragment- and compound-screening pipeline at the Swiss Light Source
    Acta Crystallographica Section D: Structural Biology. 2022; 78: 328-336. https://doi.org/10.1107/S2059798322000705
    DORA PSI
  • Kepa MW, Tomizaki T, Sato Y, Ozerov D, Sekiguchi H, Yasuda N, et al.
    Acoustic levitation and rotation of thin films and their application for room temperature protein crystallography
    Scientific Reports. 2022; 12: 5349 (14 pp.). https://doi.org/10.1038/s41598-022-09167-z
    DORA PSI
  • Mertens V, Abi Saad MJ, Coudevylle N, Wälti MA, Finke A, Marsh M, et al.
    Elucidation of a nutlin-derivative-HDM2 complex structure at the interaction site by NMR molecular replacement: a straightforward derivation
    Journal of Magnetic Resonance Open. 2022; 10-11: 100032 (5 pp.). https://doi.org/10.1016/j.jmro.2022.100032
    DORA PSI
  • Moreno-Chicano T, Carey LM, Axford D, Beale JH, Doak RB, Duyvesteyn HME, et al.
    Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature
    IUCrJ. 2022; 9(5): 610-624. https://doi.org/10.1107/S2052252522006418
    DORA PSI
  • Mous S, Gotthard G, Ehrenberg D, Sen S, Weinert T, Johnson PJM, et al.
    Dynamics and mechanism of a light-driven chloride pump
    Science. 2022; 375(6583): 845-851. https://doi.org/10.1126/science.abj6663
    DORA PSI
  • Pedrini B, Finke AD, Marsh M, Luporini P, Vallesi A, Alimenti C
    Crystal structure of the pheromone Er-13 from the ciliate Euplotes raikovi, with implications for a protein-protein association model in pheromone/receptor interactions
    Journal of Structural Biology. 2022; 214(1): 107812 (10 pp.). https://doi.org/10.1016/j.jsb.2021.107812
    DORA PSI
  • Qiao Z, Kong Q, Tee WT, Lim ARQ, Teo MX, Olieric V, et al.
    Molecular basis of the key regulator WRINKLED1 in plant oil biosynthesis
    Science Advances. 2022; 8(34): eabq1211 (10 pp.). https://doi.org/10.1126/sciadv.abq1211
    DORA PSI
  • Wang H, Mörman C, Sternke-Hoffmann R, Huang CY, Prota A, Ma P, et al.
    Cu2+ ions modulate the interaction between α-synuclein and lipid membranes
    Journal of Inorganic Biochemistry. 2022; 236: 111945 (10 pp.). https://doi.org/10.1016/j.jinorgbio.2022.111945
    DORA PSI
  • Xu Q, Sun N, Xiao Q, Huang C-ying, Xu M, Zhang W, et al.
    The crystal structure of MreC provides insights into polymer formation
    FEBS Open Bio. 2022; 12(2): 340-348. https://doi.org/10.1002/2211-5463.13296
    DORA PSI
  • Ashton A, Augustin S, Babic A, Celcer T, Ebner SG, Egli S, et al.
    Conceptual design report on controls and science IT for the SLS 2.0 upgrade project
    Villigen PSI, Switzerland: Paul Scherrer Institut; 2021. PSI Bericht: 21-03.
    DORA PSI
  • Beale JH, Marsh ME
    Optimizing the growth of endothiapepsin crystals for serial crystallography experiments
    Journal of Visualized Experiments. 2021; 168: e61896 (30 pp.). https://doi.org/10.3791/61896
    DORA PSI
  • Braun H, Garvey T, Jörg M, Ashton A, Willmott P, Kobler R, et al.
    SLS 2.0 storage ring. Technical design report
    Villigen PSI, Switzerland: Paul Scherrer Institut; 2021. PSI Bericht: 21-02.
    DORA PSI
  • Butryn A, Simon PS, Aller P, Hinchliffe P, Massad RN, Leen G, et al.
    An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
    Nature Communications. 2021; 12(1): 4461 (7 pp.). https://doi.org/10.1038/s41467-021-24757-7
    DORA PSI
  • Cinquino M, Fieramosca A, Mastria R, Polimeno L, Moliterni A, Olieric V, et al.
    Managing growth and dimensionality of quasi 2D perovskite single-crystalline flakes for tunable excitons orientation
    Advanced Materials. 2021; 33(48): 2102326 (9 pp.). https://doi.org/10.1002/adma.202102326
    DORA PSI
  • Dhanabalan B, Biffi G, Moliterni A, Olieric V, Giannini C, Saleh G, et al.
    Engineering the optical emission and robustness of metal-halide layered perovskites through ligand accommodation
    Advanced Materials. 2021; 33(13): 2008004 (11 pp.). https://doi.org/10.1002/adma.202008004
    DORA PSI
  • Gao X, Zhu K, Qin B, Olieric V, Wang M, Cui S
    Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
    Nature Communications. 2021; 12(1): 2843 (9 pp.). https://doi.org/10.1038/s41467-021-23118-8
    DORA PSI
  • Gao X, Qin B, Chen P, Zhu K, Hou P, Wojdyla JA, et al.
    Crystal structure of SARS-CoV-2 papain-like protease
    Acta Pharmaceutica Sinica B. 2021; 11(1): 237-245. https://doi.org/10.1016/j.apsb.2020.08.014
    DORA PSI
  • Gao C, Stavenhagen K, Eckmair B, McKitrick TR, Mehta AY, Matsumoto Y, et al.
    Differential recognition of oligomannose isomers by glycan-binding proteins involved in innate and adaptive immunity
    Science Advances. 2021; 7(24): eabf6834 (12 pp.). https://doi.org/10.1126/sciadv.abf6834
    DORA PSI
  • Hahn CJ, Lemaire ON, Kahnt J, Engilberge S, Wegener G, Wagner T
    Crystal structure of a key enzyme for anaerobic ethane activation
    Science. 2021; 373(6550): 118-121. https://doi.org/10.1126/science.abg1765
    DORA PSI
  • Iorio A, Roche J, Engilberge S, Coquelle N, Girard E, Sterpone F, et al.
    Biochemical, structural and dynamical studies reveal strong differences in the thermal-dependent allosteric behavior of two extremophilic lactate dehydrogenases
    Journal of Structural Biology. 2021; 213(3): 107769 (11 pp.). https://doi.org/10.1016/j.jsb.2021.107769
    DORA PSI
  • Kepa MW, Tomizaki T, Tsujino S
    Development of on-demand sample loading of ultrasound acoustic levitators by focused acoustic radiation
    In: IEEE international ultrasonics symposium (IUS 2021). Danvers, MA: IEEE; 2021:(3 pp.). https://doi.org/10.1109/IUS52206.2021.9593735
    DORA PSI
  • Li H, Huang C-Y, Govorunova EG, Sineshchekov OA, Yi A, Rothschild KJ, et al.
    The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel
    eLife. 2021; 10: e65903 (14 pp.). https://doi.org/10.7554/eLife.65903
    DORA PSI
  • Martiel I, Beale JH, Karpik A, Huang C-Y, Vera L, Olieric N, et al.
    Versatile microporous polymer-based supports for serial macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2021; 77(9): 1153-1167. https://doi.org/10.1107/S2059798321007324
    DORA PSI
  • Monsarrat C, Compain G, André C, Engilberge S, Martiel I, Oliéric V, et al.
    Iterative structure-based optimization of short peptides targeting the bacterial sliding clamp
    Journal of Medicinal Chemistry. 2021; 64(23): 17063-17078. https://doi.org/10.1021/acs.jmedchem.1c00918
    DORA PSI
  • Mühlethaler T, Gioia D, Prota AE, Sharpe ME, Cavalli A, Steinmetz MO
    Comprehensive analysis of binding sites in tubulin
    Angewandte Chemie International Edition. 2021; 60(24): 13331-13342. https://doi.org/10.1002/anie.202100273
    DORA PSI
  • Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, et al.
    Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
    Cell Reports. 2021; 36(9): 109648 (19 pp.). https://doi.org/10.1016/j.celrep.2021.109648
    DORA PSI
  • Nass K, Bacellar C, Cirelli C, Dworkowski F, Gevorkov Y, James D, et al.
    Pink-beam serial femtosecond crystallography for accurate structure-factor determination at an X-ray free-electron laser
    IUCrJ. 2021; 8: 905-920. https://doi.org/10.1107/S2052252521008046
    DORA PSI
  • Ni X, Schröder M, Olieric V, Sharpe ME, Hernandez-Olmos V, Proschak E, et al.
    Structural insights into plasticity and discovery of remdesivir metabolite GS-441524 binding in SARS-CoV-2 macrodomain
    ACS Medicinal Chemistry Letters. 2021; 12(4): 603-609. https://doi.org/10.1021/acsmedchemlett.0c00684
    DORA PSI
  • Olatunji S, Bowen K, Huang CY, Weichert D, Singh W, Tikhonova IG, et al.
    Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
    Nature Communications. 2021; 12(1): 4254 (14 pp.). https://doi.org/10.1038/s41467-021-24475-0
    DORA PSI
  • Palmerini V, Monzani S, Laurichesse Q, Loudhaief R, Mari S, Cecatiello V, et al.
    Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
    Nature Communications. 2021; 12(1): 2070 (12 pp.). https://doi.org/10.1038/s41467-021-22080-9
    DORA PSI
  • Polimeno L, Lerario G, De Giorgi M, De Marco L, Dominici L, Todisco F, et al.
    Tuning of the Berry curvature in 2D perovskite polaritons
    Nature Nanotechnology. 2021; 16: 1349-1354. https://doi.org/10.1038/s41565-021-00977-2
    DORA PSI
  • Ramberg KO, Engilberge S, Skorek T, Crowley PB
    Facile fabrication of protein-macrocycle frameworks
    Journal of the American Chemical Society. 2021; 143(4): 1896-1907. https://doi.org/10.1021/jacs.0c10697
    DORA PSI
  • Ramos J, Laux V, Haertlein M, Boeri Erba E, McAuley KE, Forsyth VT, et al.
    Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme
    IUCrJ. 2021; 8: 372-386. https://doi.org/10.1107/S2052252521001299
    DORA PSI
  • Scott DE, Francis-Newton NJ, Marsh ME, Coyne AG, Fischer G, Moschetti T, et al.
    A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
    Cell Chemical Biology. 2021; 28(6): 835-847.e5. https://doi.org/10.1016/j.chembiol.2021.02.006
    DORA PSI
  • Sharpe ME, Wojdyla JA
    Fragment-screening and automation at the Swiss Light Source macromolecular crystallography beamlines
    Nihon Kessho Gakkaishi. 2021; 63(3): 232-235. https://doi.org/10.5940/jcrsj.63.232
    DORA PSI
  • Sutanto F, Shaabani S, Oerlemans R, Eris D, Patil P, Hadian M, et al.
    Combining high-throughput synthesis and high-throughput protein crystallography for accelerated hit identification
    Angewandte Chemie International Edition. 2021; 60(33): 18231-18239. https://doi.org/10.1002/anie.202105584
    DORA PSI
  • Toomey B, Han X, Dong CD, Edward V, Kaminski JW, Shankar S
    Characterization of phases and orientations of micro-structured materials Using computational crystallography
    In: Shankar S, Muller R, Dunning T, Chen GH, eds. Computational materials, chemistry, and biochemistry: from bold initiatives to the last mile. In honor of William A. Goddard’s contributions to science and engineering. Springer series in materials science. Cham: Springer Nature; 2021:213-231. https://doi.org/10.1007/978-3-030-18778-1_11
    DORA PSI
  • de Wijn R, Rollet K, Olieric V, Hennig O, Thome N, Noûs C, et al.
    Crystallization and structural determination of an enzyme: substrate complex by serial crystallography in a versatile microfluidic chip
    Journal of Visualized Experiments. 2021; 2021(169): e61972 (15 pp.). https://doi.org/10.3791/61972
    DORA PSI
  • Assmann GM, Wang M, Diederichs K
    Making a difference in multi-data-set crystallography: simple and deterministic data-scaling/selection methods
    Acta Crystallographica Section D: Structural Biology. 2020; 76: 636-652. https://doi.org/10.1107/S2059798320006348
    DORA PSI
  • Beale JH
    Macromolecular X-ray crystallography: soon to be a road less travelled?
    Acta Crystallographica Section D: Structural Biology. 2020; 76(5): 400-405. https://doi.org/10.1107/S2059798320004660
    DORA PSI
  • Bedi RK, Huang D, Wiedmer L, Li Y, Dolbois A, Wojdyla JA, et al.
    Selectively disrupting m6A-dependent protein-RNA interactions with fragments
    ACS Chemical Biology. 2020; 15(3): 618-625. https://doi.org/10.1021/acschembio.9b00894
    DORA PSI
  • Bernstein HJ, Förster A, Bhowmick A, Brewster AS, Brockhauser S, Gelisio L, et al.
    Gold standard for macromolecular crystallography diffraction data
    IUCrJ. 2020; 7(5): 784-792. https://doi.org/10.1107/S2052252520008672
    DORA PSI
  • Bu W, Levitskaya Z, Loh ZY, Jin S, Basu S, Ero R, et al.
    Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state
    PLoS Biology. 2020; 18(7): e3000755 (24 pp.). https://doi.org/10.1371/journal.pbio.3000755
    DORA PSI
  • Cheng R, Huang C-Y, Hennig M, Nar H, Schnapp G
    In situ crystallography as an emerging method for structure solution of membrane proteins: the case of CCR2A
    FEBS Journal. 2020; 287(5): 866-873. https://doi.org/10.1111/febs.15098
    DORA PSI
  • Cinquino M, Polimeno L, Lerario G, De Giorgi M, Moliterni A, Olieric V, et al.
    One-step synthesis at room temperature of low dimensional perovskite single crystals with high optical quality
    Journal of Luminescence. 2020; 221: 117079 (8 pp.). https://doi.org/10.1016/j.jlumin.2020.117079
    DORA PSI
  • Crack JC, Amara P, Volbeda A, Mouesca J-M, Rohac R, Pellicer Martinez MT, et al.
    Electron and proton transfers modulate DNA binding by the transcription regulator RsrR
    Journal of the American Chemical Society. 2020; 142(11): 5104-5116. https://doi.org/10.1021/jacs.9b12250
    DORA PSI
  • Engilberge S, Wagner T, Carpentier P, Girard E, Shima S
    Krypton-derivatization highlights O2-channeling in a four-electron reducing oxidase
    Chemical Communications. 2020; 56(74): 10863-10866. https://doi.org/10.1039/d0cc04557h
    DORA PSI
  • Fadini A, Reiche S, Nass K, van Thor JJ
    Applications and limits of time-to-energy mapping of protein crystal diffraction using energy-chirped polychromatic XFEL pulses
    Applied Sciences. 2020; 10(7): 2599 (18 pp.). https://doi.org/10.3390/app10072599
    DORA PSI
  • Gao X, Zhu K, Wojdyl JA, Chen P, Qin B, Li Z, et al.
    Crystal structure of the NS3-like helicase from Alongshan virus
    IUCrJ. 2020; 7(3): 375-382. https://doi.org/10.1107/S2052252520003632
    DORA PSI
  • Görlich S, Samuel AJ, Best RJ, Seidel R, Vacelet J, Leonarski FK, et al.
    Natural hybrid silica/protein superstructure at atomic resolution
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2020; 117(49): 31088-31093. https://doi.org/10.1073/pnas.2019140117
    DORA PSI
  • Huang C-Y, Meier N, Caffrey M, Wang M, Olieric V
    3D-printed holders for in meso in situ fixed-target serial X-ray crystallography
    Journal of Applied Crystallography. 2020; 53: 854-859. https://doi.org/10.1107/S1600576720002897
    DORA PSI
  • Huang C-Y, Olieric V, Caffrey M, Wang M
    In meso in situ serial X-Ray crystallography (IMISX): a protocol for membrane protein structure determination at the Swiss Light Source
    In: Perez C, Maier T, eds. Expression, purification, and structural biology of membrane proteins. Methods in molecular biology. New York: Humana; 2020:293-319. https://doi.org/10.1007/978-1-0716-0373-4_20
    DORA PSI
  • Huwald D, Duda S, Gasper R, Olieric V, Hofmann E, Hemschemeier A
    Distinctive structural properties of THB11, a pentacoordinate Chlamydomonas reinhardtii truncated hemoglobin with N- and C-terminal extensions
    Journal of Biological Inorganic Chemistry. 2020; 25: 267-283. https://doi.org/10.1007/s00775-020-01759-2
    DORA PSI
  • Karpik A, Martiel I, Kristiansen PM, Padeste C
    Fabrication of ultrathin suspended polymer membranes as supports for serial protein crystallography
    Micro and Nano Engineering. 2020; 7: 100053 (6 pp.). https://doi.org/10.1016/j.mne.2020.100053
    DORA PSI
  • Leonarski F, Mozzanica A, Brückner M, Lopez-Cuenca C, Redford S, Sala L, et al.
    JUNGFRAU detector for brighter x-ray sources: solutions for IT and data science challenges in macromolecular crystallography
    Structural Dynamics. 2020; 7(1): 014305 (13 pp.). https://doi.org/10.1063/1.5143480
    DORA PSI
  • Lučić M, Chaplin AK, Moreno-Chicano T, Dworkowski FSN, Wilson MT, Svistunenko DA, et al.
    A subtle structural change in the distal haem pocket has a remarkable effect on tuning hydrogen peroxide reactivity in dye decolourising peroxidases from Streptomyces lividans
    Dalton Transactions. 2020; 49(5): 1620-1636. https://doi.org/10.1039/c9dt04583j
    DORA PSI
  • Lučić M, Svistunenko DA, Wilson MT, Chaplin AK, Davy B, Ebrahim A, et al.
    Serial femtosecond zero dose crystallography captures a water-free distal heme site in a dye‐decolourising peroxidase to reveal a catalytic role for an arginine in FeIV=O formation
    Angewandte Chemie International Edition. 2020; 59(48): 21656-21662. https://doi.org/10.1002/anie.202008622
    DORA PSI
  • Martiel I, Huang C-Y, Villanueva-Perez P, Panepucci E, Basu S, Caffrey M, et al.
    Low-dose in situ prelocation of protein microcrystals by 2D X-ray phase-contrast imaging for serial crystallography
    IUCrJ. 2020; 7(6): 1131-1141. https://doi.org/10.1107/S2052252520013238
    DORA PSI
  • Martiel I, Buntschu D, Meier N, Gobbo A, Panepucci E, Schneider R, et al.
    The TELL automatic sample changer for macromolecular crystallography
    Journal of Synchrotron Radiation. 2020; 27: 860-863. https://doi.org/10.1107/S1600577520002416
    DORA PSI
  • Martiel I, Mozzanica A, Opara NL, Panepucci E, Leonarski F, Redford S, et al.
    X-ray fluorescence detection for serial macromolecular crystallography using a JUNGFRAU pixel detector
    Journal of Synchrotron Radiation. 2020; 27: 329-339. https://doi.org/10.1107/S1600577519016758
    DORA PSI
  • Moliterni A, Altamura D, Lassandro R, Olieric V, Ferri G, Cardarelli F, et al.
    Synthesis, crystal structure, polymorphism and microscopic luminescence properties of anthracene derivative compounds
    Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials. 2020; B76: 427-435. https://doi.org/10.1107/S2052520620004424
    DORA PSI
  • Nass K, Cheng R, Vera L, Mozzanica A, Redford S, Ozerov D, et al.
    Advances in long-wavelength native phasing at X-ray free-electron lasers
    IUCrJ. 2020; 7: 965-975. https://doi.org/10.1107/S2052252520011379
    DORA PSI
  • Nass K, Redecke L, Perbandt M, Yefanov O, Klinge M, Koopmann R, et al.
    In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors
    Nature Communications. 2020; 11(1): 620 (13 pp.). https://doi.org/10.1038/s41467-020-14484-w
    DORA PSI
  • Nass K
    Pixel modelling - a new age in SFX data analysis
    IUCrJ. 2020; 7: 949-950. https://doi.org/10.1107/S2052252520014281
    DORA PSI
  • Olatunji S, Yu X, Bailey J, Huang C-Y, Zapotoczna M, Bowen K, et al.
    Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
    Nature Communications. 2020; 11(1): 140 (11 pp.). https://doi.org/10.1038/s41467-019-13724-y
    DORA PSI
  • Pfanzagl V, Beale JH, Michlits H, Schmidt D, Gabler T, Obinger C, et al.
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    Journal of Materials Chemistry C. 2016; 4(18): 3963-3969. https://doi.org/10.1039/c5tc02305j
    DORA PSI
  • Bianchi S, van Riel WE, Kraatz SHW, Olieric N, Frey D, Katrukha EA, et al.
    Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations
    Scientific Reports. 2016; 6: 30668 (16 pp.). https://doi.org/10.1038/srep30668
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  • Casanas A, Warshamanage R, Finke AD, Panepucci E, Olieric V, Nöll A, et al.
    EIGER detector: application in macromolecular crystallography
    Acta Crystallographica Section D: Structural Biology. 2016; 72(9): 1036-1048. https://doi.org/10.1107/S2059798316012304
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  • Chatterjee A, Mallin H, Klehr J, Vallapurackal J, Finke AD, Vera L, et al.
    An enantioselective artificial Suzukiase based on the biotin-streptavidin technology
    Chemical Science. 2016; 7(1): 673-677. https://doi.org/10.1039/c5sc03116h
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  • Finke AD, Panepucci E, Vonrhein C, Wang M, Bricogne G, Oliéric V
    Advanced crystallographic data collection protocols for experimental phasing
    In: Ennifar E, ed. Nucleic acid crystallography. Methods and protocols. Methods in molecular biology. New York: Humana Press; 2016:175-191. https://doi.org/10.1007%2F978-1-4939-2763-0_11
    DORA PSI
  • Finke AD, Gray DL, Moore JS
    Crystal structures of three complexes of zinc chloride with tri-tert-butylphosphane
    Acta Crystallographica Section E: Crystallographic Communications. 2016; 72: 35-39. https://doi.org/10.1107/S2056989015023373
    DORA PSI
  • Howard EI, Guillot B, Blakeley MP, Haertlein M, Moulin M, Mitschler A, et al.
    High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution
    IUCrJ. 2016; 3: 115-126. https://doi.org/10.1107/S2052252515024161
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  • Huang C-Y, Olieric V, Ma P, Howe N, Vogeley L, Liu X, et al.
    In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures
    Acta Crystallographica Section D: Structural Biology. 2016; 72(1): 93-112. https://doi.org/10.1107/S2059798315021683
    DORA PSI
  • Jaeger K, Dworkowski F, Nogly P, Milne C, Wang M, Standfuss J
    Serial millisecond crystallography of membrane proteins
    In: Moraes I, ed. The next generation in membrane protein structure determination. Advances in experimental medicine and biology. Cham: Springer; 2016:137-149. https://doi.org/10.1007/978-3-319-35072-1_10
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  • Klein A, Wojdyla JA, Joshi A, Josts I, McCaughey LC, Housden NG, et al.
    Structural and biophysical analysis of nuclease protein antibiotics
    Biochemical Journal. 2016; 473(18): 2799-2812. https://doi.org/10.1042/BCJ20160544
    DORA PSI
  • Lampart S, Roch LM, Dutta AK, Wang Y, Warshamanage R, Finke AD, et al.
    Pentaindenocorannulene: properties, assemblies, and C60 complex
    Angewandte Chemie International Edition. 2016; 55(47): 14648-14652. https://doi.org/10.1002/anie.201608337
    DORA PSI
  • Li Y-Y, Liu P-F, Lin H, Wang M-T, Chen L
    The effect of indium substitution on the structure and NLO properties of Ba6Cs2Ga10Se20Cl4
    Inorganic Chemistry Frontiers. 2016; 3(7): 952-958. https://doi.org/10.1039/c6qi00104a
    DORA PSI
  • Marsh ME, Scott DE, Ehebauer MT, Abell C, Blundell TL, Hyvönen M
    ATP half-sites in RadA and RAD51 recombinases bind nucleotides
    FEBS Open Bio. 2016; 6(5): 372-385. https://doi.org/10.1002/2211-5463.12052
    DORA PSI
  • Moschetti T, Sharpe T, Fischer G, Marsh ME, Ng HK, Morgan M, et al.
    Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51
    Journal of Molecular Biology. 2016; 428(23): 4589-4607. https://doi.org/10.1016/j.jmb.2016.10.009
    DORA PSI
  • Olieric V, Weinert T, Finke AD, Anders C, Li D, Olieric N, et al.
    Data-collection strategy for challenging native SAD phasing
    Acta Crystallographica Section D: Structural Biology. 2016; 72(3): 421-429. https://doi.org/10.1107/S2059798315024110
    DORA PSI
  • Orts J, Wälti MA, Marsh M, Vera L, Gossert AD, Güntert P, et al.
    NMR-based determination of the 3D structure of the ligand-protein interaction site without protein resonance assignment
    Journal of the American Chemical Society. 2016; 138(13): 4393-4400. https://doi.org/10.1021/jacs.5b12391
    DORA PSI
  • Pauluhn A, Huber MCE, Smith PL, Colina L
    Spectroradiometry with space telescopes
    Astronomy and Astrophysics Review. 2016; 24(1): 3 (74 pp.). https://doi.org/10.1007/s00159-015-0086-2
    DORA PSI
  • Sagalowicz L, Moccand C, Davidek T, Ghanbari R, Martiel I, Negrini R, et al.
    Lipid self-assembled structures for reactivity control in food
    Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 2016; 374(2072): 20150136 (21 pp.). https://doi.org/10.1098/rsta.2015.0136
    DORA PSI
  • Schaffer MF, Peng G, Spingler B, Schnabl J, Wang M, Olieric V, et al.
    The x-ray structures of six octameric RNA duplexes in the presence of different di- and trivalent cations
    International Journal of Molecular Sciences. 2016; 17(7): 988 (17 pp.). https://doi.org/10.3390/ijms17070988
    DORA PSI
  • Scott DE, Marsh M, Blundell TL, Abell C, Hyvönen M
    Structure-activity relationship of the peptide binding-motif mediating the BRCA2:RAD51 protein-protein interaction
    FEBS Letters. 2016; 590(8): 1094-1102. https://doi.org/10.1002/1873-3468.12139
    DORA PSI
  • Sumy DP, Finke AD, Whalley AC
    The reductive aromatization of tridecacyclene
    Chemical Communications. 2016; 52(83): 12368-12371. https://doi.org/10.1039/c6cc06078a
    DORA PSI
  • Sumy DP, Dodge NJ, Harrison CM, Finke AD, Whalley AC
    Tridecacyclene: a cyclic tetramer of acenaphthylene
    Chemistry: A European Journal. 2016; 22(14): 4709-4712. https://doi.org/10.1002/chem.201600165
    DORA PSI
  • Tong S, Lin Y, Lu S, Wang M, Bogdanov M, Zheng L
    Structural insight into substrate selection and catalysis of lipid phosphate phosphatase PgpB in the cell membrane
    Journal of Biological Chemistry. 2016; 291(35): 18342-18352. https://doi.org/10.1074/jbc.M116.737874
    DORA PSI
  • Tsujino S, Tomizaki T
    Ultrasonic acoustic levitation for fast frame rate X-ray protein crystallography at room temperature
    Scientific Reports. 2016; 6: 25558 (9 pp.). https://doi.org/10.1038/srep25558
    DORA PSI
  • Wojdyla JA, Panepucci E, Martiel I, Ebner S, Huang C-Y, Caffrey M, et al.
    Fast two-dimensional grid and transmission X-ray microscopy scanning methods for visualizing and characterizing protein crystals
    Journal of Applied Crystallography. 2016; 49: 944-952. https://doi.org/10.1107/S1600576716006233
    DORA PSI
  • Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, et al.
    X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex
    Scientific Data. 2016; 3: 160021 (13 pp.). https://doi.org/10.1038/sdata.2016.21
    DORA PSI
  • Bheemireddy SR, Ubaldo PC, Rose PW, Finke AD, Zhuang J, Wang L, et al.
    Stabilizing pentacene by cyclopentannulation
    Angewandte Chemie International Edition. 2015; 54(52): 15762-15766. https://doi.org/10.1002/anie.201508650
    DORA PSI
  • Botha S, Nass K, Barends T, Kabsch W, Latz B, Dworkowski F, et al.
    Room-temperature serial crystallography at synchrotron X-ray sources using slowly flowing free-standing high-viscosity microstreams
    Acta Crystallographica Section D: Structural Biology. 2015; 71: 387-397. https://doi.org/10.1107/S1399004714026327
    DORA PSI
  • Chang S, Sun D, Liang H, Wang J, Li J, Guo L, et al.
    Cryo-EM structure of influenza Virus RNA polymerase complex at 4.3Å resolution
    Molecular Cell. 2015; 57(5): 925-935. https://doi.org/10.1016/j.molcel.2014.12.031
    DORA PSI
  • Chiu E, Hijnen M, Bunker RD, Boudes M, Rajendran C, Aizel K, et al.
    Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization
    Proceedings of the National Academy of Sciences of the United States of America PNAS. 2015; 112(13): 3973-3978. https://doi.org/10.1073/pnas.1418798112
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    Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography
    Journal of Structural Biology. 2015; 192(3): 461-469. https://doi.org/10.1016/j.jsb.2015.10.008
    DORA PSI
  • Dong J, Zhao H, Zhou T, Spiliotopoulos D, Rajendran C, Li X-D, et al.
    Structural analysis of the binding of type I, I1/2, and II inhibitors to Eph tyrosine kinases
    ACS Medicinal Chemistry Letters. 2015; 6(1): 79-83. https://doi.org/10.1021/ml500355x
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  • Dworkowski FSN, Hough MA, Pompidor G, Fuchs MR
    Challenges and solutions for the analysis of in situ, in crystallo micro-spectrophotometric data
    Acta Crystallographica Section D: Structural Biology. 2015; 71: 27-35. https://doi.org/10.1107/S1399004714015107
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    Hydrogen bonding of the dissociated histidine ligand is not required for formation of a proximal NO adduct in cytochrome c'
    Journal of Biological Inorganic Chemistry. 2015; 20(6): 949-956. https://doi.org/10.1007/s00775-015-1278-y
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  • Grøftehauge MK, Truan D, Vasil A, Denny PW, Vasil ML, Pohl E
    Crystal structure of a hidden protein, YcaC, a putative cysteine hydrolase from Pseudomonas aeruginosa, with and without an acrylamide adduct
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  • Huang C-Y, Olieric V, Ma P, Panepucci E, Diederichs K, Wang M, et al.
    In meso in situ serial X-ray crystallography of soluble and membrane proteins
    Acta Crystallographica Section D: Structural Biology. 2015; 71(6): 1238-1256. https://doi.org/10.1107/S1399004715005210
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    Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
    Nature. 2015; 523: 561-567. https://doi.org/10.1038/nature14656
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  • Krüger H, Többens DM, Tropper P, Haefeker U, Kahlenberg V, Fuchs MR, et al.
    Single-crystal structure and Raman spectroscopy of synthetic titanite analog CaAlSiO4F
    Mineralogy and Petrology. 2015; 109(5): 631-641. https://doi.org/10.1007/s00710-015-0393-3
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  • Waltersperger S, Olieric V, Pradervand C, Glettig W, Salathe M, Fuchs MR, et al.
    PRIGo: a new multi-axis goniometer for macromolecular crystallography
    Journal of Synchrotron Radiation. 2015; 22: 895-900. https://doi.org/10.1107/S1600577515005354
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  • Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, et al.
    Fast native-SAD phasing for routine macromolecular structure determination
    Nature Methods. 2015; 12(2): 131-133. https://doi.org/10.1038/nmeth.3211
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    Structure and function of the Escherichia coli Tol-Pal stator protein TolR
    Journal of Biological Chemistry. 2015; 290(44): 26675-26687. https://doi.org/10.1074/jbc.M115.671586
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  • Xia L, Lin H, Staniek A, Panjikar S, Ruppert M, Hilgers P, et al.
    Ligand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding and inhibitory behaviours
    Journal of Enzyme Inhibition and Medicinal Chemistry. 2015; 30(3): 472-478. https://doi.org/10.3109/14756366.2014.949252
    DORA PSI

Associated Beamlines

Contact

Head of MX
and Group Leader
Dr. Meitian Wang
Telephone: +41 56 310 4175
E-mail: meitian.wang@psi.ch

Group Leader MX
Application
Katherine McAuley
Telephone: +41 56 310 3979
E-mail: katherine.mcauley@psi.ch

Group Leader MX Instrumentation
Wayne Glettig
Telephone: +41 56 310 5823
E-mail: wayne.glettig@psi.ch

Group Leader MX Samples
Dr. May Sharpe née Marsh
Telephone: +41 56 310 5437
E-mail: may.sharpe@psi.ch

Group Leader MX Data
Dr. Meitian Wang a.i.
Telephone: +41 56 310 4175
E-mail: meitian.wang@psi.ch