The observation of Higgs boson production in association with a top quark-antiquark pair is reported, based on a combined analysis of proton-proton collision data at center-of-mass energies of √s = 7,8, and 13 TeV, corresponding to integrated luminosities of up to 5.1, 19.7, and 35.9 fb-1, respectively. The data were collected with the CMS detector at the CERN LHC.