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Laboratory of Nanoscale Biology

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Cellular Engineering and Microscopy

We have a long-lasting interest in receptor trafficking and signaling. In order to measure trafficking and signaling of receptors, we developed several tools that are now widely used.

MultiLabel/ MultiPrime: This is a modular, cre/LoxP-based multigene expression system for mammalian cells.

Squassh/ SquasshAnalyst: These tools allow the segmentation of fluorescence images and the quantification of colocalization between different channels (Rizk et al., 2014; Rizk et al., 2015).

GPCR activation assays: These assays are based on split nanoluciferase. They are available for several arrestins (Spillmann et al., 2020) and for GRK-2/ -3/ -5 (Romantini et al., 2021).

Further information and contact: Dr. Philipp Berger
 

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Contact

Dr. Philipp Berger

Lab. of Nanoscale Biology
Paul Scherrer Institut
Forschungsstrasse 111
5232 Villigen PSI, Switzerland

+41 56 310 47 28

philipp.berger@psi.ch

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Paul Scherrer Institut

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