Laboratory of Biomolecular Research
Center of Radiopharmaceutical Sciences
Laboratory of Nanoscale Biology
The Laboratory of Nanoscale Biology (LNB) investigates the molecular structure and dynamics of complex molecular machines and cascades within the context of the living cell. Technological developments at the PSI provide novel approaches for studying fundamental, molecular processes of life within their physiological context. Electron diffraction and cryo-electron microscopy of bio-molecular complexes form the technological basis of the LNB, together with electron tomography and X-ray diffractive imaging of larger, nanoscopic structures. We develop these technologies in studies of fundamental, molecular aspects of neuro-degeneration and cell motility, and investigate other fundamental processes of life in collaboration. Intellectual property on novel technologies developed at the LNB may lead to commercial spin-outs.
Using a multi-disciplinary approach, including single-cell correlative imaging, micro-fabricated biointerfaces, functional genomics and machine learning, we study the coupling between cell mechanics and 3D genome organization in regulating cell-state homeostasis and its transitions. Our studies, aimed at an in-depth understanding of the mechanical regulation of genome programs, have major implications in ageing and regenerative medicine, host-pathogen interactions and early cancer diagnostics. On the computational side, our laboratory collaborates closely with Caroline Uhler’s group at ETH Zurich. Furthermore, we develop technologies to create artificial microenvironments for cell-based experiments as well as novel methods for microscopy and micromanipulation of cells.