Facilities in the Division of Biology and Chemistry
The electron microscopy facility at PSI is presently sustained by three divisions, BIO (chair), NES and ENE. With its three transmission electron microscopes, a focused ion beam instrument and plenty of preparation tools it offers a direct access to electron microscopic techniques highly required in their fields of research (biological as well as materials science samples). The facility is unique within Switzerland as it also allows the investigation of radioactive materials.
Our state-of-art cryo-EM allows for structural analysis of biological macromolecules and organelles. Cryo-EM provides images of biological macromolecules and organelles in intact hydrated states. Computational image analysis enables three-dimensional reconstruction.
For more information please follow this link or contact Dr. Elisabeth Müller.
For more information please follow this link or contact Antonia Furrer.
A distinctive advantage of LBR as a research environment is the presence, on campus, of the Swiss Light Source (SLS). The macromolecular crystallography (MX) beamlines perfectly complement the excellent infrastructure of LBR for protein preparation, crystallization, crystallographic computing and structure analysis. We work in close collaboration with the MX group at the SLS in several areas, especially crystallization, in situ diffraction screening and data acquisition.
For more information follow this link or contact Dr. May Marsh.
The BIO Division is well equipped for biophysics studies. Our biophysical instrumentation includes instruments for the characterisation of protein stability, their molecular weight and stoichiometry of proteins complexes, and affinity of biological interactions.
For more information please follow this link or contact Dr. Ashwani Sharma.
In the CRS there is a state-of-art GMP facility for the production of radiopharmaceuticals under good manufacturing practice (GMP) for clinical applications.
The CRS has a preclinical nuclear imaging facility in house. Both, single photon emission computed tomography (SPECT), and positron emission tomography (PET) with an anatomic imaging modality by computed tomography (CT). These instrumentations give us the ability to analyze and visualize biologically significant events (such as tumor growth, hypoxia, angiogenesis, apoptosis) in combination with the anatomical information provided by CT.
For more information, please contact Dr. Martin Béhé.
The sensitivity and resolution of liquid chromatography/electrospray ionization time-of-flight mass spectrometry (LCT Premier Mass Spectrometer, Waters AG) allows the determining of mass of peptides or proteins.
For more information, please contact Alain Blanc.