Lab News & Scientific Highlights
Dr. Manuel Guizar-Sicairos elected as Fellow member of The Optical Society (OSA)
Dr. Manuel Guizar-Sicairos, beamline scientist at the cSAXS beamline, was elected as a Fellow Member of The Optical Society (OSA) for seminal contributions to methods and applications of coherent lensless imaging, ptychography, x-ray nanotomography, and new modalities of x-ray microscopy.
Messungen am PSI ermöglichten detailliertes Verständnis der Gen-Schere
Das PSI gratuliert Emmanuelle Charpentier und Jennifer Doudna zum diesjährigen Nobelpreis für Chemie. Experimente an der Synchrotron Lichtquelle Schweiz SLS im Jahr 2013 ermöglichten es, die Struktur des Proteinkomplexes CRISPR-Cas9 aufzuklären.
Eine Frage der Bindung
Am PSI screenen Forschende Molekülfragmente darauf, ob diese an wichtige Proteine des Coronavirus SARS-CoV-2 binden und dieses so möglicherweise lahmlegen können. Aus den vielen Einzelinformationen erhoffen sie sich eine Antwort darauf, wie ein wirkungsvolles Medikament aussehen kann.
3D printing silica aerogels at the micrometer scale
A group of EMPA and ETH Zürich researchers have developed a new method to directly write ink made of silica aerogels in 3D. Thanks to X-ray phase contrast tomography at the TOMCAT beamline they characterized the resulting printed material with different compositions. Their results were published in Nature on August 18, 2020.
Phase contrast microtomography reveals nanoparticle accumulation in zebrafish
Metal-based nanoparticles are a promising tool in medicine – as a contrast agent, transporter of active substances, or to thermally kill tumor cells. Up to now, it has been hardly possible to study their distribution inside an organism. Researchers at the University of Basel in collaboration with the TOMCAT team have used phase contrast X-ray tomographic microscopy to take high-resolution captures of the nanoparticle aggregation inside zebrafish embryos.
The study was published in the journal Small and featured on the cover of its current issue.
Covid-19-Forschung: Antivirale Strategie mit Doppelwirkung
Frankfurter Wissenschaftler identifizieren eine mögliche Schwachstelle des SARS-CoV-2-Virus. Einen Teil ihrer Messungen führten sie an der Synchrotron Lichtquelle Schweiz SLS am PSI durch. Die Forschungsergebnisse erscheinen diese Woche im Fachblatt Nature.
First MX results of the priority COVID-19 call
The Dikic group at the Goethe University in Frankfurt am Main, Germany has published the first results following the opening of the "PRIORITY COVID-19 Call” at SLS.
Miniaturized fluidic circuitry observed in 3D
The team of Prof. Thomas Hermans at the University of Strasbourg in France managed to create wall-less aqueous liquid channels called anti-tubes. Thanks to X-ray phase contrast tomography at the TOMCAT beamline those anti-tubes could be observed in 3D. The exciting results were published in Nature on May 6, 2020.
Microcalcifications in breast tissue: Paving the way for future diagnostic solutions?
Microcalcifications are a common sign in mammography. For example, in 90% of ductal carcinoma in situ microcalcifications are the first and unique sign indicating the presence of the lesion. Nevertheless, up to around 50% of the resulting biopsies reveal a benign lesion, a 'false positive'. Researchers were able to show now that breast microcalcifications detected in tumors have specific chemical and crystalline features different from those observed in benign samples. Moreover, microcalcifications detected in tumors but located outside the lesion show malignant features too. This indicates that cancer influences the surrounding tissue even if it exhibits apparently healthy morphological features. These results indicate that the biochemical differences between benign and malignant microcalcifications can be potentially identified by light-based tools, able to investigate microcalcifications inside the breast without performing biopsies.