Dr. Jinghui Luo

Scientist
Paul Scherrer Institut
Forschungsstrasse 111
5232 Villigen PSI
Schweiz
Forschungsstrasse 111
5232 Villigen PSI
Schweiz
Telefon
E-Mail
Research interests
1. Structural and biophysical characterization of amyloid proteins
2. Single-channel electrical and optical studies of ion channel, amyloid and other membrane proteins in the lipid bilayer
2. Single-channel electrical and optical studies of ion channel, amyloid and other membrane proteins in the lipid bilayer
Short CV
2017.07-now: Principal Investigator, Paul Scherrer Institute, Switzerland
2014.12-2017.06: Research Fellow, Oxford University, UK
2014.06: PhD, Leiden University, the Netherlands
2009.06-2009.12: Traineeship, EMBL, Germany
2009.06: MSc, Uppsala University, Sweden
2014.12-2017.06: Research Fellow, Oxford University, UK
2014.06: PhD, Leiden University, the Netherlands
2009.06-2009.12: Traineeship, EMBL, Germany
2009.06: MSc, Uppsala University, Sweden
Publications
2019
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Nuclear Pore Membrane Proteins Self-Assemble into Nanopores
BIOCHEMISTRY 58, 484 (2019).DOI: 10.1021/acs.biochem.8b01179
2018
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Membrane-mimetic systems for biophysical studies of the amyloid-? peptide
BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS AND PROTEOMICS , S1570963918302036 (2018).DOI: 10.1016/j.bbapap.2018.11.005
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The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-? (A?) Peptide at the Oligomeric Stage
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140, 8138 (2018).DOI: 10.1021/jacs.7b13623
2017
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Alzheimer?s disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-? peptide aggregation
Scientific Reports 7, 14423 (2017).DOI: 10.1038/s41598-017-13759-5
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Maleimido-proxyl as an EPR spin label for the evaluation of conformational changes of albumin
European Biophysics Journal 46, 773 (2017).DOI: 10.1007/s00249-017-1257-z
2016
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Characterization of Mn(II) ion binding to the amyloid-? peptide in Alzheimer?s disease
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY , (2016).DOI: 10.1016/j.jtemb.2016.03.009
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Coupled commensurate charge density wave and lattice distortion in Na2Ti2Pn2O(Pn=As,Sb) determined by x-ray diffraction and angle-resolved photoemission spectroscopy
PHYSICAL REVIEW B 94, 104515 (2016).DOI: 10.1103/PhysRevB.94.104515
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Cross-interactions between the Alzheimer Disease Amyloid-? Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis
JOURNAL OF BIOLOGICAL CHEMISTRY 291, 16485 (2016).DOI: 10.1074/jbc.R116.714576
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Non-covalent S?O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation
CHEMICAL SCIENCE 7, 6435 (2016).DOI: 10.1039/C6SC00756B
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Reciprocal Molecular Interactions between the A? Peptide Linked to Alzheimer?s Disease and Insulin Linked to Diabetes Mellitus Type II
ACS Chemical Neuroscience 7, 269 (2016).DOI: 10.1021/acschemneuro.5b00325
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Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species
Journal of Alzheimer's Disease 54, 971 (2016).DOI: 10.3233/JAD-160427
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The Amyloid-? Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions
ISRAEL JOURNAL OF CHEMISTRY 57, 674 (2016).DOI: 10.1002/ijch.201600105
2014
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Alzheimer Peptides Aggregate into Transient Nanoglobules That Nucleate Fibrils
BIOCHEMISTRY 53, 6302 (2014).DOI: 10.1021/bi5003579
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ChemInform Abstract: Cyclic Peptides as Inhibitors of Amyloid Fibrillation
ChemInform 45, no (2014).DOI: 10.1002/chin.201422265
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Cyclic Peptides as Inhibitors of Amyloid Fibrillation
CHEMISTRY - A EUROPEAN JOURNAL 20, 2410 (2014).DOI: 10.1002/chem.201304253
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Endogenous Polyamines Reduce the Toxicity of Soluble A? Peptide Aggregates Associated with Alzheimer?s Disease
BIOMACROMOLECULES 15, 1985 (2014).DOI: 10.1021/bm401874j
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Non-chaperone Proteins Can Inhibit Aggregation and Cytotoxicity of Alzheimer Amyloid ? Peptide
JOURNAL OF BIOLOGICAL CHEMISTRY 289, 27766 (2014).DOI: 10.1074/jbc.M114.574947
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The A- peptide forms non-amyloid fibrils in the presence of carbon nanotubes
NANOSCALE 6, 6720 (2014).DOI: 10.1039/c4nr00291a
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The hairpin conformation of the amyloid ? peptide is an important structural motif along the aggregation pathway
JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19, 623 (2014).DOI: 10.1007/s00775-014-1131-8
2013
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An efficient nanolitre-volume multi-channel device for highly viscous materials used in membrane protein crystallization
JOURNAL OF APPLIED CRYSTALLOGRAPHY 46, 829 (2013).DOI: 10.1107/S0021889813006742
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Biophysical Studies of the Amyloid ?-Peptide: Interactions with Metal Ions and Small Molecules
CHEMBIOCHEM 14, 1692 (2013).DOI: 10.1002/cbic.201300262
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Cellular Polyamines Promote Amyloid-Beta (A?) Peptide Fibrillation and Modulate the Aggregation Pathways
ACS Chemical Neuroscience 4, 454 (2013).DOI: 10.1021/cn300170x
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Exploiting preQ 1 Riboswitches To Regulate Ribosomal Frameshifting
ACS CHEMICAL BIOLOGY 8, 733 (2013).DOI: 10.1021/cb300629b
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Human lysozyme inhibits the in vitro aggregation of A? peptides, which in vivo are associated with Alzheimer's disease
CHEMICAL COMMUNICATIONS 49, 6507 (2013).DOI: 10.1039/c3cc42325e
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Inhibiting and Reversing Amyloid-? Peptide (1-40) Fibril Formation with Gramicidin S and Engineered Analogues
CHEMISTRY - A EUROPEAN JOURNAL 19, 17338 (2013).DOI: 10.1002/chem.201301535
2012
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Catalytic promiscuity in Pseudomonas aeruginosa arylsulfatase as an example of chemistry-driven protein evolution
FEBS LETTERS 586, 1622 (2012).DOI: 10.1016/j.febslet.2012.04.012
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Conformation Effects of CpG Methylation on Single-Stranded DNA Oligonucleotides: Analysis of the Opioid Peptide Dynorphin-Coding Sequences
PLOS ONE 7, e39605 (2012).DOI: 10.1371/journal.pone.0039605
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Examining the promiscuous phosphatase activity of Pseudomonas aeruginosa arylsulfatase: A comparison to analogous phosphatases
PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS 80, 1211 (2012).DOI: 10.1002/prot.24020
2011
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A Straightforward and Robust Method for Introducing Human Hair as a Nucleant into High Throughput Crystallization Trials
CRYSTAL GROWTH & DESIGN 11, 1170 (2011).DOI: 10.1021/cg101374r
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Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2
JOURNAL OF PEPTIDE SCIENCE 17, 756 (2011).DOI: 10.1002/psc.1399
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Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): A combined experimental and theoretical study
JOURNAL OF INORGANIC BIOCHEMISTRY 105, 1422 (2011).DOI: 10.1016/j.jinorgbio.2011.07.003
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Ribonucleotide reductase inhibition by p-alkoxyphenols studied by molecular docking and molecular dynamics simulations
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 516, 29 (2011).DOI: 10.1016/j.abb.2011.09.003
2010
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In Silico Analysis of the Apolipoprotein E and the Amyloid ? Peptide Interaction: Misfolding Induced by Frustration of the Salt Bridge Network
PLOS COMPUTATIONAL BIOLOGY 6, e1000663 (2010).DOI: 10.1371/journal.pcbi.1000663
Group Members
Jinming Wu
Ph.D. Student
Hongzhi Wang
Ph.D. Student
Former Group Members
Hegne Pupart (2018 Summer Intern)