celestino padeste.jpg

Dr. Celestino Padeste

Senior Scientist
Lab for Micro- and Nanotechnology

Paul Scherrer Institut
5232 Villigen PSI

Telephone: +41 56 310 2141
E-mail: celestino.padeste@psi.ch


Main interest:
Functional Surfaces and Surface Functionalization

Current Focus:
Combination of advanced micro- and nanostructuring techniques with surface chemistry to obtain surfaces with specific properties.
  • Polymer grafting
    • Creation of nanostructured polymer brushes
    • Adaptation of surface properties of polymer materials
    • Adaptive and switchable surface properties
  • Designed surfaces for bio-applications
    • Micro- and nanopatterns of functional proteins
    • Designed surface topographies for implant research
  • Protein Crystallography
    • Thin-film supports for XFEL-based protein crystallography
    • Nanostructured substrates to induce protein crystallization


Chemistry I in the Materials Science Bachelor Degree Course at ETHZ


Complete List of Publications

Celestino Padeste und Sonja Neuhaus
Polymer Micro- and Nanografting
Based on own work and literature reports this book provides a summary of strategies for the formation of functional polymer patterns and structures on or in polymeric substrates using grafting processes.
Elsevier 2015; ISBN: 978-0-323-35322-9
Online Edition Elsevier Book Store

Selected Papers

Polymer Micro- and Nanografting

M. Dübner, V.J. Cadarso, T.N. Gevrek, A. Sanyal, N.D. Spencer, and C. Padeste
"Reversible Light-Switching of Enzymatic Activity on Orthogonally Functionalized Polymer Brushes"
ACS Appl. Mater. Interfaces 2017, 9 (11), pp 9245-9249.

M. Dübner, M.E. Naoum, N.D. Spencer, C.Padeste,
“From pH- to Light-Response: Post-Polymerization Modification of Polymer Brushes Grafted onto Microporous Polymeric Membranes”,
ACS Omega, 2, 2017, 455-461., ACS LiveSlides™ presentation

K. Gajos, V.A. Guzenko, M. Dübner, J. Haberko, A. Budkowski, C. Padeste
"Electron-beam lithographic grafting of functional polymer structures from fluoropolymer substrates"
Langmuir 32(41), 2016, 10641–10650

G. Panzarasa, M. Dübner, V. Pifferi, G. Soliveri, C. Padeste
"ON/OFF Switching of Silicon Wafer Electrochemistry by pH-Responsive Polymer Brushes."
J. Mater. Chem. C 4,26 (2016) 6287-6294

M. Dübner, T.N. Gevrek, A. Sanyal, N.D. Spencer, C. Padeste,
“Fabrication of Thiol−Ene “Clickable” Copolymer-Brush Nanostructures on Polymeric Substrates via Extreme Ultraviolet Interference Lithography”,
ACS Applied Materials and Interfaces, 7 (2015) 11337−11345

M. Dübner, N.D. Spencer, C. Padeste,
"Light-Responsive Polymer Surfaces via Postpolymerization Modification of Grafted Polymer-Brush Structures",
Langmuir, 30 (2014) 14971−14981

S. Neuhaus, C. Padeste, N.D. Spencer,
“Versatile Wettability Gradients Prepared by Chemical Modification of Polymer Brushes”
Langmuir 27 (2011) 6855-–6861.

S. Neuhaus, C. Padeste, N.D. Spencer,
“Functionalization of Fluropolymers and Polyolefins via Grafting of Polyelectrolyte Brushes from Atmospheric-Pressure Plasma Activated Surfaces”
Plasma Processes and Polymers 8, 6 (2011) 512-522.

S. Neuhaus, C. Padeste, H.H. Solak, N.D. Spencer,
“Functionalization of fluoropolymer surfaces with nanopatterned polyelectrolyte brushes”
Polymer 51 (2010) 4037-4043.

P. Farquet, A. Kunze, C. Padeste, H.H. Solak, S. Alkan Gürsel, G.G. Scherer and A. Wokaun,
“Influence of the solvent viscosity on surface graft-polymerization reactions”,
Polymer, 48 (2007) 4936-4942

H.-P. Brack, C. Padeste, M. Slaski, S. Alkan, and H. H. Solak,
„Preparation of Micro- and Nanopatterns of Polymer Chains Grafted onto Flexible Polymer Substrates”
J. Am. Chem. Soc., 126, 4 (2004) 1004-1005.

Solid supports for serial protein crystallography

Nadia Opara, Isabelle Martiel, Stefan A. Arnold, Thomas Braun, Henning Stahlberg, Mikako Makita, Christian David and Celestino Padeste
"Direct protein crystallization on ultrathin membranes for diffraction measurements at X-ray free electron lasers."
Journal of Applied Crystallography, accepted for publication.

B. Pedrini, C.J. Tsai, G. Capitani, C. Padeste, M.S. Hunter, N.A. Zatsepin, A. Barty, W.H. Benner, S. Boutet, G.K. Feld, S.P. Hau-Riege, R.A. Kirian, C. Kupitz, M. Messerschmitt, J.I. Ogren, T. Pardini, B. Segelke, G.J. Williams, J.C.H. Spence, R. Abela, M. Coleman, J.E. Evans, G. Schertler, M. Frank and X.D. Li,
“7 Å resolution in protein two-dimensional-crystal X-ray diffraction at Linac Coherent Light Source.”
Phil. Trans. R. Soc. B 369 (2014) 20130500.

Bio-functional surfaces and Biosensors

S.A. Ranamukhaarachchi, C. Padeste, M. Dübner, U.O. Häfeli, B. Stoeber, V.J. Cadarso,
Integrated hollow microneedle-optofluidic biosensor for therapeutic drug monitoring in sub-nanoliter volumes
Scientific reports 2016, 6, 29075; DOI: 10.1038/srep29075

J. Althaus, C. Padeste, J. Köser, U. Pieles, K. Peters and B. Müller,
“Nanostructuring Polyetheretherketone for Medical Implants”
European Journal of Nanomedicine 4(1) (2012) 7-15

C. Padeste, H. Özçelik, J. Ziegler, A. Schleunitz, M. Bednarzik, D. Yücel, V. Hasirci,
“Replication of high aspect ratio pillar array structures in biocompatible polymers for tissue engineering applications”,
Microelectron. Engineering, 88 (2011) 1836–1839

C. Padeste, B. Steiger, A. Grubelnik and L. Tiefenauer,
„Molecular Assembly of Redox-Conductive Ferrocene-Streptavidin Conjugates – Towards Bio-Electrochemical Devices”
Biosensors and Bioelectronics 20 (2004) 545-552.

H. Sorribas, C. Padeste and L. Tiefenauer,
"Photolithographic Generation of Protein Micropatterns for Neuron Culture Applications",
Biomaterials 23, 3 (2002) 893-900.

(Nano)-Structuring and Surface Functionalization

S. Neuhaus, N.D. Spencer, C. Padeste,
“Anisotropic Wetting of Microstructured Polymers as a Function of Surface Chemistry”
ACS Applied Materials and Interfaces 4 (2012) 123-127.

A. Savouchkina, A. Foelske-Schmitz, R. Kötz, A. Wokaun, G. G. Scherer, C. Padeste, J. Ziegler, V. Auzelyte, H. H. Solak,
“Extreme Ultraviolet Interference Lithography for Generation of Platinum Nanoparticles on Glassy Carbon”
ECS Transactions, 25, 24 (2010) 175-184.

Short CV

  • Diploma in Chemistry and PhD in inorganic solid state chemistry, University of Zürich, Switzerland
  • Post-Doc in surface science of catalysts, University of New South Wales, Sydney, Australia

Employment At PSI / LMN since August 1993

1993-2003: Molecular Nanotechnology
  • surface design
  • surface modification
  • protein immobilization
  • electrochemical detection of labelled proteins
Since 2003: Nanofabrication Technologies / Polymer Nanotechnology
  • polymer micro- and nanografting
  • x-ray interference lithography (XIL)
  • creation of protein patterns and chemical nanopatterns
responsible for the www-pages of LMN