Facilities

PSI Protein Production Platform (P4)

The PSI Protein Production Platform (P4) is a research facility specialized in recombinant protein production, with state-of-the-art equipment and a team of highly skilled and dedicated professionals with extensive experience in protein expression and purification. We offer recombinant protein production in bacterial, yeast, protozoan, insect and mammalian cells.

For more information please follow this link or contact Dr. Richard Kammerer.

Biophysical Instruments

LBR is exceptionally well equipped for biophysics studies. Our biophysical instrumentation includes a number of instruments for characterisation of protein stability, their molecular weight and stoichiometry of proteins complexes, and affinity of biological interactions. These include a qPCR instrument suitable for protein stability measurements, a circular dichroism (CD) spectrometer, isothermal titration calorimeter (ITC), bench top fluorimeter equipped with polarisers and automated titrators, multimode plate readers, multi angle light scattering instrument (SEC-MALS), absorbance spectrometers and analytical ultracentrifuge (Beckman XLI) equipped with absorbance, interference and fluorescence detection systems.

For more information please follow this link or contact Dr. Dmitry Veprintsev.

Crystallography

A distinctive advantage of LBR as a research environment is the presence, on campus, of the Swiss Light Source (SLS). The macromolecular crystallography (MX) beamlines perfectly complement the excellent infrastructure of LBR for protein preparation, crystallization, crystallographic computing and structure analysis. We work in close collaboration with the MX group at the SLS in several areas, especially crystallization, in situ diffraction screening and data acquisition.

For more information follow this link or contact Dr. Guido Capitani.

Electron Microscopy

In LBR there is a state-of-art cryo-EM facility for structural analysis of biological macromolecules and organelles. Cryo-EM provides images of biological macromolecules and organelles in intact hydrated states. Computational image analysis enables three-dimensional reconstruction.

For more information please follow this link or contact Dr. Takashi Ishikawa.

Cellular Imaging

LBR is very well equipped for the imaging of fixed and living eukaryotic cells. Our microscopes are mainly used to monitor subcellular localization of heterologously expressed proteins and to analyze cellular processes.

For more information please follow this link or contact Dr. Philipp Berger.