Laboratory of Nanoscale Biology (LNB)
The Laboratory of Nanoscale Biology (LNB) investigates the molecular structure and dynamics of complex molecular machines and cascades in the context of the living cell. Current strengths of LNB include technology innovation and the uncovering of structure-function relationships in specific biological contexts. Using our distinct expertise, we engage in the development and improvement of novel methods for electron microscopy and diffraction. In addition, we have unique capabilities in protein bioengineering, (bio-)microfabrication and correlative imaging methods. LNB’s scientific strengths are to link structural information to functional contexts at length scales ranging from proteins to single cells to tissue. Typical examples include it situ studies on eukaryotic cilia proteins in their natural context, studies of protein aggregation or chromatin structure in the context of cell function as well as computation of connectome maps of the brain based on bio-imaging data to reveal new insights into brain function.
>>> LNB Mission and Organization
>>> Research and Technology Innovation
LNB News and Scientific Highlights
Imaging biomarkers for Alzheimer’s disease
Artificial intelligence pinpoints cells indicative of Alzheimer’s disease based on DNA packing in mouse brain images, shows study in Nature Communications
Automated synapse-level reconstruction of neural circuits in the larval zebrafish brain
Researchers from the Max Planck Institute for Biological Intelligence, Google Inc. and the Paul Scherrer Institute published a new method and data resource that makes connectomic analyses of the entire larval zebrafish brain possible.
L’Institut Paul Scherrer et Apollo Health Ventures lancent Focal Biosciences
La nouvelle société Focal Biosciences va s’attacher à réunir des expertes et experts de premier plan et des découvertes scientifiques afin d’exploiter la reprogrammation cellulaire au profit de la lutte contre les maladies courantes liées à l’âge.