Aller au contenu principal
  • Paul Scherrer Institut PSI
  • PSI Research, Labs & User Services

Digital User Office

  • Digital User Office
  • DE
  • EN
  • FR
Paul Scherrer Institut (PSI)
Rechercher
Paul Scherrer Institut (PSI)

Hauptnavigation

  • Research at PSIOuvrir ce point de menu principal
    • Research Initiatives
    • Ethics and Research integrity
    • Scientific Highlights
    • Scientific Events
    • Scientific Career
    • PSI-FELLOW
    • PSI Data Policy
  • Research Divisions and LabsOuvrir ce point de menu principal
    • Overview
    • Research with Neutrons and Muons
    • Photon Science
    • Energy and Environment
    • Nuclear Energy and Safety
    • Biology and Chemistry
    • Scientific Computing, Theory and Data
    • Large Research Facilities
  • Facilities and InstrumentsOuvrir ce point de menu principal
    • Overview
    • Large Research Facilities
    • Facilities
    • PSI Facility Newsletter
  • PSI User ServicesOuvrir ce point de menu principal
    • User Office
    • Methods at the PSI User Facilities
    • Proposals for beam time
    • Proposal Deadlines
    • Data Analysis Service (PSD)
    • EU support programmes
  • New ProjectsOuvrir ce point de menu principal
    • SLS 2.0
    • IMPACT
  • DE
  • EN
  • FR

Digital User Office (mobile)

  • Digital User Office

Vous êtes ici:

  1. PSI Home
  2. Labs & User Services
  3. BIO
  4. LNB
  5. Research and Technology Innovation
  6. Nanodiffraction

Navigation secondaire

Laboratory of Nanoscale Biology

  • About LNB
  • Research and Technology Innovation Sous-menu élargi
    • Electron diffraction of biological specimens
    • EM&D Group, Electron Microscopy Facility
    • Cellular structural biology and imaging
    • Structural Neurobiology
    • Mechano-Genomics
    • Cellular Engineering and Microscopy
    • Biointerfaces: Enabling Technology for Bio-Research
    • Ultrasound Mechanobiology
  • Knowledge Transfer and Education
  • Facilities
  • Scientific Highlights
  • Publications
  • People
  • Emeriti / Alumni

Info message

Ce contenu n'est pas disponible en français.

Electron diffraction of biological specimens

We develop novel methods for visualizing life at atomic resolution using electron diffraction and coherent electron diffractive imaging

single molecule electron-diffraction
Collection of electron diffraction patterns of molecules in random orientations.

To comprehend how matter creates life requires visualising the living cell in atomic detail. To this aim, we develop novel technologies that are based on electron diffraction of frozen, hydrated biological samples. We have demonstrated (using biological and organic nano-crystals) that electron diffraction data can in principle unlock high-resolution information way beyond what conventional electron microscopy can deliver, and that this also applies to other biological samples. To exploit this novel approach in the study of cellular processes, we scan samples with a coherent beam with a diameter down to several nanometers, and measure the diffracted electrons using modern hybrid pixel detectors as developed by PSI’s detector group. For phasing of these data, we develop a range of methods that combine experimental and computational approaches. We apply our research to the study of the molecular response to mitochondrial stress central to neuro-degeneration and aging.

Structure determination from electron diffraction data
Structure determination from single molecule electron diffraction data: 2D experimental diffraction patterns are analysed and aligned into a 3D diffraction pattern. The 3D structure is reconstructed by iterative phase retrieval.

 

For more information please contact:

Jan Pieter Abrahams 
Group leader
Physics of electron diffraction by living matter; mitochondrial stress

Tatiana Latychevskaia
Scientist
Decoding electron diffraction data

Eric van Genderen
Scientist
Optimal electron diffraction of living matter

Jinghui Luo
Associated Scientist (Structural Biology of Neuronal Systems) 

Sidebar

For more information please contact:

Jan Pieter Abrahams 
Group leader
Physics of electron diffraction by living matter; mitochondrial stress

Tatiana Latychevskaia
Scientist
Decoding electron diffraction data

Eric van Genderen
Scientist
Optimal electron diffraction of living matter

top

Pied de page

Paul Scherrer Institut

Forschungsstrasse 111
5232 Villigen PSI
Suisse

Téléphone: +41 56 310 21 11
Téléfax: +41 56 310 21 99

Comment nous trouver 
Contact

Centre de visiteurs psi forum
Laboratoire élèves iLab (en allemand)
Centre de protonthérapie
Centre de Formation du PSI
PSI Guest House (en anglais)
PSI Gastronomie (en allemand)
psi forum shop

Service & Support

  • Annuaire
  • User Office
  • Accelerator Status
  • Publications du PSI
  • Fournisseurs
  • E-facture
  • Computing (en anglais)
  • Sicherheit (en allemand)

Carrière

  • Travailler au PSI
  • Offres d'emploi
  • Formation initiale et formation continue
  • Career Center
  • Formation professionnelle (en allemand)
  • Centre de Formation du PSI

Pour les médias

  • Le PSI en bref
  • Chiffres et faits
  • Le coin médias
  • Communiqués de presse
  • Réseaux sociaux

Suivez le PSI: Twitter (in English) LinkedIn Youtube Facebook Instagram Issuu RSS

Footer legal

  • Impressum
  • Conditions d'utilisation
  • Login éditeurs