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Laboratory of Nanoscale Biology

  • About LNB
  • Research and Technology Innovation
    • Electron diffraction of biological specimens
    • EM&D Group, Electron Microscopy Facility
    • Cellular structural biology and imaging
    • Structural Neurobiology
    • Mechano-Genomics
    • Cellular Engineering and Microscopy
    • Biointerfaces: Enabling Technology for Bio-Research
    • Ultrasound Mechanobiology
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LNB science technology innovation
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About the Laboratory of Nanoscale Biology

The mission of LNB is to develop cellular structural biology and multi-scale bioimaging programs, complementing the efforts of the sister Labs in the Bio Division, LBR and CRS, which focus on molecular-scale structure-function relationships and on the synthesis of novel radionuclides for cancer therapy models, respecitvely. LNB’s core research programs are also highly integrated with the large-scale facilities at PSI for technology innovation and the bioimaging programs. Together with the newly initiated Scientific Computing Division at PSI, LNB is positioned very well to provide an integrated theme of cellular structure-function relationships driven by theory and data science.

The research groups of LNB are organized into three themes.

Theme-1 consolidates our efforts in Electron Microscopy and Diffraction with a particular focus on methods development.

Theme-2, Cellular Structural Biology & Multi-scale Bioimaging, focuses on in situ Structural Biology with a focus on Cilia, Membrane-protein complexes and Protein aggregation. This theme was recently strengthened through an ERC funded group focusing on Multi-scale Bioimaging to link nanoscale synaptic junctions to the connectome map of the brain.

Theme-3, Mechano-Genomics, is a new theme to LNB. The major focus of this topic is to understand how nanoscale extracellular microenvironmental signals regulate genome programs and cell behavior in health and disease. A targeted recruitment in Computational Biology is currently planned to strengthen this theme.

LNB organization

Theme-I: Electron Microscopy & Diffraction

Nano-Diffraction Group

  • Group Leader: Jan Pieter Abrahams
  • Scientist: Tatiana Latychevskaia
  • Engineer: Eric van Genderen
  • Associated Scientist: Jinghui Luo

Electron Microscopy & Diffraction Group, Electron Microscopy Facility of PSI

  • Group Leader: Elisabeth Müller
  • Scientist: Emiliya Poghosyan

Theme-II: Cellular Structural Biology & Multi-scale Bioimaging

Cellular Structural Biology Group

  • Group Leader: Takashi Ishikawa
  • Scientist: Roger Benoit

Structural Neurobiology Group

  • Group Leader: Adrian Wanner

Structural Biology of Neuronal Systems

  • Scientist: Jinghui Luo

Theme-III: Mechano-Genomics & Computational Biology

Mechano-Genomics Group

  • Group Leader and Head of LNB: G.V. Shivashankar

Computational Biology Group (to be established)

Associated scientists

  • Philipp Berger (Cellular engineering and microscopy)
  • Celestino Padeste (Biointerfaces, supports for protein crystallography)
  • Soichiro Tsujino (Ultrasound mechanobiology)

 

>>> LNB Research and Technology Innovation

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Contact

G.V. Shivashankar
Professor of Mechano-Genomics
Department of Health Sciences and Technology, ETH Zurich
& Paul Scherrer Institute, Switzerland

Head of the Laboratory
of Nanoscale Biology

Paul Scherrer Institute
Laboratory of Nanoscale Biology
OFLC/107
Forschungsstrasse 111
CH-5232 Villigen PSI
Switzerland

gshivasha@ethz.ch
gv.shivashankar@psi.ch


Secretariat

Anita Strittmatter
Secretary

Paul Scherrer Institut
Division of Biology and Chemistry
OFLC/108
Forschungsstrasse 111
CH-5232 Villigen PSI
Switzerland

Phone: +41 56 310 20 35
Fax: +41 56 310 21 99
anita.strittmatter@psi.ch

BIO Open positions

Current openings in the Division of Biology and Chemistry


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Téléphone: +41 56 310 21 11
Téléfax: +41 56 310 21 99

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