Medicine
"We want to understand how this virus works"
The Swiss Light Source SLS at PSI is still in operation despite the Covid-19 pandemic – and may be urgently needed, especially in these difficult times. Oliver Bunk, head of the Laboratory for Macromolecules and Bioimaging, explains why.
"Strategy and networking are enormously important"
Gebhard Schertler, head of the Biology and Chemistry Division at PSI and professor of structural biology at ETH Zurich, explains what research is being done on the coronavirus at PSI and why collaboration with researchers from other institutions plays such an important role in this.
Brilliant medicines
In the service of health, scientists at the Paul Scherrer Institute PSI work with radionuclides and develop agents to treat cancer and to detect tumours. Their research provides support to hospitals and is of great interest to Swiss industry.
Open fire on tumours
At the treatment stations of the Centre for Proton Therapy at PSI, tumours can be precisely irradiated from any direction. An interactive graphic explains how the protons get from the source to the body in order to trigger the elimination of tumour tissue.
"It's important to keep doing research"
Proton therapy is time-consuming and more costly than conventional radiation therapy, but its accuracy in targeting tumours is unsurpassed. An interview with Damien Weber, head of the Centre for Proton Therapy at PSI.
Cancer cells under attack
At PSI, cancer patients receive a therapy that is unique in Switzerland. Bombardment with protons wipes out cancer cells – and does so more precisely than with any other form of irradiation.
Preventing tumour metastasis
Researchers at the Paul Scherrer Institute PSI, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step towards the development of an active substance against the metastasis of certain cancers. Using the Swiss Light Source SLS, they deciphered the structure of a receptor that plays a crucial role in the migration of cancer cells.
Molecular scissors stabilise the cell's cytoskeleton
Researchers at the Paul Scherrer Institute PSI have an important part of the regulatory cycle that is involved in the formation and degradation of the cytoskeleton. Among other things, they have watched molecular scissors at work.
Bringing information into the cell
Researchers at the Paul Scherrer Institute PSI have elucidated an important part of a siganalling pathway that transmits information through the cell membrane into the interior of a cell. This exists in all mammals and plays an important role, among other things, in the regulation of the heartbeat. The new findings could lead to new therapies.
Children are her passion
At PSI, Beate Timmermann built up a programme providing proton therapy for children with cancer at the same time she was raising her own son. Today she is head of the Clinic for Particle Therapy at the West German Proton Therapy Centre in Essen (WPE) and is considered one of the most accomplished experts in this field.
Licence agreement with Swiss pharma firm for development of a cancer drug
A radioactive agent, developed at the Paul Scherrer Institute PSI to fight an especially malignant form of thyroid cancer, has the potential to become a blockbuster drug. Due to its structure, it might also be able to dock onto cells of other tumours and destroy them with its radiation. The Lausanne-based biopharmaceutical company Debiopharm wants to further develop the PSI agent to the point where it is approved as a drug. Debiopharm and PSI have now created the contractual basis for this.
A biotechnological revolution
Gebhard Schertler is head of the research division Biology and Chemistry at the Paul Scherrer Institute PSI and professor for Structural Biology at ETH Zurich. In this interview he talks about biological research at PSI and the future of drug development.
Light for biomolecules and super-fast processes
The 16th of May is the International Day of Light. The research carried out with light at PSI enables advances in biology and pharmacology and also promotes the development of new materials for data storage and new technologies for personalised medicine.
Opening: Advanced technology against cancer
With proton therapy, certain tumours can be irradiated with exceptional precision – while, the surrounding healthy tissue is optimally protected. In Switzerland, this kind of radiation therapy is only possible at PSI. In a joint project with the University Hospital Zurich and the University of Zurich, PSI has expanded its capacity with a state-of-the-art treatment facility: the new, 270-ton Gantry 3.
Testing the Limits for the Patients' Benefit
Proton therapy is already a success story at the Paul Scherrer Institute PSI but researchers remain dedicated to making treatment faster and safer.
Big help for small children
When small children develop cancer, the whole family is affected. Staff at the Paul Scherrer Institute PSI’s Centre for Proton Therapy combine target-oriented proton beam irradiation and a caring, warm-hearted atmosphere to help these children.
Getting a Handle on Safety
Proton beams don’t just cure cancer. They can also damage healthy tissue. To make sure that this doesn’t happen, PSI’s Centre for Proton Therapy carries out over 350 safety tests a year. The results speak for themselves: several thousand patients have undergone proton irradiation treatment here in Villigen. There’s never been an accident.
Rays of hope for patients
For over 30 years, patients with a particular form of ocular tumour have been treated at PSI by means of proton irradiation. The tiny particles hit their target with millimetre precision, without endangering other structures of the eye. The irradiation facility OPTIS, developed at the PSI Center for Proton Therapy of the PSI, is a success story, considering that for more than 90 percent of the patients treated to date, the eye could be saved.
In start-up companies, getting it done is a matter of survival
A pharmaceuticals manager at Roche for a long time, now he is the founder of a biotech firm on the campus of the Paul Scherrer Institute PSI: Michael Hennig knows the trends in the medical sector. In this interview he explains why the medicine of the future needs the innovation power of publicly funded research, and why he chose to locate his start-up leadXpro so close to PSI.
In cold water
Martin Ostermaier wanted to break out of the comfort zone of science. Now, instead of pipettes, the biochemist is dealing with investors and patent law.