Dr. Jinghui Luo

Scientist
Paul Scherrer Institute
Forschungsstrasse 111
5232 Villigen PSI
Suisse
Forschungsstrasse 111
5232 Villigen PSI
Suisse
Téléphone
Courriel
Research interests
1. Structural and biophysical characterization of amyloid proteins
2. Single-channel electrical and optical studies of ion channel, amyloid and other membrane proteins in the lipid bilayer
2. Single-channel electrical and optical studies of ion channel, amyloid and other membrane proteins in the lipid bilayer
Short CV
2017.07-now: Principal Investigator, Paul Scherrer Institute, Switzerland
2014.12-2017.06: Research Fellow, Oxford University, UK
2014.06: PhD, Leiden University, the Netherlands
2009.06-2009.12: Traineeship, EMBL, Germany
2009.06: MSc, Uppsala University, Sweden
2014.12-2017.06: Research Fellow, Oxford University, UK
2014.06: PhD, Leiden University, the Netherlands
2009.06-2009.12: Traineeship, EMBL, Germany
2009.06: MSc, Uppsala University, Sweden
Publications
2019
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Nuclear Pore Membrane Proteins Self-Assemble into Nanopores
BIOCHEMISTRY 58, 484 (2019).DOI: 10.1021/acs.biochem.8b01179
2018
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Membrane-mimetic systems for biophysical studies of the amyloid-? peptide
BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS AND PROTEOMICS , S1570963918302036 (2018).DOI: 10.1016/j.bbapap.2018.11.005
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The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-? (A?) Peptide at the Oligomeric Stage
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140, 8138 (2018).DOI: 10.1021/jacs.7b13623
2017
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Alzheimer?s disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-? peptide aggregation
Scientific Reports 7, 14423 (2017).DOI: 10.1038/s41598-017-13759-5
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Maleimido-proxyl as an EPR spin label for the evaluation of conformational changes of albumin
European Biophysics Journal 46, 773 (2017).DOI: 10.1007/s00249-017-1257-z
2016
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Characterization of Mn(II) ion binding to the amyloid-? peptide in Alzheimer?s disease
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY , (2016).DOI: 10.1016/j.jtemb.2016.03.009
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Coupled commensurate charge density wave and lattice distortion in Na2Ti2Pn2O(Pn=As,Sb) determined by x-ray diffraction and angle-resolved photoemission spectroscopy
PHYSICAL REVIEW B 94, 104515 (2016).DOI: 10.1103/PhysRevB.94.104515
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Cross-interactions between the Alzheimer Disease Amyloid-? Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis
JOURNAL OF BIOLOGICAL CHEMISTRY 291, 16485 (2016).DOI: 10.1074/jbc.R116.714576
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Non-covalent S?O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation
CHEMICAL SCIENCE 7, 6435 (2016).DOI: 10.1039/C6SC00756B
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Reciprocal Molecular Interactions between the A? Peptide Linked to Alzheimer?s Disease and Insulin Linked to Diabetes Mellitus Type II
ACS Chemical Neuroscience 7, 269 (2016).DOI: 10.1021/acschemneuro.5b00325
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Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species
Journal of Alzheimer's Disease 54, 971 (2016).DOI: 10.3233/JAD-160427
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The Amyloid-? Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions
ISRAEL JOURNAL OF CHEMISTRY 57, 674 (2016).DOI: 10.1002/ijch.201600105
2014
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Alzheimer Peptides Aggregate into Transient Nanoglobules That Nucleate Fibrils
BIOCHEMISTRY 53, 6302 (2014).DOI: 10.1021/bi5003579
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ChemInform Abstract: Cyclic Peptides as Inhibitors of Amyloid Fibrillation
ChemInform 45, no (2014).DOI: 10.1002/chin.201422265
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Cyclic Peptides as Inhibitors of Amyloid Fibrillation
CHEMISTRY - A EUROPEAN JOURNAL 20, 2410 (2014).DOI: 10.1002/chem.201304253
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Endogenous Polyamines Reduce the Toxicity of Soluble A? Peptide Aggregates Associated with Alzheimer?s Disease
BIOMACROMOLECULES 15, 1985 (2014).DOI: 10.1021/bm401874j
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Non-chaperone Proteins Can Inhibit Aggregation and Cytotoxicity of Alzheimer Amyloid ? Peptide
JOURNAL OF BIOLOGICAL CHEMISTRY 289, 27766 (2014).DOI: 10.1074/jbc.M114.574947
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The A- peptide forms non-amyloid fibrils in the presence of carbon nanotubes
NANOSCALE 6, 6720 (2014).DOI: 10.1039/c4nr00291a
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The hairpin conformation of the amyloid ? peptide is an important structural motif along the aggregation pathway
JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19, 623 (2014).DOI: 10.1007/s00775-014-1131-8
2013
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An efficient nanolitre-volume multi-channel device for highly viscous materials used in membrane protein crystallization
JOURNAL OF APPLIED CRYSTALLOGRAPHY 46, 829 (2013).DOI: 10.1107/S0021889813006742
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Biophysical Studies of the Amyloid ?-Peptide: Interactions with Metal Ions and Small Molecules
CHEMBIOCHEM 14, 1692 (2013).DOI: 10.1002/cbic.201300262
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Cellular Polyamines Promote Amyloid-Beta (A?) Peptide Fibrillation and Modulate the Aggregation Pathways
ACS Chemical Neuroscience 4, 454 (2013).DOI: 10.1021/cn300170x
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Exploiting preQ 1 Riboswitches To Regulate Ribosomal Frameshifting
ACS CHEMICAL BIOLOGY 8, 733 (2013).DOI: 10.1021/cb300629b
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Human lysozyme inhibits the in vitro aggregation of A? peptides, which in vivo are associated with Alzheimer's disease
CHEMICAL COMMUNICATIONS 49, 6507 (2013).DOI: 10.1039/c3cc42325e
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Inhibiting and Reversing Amyloid-? Peptide (1-40) Fibril Formation with Gramicidin S and Engineered Analogues
CHEMISTRY - A EUROPEAN JOURNAL 19, 17338 (2013).DOI: 10.1002/chem.201301535
2012
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Catalytic promiscuity in Pseudomonas aeruginosa arylsulfatase as an example of chemistry-driven protein evolution
FEBS LETTERS 586, 1622 (2012).DOI: 10.1016/j.febslet.2012.04.012
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Conformation Effects of CpG Methylation on Single-Stranded DNA Oligonucleotides: Analysis of the Opioid Peptide Dynorphin-Coding Sequences
PLOS ONE 7, e39605 (2012).DOI: 10.1371/journal.pone.0039605
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Examining the promiscuous phosphatase activity of Pseudomonas aeruginosa arylsulfatase: A comparison to analogous phosphatases
PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS 80, 1211 (2012).DOI: 10.1002/prot.24020
2011
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A Straightforward and Robust Method for Introducing Human Hair as a Nucleant into High Throughput Crystallization Trials
CRYSTAL GROWTH & DESIGN 11, 1170 (2011).DOI: 10.1021/cg101374r
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Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2
JOURNAL OF PEPTIDE SCIENCE 17, 756 (2011).DOI: 10.1002/psc.1399
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Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): A combined experimental and theoretical study
JOURNAL OF INORGANIC BIOCHEMISTRY 105, 1422 (2011).DOI: 10.1016/j.jinorgbio.2011.07.003
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Ribonucleotide reductase inhibition by p-alkoxyphenols studied by molecular docking and molecular dynamics simulations
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 516, 29 (2011).DOI: 10.1016/j.abb.2011.09.003
2010
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In Silico Analysis of the Apolipoprotein E and the Amyloid ? Peptide Interaction: Misfolding Induced by Frustration of the Salt Bridge Network
PLOS COMPUTATIONAL BIOLOGY 6, e1000663 (2010).DOI: 10.1371/journal.pcbi.1000663
Group Members
Jinming Wu
Ph.D. Student
Hongzhi Wang
Ph.D. Student
Former Group Members
Hegne Pupart (2018 Summer Intern)